KEGG   ORTHOLOGY: K00918
Entry
K00918                      KO                                     

Name
pfkC
Definition
ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00030  Pentose phosphate pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
   00030 Pentose phosphate pathway
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
  09102 Energy metabolism
   00680 Methane metabolism
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.146  ADP-specific phosphofructokinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
    2.7.1.147  ADP-specific glucose/glucosamine kinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
Other DBs
RN: R05805 R09084 R09085 R09086
COG: COG4809
GO: 0043844 0043843
Genes
GRC: GI584_20260
TCO: Theco_1176
CSCI: HDCHBGLK_00653
CSH: Closa_0608
HALS: D7D81_07845
LPIL: LIP_1249
MBAS: ALGA_3097
ASAC: ATHSA_0704
MJA: MJ_1604
MFE: Mefer_1517
MMP: MMP1296(pfkC)
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
PHO: PH0589(PH0589) PH1645(PH1645)
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
MAC: MA_3562(glkA) MA_3563(pfk)
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
NMG: Nmag_3826
 » show all
Reference
  Authors
Verhees CH, Kengen SW, Tuininga JE, Schut GJ, Adams MW, De Vos WM, Van Der Oost J
  Title
The unique features of glycolytic pathways in Archaea.
  Journal
Biochem J 375:231-46 (2003)
DOI:10.1042/BJ20021472
Reference
  Authors
Sakuraba H, Yoshioka I, Koga S, Takahashi M, Kitahama Y, Satomura T, Kawakami R, Ohshima T
  Title
ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus jannaschii.
  Journal
J Biol Chem 277:12495-8 (2002)
DOI:10.1074/jbc.C200059200
  Sequence
[mja:MJ_1604]
LinkDB

KEGG   ENZYME: 2.7.1.146
Entry
EC 2.7.1.146                Enzyme                                 

Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase;
ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
R05805 > R09084
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
History
EC 2.7.1.146 created 2001
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
Genes
GRC: GI584_20260
TCO: Theco_1176
CSCI: HDCHBGLK_00653
CSH: Closa_0608
HALS: D7D81_07845
LPIL: LIP_1249
MBAS: ALGA_3097
ASAC: ATHSA_0704
MJA: MJ_1604
MFE: Mefer_1517
MMP: MMP1296(pfkC)
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
PHO: PH0589(PH0589) PH1645(PH1645)
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
MAC: MA_3562(glkA) MA_3563(pfk)
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
NMG: Nmag_3826
 » show all
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 274:21023-8 (1999)
DOI:10.1074/jbc.274.30.21023
  Sequence
[pfu:PF1784]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.146
IUBMB Enzyme Nomenclature: 2.7.1.146
ExPASy - ENZYME nomenclature database: 2.7.1.146
BRENDA, the Enzyme Database: 2.7.1.146
CAS: 237739-62-7
LinkDB

KEGG   REACTION: R09084
Entry
R09084                      Reaction                               

Name
ADP:D-fructose-6-phosphate 1-phosphotransferase
Definition
beta-D-Fructose 6-phosphate + ADP <=> beta-D-Fructose 1,6-bisphosphate + AMP
Equation
Reaction class
RC00002  C00008_C00020
RC00017  C05345_C05378
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00030  Pentose phosphate pathway
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
LinkDB

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