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Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

Nat Immunol 25:764-777 (2024)
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Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

Genes Immun 8:416-21 (2007)
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