Oculomotor-abducens synkinesis (OCABSN) is the involuntary movement of the eyes or eyelids with a voluntary attempt at another eye or facial movement. It has been reported that mutations in ACKR3 cause this disease. The chemokine receptor CXCR4 and its ligand CXCL12 regulate oculomotor nerve development. ACKR3 encodes an atypical chemokine receptor that binds CXCL12 and functions as a scavenger receptor, regulating levels of CXCL12 available for CXCR4 signaling.
