KEGG   DISEASE: 頭頸部扁平上皮癌
エントリ  
H02610                                                             
名称    
頭頸部扁平上皮癌
概要    
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, affecting the pharynx, larynx and oral cavity. It is well known that smoking and alcohol abuse are major risk factors for HNSCC. Additionally, human papillomavirus infection is another implicated risk factor. Although lifestyle factors account for the majority of HNSCCs, genetic alterations will cause some individuals to be more sensitive to these environmental factors.
カテゴリ  
がん
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍転移
    リンパ節での悪性腫瘍転移
     2D60  リンパ節の単一部位での悪性腫瘍転移
      H02610  頭頸部扁平上皮癌
パスウェイに基づく疾患分類 [BR:jp08402]
 細胞プロセス
  nt06524  アポトーシス
   H02610  頭頸部扁平上皮癌
  nt06527  ネクロトーシス
   H02610  頭頸部扁平上皮癌
パスウェイ 
hsa04210  Apoptosis
hsa04217  Necroptosis
ネットワーク
nt06524 Apoptosis
nt06527 Necroptosis
病因遺伝子 
TNFRSF10B [HSA:8795] [KO:K04722]
ING1 [HSA:3621] [KO:K19197]
リンク   
ICD-11: 2D60.0
MeSH: D000077195
OMIM: 275355
文献    
  著者
Li X, Kikuchi K, Takano Y
  タイトル
ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.
  雑誌
J Oncol 2011:963614 (2011)
DOI:10.1155/2011/963614
文献    
  著者
Tahir RA, Sehgal SA, Khattak NA, Khan Khattak JZ, Mir A
  タイトル
Tumor necrosis factor receptor superfamily 10B (TNFRSF10B): an insight from structure modeling to virtual screening for designing drug against head and neck  cancer.
  雑誌
Theor Biol Med Model 10:38 (2013)
DOI:10.1186/1742-4682-10-38
文献    
PMID:9721851 (TNFRSF10B)
  著者
Pai SI, Wu GS, Ozoren N, Wu L, Jen J, Sidransky D, El-Deiry WS
  タイトル
Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
  雑誌
Cancer Res 58:3513-8 (1998)
文献    
PMID:10866301 (ING1)
  著者
Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K
  タイトル
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
  雑誌
Cancer Res 60:3143-6 (2000)
LinkDB    

» English version

DBGET integrated database retrieval system