KEGG   ORTHOLOGY: K00918
Entry
K00918                      KO                                     
Symbol
pfkC
Name
ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00030  Pentose phosphate pathway
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Reaction
R05805  ADP:D-fructose-6-phosphate 1-phosphotransferase
R09084  ADP:D-fructose-6-phosphate 1-phosphotransferase
R09085  ADP:D-glucose 6-phosphotransferase
R09086  ADP:D-glucose 6-phosphotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
   00030 Pentose phosphate pathway
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
  09102 Energy metabolism
   00680 Methane metabolism
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.146  ADP-specific phosphofructokinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
    2.7.1.147  ADP-specific glucose/glucosamine kinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
Other DBs
COG: COG4809
GO: 0043844 0043843
Genes
MBAS: ALGA_3097
ATHO: M15_21860
GRC: GI584_20260
PWN: QNH46_01615
TCO: Theco_1176
CSCI: HDCHBGLK_00653
CHYL: CE91St63_33110
CSH: Closa_0608
QDO: H9Q78_06885
KSI: V6984_06605
LBP: V1224_00505
HALS: D7D81_07845
LPIL: LIP_1249
ASAC: ATHSA_0704
MJA: MJ_1604
MFE: Mefer_1517
MVU: Metvu_0786
MFS: MFS40622_0160
MIF: Metin_0227
MJH: JH146_0031
MESG: MLAUSG7_0561(pfkC)
MESA: MLASG1_0234(pfkC)
MIG: Metig_1734
MMP: MMP1296(pfkC)
MMQ: MmarC5_0297
MMX: MmarC6_1378
MMZ: MmarC7_0541
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
MVN: Mevan_0606
MVO: Mvol_0050 Mvol_0110
MOK: Metok_1190
METF: CFE53_04560
PFU: PF0312 PF1784
PFI: PFC_00640 PFC_09670
PHO: PH0589(PH0589) PH1645(PH1645)
PAB: PAB0967 PAB2013
PYN: PNA2_0229 PNA2_1204
PYA: PYCH_02450 PYCH_10910
PYS: Py04_0618 Py04_1537
PYC: TQ32_02010 TQ32_08590
TKO: TK0376 TK1110
TON: TON_0246 TON_1012
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: TSIB_0252 TSIB_1220
TBA: TERMP_00004 TERMP_01160
THE: GQS_04080 GQS_10400
THA: TAM4_1728 TAM4_738
THM: CL1_0470 CL1_1657
TLT: OCC_01044 OCC_09701
THS: TES1_0130 TES1_1218
TNU: BD01_0151 BD01_1045
TEU: TEU_06460 TEU_11110
TGY: X802_00245 X802_07910
THV: ADU37_CDS01920 ADU37_CDS09450
TCH: CHITON_1323 CHITON_1878
TPEP: A0127_02440 A0127_09685
TGG: A3K92_05080 A3K92_05775
TCE: A3L02_00520 A3L02_03710
TBS: A3L01_01790 A3L01_05875
THH: CDI07_01765 CDI07_05830(pfkC)
TSL: A3L11_05625 A3L11_10255
TTD: A3L14_03240 A3L14_08235
TPRF: A3L09_05575 A3L09_08760
TRL: A3L10_00730 A3L10_04695
TPAF: A3L08_05185 A3L08_09265
THY: A3L12_01825 A3L12_06865
TIC: FH039_03970 FH039_09365(pfkC)
TCQ: TIRI35C_0588(glkA) TIRI35C_1487(pfkC)
THEM: FPV09_00340(pfkC) FPV09_05320
THEI: K1720_04385 K1720_09185(pfkC)
TAGG: NF865_01525 NF865_08430(pfkC)
PPAC: PAP_01430 PAP_04875
MBA: Mbar_A2004 Mbar_A2005
MBY: MSBRM_2497 MSBRM_2498
MBW: MSBRW_2730 MSBRW_2731
MBAR: MSBR2_2474 MSBR2_2475
MBAK: MSBR3_2515 MSBR3_2516
MAC: MA_3562(glkA) MA_3563(pfk)
MMA: MM_0472 MM_0473
MMJ: MSMAS_0831 MSMAS_0832
MMAC: MSMAC_0811 MSMAC_0812
MVC: MSVAZ_2547 MSVAZ_2548
MEK: MSKOL_2555 MSKOL_2556
MLS: MSLAZ_2352 MSLAZ_2353
METM: MSMTP_2385 MSMTP_2386
MEF: MSWH1_2360 MSWH1_2361
MEQ: MSWHS_2732 MSWHS_2733
MSJ: MSSAC_3156 MSSAC_3157
MSZ: MSSIH_0989 MSSIH_0990
MSW: MSSIT_1026 MSSIT_1027
MTHR: MSTHT_1057 MSTHT_1058
MTHE: MSTHC_2246 MSTHC_2247
MHOR: MSHOH_0977 MSHOH_0978
MFZ: AOB57_011160 AOB57_011165(pfkC)
MHAB: RSJ42_11355 RSJ42_11360(pfkC)
METW: AAY43_08485 AAY43_08490
MBU: Mbur_1338 Mbur_1339
MMET: MCMEM_1827 MCMEM_1828
MELO: J7W08_08075 J7W08_08080(pfkC)
MMH: Mmah_1645 Mmah_1646
MHAZ: BHR79_05490 BHR79_05495
MPOT: BKM01_01570 BKM01_01575
MEV: Metev_0816 Metev_0817
MZH: Mzhil_0819 Mzhil_0820
MPY: Mpsy_1159 Mpsy_1160
MZI: HWN40_02795 HWN40_02800
MMAV: RE476_07455 RE476_07460(pfkC)
MSEB: RE474_03715 RE474_03720(pfkC)
MHZ: Metho_2034 Metho_2035
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
HSN: DV733_07550
SRUB: C2R22_19410
HALU: HUG12_09055
NMG: Nmag_3826
NGE: Natgr_2898
HLC: CHINAEXTREME19235
HRU: Halru_0715 Halru_2961
SAWL: NGM29_19280
NAJ: B1756_05745
NAG: AArcMg_1072
NAN: AArc1_2551
NARA: QQ977_08830
NBG: DV706_17425
NAS: GCU68_12220
NAC: AQV86_01495
FLT: Sv326_0933
NCON: LC1Nh_0114
NOCC: SVXNc_0128(pfk2)
 » show all
Reference
PMID:12921536
  Authors
Verhees CH, Kengen SW, Tuininga JE, Schut GJ, Adams MW, De Vos WM, Van Der Oost J
  Title
The unique features of glycolytic pathways in Archaea.
  Journal
Biochem J 375:231-46 (2003)
DOI:10.1042/BJ20021472
Reference
PMID:11856730
  Authors
Sakuraba H, Yoshioka I, Koga S, Takahashi M, Kitahama Y, Satomura T, Kawakami R, Ohshima T
  Title
ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus jannaschii.
  Journal
J Biol Chem 277:12495-8 (2002)
DOI:10.1074/jbc.C200059200
  Sequence
[mja:MJ_1604]
LinkDB

KEGG   ENZYME: 2.7.1.146
Entry
EC 2.7.1.146                Enzyme                                 
Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase;
ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
R05805 > R09084
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
History
EC 2.7.1.146 created 2001
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
Genes
MBAS: ALGA_3097
ATHO: M15_21860
GRC: GI584_20260
PWN: QNH46_01615
TCO: Theco_1176
CSCI: HDCHBGLK_00653
CHYL: CE91St63_33110
CSH: Closa_0608
QDO: H9Q78_06885
KSI: V6984_06605
LBP: V1224_00505
HALS: D7D81_07845
LPIL: LIP_1249
ASAC: ATHSA_0704
MJA: MJ_1604
MFE: Mefer_1517
MVU: Metvu_0786
MFS: MFS40622_0160
MIF: Metin_0227
MJH: JH146_0031
MESG: MLAUSG7_0561(pfkC)
MESA: MLASG1_0234(pfkC)
MIG: Metig_1734
MMP: MMP1296(pfkC)
MMQ: MmarC5_0297
MMX: MmarC6_1378
MMZ: MmarC7_0541
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
MVN: Mevan_0606
MVO: Mvol_0050 Mvol_0110
MOK: Metok_1190
METF: CFE53_04560
PFU: PF0312 PF1784
PFI: PFC_00640 PFC_09670
PHO: PH0589(PH0589) PH1645(PH1645)
PAB: PAB0967 PAB2013
PYN: PNA2_0229 PNA2_1204
PYA: PYCH_02450 PYCH_10910
PYS: Py04_0618 Py04_1537
PYC: TQ32_02010 TQ32_08590
TKO: TK0376 TK1110
TON: TON_0246 TON_1012
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: TSIB_0252 TSIB_1220
TBA: TERMP_00004 TERMP_01160
THE: GQS_04080 GQS_10400
THA: TAM4_1728 TAM4_738
THM: CL1_0470 CL1_1657
TLT: OCC_01044 OCC_09701
THS: TES1_0130 TES1_1218
TNU: BD01_0151 BD01_1045
TEU: TEU_06460 TEU_11110
TGY: X802_00245 X802_07910
THV: ADU37_CDS01920 ADU37_CDS09450
TCH: CHITON_1323 CHITON_1878
TPEP: A0127_02440 A0127_09685
TGG: A3K92_05080 A3K92_05775
TCE: A3L02_00520 A3L02_03710
TBS: A3L01_01790 A3L01_05875
THH: CDI07_01765 CDI07_05830(pfkC)
TSL: A3L11_05625 A3L11_10255
TTD: A3L14_03240 A3L14_08235
TPRF: A3L09_05575 A3L09_08760
TRL: A3L10_00730 A3L10_04695
TPAF: A3L08_05185 A3L08_09265
THY: A3L12_01825 A3L12_06865
TIC: FH039_03970 FH039_09365(pfkC)
TCQ: TIRI35C_0588(glkA) TIRI35C_1487(pfkC)
THEM: FPV09_00340(pfkC) FPV09_05320
THEI: K1720_04385 K1720_09185(pfkC)
TAGG: NF865_01525 NF865_08430(pfkC)
PPAC: PAP_01430 PAP_04875
MBA: Mbar_A2004 Mbar_A2005
MBY: MSBRM_2497 MSBRM_2498
MBW: MSBRW_2730 MSBRW_2731
MBAR: MSBR2_2474 MSBR2_2475
MBAK: MSBR3_2515 MSBR3_2516
MAC: MA_3562(glkA) MA_3563(pfk)
MMA: MM_0472 MM_0473
MMJ: MSMAS_0831 MSMAS_0832
MMAC: MSMAC_0811 MSMAC_0812
MVC: MSVAZ_2547 MSVAZ_2548
MEK: MSKOL_2555 MSKOL_2556
MLS: MSLAZ_2352 MSLAZ_2353
METM: MSMTP_2385 MSMTP_2386
MEF: MSWH1_2360 MSWH1_2361
MEQ: MSWHS_2732 MSWHS_2733
MSJ: MSSAC_3156 MSSAC_3157
MSZ: MSSIH_0989 MSSIH_0990
MSW: MSSIT_1026 MSSIT_1027
MTHR: MSTHT_1057 MSTHT_1058
MTHE: MSTHC_2246 MSTHC_2247
MHOR: MSHOH_0977 MSHOH_0978
MFZ: AOB57_011160 AOB57_011165(pfkC)
MHAB: RSJ42_11355 RSJ42_11360(pfkC)
METW: AAY43_08485 AAY43_08490
MBU: Mbur_1338 Mbur_1339
MMET: MCMEM_1827 MCMEM_1828
MELO: J7W08_08075 J7W08_08080(pfkC)
MMH: Mmah_1645 Mmah_1646
MHAZ: BHR79_05490 BHR79_05495
MPOT: BKM01_01570 BKM01_01575
MEV: Metev_0816 Metev_0817
MZH: Mzhil_0819 Mzhil_0820
MPY: Mpsy_1159 Mpsy_1160
MZI: HWN40_02795 HWN40_02800
MMAV: RE476_07455 RE476_07460(pfkC)
MSEB: RE474_03715 RE474_03720(pfkC)
MHZ: Metho_2034 Metho_2035
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
HSN: DV733_07550
SRUB: C2R22_19410
HALU: HUG12_09055
NMG: Nmag_3826
NGE: Natgr_2898
HLC: CHINAEXTREME19235
HRU: Halru_0715 Halru_2961
SAWL: NGM29_19280
NAJ: B1756_05745
NAG: AArcMg_1072
NAN: AArc1_2551
NARA: QQ977_08830
NBG: DV706_17425
NAS: GCU68_12220
NAC: AQV86_01495
FLT: Sv326_0933
NCON: LC1Nh_0114
NOCC: SVXNc_0128(pfk2)
 » show all
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 274:21023-8 (1999)
DOI:10.1074/jbc.274.30.21023
  Sequence
[pfu:PF1784]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.146
IUBMB Enzyme Nomenclature: 2.7.1.146
ExPASy - ENZYME nomenclature database: 2.7.1.146
BRENDA, the Enzyme Database: 2.7.1.146
CAS: 237739-62-7
LinkDB

KEGG   REACTION: R09084
Entry
R09084                      Reaction                               
Name
ADP:D-fructose-6-phosphate 1-phosphotransferase
Definition
beta-D-Fructose 6-phosphate + ADP <=> beta-D-Fructose 1,6-bisphosphate + AMP
Equation
C05345 + C00008 <=> C05378 + C00020
Reaction class
RC00002  C00008_C00020
RC00017  C05345_C05378
Enzyme
2.7.1.146
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.146
     R09084  beta-D-Fructose 6-phosphate + ADP <=> beta-D-Fructose 1,6-bisphosphate + AMP
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.7.1.146
   R05805  D-Fructose 6-phosphate <=> D-Fructose 1,6-bisphosphate
    R09084  beta-D-Fructose 6-phosphate <=> beta-D-Fructose 1,6-bisphosphate
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
LinkDB

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