KEGG ORTHOLOGY: K00089

ORTHOLOGY: K00089

Entry

K00089                      KO

Symbol

AKR1C2

Name

3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map05204

Chemical carcinogenesis - DNA adducts

map05208

Chemical carcinogenesis - reactive oxygen species

Module

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R02476

androsterone:NAD+ oxidoreductase

R02477

androsterone:NADP+ oxidoreductase

R04330

androstan-3alpha,17beta-diol:NAD+ oxidoreductase

R08955

3alpha,21-dihydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)

R08957

3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)

R08960

5alpha-pregnane-3alpha,20alpha-diol:NADP+ oxidoreductase (A-specific)

R08963

androstan-3alpha,17beta-diol:NADP+ oxidoreductase

R13216

5alpha-pregnane-3alpha,17alpha-diol-20-one:NAD+ oxidoreductase

R13217

5alpha-pregnane-3alpha,17alpha-diol-20-one:NADP+ 3-oxidoreductase

Disease

H00607

46,XY gonadal dysgenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
   05208 Chemical carcinogenesis - reactive oxygen species
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase

Other DBs

GO:

0047026

Genes