Homo sapiens (human): 4314
Help
Entry
4314 CDS
T01001
Symbol
MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1
Name
(RefSeq) matrix metallopeptidase 3
KO
K01394
matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:
3.4.24.17
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04657
IL-17 signaling pathway
hsa04668
TNF signaling pathway
hsa05171
Coronavirus disease - COVID-19
hsa05202
Transcriptional misregulation in cancer
hsa05215
Prostate cancer
hsa05323
Rheumatoid arthritis
hsa05417
Lipid and atherosclerosis
Network
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06240
Transcription (cancer)
nt06272
Prostate cancer
Element
N00128
TMPRSS2-ERG fusion to transcriptional activation
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Disease
H01742
Coronary artery disease
Drug target
Marimastat:
D03795
Prinomastat:
D03797
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
4314 (MMP3)
09150 Organismal Systems
09151 Immune system
04657 IL-17 signaling pathway
4314 (MMP3)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
4314 (MMP3)
09162 Cancer: specific types
05215 Prostate cancer
4314 (MMP3)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
4314 (MMP3)
09163 Immune disease
05323 Rheumatoid arthritis
4314 (MMP3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4314 (MMP3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
4314 (MMP3)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.17 stromelysin 1
4314 (MMP3)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M10
4314 (MMP3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_M10
Hemopexin
PG_binding_1
Astacin
DUF4953
Reprolysin_4
Reprolysin_3
Reprolysin_5
Reprolysin_2
Motif
Other DBs
NCBI-GeneID:
4314
NCBI-ProteinID:
NP_002413
OMIM:
185250
HGNC:
7173
Ensembl:
ENSG00000149968
UniProt:
P08254
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(102835801..102843609)
Genome browser
AA seq
477 aa
AA seq
DB search
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
NT seq
1434 nt
NT seq
+upstream
nt +downstream
nt
atgaagagtcttccaatcctactgttgctgtgcgtggcagtttgctcagcctatccattg
gatggagctgcaaggggtgaggacaccagcatgaaccttgttcagaaatatctagaaaac
tactacgacctcaaaaaagatgtgaaacagtttgttaggagaaaggacagtggtcctgtt
gttaaaaaaatccgagaaatgcagaagttccttggattggaggtgacggggaagctggac
tccgacactctggaggtgatgcgcaagcccaggtgtggagttcctgatgttggtcacttc
agaacctttcctggcatcccgaagtggaggaaaacccaccttacatacaggattgtgaat
tatacaccagatttgccaaaagatgctgttgattctgctgttgagaaagctctgaaagtc
tgggaagaggtgactccactcacattctccaggctgtatgaaggagaggctgatataatg
atctcttttgcagttagagaacatggagacttttacccttttgatggacctggaaatgtt
ttggcccatgcctatgcccctgggccagggattaatggagatgcccactttgatgatgat
gaacaatggacaaaggatacaacagggaccaatttatttctcgttgctgctcatgaaatt
ggccactccctgggtctctttcactcagccaacactgaagctttgatgtacccactctat
cactcactcacagacctgactcggttccgcctgtctcaagatgatataaatggcattcag
tccctctatggacctccccctgactcccctgagacccccctggtacccacggaacctgtc
cctccagaacctgggacgccagccaactgtgatcctgctttgtcctttgatgctgtcagc
actctgaggggagaaatcctgatctttaaagacaggcacttttggcgcaaatccctcagg
aagcttgaacctgaattgcatttgatctcttcattttggccatctcttccttcaggcgtg
gatgccgcatatgaagttactagcaaggacctcgttttcatttttaaaggaaatcaattc
tgggctatcagaggaaatgaggtacgagctggatacccaagaggcatccacaccctaggt
ttccctccaaccgtgaggaaaatcgatgcagccatttctgataaggaaaagaacaaaaca
tatttctttgtagaggacaaatactggagatttgatgagaagagaaattccatggagcca
ggctttcccaagcaaatagctgaagactttccagggattgactcaaagattgatgctgtt
tttgaagaatttgggttcttttatttctttactggatcttcacagttggagtttgaccca
aatgcaaagaaagtgacacacactttgaagagtaacagctggcttaattgttga
DBGET
integrated database retrieval system
