KEGG T01001: 629

Homo sapiens (human): 629

Entry

629               CDS       T01001

Symbol

CFB, AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2

Name

(RefSeq) complement factor B

K01335

complement factor B [EC:3.4.21.47]

Organism

hsa Homo sapiens (human)

Pathway

hsa04610

Complement and coagulation cascades

hsa05150

Staphylococcus aureus infection

hsa05171

Coronavirus disease - COVID-19

Network

nt06513 Complement cascade

Element

N01493

Alternative pathway of complement cascade, C3 convertase formation

N01494

Alternative pathway of complement cascade, C3/5 convertase formation

Disease

H00104

Alternative complement pathway component defects

H00821

Age-related macular degeneration

H01434

Atypical hemolytic uremic syndrome

Drug target

Iptacopan (DG03207):

D12251 D12252<JP/US>

Ruxoprubart:

D12857

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    629 (CFB)
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    629 (CFB)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    629 (CFB)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    629 (CFB)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.47  alternative-complement-pathway C3/C5 convertase
     629 (CFB)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
  Family S1: chymotrypsin family
   629 (CFB)

SSDB

Motif

Pfam:

Trypsin VWA Sushi VWA_2 DUF1986 HRM Trypsin_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

CPD:

UniProt:

Structure

LinkDB

Position

6:31946095..31952084

AA seq 764 aa
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL

NT seq 2295 nt +upstreamnt +downstreamnt
atggggagcaatctcagcccccaactctgcctgatgccctttatcttgggcctcttgtct
ggaggtgtgaccaccactccatggtctttggcccggccccagggatcctgctctctggag
ggggtagagatcaaaggcggctccttccgacttctccaagagggccaggcactggagtac
gtgtgtccttctggcttctacccgtaccctgtgcagacacgtacctgcagatctacgggg
tcctggagcaccctgaagactcaagaccaaaagactgtcaggaaggcagagtgcagagca
atccactgtccaagaccacacgacttcgagaacggggaatactggccccggtctccctac
tacaatgtgagtgatgagatctctttccactgctatgacggttacactctccggggctct
gccaatcgcacctgccaagtgaatggccgatggagtgggcagacagcgatctgtgacaac
ggagcggggtactgctccaacccgggcatccccattggcacaaggaaggtgggcagccag
taccgccttgaagacagcgtcacctaccactgcagccgggggcttaccctgcgtggctcc
cagcggcgaacgtgtcaggaaggtggctcttggagcgggacggagccttcctgccaagac
tccttcatgtacgacacccctcaagaggtggccgaagctttcctgtcttccctgacagag
accatagaaggagtcgatgctgaggatgggcacggcccaggggaacaacagaagcggaag
atcgtcctggacccttcaggctccatgaacatctacctggtgctagatggatcagacagc
attggggccagcaacttcacaggagccaaaaagtgtctagtcaacttaattgagaaggtg
gcaagttatggtgtgaagccaagatatggtctagtgacatatgccacataccccaaaatt
tgggtcaaagtgtctgaagcagacagcagtaatgcagactgggtcacgaagcagctcaat
gaaatcaattatgaagaccacaagttgaagtcagggactaacaccaagaaggccctccag
gcagtgtacagcatgatgagctggccagatgacgtccctcctgaaggctggaaccgcacc
cgccatgtcatcatcctcatgactgatggattgcacaacatgggcggggacccaattact
gtcattgatgagatccgggacttgctatacattggcaaggatcgcaaaaacccaagggag
gattatctggatgtctatgtgtttggggtcgggcctttggtgaaccaagtgaacatcaat
gctttggcttccaagaaagacaatgagcaacatgtgttcaaagtcaaggatatggaaaac
ctggaagatgttttctaccaaatgatcgatgaaagccagtctctgagtctctgtggcatg
gtttgggaacacaggaagggtaccgattaccacaagcaaccatggcaggccaagatctca
gtcattcgcccttcaaagggacacgagagctgtatgggggctgtggtgtctgagtacttt
gtgctgacagcagcacattgtttcactgtggatgacaaggaacactcaatcaaggtcagc
gtaggaggggagaagcgggacctggagatagaagtagtcctatttcaccccaactacaac
attaatgggaaaaaagaagcaggaattcctgaattttatgactatgacgttgccctgatc
aagctcaagaataagctgaaatatggccagactatcaggcccatttgtctcccctgcacc
gagggaacaactcgagctttgaggcttcctccaactaccacttgccagcaacaaaaggaa
gagctgctccctgcacaggatatcaaagctctgtttgtgtctgaggaggagaaaaagctg
actcggaaggaggtctacatcaagaatggggataagaaaggcagctgtgagagagatgct
caatatgccccaggctatgacaaagtcaaggacatctcagaggtggtcacccctcggttc
ctttgtactggaggagtgagtccctatgctgaccccaatacttgcagaggtgattctggc
ggccccttgatagttcacaagagaagtcgtttcattcaagttggtgtaatcagctgggga
gtagtggatgtctgcaaaaaccagaagcggcaaaagcaggtacctgctcacgcccgagac
tttcacatcaacctctttcaagtgctgccctggctgaaggagaaactccaagatgaggat
ttgggttttctataa

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