KEGG ORTHOLOGY: K00497

ORTHOLOGY: K00497

Entry

K00497                      KO

Symbol

CYP11B1

Name

steroid 11beta-monooxygenase [EC:1.14.15.4]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

Reaction

R02218

progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02725

androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02843

steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03329

steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03851

11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R04850

17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)

R08949

11-deoxycorticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta,18-hydroxylating)

Disease

H00216

Congenital adrenal hyperplasia

H00602

Glucocorticoid-remediable aldosteronism (GRA)

H01603

Primary aldosteronism

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00497  CYP11B1; steroid 11beta-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K00497  CYP11B1; steroid 11beta-monooxygenase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00497  CYP11B1; steroid 11beta-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00497  CYP11B1; steroid 11beta-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K00497  CYP11B1; steroid 11beta-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP11 family
   K00497  CYP11B1; steroid 11beta-monooxygenase

Other DBs

GO:

0004507

Genes

HSA:	1584(CYP11B1)

PTR:	464437(CYP11B1)

PPS:	100971586(CYP11B1)

GGO:

PON:

PPYG:

NLE:

HMH:	116465197 116465198

SSYN:

129486883

MCC:	695793(CYP11B1)

MCF:	102136659(CYP11B1)

MTHB:

126961618

MNI:

105488429

CSAB:

103237546(CYP11B1)

CATY:

105581188

PANU:

101002490 116276421

TGE:	112630213 112630247

MLEU:

105536287

RRO:

104679773

RBB:

108536535

TFN:	117079172 117079174

PTEH:

111535654

CANG:

105509013

CJC:	100415667(CYP11B1)

SBQ:

101048076

CSYR:

103276447

OGA:

100948075

MMU:	110115(Cyp11b1) 13072(Cyp11b2)

MCAL:

110310257 110310258

MPAH:

110334511 110335023

RNO:	120093683(Cyp11b2l1) 24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)

MCOC:

116073894 116082436

ANU:	117719036 117719092

MUN:	110544545 110562757

CGE:	100771648 107977023

MAUA:

101823339 101823606

PROB:

127225603 127225649 127225650

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103748431 103748432

HGL:

CPOC:

CCAN:

DORD:

DSP:	122125332 122125344

PLOP:

125360501 125361022

NCAR:

124991075 124991346

MMMA:

107142805 107143071

OCU:	100328543(CYP11B2) 100342863

OPI:

101518686

TUP:	102471986 102492986

CFA:	482071(CYP11B2)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:	125281062 125281076

UAR:	123779294 123796461

ELK:

111146729

LLV:	125098158 125099244

MNP:

132013308

MLK:	131827767 131827768

NVS:	122905498 122905499

ORO:

101364874

EJU:	114204069 114204070

ZCA:	113911085 118356903

MLX:

118015252

NSU:

110578976

LWW:

102732818

FCA:	101097790(CYP11B1)

PYU:	121024468 121043245

PCOO:

112859405

PBG:	122496110 122496111

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:	106989683 128312793

HHV:

120227687

BTA:	282422(CYP11B1) 787628

BOM:	102272939 102280195

BIU:	109568177 109568372 109568377

BBUB:

112577757 112579063

BBIS:

104997957

CHX:	102188238 102188517

OAS:	101102377 767576(CYP11B1)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100063612 100063645

EPZ:

103543718

EAI:	106827552 123275604

MYD:

MMYO:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:	105302023 105310134

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

TGU:

LSR:

PHI:

FPG:

FCH:

AROW:

ASN:

AMJ:	102575737(CYP11B1)

CPOO:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:

XTR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	791124(cyp11c1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TDW:

MANU:

IPU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00015374G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

ASTR:

137601281(cyp11c1)

MZE:

101463871

ONL:	100533461(cyp11b)

OAU:

116320943

OLA:	100125822(cyp11b)

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

OTW:

OMY:	100135891(cyp11b) 110534298

OGO:	123998350 124004644

ONE:

115122985

OKI:

109881262

OKE:	118373241 127915287

SALP:

SNH:

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

Reference

PMID:2592361

Authors

Mornet E, Dupont J, Vitek A, White PC

Title

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Journal

J Biol Chem 264:20961-7 (1989)

Sequence

[hsa:1584]

Reference

PMID:3485096

Authors

Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P

Title

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.

Journal

J Biol Chem 261:3556-62 (1986)

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