KEGG   ORTHOLOGY: K00505
Entry
K00505                      KO                                     
Symbol
TYR
Name
tyrosinase [EC:1.14.18.1]
Pathway
map00350  Tyrosine metabolism
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04916  Melanogenesis
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Reaction
R00731  L-tyrosine:oxygen oxidoreductase
R02078  L-tyrosine,L-dopa:oxygen oxidoreductase
R02363  hydroquinone:oxygen oxidoreductase
R02383  monophenol,L-dopa:oxygen oxidoreductase
R04693  monophenol,L-dopa:oxygen oxidoreductase
R04884  5,6-dihydroxyindole:oxygen oxidoreductase
Disease
H00168  Oculocutaneous albinism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00505  TYR; tyrosinase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00505  TYR; tyrosinase
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K00505  TYR; tyrosinase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.1  tyrosinase
     K00505  TYR; tyrosinase
Other DBs
GO: 0004503
Genes
HSA: 7299(TYR)
PTR: 451473(TYR)
PPS: 100989128(TYR)
GGO: 101148846(TYR)
PON: 100453479(TYR)
PPYG: 129007943(TYR)
NLE: 100594055 115838630
HMH: 116477395(TYR)
SSYN: 129483935(TYR)
MCC: 705792(TYR)
MCF: 102141480(TYR)
MTHB: 126934746
MNI: 105468895(TYR)
CSAB: 103248194(TYR)
CATY: 105592966(TYR)
PANU: 101020866(TYR)
TGE: 112606374(TYR)
MLEU: 105543124(TYR)
RRO: 104657434(TYR)
RBB: 108539149(TYR)
TFN: 117080742(TYR)
PTEH: 111540685(TYR)
CANG: 105509297(TYR)
CJC: 100399713(TYR)
SBQ: 101043674(TYR)
CIMI: 108296777
ANAN: 105711938(TYR)
CSYR: 103255375(TYR)
MMUR: 105865099(TYR)
LCAT: 123642237(TYR)
PCOQ: 105808221(TYR)
OGA: 100962911(TYR)
MMU: 22173(Tyr)
MCAL: 110298406(Tyr)
MPAH: 110327286(Tyr)
RNO: 308800(Tyr)
MCOC: 116100639(Tyr)
ANU: 117711951(Tyr)
MUN: 110565894(Tyr)
CGE: 100752294
MAUA: 101840761(Tyr)
PROB: 127227250(Tyr)
PLEU: 114682739(Tyr)
MORG: 121453201(Tyr)
MFOT: 126491512
AAMP: 119803035(Tyr)
NGI: 103743041(Tyr)
HGL: 101696609(Tyr)
CPOC: 100713552(Tyr)
DORD: 105983956(Tyr)
DSP: 122116277(Tyr)
PLOP: 125361622(Tyr)
NCAR: 124960121
MMMA: 107160413(Tyr)
OCU: 100008753(TYR)
OPI: 101520677(TYR)
TUP: 102485831(TYR)
GVR: 103600166(TYR)
CFA: 403405(TYR)
CLUD: 112641956(TYR)
VVP: 112932288(TYR)
VLG: 121476446(TYR)
NPO: 129506715(TYR)
AML: 100475022(TYR)
UMR: 103675370(TYR)
UAH: 113269420(TYR)
UAR: 123792343(TYR)
ELK: 111154441
LLV: 125078919
MPUF: 101683509(TYR)
MNP: 132012084(TYR)
MLK: 131839453(TYR)
NVS: 122912503(TYR)
ORO: 101363864(TYR)
EJU: 114199718(TYR)
ZCA: 113914930(TYR)
MLX: 118013459(TYR)
NSU: 110570998(TYR)
LWW: 102742435(TYR)
FCA: 751100(TYR)
PYU: 121039397(TYR)
PCOO: 112866043(TYR)
PBG: 122483228(TYR)
PVIV: 125146819(TYR)
LRUF: 124504571
PTG: 102957473(TYR)
PPAD: 109267329(TYR)
PUC: 125929456
AJU: 106967790
HHV: 120246243(TYR)
BTA: 280951(TYR)
BOM: 102272000(TYR)
BIU: 109554196(TYR)
BBUB: 102408280(TYR)
BBIS: 104993808(TYR)
CHX: 102182281(TYR)
OAS: 780502(TYR)
BTAX: 128069103(TYR)
ODA: 120874821(TYR)
CCAD: 122431382(TYR)
MBEZ: 129548563(TYR)
SSC: 407745(TYR)
CFR: 102509800(TYR)
CBAI: 105083516(TYR)
CDK: 105088592(TYR)
VPC: 102543612(TYR)
BACU: 103016545(TYR)
BMUS: 118899345(TYR)
OOR: 101280655(TYR)
DLE: 111184818(TYR)
PCAD: 102989004(TYR)
PSIU: 116757930(TYR)
NASI: 112410924(TYR)
ECB: 100060227(TYR)
EPZ: 103547855(TYR)
EAI: 106822679(TYR)
MYB: 102260258(TYR)
MYD: 102762530(TYR)
MMYO: 118662722(TYR)
MLF: 102430118(TYR)
MDT: 132240690(TYR)
PKL: 118713257(TYR)
EFUS: 103296990(TYR)
MNA: 107532399(TYR)
DRO: 112316020(TYR)
SHON: 118984758(TYR)
AJM: 119043575(TYR)
PDIC: 114500350(TYR)
PHAS: 123805508(TYR)
MMF: 118628030(TYR)
PPAM: 129072658(TYR)
HAI: 109374039(TYR)
RFQ: 117030409(TYR)
PALE: 102894376(TYR)
PGIG: 120590532(TYR)
PVP: 105294192(TYR)
RAY: 107514939(TYR)
MJV: 108390598(TYR)
TOD: 119254714(TYR)
SARA: 101538402(TYR)
SETR: 126019139(TYR)
LAV: 100676924(TYR)
TMU: 101358815
ETF: 101660164(TYR)
DNM: 101436149(TYR)
MDO: 100010166(TYR)
GAS: 123238815(TYR)
SHR: 100928294(TYR)
AFZ: 127555166
PCW: 110213345(TYR)
TVP: 118838649(TYR)
OAA: 100080574(TYR)
GGA: 373971(TYR)
PCOC: 116241921(TYR)
MGP: 100538462(TYR)
CJO: 107308457(TYR)
TPAI: 128074250(TYR)
LMUT: 125691153(TYR)
NMEL: 110390794(TYR)
APLA: 101791683(TYR)
ACYG: 106034185(TYR)
CATA: 118245940(TYR)
AFUL: 116501296(TYR)
TGU: 100225893(TYR)
LSR: 110478390(TYR)
SCAN: 103827249(TYR)
PMOA: 120506781(TYR)
OTC: 121340987(TYR)
PRUF: 121362296(TYR)
GFR: 102035437(TYR)
FAB: 101814779(TYR)
OMA: 130255126(TYR)
PHI: 102104800(TYR)
PMAJ: 107199861(TYR)
CCAE: 111924932(TYR)
CCW: 104690323(TYR)
CBRC: 103616715(TYR)
ETL: 114063514(TYR)
ZAB: 102073575(TYR)
ZLE: 135459902(TYR)
ACHL: 103798447
SVG: 106853986(TYR)
MMEA: 130577944(TYR)
HRT: 120748820(TYR)
SATI: 136374071(TYR)
FPG: 101915664(TYR)
FCH: 102054260(TYR)
CCRI: 104166714(TYR)
NNT: 104405533(TYR)
SHAB: 115603879(TYR)
ACUN: 113480760(TYR)
TALA: 104361858(TYR)
ACHC: 115353600(TYR)
HALD: 104317037(TYR)
HLE: 104838488(TYR)
AGEN: 126048436
GCL: 127028421
CSTI: 104561248(TYR)
LDI: 104344032(TYR)
MNB: 103779458(TYR)
DPUB: 104301160(TYR)
AVIT: 104268688(TYR)
BRHI: 104496235(TYR)
EGZ: 104128835(TYR)
NNI: 104017355(TYR)
PCRI: 104025917(TYR)
PCAO: 104050100(TYR)
PADL: 103926027(TYR)
AFOR: 103904764(TYR)
FGA: 104069806(TYR)
GSTE: 104263230(TYR)
CLV: 102093703(TYR)
MUI: 104539276(TYR)
PGUU: 104465724(TYR)
PLET: 104627842(TYR)
EHS: 104503590(TYR)
CMAC: 104473847(TYR)
CUCA: 104064099(TYR)
TEO: 104370913(TYR)
BREG: 104632917(TYR)
OHA: 104327638(TYR)
ACAR: 104522941(TYR)
CPEA: 104393152(TYR)
CVF: 104283043(TYR)
RTD: 128904187(TYR)
AAM: 106495505(TYR)
AROW: 112973714(TYR)
NPD: 112951483(TYR)
TGT: 104579092(TYR)
DNE: 112988550(TYR)
SCAM: 104153274(TYR)
ASN: 102385049(TYR)
AMJ: 102560883(TYR)
CPOO: 109306793(TYR)
GGN: 109303235(TYR)
PSS: 102454532(TYR)
CMY: 102935011(TYR)
CCAY: 125632955(TYR)
DCC: 119843677(TYR)
CPIC: 101935010(TYR)
TST: 117871862(TYR)
CABI: 116818084(TYR)
MRV: 120383812(TYR)
ACS: 100552257(tyr)
ASAO: 132772243(TYR)
PVT: 110088582(TYR)
SUND: 121926332(TYR)
PBI: 103060005(TYR) 103063605
PMUR: 107286363(TYR)
CTIG: 120307809(TYR)
TSR: 106547651(TYR)
PGUT: 117660003(TYR)
APRI: 131199856(TYR)
PTEX: 113440467(TYR)
NSS: 113420140(TYR)
VKO: 123029400(TYR)
PMUA: 114595291(TYR)
PRAF: 128412528(TYR)
ZVI: 118085685(TYR)
HCG: 128349049(TYR)
GJA: 107119489(TYR)
STOW: 125431508(TYR)
EMC: 129326090(TYR)
MUO: 115467853(TYR)
GSH: 117362868(TYR)
DRE: 30207(tyr)
SRX: 107731812 107737432(tyr)
SGH: 107558837(tyr)
CGIB: 128029069
PTET: 122358820(tyr)
LROH: 127177360(tyr)
OMC: 131554175(tyr)
PPRM: 120470727(tyr)
RKG: 130101119(tyr)
MAMB: 125248595(tyr)
CIDE: 127496052
CERY: 137004332(tyr)
TROS: 130564732(tyr)
TDW: 130428409(tyr)
MANU: 129438659(tyr)
IPU: 100304491 108277956(tyr)
IFU: 128620020 128621333(tyr)
SMEO: 124393257 124394828(tyr)
TFD: 113637826(tyr) 113659178
TVC: 132857969(tyr) 132863019
TRN: 134332925 134334725(tyr)
AMEX: 103040843(tyr) 103041136
CMAO: 118800559(tyr) 118824597
EEE: 113578741(tyr) 113581657
TRU: 101064772(tyr) 101080145
LCO: 104920119(tyr)
NCC: 104963013(tyr)
TBEN: 117470246(tyr) 117490431
CGOB: 115017793(tyr) 115018879
PGEO: 117457806(tyr) 117458840
GACU: 117534898(tyr) 117535274
EMAC: 134871964 134880315(tyr)
SLUC: 116037037 116048241(tyr)
ECRA: 117942457(tyr) 117954992
ESP: 116687073(tyr) 116700242
PFLV: 114552647(tyr) 114566690
GAT: 120822041 120828666(tyr)
PPUG: 119213809(tyr) 119215419
AFB: 129091276(tyr) 129113883
CLUM: 117741431(tyr) 117742834
PSWI: 130189390 130211087(tyr)
MSAM: 119883400(tyr) 119895337
CUD: 121518828 121524120(tyr)
ALAT: 119006367(tyr) 119030940
ASTR: 137596608(tyr) 137606556
ONL: 100700374 100707700(tyr)
OAU: 116322990(tyr) 116331461
OLA: 100049427(tyr) 101171514
OML: 112139508 112150029(tyr)
CSAI: 133441684(tyr) 133459415
XMA: 102216777 102222951(tyr)
XCO: 114153091 114161843(tyr)
XHE: 116708061(tyr) 116728342
PRET: 103474486(tyr) 103475522
PFOR: 103140502 103146266(tyr)
PLAI: 106950591 106958863(tyr)
PMEI: 106914104 106918015(tyr)
GAF: 122833005(tyr) 122844839
PPRL: 129359260(tyr) 129368489
CVG: 107087918 107091929(tyr)
CTUL: 119771817(tyr) 119783464
GMU: 124876592 124884508(tyr)
NFU: 107380455(tyr) 107386962
KMR: 108236980 108244618(tyr)
ALIM: 106514125 106517255(tyr)
NWH: 119411088(tyr) 119420008
MCEP: 125014064(tyr) 125021303
CSEM: 103378543(tyr) 103395402
POV: 109634605(tyr) 109635738
SSEN: 122773016(tyr) 122779548
HHIP: 117772813(tyr) 117773990
HSP: 118106457(tyr) 118122668
PPLT: 128440257(tyr)
SMAU: 118299879(tyr) 118301560
HCQ: 109509733 109525374(tyr)
SBIA: 133491776 133504590(tyr)
PEE: 133404965(tyr) 133416504
PTAO: 133467407 133482359(tyr)
BPEC: 110158560 110174305(tyr)
MALB: 109959313 109971605(tyr)
BSPL: 114868616(tyr) 114868934
OTW: 112232177 112267296(tyr)
OMY: 100135825 100135828(tyr)
ELS: 105024066(tyr) 105026640
SFM: 108923732 108932465(tyr)
LOC: 102687207(tyr)
PSPA: 121302601(tyr)
PSEX: 120519559
LCM: 102365572(TYR)
CMK: 103185187(tyr)
RTP: 109921379(tyr)
CPLA: 122550589(tyr)
LERI: 129698248(tyr)
PMRN: 116953350(TYR)
LRJ: 133351432(TYR)
SCLV: 120342909
DME: Dmel_CG42639(PPO1) Dmel_CG42640(PPO3)
DSE: 6609708
DSI: Dsimw501_GD11733(Dsim_GD11733) Dsimw501_GD25430(Dsim_GD25430)
DAN: 6496059
DSR: 110177925
DPO: 4804100
DPE: 6589981
DMN: 108160538
DWI: 6643368
DGR: 6560300
DAZ: 108616230
DNV: 108654794
DHE: 111597672
DVI: 6626051
CCAT: 101460986
RZE: 108366181
GFS: 119639699
ECOE: 129949398
HIS: 119646185
AFUN: 125772415
CNS: 116351145
DSM: 124412090
NPT: 124224816
NFB: 124187883
NLO: 107224379
NVG: 124301309
CSEC: 111863773
FCD: 110850352
PVM: 113827912
PMOO: 119583423
HAZT: 108679769
TUT: 107369608
CSCU: 111641656
PTEP: 107444762
SDM: 118205071
CEL: CELE_C34G6.2(tyr-4)
CBR: CBG_04025(Cbr-tyr-4)
BMY: BM_BM3483(Bm3483)
PCAN: 112576568
GAE: 121390964
HRJ: 124268408
CANU: 128187051
OED: 125682877
MMER: 123535176
RPHI: 132742487
MAEA: 128244825
OSN: 115219783
LLON: 135487855
NTE: NEUTE1DRAFT103253(NEUTE1DRAFT_103253) NEUTE1DRAFT117718(NEUTE1DRAFT_117718) NEUTE1DRAFT118745(NEUTE1DRAFT_118745) NEUTE1DRAFT124197(NEUTE1DRAFT_124197) NEUTE1DRAFT125579(NEUTE1DRAFT_125579) NEUTE1DRAFT93419(NEUTE1DRAFT_93419)
SMP: 10802107(SMAC4_09195) 10805042(SMAC4_04920) 10808536(SMAC4_04270) 10808577(SMAC4_04313) 10808704(SMAC4_06010) 10809071(SMAC4_00012) 10810251(SMAC4_01459) 10810296(SMAC4_01505) 10810380(SMAC4_01592)
TATV: 25776692(TrAtP1_012215) 25777593(TrAtP1_007661) 25780128(TrAtP1_010231)
TASP: 36609524(TrAFT101_010490) 36612211(TrAFT101_009492) 36615182(TrAFT101_007774) 36616461(TrAFT101_009487)
MAW: 19247028(J3458_000472) 19247267(J3458_022097) 19247976(J3458_005087) 19250027(J3458_015295) 19252269(J3458_021163) 90964211(J3458_021199)
MBRN: 26238408(ustQ_0) 26239659(TYR) 26242521(tyr1_1) 26243569(tyr1_2) 26246866(ustQ_1) 26247267(orsC_1) 26247667(orsC_0)
PLJ: 28883541(PLICBS_000498) 28892626(PLICBS_006597)
CDET: 87936518(CDEST_00015) 87938025(CDEST_01522) 87938242(CDEST_01739) 87939604(CDEST_03101) 87939610(CDEST_03107) 87939836(CDEST_03333) 87942221(CDEST_05718) 87943905(CDEST_07402) 87944196(CDEST_07693) 87944479(CDEST_07976) 87944521(CDEST_08018) 87944815(CDEST_08312) 87947207(CDEST_10707) 87947348(CDEST_10848) 87947666(CDEST_11166) 87948520(CDEST_12020) 87948574(CDEST_12074) 87949534(CDEST_13034) 87949803(CDEST_13303) 87951267(CDEST_14767)
ABE: ARB_00532
TVE: TRV_00392
PTRR: 6338404(PtrM4_021610) 6339083(PtrM4_018500) 6339505(PtrM4_021070) 6340539(PtrM4_058880) 6340608(PtrM4_058520) 6341599(PtrM4_069970) 6343058(PtrM4_117720) 6346288(PtrM4_136270) 6347183(PtrM4_033720) 6347581(PtrM4_124720) 6349122(PtrM4_130770) 90957305(PtrM4_124910) 90958249(PtrM4_152690)
ABP: AGABI1DRAFT114468(AGABI1DRAFT_114468) AGABI1DRAFT114491(AGABI1DRAFT_114491) AGABI1DRAFT114493(AGABI1DRAFT_114493) AGABI1DRAFT116717(AGABI1DRAFT_116717) AGABI1DRAFT62737(AGABI1DRAFT_62737) AGABI1DRAFT85838(AGABI1DRAFT_85838)
ABV: AGABI2DRAFT135027(AGABI2DRAFT_135027) AGABI2DRAFT191507(AGABI2DRAFT_191507) AGABI2DRAFT191532(AGABI2DRAFT_191532) AGABI2DRAFT194055(AGABI2DRAFT_194055) AGABI2DRAFT239416(AGABI2DRAFT_239416)
SCM: SCHCO_02601704(SCHCODRAFT_02601704)
EBB: F652_1501
LEM: LEN_2997(melC2)
PPUN: PP4_19320
PFO: Pfl01_3461(melC2)
PFC: PflA506_4965(melC2)
PFB: VO64_2552
PCHP: C4K32_2614
PSIL: PMA3_28020
SDE: Sde_0316
HCH: HCH_03392
RSY: RSUY_22190(melC2_1) RSUY_29370(melC2_2)
BPS: BPSS1731
BPSE: BDL_5087(melO)
BPSM: BBQ_4408(melO)
BPSU: BBN_5187(melO)
BPSD: BBX_4253(melO)
BPK: BBK_4451(melO)
BPSH: DR55_3536(melO)
BPSA: BBU_4293(melO)
BPSO: X996_5813(melO)
BUT: X994_5374(melO)
BTQ: BTQ_3941(melO)
BTJ: BTJ_4973(melO)
BTZ: BTL_3442(melO)
BTD: BTI_3837
BTV: BTHA_4444(melO)
BTHE: BTN_5428(melO)
BTHM: BTRA_5703(melO)
BTHA: DR62_5606
BTHL: BG87_3396(melO)
BOK: DM82_4935(melC2) DM82_5976(melO)
BOC: BG90_4662(melO) BG90_5660(melC2)
BCON: NL30_37765
BUB: BW23_4486(melO) BW23_6019
BSTG: WT74_18825
BUL: BW21_5830
BPH: Bphy_4746
CABA: SBC2_28520
DAC: Daci_1610
NEU: NE1241
MHUA: MCHK_11960
SMX: SM11_pC0105(mepA1) SM11_pC0156(mepA2)
AVI: Avi_2427
RHN: AMJ98_PC00117(melA)
REZ: AMJ99_PB00114(melA)
AOL: S58_42440
BARH: WN72_11285
RPB: RPB_2167
NWI: Nwi_0968
MET: M446_5336
MSC: BN69_0277
LABT: FIU93_19085(melC2)
SIL: SPO1405
MALG: MALG_04738
RSU: NHU_02308
SCL: sce8942
BCA: BCE_A0211
BMQ: BMQ_3385
BMD: BMD_3389
BMH: BMWSH_1797(melC1)
BMEG: BG04_300(melC2)
BEO: BEH_25025
MBOK: MBOE_44510
CEF: CE1756
CFAC: CFAEC_07835(melC2)
SCO: SCO2700(melC2)
SMA: SAVERM_1137(melC2) SAVERM_5362(melC2-2)
SGR: SGR_2447(melC2-2) SGR_527(melC2-1)
SGB: WQO_32205
SFI: SFUL_6847
SCB: SCAB_59241(melC2) SCAB_85681(melC2B)
SHY: SHJG_4198
SFA: Sfla_5963
SDV: BN159_5596(melC2) BN159_7561 BN159_8269(melC2)
STRP: F750_0607
SLV: SLIV_24170(melC2)
SAMB: SAM23877_2730(melC)
SPRI: SPRI_2876
SRW: TUE45_00932(melC2_1) TUE45_03314(melC2_2)
SLE: sle_45350(sle_45350)
SRN: A4G23_03056(melC2)
STRD: NI25_25425
SLAU: SLA_4839
SLX: SLAV_04435(melC1) SLAV_04520(melC2) SLAV_32845(melC3) SLAV_35305(melC4)
SFK: KY5_2844c
SGE: DWG14_05427(melC2_1) DWG14_07892(melC2_2)
SRJ: SRO_4762
SNF: JYK04_07745(melC2_2) JYK04_07760(melC2_3)
SHUN: DWB77_04340(melC2_1) DWB77_06688(melC2_2)
SCYG: S1361_03250(melC1) S1361_14845(melC2)
SAUH: SU9_033190
SXT: KPP03845_106703(melC2_1) KPP03845_106718(melC2_2)
SMIB: SMIR_39840
FAL: FRAAL0531
SESP: BN6_45030(melC2)
ALO: CRK59534
ACTU: Actkin_04030(melC2)
ASE: ACPL_5017(griF)
ACTS: ACWT_4887
RXY: Rxyl_1947
AMR: AM1_B0356
NSH: GXM_05756
CTHE: Chro_3115
LUI: llg_31770
GAW: V144x_27600(griF)
FTJ: FTUN_5759
SACI: Sinac_0162
SUS: Acid_5081
ABAC: LuPra_00956 LuPra_02564(melC2)
FLN: FLA_2632
DFE: Dfer_1836
CBAL: M667_12305
CBAT: M666_12215
KOS: KORDIASMS9_02290(melC2)
TAA: NMY3_00348(griF) NMY3_03193(melC2)
 » show all
Reference
PMID:1903356
  Authors
Giebel LB, Strunk KM, Spritz RA
  Title
Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment.
  Journal
Genomics 9:435-45 (1991)
DOI:10.1016/0888-7543(91)90409-8
  Sequence
[hsa:7299]
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