KEGG ORTHOLOGY: K20894

ORTHOLOGY: K20894

Entry

K20894                      KO

Symbol

SHARPIN

Name

shank-associated RH domain-interacting protein

Pathway

map04217

Necroptosis

map04621

NOD-like receptor signaling pathway

map05131

Shigellosis

Disease

H02826

Autoinflammation with episodic fever and immune dysregulation

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K20894  SHARPIN; shank-associated RH domain-interacting protein
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K20894  SHARPIN; shank-associated RH domain-interacting protein
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K20894  SHARPIN; shank-associated RH domain-interacting protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K20894  SHARPIN; shank-associated RH domain-interacting protein
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   LUBAC complex
    K20894  SHARPIN; shank-associated RH domain-interacting protein

Genes

HSA:	81858(SHARPIN)

PTR:

747207

PPS:	100996234(SHARPIN)

GGO:	101134847(SHARPIN)

PON:	100452103(SHARPIN)

PPYG:

129042179(SHARPIN)

NLE:	100589034(SHARPIN)

HMH:	116813688(SHARPIN)

SSYN:

129486924(SHARPIN)

MCC:	713534(SHARPIN)

MCF:	102115687(SHARPIN)

MTHB:

126960977

MNI:	105488486(SHARPIN)

CSAB:

103237608(SHARPIN)

CATY:

105581236

PANU:

101022832(SHARPIN)

TGE:

112629910

RRO:	104671684(SHARPIN)

RBB:	108536591(SHARPIN)

TFN:	117079303(SHARPIN)

PTEH:

111523544(SHARPIN)

CANG:

105508980(SHARPIN)

CJC:	100392136(SHARPIN)

SBQ:

101027416

CIMI:

108291319

ANAN:

105731521(SHARPIN)

CSYR:

103272504(SHARPIN)

MMUR:

105868859(SHARPIN)

LCAT:

123644872(SHARPIN)

PCOQ:

105813407(SHARPIN)

OGA:

100955509

MMU:	106025(Sharpin)

MCAL:

110310465

MPAH:

110334869(Sharpin)

RNO:

81859

MCOC:

116074589

ANU:

117718674

ASYL:

127667465(Sharpin)

MUN:	110562133(Sharpin)

CGE:	100765740(Sharpin)

MAUA:

101827548(Sharpin)

PROB:

127225693(Sharpin)

PLEU:

114694171(Sharpin)

PMAV:

MORG:

MFOT:

AAMP:

NGI:	103735263(Sharpin)

HGL:	101697173(Sharpin)

CPOC:

100713439

CCAN:

109690793

DORD:

106002166

DSP:	122098856(Sharpin)

DMER:

138806081 138829609

PLOP:

125360532(Sharpin)

NCAR:

124976424

MMMA:

107142814

ITI:	101978327(Sharpin)

OPI:	101524781(SHARPIN)

OCZ:

121163901

TUP:	102471523(SHARPIN)

GVR:	103589665(SHARPIN)

CFA:

475122

CLUD:

112662180(SHARPIN)

VVP:

112911143

VLG:

121498709

NPO:	129502530(SHARPIN)

AML:	100480605(SHARPIN)

UMR:	103656656(SHARPIN)

UAH:	113247618(SHARPIN)

UAR:	123779342(SHARPIN)

ELK:

111146543

LLV:

125097462

MPUF:

101673087

MNP:	132014385(SHARPIN)

MLK:	131826345(SHARPIN)

NVS:	122904228(SHARPIN)

ORO:	101364591(SHARPIN)

EJU:

114201082

ZCA:	113926238(SHARPIN)

MLX:	118015300(SHARPIN)

NSU:	110578998(SHARPIN)

LWW:	102742620(SHARPIN)

FCA:	101094481(SHARPIN)

PYU:	121043132(SHARPIN)

PCOO:

112859672

PBG:	122495922(SHARPIN)

PVIV:

125156047(SHARPIN)

LRUF:

124507881

LGF:	123586415(SHARPIN)

AJU:

106976796

PTG:	102967246(SHARPIN)

PPAD:

109258333(SHARPIN)

PUC:

125924312

PLEZ:

122210970(SHARPIN)

HHV:	120246504(SHARPIN)

BTA:

512499

BOM:

102275808

BIU:

109568382

BBUB:

102396688(SHARPIN)

BBIS:

CHX:

OAS:

BTAX:

CSUM:

ODA:	120878736(SHARPIN)

CCAD:

122451446(SHARPIN)

MREE:

136145159(SHARPIN)

OVR:	110131375(SHARPIN)

MBEZ:

129560231

SSC:	100526216(SHARPIN)

CFR:	102504367(SHARPIN)

CBAI:

105073808

CDK:	105105007(SHARPIN)

VPC:	102529253(SHARPIN) 116280467

BACU:

103003231(SHARPIN)

BMUS:

118883413(SHARPIN)

LVE:

103081711

OOR:	101284551(SHARPIN)

LALB:

132508218(SHARPIN)

GMF:	115863345(SHARPIN)

DDP:	132413344(SHARPIN)

DLE:	111165113(SHARPIN)

PCAD:

102988834(SHARPIN)

PSIU:

116742341(SHARPIN)

PPHC:

136137039

NASI:

112397063(SHARPIN)

ECB:	100065232(SHARPIN) 100071666

EPZ:	103560810(SHARPIN)

EAI:	106841903(SHARPIN)

MYB:	102262057(SHARPIN)

MYD:	102760604(SHARPIN)

MMYO:

118653079(SHARPIN)

MLF:	102422961(SHARPIN)

MDT:	132219845(SHARPIN)

MYUM:

138993338(SHARPIN)

PKL:	118710163(SHARPIN)

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

114514561(SHARPIN)

PHAS:

123832968

MMF:

118643331

PPAM:

129084405

HAI:	109375087(SHARPIN)

RFQ:	117033870(SHARPIN)

PALE:

102885744(SHARPIN)

PGIG:

120588812(SHARPIN)

PVP:

105302009

RAY:

107503469

MJV:

108410230

TOD:	119232192(SHARPIN)

SARA:

SFUM:

SETR:

TMU:

ETF:

DNM:

MDO:	100017663(SHARPIN)

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

OAA:	114811272(SHARPIN)

LSR:	110479466 110482412

DRE:

SRX:

SANH:

SGH:

CCAR:

109094266(sharpin)

CAUA:

113039534

CGIB:

128022178

PTET:

122332409(sharpin)

LROH:

127176400(sharpin)

GRF:	141343538(sharpin)

OMC:	131531614(sharpin)

PPRM:

120488943(sharpin)

RKG:	130099645(sharpin)

MAMB:

125250449(sharpin)

CIDE:

127503207

CERY:

137002503(sharpin)

MASI:

127442914

TROS:

130554361(sharpin)

TDW:	130418222(sharpin)

MANU:

129441511(sharpin)

PDAB:

135767222(sharpin)

IPU:

108267320

IFU:	128610405(sharpin)

PHYP:

113547213

SMEO:

124387815(sharpin)

TFD:	113650561(sharpin)

TVC:	132848987(sharpin)

CGAR:

128524524(sharpin)

NGRA:

132881251(sharpin)

TRN:	134311743(sharpin)

AMEX:

103036427(sharpin)

CMAO:

118825706(sharpin)

EEE:

113591280

CHAR:

105899151(sharpin)

SPIL:

134074224

ASAD:

121704039

TRU:	101070617(sharpin)

TFS:

130539507

TNG:	GSTEN00000957G001 GSTEN00002997G001 GSTEN00016208G001

LCO:

104931528

NCC:

104941173

TBEN:

117488298

CGOB:

115022100(sharpin)

PGEO:

117462095(sharpin)

GACU:

117558441

EMAC:

134866599

ELY:	117271817(sharpin)

EFO:

125901685

PLEP:

121951017(sharpin)

SLUC:

116046019

ECRA:

117954411(sharpin)

ESP:	116698668(sharpin)

PFLV:

114565708(sharpin)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130198381(sharpin)

CANA:

137804892(sharpin)

CVE:	137888371(sharpin)

MSAM:

119902032

SCHU:

122887395(sharpin)

CUD:

121520528

SPUL:

138611781(sharpin)

LMIX:

132979216

HTC:	141803813(sharpin)

ALAT:

119010745(sharpin)

ASTR:

137612018(sharpin)

MZE:	101481113(sharpin)

ONL:	100703491(sharpin)

OAU:

120434246

OLA:

101172531

OML:	112147459(sharpin)

XMA:	102238252(sharpin)

XCO:	114146400(sharpin)

XHE:	116721776(sharpin)

PRET:

103479660(sharpin)

PFOR:

103135797(sharpin)

PLAI:

106955451(sharpin)

PMEI:

106931006(sharpin)

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:	107383898(sharpin)

KMR:	108239662(sharpin)

ALIM:

106532591

NWH:	119414201(sharpin)

AOCE:

111568702

EJA:	138203009(sharpin)

BFRE:

138617266(sharpin)

MCEP:

125011312

POV:	109637830 109642246

SSEN:

122773429(sharpin)

SSOE:

131473003

HHIP:

117778885

HSP:

118117543

PPLT:

128454088(sharpin)

SMAU:

118310425

LCF:

108883400

SDU:	111231099(sharpin)

SLAL:

111661091

XGL:

120798672

HCQ:	109521350(sharpin)

SSCV:

125985300(sharpin)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140356575(sharpin)

MALB:

109957649(sharpin)

BSPL:

SJO:

SSCO:

TTY:

GMH:

SASA:

STRU:

115157152 115169623(sharpin)

OTW:	112226828 112247489

OMY:	110508618 110530450

OGO:

124041766

ONE:	115102982 115114861

OKI:	109872082 109874667

OKE:	118394778 118401989

OMM:	135512841 135558807

OCLA:

139376153

SALP:

111957187 111979501

SNH:	120020292 120055955

SFON:

129824127

CCLU:

121534445 121581527

ELS:	105019274(sharpin)

OEP:

AANG:

AROT:

CCOG:

RTP:

Reference

PMID:20179993

Authors

Jung J, Kim JM, Park B, Cheon Y, Lee B, Choo SH, Koh SS, Lee S

Title

Newly identified tumor-associated role of human Sharpin.

Journal

Mol Cell Biochem 340:161-7 (2010)
DOI:10.1007/s11010-010-0413-x

Sequence

[hsa:81858]

LinkDB

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