KEGG ORTHOLOGY: K01335

ORTHOLOGY: K01335

Entry

K01335                      KO

Symbol

CFB

Name

complement factor B [EC:3.4.21.47]

Pathway

map04610

Complement and coagulation cascades

map05150

Staphylococcus aureus infection

map05171

Coronavirus disease - COVID-19

Disease

H00104

Alternative complement pathway component defects

H00821

Age-related macular degeneration

H01434

Atypical hemolytic uremic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01335  CFB; complement factor B
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01335  CFB; complement factor B
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K01335  CFB; complement factor B
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01335  CFB; complement factor B
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.47  alternative-complement-pathway C3/C5 convertase
     K01335  CFB; complement factor B
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01335  CFB; complement factor B

Genes

HSA:

629(CFB)

PTR:	494140(CFB)

PPS:	100990821(CFB)

GGO:	101141641(CFB)

PON:	103890868(CFB)

PPYG:

129039426(CFB)

NLE:	100595765(CFB)

HMH:	116460293(CFB)

SSYN:

129473845(CFB)

MCC:	716809(CFB)

MCF:	102133787(CFB)

MTHB:

126953215

MNI:	105497598(CFB)

CSAB:

108449896(CFB)

CATY:

105583239(CFB)

TGE:	112622244(CFB)

MLEU:

105554196(CFB)

RRO:	104678121(CFB)

RBB:	108520262(CFB)

TFN:	117086976(CFB)

PTEH:

111523926

CANG:

105513764(CFB)

CJC:	100409227(CFB)

SBQ:	101036079(CFB)

CIMI:

108299810(CFB)

ANAN:

105706374(CFB)

CSYR:

103271298(CFB)

MMUR:

105858159(CFB)

LCAT:

123631760(CFB)

PCOQ:

105817868(CFB)

OGA:	100949772(CFB)

MMU:	14962(Cfb)

MCAL:

110312388(Cfb)

MPAH:

110336125(Cfb)

RNO:	294257(Cfb)

MCOC:

116075349(Cfb)

ANU:	117724306(Cfb)

ASYL:

127670194(Cfb)

MUN:	110560137(Cfb)

CGE:	100758781(Cfb)

MAUA:

101829676(Cfb)

PROB:

127224317

PLEU:

114705866(Cfb)

MORG:

121435234(Cfb)

MFOT:

126495379

AAMP:

119822468(Cfb)

NGI:	108490121(Cfb)

HGL:	101725137(Cfb)

CPOC:

100715616(Cfb)

CCAN:

109689576(Cfb)

DORD:

105999873(Cfb)

DSP:	122111494(Cfb)

PLOP:

125352765(Cfb)

NCAR:

124989525

MMMA:

107143742(Cfb)

ITI:	101977232(Cfb)

OCU:	100355944 127493062

OPI:	101536636(CFB)

TUP:	102480574(CFB)

GVR:	103592350(CFB)

CFA:	100688056(CFB)

CLUD:

112641336(CFB)

VVP:	112913626(CFB)

VLG:	121500776(CFB)

NPO:	129513062(CFB)

AML:	100474759(CFB)

UMR:	103682288(CFB)

UAH:	113243739(CFB)

UAR:	123790973(CFB)

ELK:

111152198

LLV:

125101522

MPUF:

101692539(CFB)

MNP:	132017820(CFB)

MLK:	131834324(CFB)

NVS:	122911427(CFB)

ORO:	101378817(CFB)

EJU:	114222131(CFB)

ZCA:	113927725(CFB)

MLX:	118027314(CFB)

NSU:	110586797(CFB)

LWW:	102736578(CFB)

FCA:	101093018(CFB)

PYU:	121022337(CFB)

PCOO:

112853528(CFB)

PBG:	122478265(CFB)

PVIV:

125166111(CFB)

LRUF:

124528856

LGF:	123608170(CFB)

AJU:

106983483

PTG:	102969938(CFB)

PPAD:

109260506(CFB)

PUC:

125938421

PLEZ:

122219716(CFB)

HHV:	120221920(CFB)

BTA:	514076(CFB)

BOM:	102267775(CFB)

BIU:	109576933(CFB)

BBUB:

102404663(CFB)

BBIS:

104983806(CFB)

CHX:	102175816(CFB)

OAS:	101115072(CFB)

BTAX:

128055296(CFB)

CSUM:

138069479(CFB)

ODA:	120870573(CFB)

CCAD:

122429827(CFB)

MREE:

136151284(CFB)

OVR:	110139429(CFB)

MBEZ:

129543123(CFB)

SSC:	100124383(CFB)

CFR:	102519366(CFB)

CBAI:

105074040

CDK:	105087438(CFB)

VPC:	102528827(CFB)

BACU:

103017988(CFB)

BMUS:

118903152(CFB)

LVE:	103071310(CFB)

OOR:	101281312(CFB)

LALB:

132527458(CFB)

DLE:	111170703(CFB)

PCAD:

102991673(CFB)

PSIU:

116762859(CFB)

NASI:

112395373(CFB)

ECB:	100051124(CFB)

EPZ:	103563301(CFB)

EAI:	106831003(CFB)

MYB:	102262757(CFB)

MYD:	102766003(CFB)

MMYO:

118679565(CFB)

MLF:	102435318(CFB)

MDT:	132237690(CFB)

MYUM:

139012677(CFB)

PKL:	118705365(CFB)

EFUS:

103300456(CFB)

MNA:	107538978(CFB)

DRO:

112302049

SHON:

118979559(CFB)

AJM:	119053693(CFB)

PDIC:

114494197(CFB)

PHAS:

123810444(CFB)

MMF:	118621310(CFB)

PPAM:

129067330(CFB)

HAI:	109373064(CFB)

RFQ:	117020466(CFB)

PALE:

102877940(CFB)

PGIG:

120618897(CFB)

PVP:	105305289(CFB)

RAY:	107498437(CFB)

MJV:	108393990(CFB)

TOD:	119252230(CFB)

SARA:

101542103

SFUM:

130036184(CFB)

SETR:

125996204(CFB)

LAV:	100668025(CFB)

TMU:

101350698

ETF:	101661853(CFB)

DNM:

101435826

MDO:	107648882(CFB)

GAS:	123245151(CFB)

AFZ:

127561088

PCW:	110199443(CFB)

TVP:	118857288(CFB)

PBRV:

138149990(CFB)

TACU:

119947055(CFB)

LMUT:

125686229

ATRC:

139586860(CFB)

PHI:	106628820(CFB)

ACOE:

138100763(CFB)

MMEA:

130587546

AMJ:	102574048(CFB) 109280870

CCAY:

125620991(CFB) 125638670

DCC:	119842618(CFB)

CPIC:

101943785 101945361

MRV:

120403300

ACS:	100555786 100555981(cfb)

ASAO:

132765242

PVT:	110088690(CFB)

SUND:

121922134

PBI:

103054626

PMUR:

107287873 107300231 107302884

CTIG:

120309287 120309288

TSR:	106539402 106544271

PGUT:

117667853(CFB)

APRI:

131193051

PTEX:

113449071 113452771

NSS:	113424958(CFB)

PMUA:

114590977(CFB)

HCG:	128343946(CFB)

GJA:	107105481(CFB)

EMC:	129329016(CFB)

XLA:	108698939 373577(cfb.S) 397725(cfb.L)

XTR:	100491419(cfb)

NPR:

108786506

RTEM:

120913256

BBUF:

120977484 120977492 120977496 120978194 120978195 120978196

BGAR:

122919722 122946120 122946787 122946788 122946789

PWL:	138299143 138299144 138299145

MUO:	115466210(CFB)

GSH:	117346945(CFB)

DRE:	30604(cfb) 792472(cfbl)

SRX:	107715263 107715390 107715393 107723846 107756066 107756181

SANH:

107669352 107669354 107693811 107693822

SGH:	107568309 107572119 107574087 107574090

CCAR:

109052424 109052426 109052431 109052954

CAUA:

113038495 113038496 113063652 113064084 113064085 113064160 113071732 113078027

CGIB:

127941543 127941544 127941545 127986601 127986602

PTET:

122326861 122326862 122326863

LROH:

127152807 127152808 127162231

OMC:	131528199 131528201 131528455 131528456

PPRM:

120494436(cfb) 120494437

RKG:	130095288 130095290(cfbl) 130095291

MAMB:

125252216 125252217 125252218 125252219 125252222(cfbl)

CIDE:

127503140 127503142

CERY:

137012467(cfb) 137012469 137012470

MASI:

127428639 127430541 127430554

TDW:	130407559 130407560 130407561

MANU:

129423416 129423417 129423419 129423420

PDAB:

135776415 135776416(cfb) 135776417 135776418 135776784

IPU:

IFU:

PHYP:

SMEO:

TFD:	113662099 113662100

TVC:

132859841

CGAR:

128507487 128507792

NGRA:

132895565

TRN:	134330163 134330321(cfbl) 134330322

AMEX:

103039688 103040831

CMAO:

118802480 118819931 118819932(cfbl)

EEE:	113568769 113585998

CHAR:

105904728 105909372 105909521

SPIL:

134070392 134070393

TRU:	101069540 101069998

TFS:	130537476 130537477

TNG:	GSTEN00018968G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130189422(cfb)

CANA:

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:

ONL:

OAU:	116317731 116336174

OLA:	100049430(bf/c2)

OML:	112142732 112142733

CSAI:

133459640(cfbl)

XMA:	102216506 102235456

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122844416 122844417

PPRL:

129368830

CVG:	107098502 107098503

CTUL:

119775850(bfb) 119775881

GMU:	124876043 124876048

NFU:	107379288 107379289 107386372

KMR:

ALIM:

NWH:

AOCE:

EJA:	138196410(cfbl)

BFRE:

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140360778 140360779

MALB:

109959265

BSPL:

114869783 114869784 114869785

SJO:	128370997 128371817

SSCO:

133994436

GMH:

115546677

SASA:

106563698 106569366 106602980

STRU:

115154834 115157306 115204449

OTW:	112228943 112231175(cfbl) 112260753

OMY:	100136605(cfbl) 100653464 110534129(cfb)

OGO:	124006256 124007468 124010056

ONE:	115101442 115114668 115135507

OKI:	109872818 109873985 109875216

OKE:	118384990(cfbl) 118390500 118401882

OMM:	135511501 135544149 135550294

OCLA:

139387084 139387860 139418653

SALP:

111956628 111964346

SNH:	120021442(cfbl) 120056081 120057316

CCLU:

121542096 121579609 123481564

ELS:	105030044 105030049

OEP:	134013943 134016123

SFM:	108934440(cfb) 108938433

PKI:	111839196 111860092

AANG:

118234983(cfbl)

AROT:

135262341

CCOG:

133132232(cfbl)

PSPA:

121299068(cfbl)

ARUT:

117398282 117430318 117434000 117434001 117964868 117964901 117964906

LCM:	102360252 102360987(CFB)

RTP:

109921430

CPLA:

122541420 122541423 122564127

HOC:	132832720 132832721

LERI:

129710735 129716249

PMRN:

116942790 116946924

LRJ:	133342838 133351216

BBEL:

109471260

CIN:	497244(bf-3)

SCLV:

120329807 120344514 120344863 120344889 120345032 120345064

SPU:	373308(bf)

AJJ:	139964109 139964110 139964111 139964112 139964114 139964115 139964116

APLC:

110989106 110989117

AFIL:

140138742 140138743 140159442

SKO:

100373330

PFLL:

139117223 139144231 139152786 139152788

RSAN:

RMP:

CSCU:

PTEP:

ABRU:

UDV:	129224726 129234609

SDM:	118189532 118204855

LPOL:

106464946

MMER:

123548952 123552382

RPHI:

132723260 132731317 132741992

MAEA:

128223123 128233754

LLON:

135500952 135501235 135501597 135501666 135503291

ATEN:

116300929

PDAM:

113673827

SPIS:

111333045

DGT:	114533679 114533680

XEN:	124438971 124439145

» show all

Reference

PMID:14748705

Authors

Sim RB, Tsiftsoglou SA

Title

Proteases of the complement system.

Journal

Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021

Reference

PMID:2249879

Authors

Davrinche C, Abbal M, Clerc A

Title

Molecular characterization of human complement factor B subtypes.

Journal

Immunogenetics 32:309-12 (1990)
DOI:10.1007/bf00211644

Sequence

[hsa:629]

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