KEGG   ORTHOLOGY: K00066
Entry
K00066                      KO                                     
Symbol
algD
Name
GDP-mannose 6-dehydrogenase [EC:1.1.1.132]
Pathway
map00051  Fructose and mannose metabolism
map00520  Amino sugar and nucleotide sugar metabolism
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
map02020  Two-component system
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    K00066  algD; GDP-mannose 6-dehydrogenase
   00520 Amino sugar and nucleotide sugar metabolism
    K00066  algD; GDP-mannose 6-dehydrogenase
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K00066  algD; GDP-mannose 6-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.132  GDP-mannose 6-dehydrogenase
     K00066  algD; GDP-mannose 6-dehydrogenase
Other DBs
RN: R00880
GO: 0047919
Genes
LARE: HIV01_005960
PAE: PA3540(algD)
PAEV: N297_3663(algD)
PAEI: N296_3663(algD)
PAU: PA14_18580(algD)
PAP: PSPA7_1605(algD)
PAG: PLES_14931(algD)
PAF: PAM18_1446(algD)
PNC: NCGM2_4665(algD)
PAEB: NCGM1900_2744(algD)
PAEP: PA1S_07720
PAEM: U769_07195
PAEL: T223_07435
PAEU: BN889_03910(algD)
PAEG: AI22_26185
PAEC: M802_3660(algD)
PAEO: M801_3528(algD)
PMK: MDS_1082
PRE: PCA10_11880(algD) PCA10_38230(algD)
PCQ: PcP3B5_50680(algD)
PPU: PP_1288(algD)
PPF: Pput_4437
PPT: PPS_4403
PPI: YSA_03091
PPX: T1E_3168(algD)
PPUH: B479_22150
PPUT: L483_27235
PPUN: PP4_08000(algD)
PPUD: DW66_4794
PMON: X969_21685
PMOT: X970_21320
PST: PSPTO_1243(algD)
PSB: Psyr_1063
PSYR: N018_20355
PSP: PSPPH_1118(algD)
PVD: CFBP1590__4277(algD)
PFL: PFL_1024(algD)
PPRC: PFLCHA0_c10440(algD)
PPRO: PPC_1062
PFO: Pfl01_0960(algD)
PFS: PFLU_0990(algD)
PFC: PflA506_0970(algD)
PFB: VO64_4071
PMAN: OU5_2447
PFW: PF1751_v1c09480(algD)
PEN: PSEEN3453(algD-2) PSEEN4535(algD)
PPUU: PputUW4_04471(algD)
PKC: PKB_0968(algD)
PSES: PSCI_0721
PSEM: TO66_05210
PSEC: CCOS191_0912(algD1) CCOS191_2029(algD2)
PSOS: POS17_1030
PANR: A7J50_0992
PSIL: PMA3_24585
PKH: JLK41_05220(algD)
PSEP: C4K39_1041
PWZ: J7655_04690(algD)
PTW: TUM18999_50120(algD)
AVN: Avin_10970(algD)
AVL: AvCA_10970(algD)
AVD: AvCA6_10970(algD)
ACX: Achr_31180(algD)
PAT: Patl_1531
ABO: ABO_0384(algD)
TAU: Tola_1407
SVA: SVA_1550
PLG: NCTC10937_04283(algD)
RFR: Rfer_0673
JAG: GJA_3986(algD)
EBA: ebA4268(algD)
AZO: azo3269(algD)
AOA: dqs_3408
NIS: NIS_0191
DVE: DESUT3_23450(algD)
DTO: TOL2_C36540(algD)
BJA: blr6296(blr6296)
BRA: BRADO7047
BRS: S23_62720
BARH: WN72_18950
MNO: Mnod_5882
BID: Bind_3885
MMED: Mame_02304(algD)
RBM: TEF_19885
DSH: Dshi_1896(algD)
MALG: MALG_02776
NAR: Saro_3220
SPHI: TS85_22025
SSAN: NX02_04640
SECH: B18_00665
ERF: FIU90_00265(algD)
HTQ: FRZ44_03090(algD)
HADH: FRZ61_03380(algD)
BMX: BMS_2990
MSM: MSMEG_5957(algD)
MVA: Mvan_1699
MTY: MTOK_31270(algD)
MSAR: MSAR_24600(algD)
MANY: MANY_49000(algD)
MPOF: MPOR_19690
ROP: ROP_57960(algD)
SCO: SCO0382(SCF62.08)
SHY: SHJG_7006
SBH: SBI_09543
SVE: SVEN_7199
SALU: DC74_1121
SALL: SAZ_06100
SLV: SLIV_36030(algD)
STRE: GZL_08291
SLD: T261_7968
SPRI: SPRI_2000
SNR: SNOUR_37270(algD)
STRD: NI25_00640
SALF: SMD44_08071(algD)
SFK: KY5_0166c
SGE: DWG14_01282(algD_2)
SHUN: DWB77_00748(algD)
SCYG: S1361_04630(algD)
ACH: Achl_2940
NDK: I601_0111(algD)
SRO: Sros_0655
BSD: BLASA_0423(algD)
AMD: AMED_0547(algD)
AMN: RAM_02805
AMM: AMES_0545(algD)
AMZ: B737_0546(algD)
AOI: AORI_0554(algD)
AJA: AJAP_36870(algD)
AMQ: AMETH_0542(ugd)
AMYY: YIM_21485(algD)
AORI: SD37_38440
PDX: Psed_1848
NSH: GXM_00034
CTHE: Chro_0719
STI: Sthe_1134
AHEL: Q31a_57060(algD)
MRI: Mal4_03640(algD)
SDYN: Mal52_06430(algD)
FTJ: FTUN_5650
SUS: Acid_0553
ZGA: ZOBELLIA_1984(algD)
CACI: CLOAM0663
NMV: NITMOv2_2630(algD)
 » show all
Reference
  Authors
Snook CF, Tipton PA, Beamer LJ
  Title
Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa.
  Journal
Biochemistry 42:4658-68 (2003)
DOI:10.1021/bi027328k
Reference
PMID:3108855
  Authors
Deretic V, Gill JF, Chakrabarty AM
  Title
Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene.
  Journal
Nucleic Acids Res 15:4567-81 (1987)
DOI:10.1093/nar/15.11.4567
  Sequence
[pae:PA3540]
LinkDB

KEGG   ENZYME: 1.1.1.132
Entry
EC 1.1.1.132                Enzyme                                 
Name
GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-D-mannose:NAD+ 6-oxidoreductase
Reaction(IUBMB)
GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]
Reaction(KEGG)
R00880
Substrate
GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.
History
EC 1.1.1.132 created 1972
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K00066  GDP-mannose 6-dehydrogenase
Genes
LAREHIV01_005960
PAEPA3540(algD)
PAEVN297_3663(algD)
PAEIN296_3663(algD)
PAUPA14_18580(algD)
PAPPSPA7_1605(algD)
PAGPLES_14931(algD)
PAFPAM18_1446(algD)
PNCNCGM2_4665(algD)
PAEBNCGM1900_2744(algD)
PDKPADK2_06665
PSGG655_07100
PRPM062_18755
PAEPPA1S_07720
PAERPA1R_gp1358
PAEMU769_07195
PAELT223_07435
PAESSCV20265_1523
PAEUBN889_03910(algD)
PAEGAI22_26185
PAECM802_3660(algD)
PAEOM801_3528(algD)
PMYPmen_1031 Pmen_1678
PMKMDS_1082
PREPCA10_11880(algD) PCA10_38230(algD)
PFUWKF707C_11170
PALCA0T30_11805
PCQPcP3B5_50680(algD)
PMUIG4G71_08975
PPUPP_1288(algD)
PPFPput_4437
PPGPputGB1_4561
PPWPputW619_0889
PPTPPS_4403
PPBPPUBIRD1_4273
PPIYSA_03091
PPXT1E_3168(algD)
PPUHB479_22150
PPUTL483_27235
PPUNPP4_08000(algD)
PPUDDW66_4794
PFVPsefu_3880
PMONX969_21685
PMOTX970_21320
PMOSO165_013045 O165_018560
PPJRK21_00119
PMOLCLJ08_08380 CLJ08_22925
PSTPSPTO_1243(algD)
PSBPsyr_1063
PSYRN018_20355
PSPPSPPH_1118(algD)
PSAVPSA3335_09095
PAMGBKM19_008085
PCIPCH70_10130
PAVLBKM03_07020
PVDCFBP1590__4277(algD)
PCABJGS08_19525
PFLPFL_1024(algD)
PPRCPFLCHA0_c10440(algD)
PPROPPC_1062
PFEPSF113_4752
PFNHZ99_11915
PFOPfl01_0960(algD)
PFSPFLU_0990(algD)
PFCPflA506_0970(algD)
PPZH045_01690
PFBVO64_4071
PMANOU5_2447
PTVAA957_09045
PCGAXG94_09975
PVRPverR02_05230
PAZOAYR47_12230
POIBOP93_04735
PRXHRH33_05805
PFWPF1751_v1c09480(algD)
PFFPFLUOLIPICF703390
PFXA7318_04290
PENPSEEN3453(algD-2) PSEEN4535(algD)
PBAPSEBR_a4590
PBCCD58_24305
PPUUPputUW4_04471(algD)
PDRH681_19425
PSVPVLB_04235 PVLB_15470
PSKU771_06125
PKCPKB_0968(algD)
PCHEY04_04520
PCZPCL1606_50710
PCPJM49_25125
PFZAV641_18510
PLQAA042_15150
PALKPSAKL28_08740 PSAKL28_31810
PPVNJ69_13830
PSESPSCI_0721
PSEMTO66_05210
PSECCCOS191_0912(algD1) CCOS191_2029(algD2)
PPSYAOC04_15730
PSOSPOS17_1030
PKRAYO71_07540
PFKPFAS1_06330
PANRA7J50_0992
PSETTHL1_1268 THL1_3804
PSILPMA3_24585
PYMAK972_0838
PKEDLD99_05160
PALLUYA_04885 UYA_15320
PUMHGP31_04975
POJPtoMrB4_26000(algD) PtoMrB4_46190
PGGFX982_00687
PGYAWU82_19080 AWU82_29005
PLALFXN65_05555
PSEJHNQ25_10170 HNQ25_19280
PVKEPZ47_24330
PEZHWQ56_05050
PBZGN234_24015
PKHJLK41_05220(algD)
PTYJWV26_01370 JWV26_15965(algD)
PATAJWU58_22750
PDWBV82_3321 BV82_4690
PZEHU754_006270
PMOEHV782_005850
PCAMHNE05_07125
PSEPC4K39_1041
PVWHU752_027430
PTRTHU722_0006165
PXAKSS93_07790
PSAMHU731_021005
PTZHU718_005910
PQIKH389_10480 KH389_22245
PSHHHU773_022835
PXNHU772_004420 HU772_009430
PHVHU739_012710
PPRGHU725_004085 HU725_014400
PANHHU763_020330
PASGKSS96_05695
PFAKKSS94_04615
PMUYKSS95_07475 KSS95_11760
PMAMKSS90_04835 KSS90_09905
PAZEKSS91_23845
PALVKSS97_06295
PPHABVH74_05210
PORYEJA05_04800
PWZJ7655_04690(algD)
PTKEXN22_12380 EXN22_22955
PTWTUM18999_50120(algD)
PZAHU749_024140
PIEHU724_005670
PWYHU734_005480
AVNAvin_10970(algD)
AVLAvCA_10970(algD)
AVDAvCA6_10970(algD)
ACXAchr_31180(algD)
MSRAU15_13665
PATPatl_1531
GAGGlaag_2800
PMESFX988_01104
HMIsoil367_08790
CEGD0C16_11005
THIMKFB96_07615
ABOABO_0384(algD)
ALNAS19_03970
GSNYC6258_00963
OMEOLMES_2098 OLMES_4477
TAUTola_1407
SVASVA_1550
REVHUE57_13005
PLGNCTC10937_04283(algD)
RFRRfer_0673
JAGGJA_3986(algD)
JALBZG29_08185
JASFJQ89_25120
JLVG3257_08340
MNRACZ75_11680
MASZC9I28_09765
MASYDPH57_12210
MFLAGO485_23875
MPLIE1742_23455
EBAebA4268(algD)
AZOazo3269(algD)
AOAdqs_3408
ACOMCEW83_18780
APPCAP2UW1_0858 CAP2UW1_1431
NISNIS_0191
CMEDFE773_08555
CPAFC6V80_01890
DVEDESUT3_23450(algD)
DSADesal_3469
DTOTOL2_C36540(algD)
ARUIG6M88_17210
RHLLPU83_pLPU83d0171(algD1) LPU83_pLPU83d1236(algD3)
RGRFZ934_26065
BJAblr6296(blr6296)
BRABRADO7047
BRSS23_62720
BRCBCCGELA001_11045
BICLMTR13_08410
BRKCWS35_18850
BRQCIT40_06180
BSYMCIT39_05020
BARHWN72_18950
BELBE61_69060
BSEPHAP48_0031560
BQBJ4P68_0032835
MNOMnod_5882
METIDK427_06650
BIDBind_3885
MPARF7D14_18240
MAADAZF01_02675
MMEDMame_02304(algD)
MLUTJET14_03725
RBMTEF_19885
LABRCHH27_22980
LABPFJ695_16660
ACUTMRB58_00060
DSHDshi_1896(algD)
MALGMALG_02776
CONTQ29_00725
YPACCEW88_18640
YANAYJ57_24995
SULZC1J03_23160
TOMBWR18_20775
THAACFI11_06320 CFI11_06490
HATRC74_06375
THWBMG03_12925
LITFPZ52_00565
PPRUFDP22_22880
POZI0K15_05930
CACTHZ995_12210
HDHG5B40_09200
FAQG5B39_18330
NARSaro_3220
SPHITS85_22025
SSANNX02_04640
SECHB18_00665
EGNBMF35_a0516
ERFFIU90_00265(algD)
PHZCHX26_00290
POTE2E27_01460
HTQFRZ44_03090(algD)
HADHFRZ61_03380(algD)
BMXBMS_2990
PARHI5S86_05480
MGOAFA91_10990 AFA91_29875
MDFK0O62_25565
MSMMSMEG_5957(algD)
MSGMSMEI_5797
MSBLJ00_29460
MSNLI99_29465
MSHLI98_29470
MVAMvan_1699
MSPMspyr1_41390
MNED174_24385
MYNMyAD_23925
MTYMTOK_31270(algD)
MSARMSAR_24600(algD)
MANYMANY_49000(algD)
MPOFMPOR_19690
NHUH0264_19875
ROPROP_57960(algD)
RKOJWS14_31405
TOYFO059_04060
SCOSCO0382(SCF62.08)
SCBSCAB_23351
SVLStrvi_5599
SHYSHJG_7006
SHOSHJGH_6766
SRCM271_40840
SBHSBI_09543
SVESVEN_7199
SALUDC74_1121
SALLSAZ_06100
SLVSLIV_36030(algD)
SVTSVTN_36100
STREGZL_08291
SLDT261_7968
SPRISPRI_2000
STRFASR50_26930
SPAVSpa2297_31800
STRTA8713_24610
SCLFBB341_00345
SGSAVL59_31095
SALWCP975_03365
SGMGCM10017557_19510
SLSSLINC_8140
SNRSNOUR_37270(algD)
SPLULK06_025850
STRDNI25_00640
SSIAA7J05_09315
SGVB1H19_04475
SALFSMD44_08071(algD)
STROSTRMOE7_01550
SFKKY5_0166c
SGEDWG14_01282(algD_2)
SLKSLUN_34570
SQZFQU76_01535
SCYAEJ357_37150
SKACP970_42095
SVRCP971_03305
SFYGFH48_34990
SBYH7H31_29485
SFUGCNQ36_29650
STSUB7R87_32065
SCHACP983_11050
SGXH4W23_37670
SCOECP976_05755
SSPBCP982_01460
SHUNDWB77_00748(algD)
SCYGS1361_04630(algD)
SFEUIM697_33530
SROIIAG44_00725
SXNIAG42_07115
SGJIAG43_29305
SHKJ2N69_02610
HEAHL652_13685
ACHAchl_2940
TEHGKE56_16015
NDKI601_0111(algD)
SROSros_0655
NOABKM31_42710
NGNLCN96_02635
BSDBLASA_0423(algD)
AMDAMED_0547(algD)
AMNRAM_02805
AMMAMES_0545(algD)
AMZB737_0546(algD)
AOIAORI_0554(algD)
AJAAJAP_36870(algD)
AMQAMETH_0542(ugd)
AMYBBKN51_36975
AMYYYIM_21485(algD)
AORISD37_38440
AACDLWP59_02525
PDXPsed_1848
PBROHOP40_15385
PMADBAY61_02365
HAOPCC7418_0427
NPUNpun_F5503
NSHGXM_00034
CTHEChro_0719
STISthe_1134
ROOG5S37_25645
AHELQ31a_57060(algD)
MRIMal4_03640(algD)
SDYNMal52_06430(algD)
FTJFTUN_5650
ABAAcid345_3792
TRSTerro_2830
SUSAcid_0553
BDOEL88_09425
NKONiako_7100
CMRCycma_0720
SPIBG8759_29085
SRHOHH216_01470
DSNHWI92_00320
FIBA6C57_20705
PKOPKOR_16530
ZGAZOBELLIA_1984(algD)
CACICLOAM0663
TAMTheam_0797
NMVNITMOv2_2630(algD)
 » show all
Reference
1  [PMID:14245351]
  Authors
PREISS J.
  Title
SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.
  Journal
J Biol Chem 239:3127-32 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.132
IUBMB Enzyme Nomenclature: 1.1.1.132
ExPASy - ENZYME nomenclature database: 1.1.1.132
BRENDA, the Enzyme Database: 1.1.1.132
CAS: 37250-63-8
LinkDB

KEGG   REACTION: R00880
Entry
R00880                      Reaction                               
Name
GDP-D-mannose:NAD+ 6-oxidoreductase
Definition
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
Equation
C00096 + C00001 + 2 C00003 <=> C00976 + 2 C00004 + 2 C00080
Reaction class
RC00001  C00003_C00004
RC00291  C00096_C00976
Enzyme
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Orthology
K00066  GDP-mannose 6-dehydrogenase [EC:1.1.1.132]
Other DBs
RHEA: 21731
LinkDB

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