KEGG ORTHOLOGY: K02318

ORTHOLOGY: K02318

Entry

K02318                      KO

Symbol

COASY

Name

phosphopantetheine adenylyltransferase / dephospho-CoA kinase [EC:2.7.7.3 2.7.1.24]

Pathway

map00770

Pantothenate and CoA biosynthesis

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Module

M00120

Coenzyme A biosynthesis, pantothenate => CoA

Reaction

R00130

ATP:dephospho-CoA 3'-phosphotransferase

R03035

ATP:pantetheine-4'-phosphate adenylyltransferase

Disease

H00833

Neurodegeneration with brain iron accumulation

H00897

Pontocerebellar hypoplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K02318  COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K02318  COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.24  dephospho-CoA kinase
     K02318  COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase
   2.7.7  Nucleotidyltransferases
    2.7.7.3  pantetheine-phosphate adenylyltransferase
     K02318  COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    K02318  COASY; phosphopantetheine adenylyltransferase / dephospho-CoA kinase

Other DBs

GO:	0004595 0004140

Genes

HSA:	80347(COASY)

PTR:	454690(COASY)

PPS:	100991461(COASY)

GGO:	101151903(COASY)

PON:	100456097(COASY)

PPYG:

129017281(COASY)

NLE:	100600459(COASY)

HMH:	116474872(COASY)

SSYN:

129469747(COASY)

MCC:	710491(COASY)

MCF:	102124775(COASY)

MTHB:

126938456

MNI:	105472113(COASY)

CSAB:

103243403(COASY)

CATY:

105579675(COASY)

PANU:

101005578(COASY)

TGE:	112609033(COASY)

MLEU:

105552954(COASY)

RRO:	104680238(COASY)

RBB:	108518329(COASY)

TFN:	117066952(COASY)

PTEH:

111537361(COASY)

CANG:

105503000(COASY)

CJC:	100409362(COASY)

SBQ:	101039046(COASY)

CIMI:

108289767(COASY)

ANAN:

105711252(COASY)

CSYR:

103250235(COASY)

MMUR:

105859403(COASY)

LCAT:

123620964(COASY)

PCOQ:

105820235(COASY)

OGA:	100955120(COASY)

MMU:	71743(Coasy)

MCAL:

110305492(Coasy)

MPAH:

110331632(Coasy)

RNO:	287711(Coasy)

MCOC:

116078329(Coasy)

ANU:	117710090(Coasy)

ASYL:

127694246(Coasy)

MUN:	110550914(Coasy)

CGE:	100757898(Coasy)

MAUA:

101832356(Coasy)

PROB:

127216463(Coasy)

PLEU:

114682796(Coasy)

MORG:

121442413(Coasy)

MFOT:

126510102

AAMP:

119811849(Coasy)

NGI:	103735902(Coasy)

HGL:	101718395(Coasy)

CPOC:

100718478(Coasy)

CCAN:

109687307(Coasy)

DORD:

106003252(Coasy)

DSP:	122103399(Coasy)

PLOP:

125366465(Coasy)

NCAR:

124981116

MMMA:

107150566(Coasy)

ITI:	101967739(Coasy)

OCU:

100344683

OPI:	101520064(COASY)

TUP:	102494262(COASY)

GVR:	103589836(COASY)

CFA:	480517(COASY)

CLUD:

112655381(COASY)

VVP:	112910766(COASY)

VLG:	121472813(COASY)

NPO:	129512514(COASY)

AML:	100479996(COASY)

UMR:	103672577(COASY)

UAH:	113265414(COASY)

UAR:	123781955(COASY)

ELK:

111151242

LLV:

125087287

MPUF:

101687112(COASY)

MNP:	132004089(COASY)

MLK:	131817100(COASY)

NVS:	122906188(COASY)

ORO:	101375788(COASY)

EJU:	114201357(COASY)

ZCA:	113912972 113939596(COASY)

MLX:	118024918(COASY)

NSU:	110573225(COASY)

FCA:	101091667(COASY)

PYU:	121045030(COASY)

PCOO:

112854110(COASY)

PBG:	122485609(COASY)

PVIV:

125158423(COASY)

LRUF:

124522113

LGF:	123603738(COASY)

AJU:

106972612

PTG:	102959694(COASY)

PPAD:

109258567(COASY)

PUC:

125926576

PLEZ:

122206311(COASY)

HHV:	120248444(COASY)

BTA:	614728(COASY)

BOM:	102280791(COASY)

BIU:	109553164 109574082(COASY)

BBUB:

102412358(COASY)

BBIS:

104990437(COASY)

CHX:	102187624(COASY)

OAS:	101102655(COASY)

BTAX:

128064921(COASY)

CSUM:

138083407(COASY)

ODA:	120867086(COASY)

CCAD:

122441487(COASY)

MREE:

136149650(COASY)

OVR:	110133815(COASY)

MBEZ:

129544430(COASY)

SSC:	396688(COASY)

CFR:	102518963(COASY)

CBAI:

105080109(COASY)

CDK:	105090464(COASY)

VPC:	102539704(COASY)

BACU:

103017923 103018758

BMUS:

118887436(COASY)

LVE:	103070347(COASY)

OOR:	101283706(COASY)

LALB:

132512005(COASY)

DLE:	111166389(COASY)

PCAD:

102974646(COASY)

PSIU:

116746272(COASY)

NASI:

112400155(COASY)

ECB:	100066023(COASY)

EPZ:	103550361(COASY)

EAI:	106826276(COASY)

MYB:	102261991(COASY)

MYD:	102753266(COASY)

MMYO:

118671494(COASY)

MLF:	102419716(COASY)

MDT:	132218659(COASY)

MYUM:

138994801(COASY)

PKL:	118726368(COASY)

EFUS:

103293088(COASY)

MNA:	107528867(COASY)

DRO:	112298565(COASY)

SHON:

118978008(COASY)

AJM:	119052096(COASY)

PDIC:

114503453(COASY)

PHAS:

123817678(COASY)

MMF:	118633904(COASY)

PPAM:

129087020(COASY)

HAI:	109395775(COASY)

RFQ:	117013830(COASY)

PALE:

102882271(COASY)

PGIG:

120611082(COASY)

PVP:	105306287(COASY)

RAY:	107513829(COASY)

MJV:	108386061(COASY)

TOD:	119232056(COASY)

SARA:

101559230(COASY)

SFUM:

130035371(COASY)

SETR:

126017466(COASY)

LAV:	100673299(COASY)

TMU:

101353624

ETF:	101662897(COASY)

DNM:	101420772(COASY)

MDO:	100011732(COASY)

GAS:	123247960(COASY)

SHR:	100933060(COASY)

AFZ:

127560107

PCW:	110198394(COASY)

TVP:	118848512(COASY)

PBRV:

138145948(COASY)

OAA:	100680675(COASY)

TACU:

119935051(COASY)

PCOC:

116233604(COASY)

MGP:	100549752(COASY)

CJO:	107325150 107325315

TPAI:

128089004(COASY)

LMUT:

125684446(COASY)

NMEL:

110388419(COASY)

APLA:

101802327(COASY)

ACYG:

106047994(COASY)

CATA:

118259146(COASY)

AFUL:

116498260(COASY)

TGU:	101233652(COASY)

LSR:	110471885(COASY)

SCAN:

103821708(COASY)

PMOA:

120496588(COASY)

OTC:	121347673(COASY)

PRUF:

121351150(COASY)

ATRC:

139601729(COASY)

GFR:	102042995(COASY)

FAB:	101819981(COASY)

OMA:	130263977(COASY)

PHI:	102100635(COASY)

PMAJ:

107215089(COASY)

CCAE:

111945936(COASY)

CCW:	104697816(COASY)

ACOE:

138099377(COASY)

ETL:	114063615(COASY)

ZAB:	102062443(COASY)

ZLE:	135458412(COASY)

SVG:	106858618(COASY)

MMEA:

130581453(COASY)

HRT:	120763630(COASY)

SATI:

136372235(COASY)

CCIC:

134053026(COASY)

FPG:	101919756(COASY)

FCH:	102049823(COASY)

SHAB:

115617611(COASY)

TALA:

116959949 122152775(COASY)

ACHC:

115344619(COASY)

HLE:	104842948(COASY)

AGEN:

126038645

HHAR:

128141003(COASY)

GCL:

127026778

CSTI:

104555232(COASY)

DPUB:

104309600(COASY)

PPUS:

135191745(COASY)

EGZ:	104135071(COASY)

NNI:	104009929(MLX)

PADL:

103920531(COASY)

AFOR:

103902273(COASY)

CLV:	102098259(COASY)

MUI:	104546991(COASY)

PLET:

104618571(COASY)

CUCA:

104054475(COASY)

CPEA:

104385700(COASY)

CVF:

104296003

RTD:	128919374(COASY)

CRID:

134524495(COASY)

AAM:

106491089

AROW:

112968701(COASY)

NPD:	112951829(COASY)

DNE:	112993841(COASY)

SCAM:

104143588(COASY)

ASN:	102382044(COASY)

AMJ:	102565422(COASY)

CPOO:

109322943(COASY)

PSS:	102462841(COASY)

CMY:	102934092(COASY)

CCAY:

125626687(COASY)

DCC:	119849094(COASY)

CPIC:

101934771(COASY)

TST:	117869287(COASY)

CABI:

116820367(COASY)

MRV:	120392277(COASY)

ACS:	100567142(coasy)

ASAO:

132778212(COASY)

PVT:	110074872(COASY)

SUND:

121934896(COASY)

PBI:	103048219(COASY)

PMUR:

107282647(COASY)

CTIG:

120303499(COASY)

TSR:	106541159(COASY)

PGUT:

117664589(COASY)

APRI:

131197118(COASY)

PTEX:

113442882(COASY)

NSS:	113413511(COASY)

VKO:	123030671(COASY)

PMUA:

114581930(COASY)

PRAF:

128400802(COASY)

ZVI:	118094460(COASY)

HCG:	128331589(COASY)

GJA:	107111463(COASY)

STOW:

125444001(COASY)

EMC:	129338161(COASY)

XLA:	444569(coasy.L)

XTR:	100490454(coasy)

NPR:	108799037(COASY)

RTEM:

120919579(COASY)

BBUF:

121004735(COASY)

BGAR:

122941853(COASY)

PWL:	138299455(COASY)

MUO:	115481728(COASY)

GSH:	117347879(COASY)

DRE:	447838(coasy)

SRX:	107718069 107732065(coasy)

SANH:

107667171 107677173

SGH:	107554408 107599685(coasy)

CCAR:

109049463 109075411

CAUA:

113042587 113084853 113092755

CGIB:

127945930 128013248

PTET:

122329750(coasy)

LROH:

127155718(coasy)

OMC:	131532992(coasy)

PPRM:

120488049(coasy)

RKG:	130084149(coasy)

MAMB:

125258357(coasy)

CIDE:

127506208

CERY:

137014160(coasy)

MASI:

127431560 127434542

TROS:

130546960(coasy)

TDW:	130413222(coasy)

MANU:

129426488(coasy)

PDAB:

135740376(coasy)

IPU:

108264103

IFU:	128601151(coasy)

PHYP:

113533963(coasy)

SMEO:

124384071(coasy)

TFD:	113659050(coasy)

TVC:	132846379(coasy)

CGAR:

128520685(coasy)

NGRA:

132886431(coasy)

TRN:	134310939(coasy)

AMEX:

103045691(coasy)

CMAO:

118822613(coasy)

EEE:	113583783(coasy)

CHAR:

105905437(coasy)

SPIL:

134069658(coasy)

TRU:	101061926(coasy)

TFS:	130521765(coasy)

TNG:	GSTEN00008647G001

LCO:	104932149(coasy)

NCC:	104943459(coasy)

TBEN:

117473464(coasy)

CGOB:

115024531(coasy)

PGEO:

117464857(coasy)

GACU:

117543232(coasy)

EMAC:

134870832(coasy)

ELY:	117246629(coasy)

EFO:	125880830(coasy)

PLEP:

121958371(coasy) 121963545

SLUC:

116061233(coasy)

ECRA:

117936493(coasy)

ESP:	116671709(coasy)

PFLV:

114548103(coasy)

GAT:	120818926(coasy)

PPUG:

119213298(coasy)

AFB:	129091286(coasy)

CLUM:

117748709(coasy)

PSWI:

130203417(coasy)

CANA:

137789170(coasy)

CVE:	137886753(coasy)

MSAM:

119915527(coasy)

SCHU:

122868167(coasy)

CUD:	121528896(coasy)

SPUL:

138593909(coasy)

LMIX:

132956015(coasy)

ALAT:

119009848(coasy)

ASTR:

137588216(coasy)

MZE:	101470739(coasy)

ONL:	100703514(coasy)

OAU:	116327486(coasy)

OLA:	101173746(coasy)

OML:	112154027(coasy)

CSAI:

133418945(coasy)

XMA:	102228936(coasy)

XCO:	114152073(coasy)

XHE:	116727201(coasy)

PRET:

103481491(coasy)

PFOR:

103142340(coasy)

PLAI:

106937474(coasy)

PMEI:

106920260(coasy)

GAF:	122822834(coasy)

PPRL:

129368158(coasy)

CVG:	107088805(coasy)

CTUL:

119774919(coasy)

GMU:	124875169(coasy)

NFU:	107387567(coasy)

KMR:	108249049(coasy)

ALIM:

106516999(coasy)

NWH:	119424014(coasy)

AOCE:

111579055(coasy)

EJA:	138201902(coasy)

BFRE:

138617083(coasy)

MCEP:

125022709(coasy)

CSEM:

103381493(coasy)

POV:	109626964(coasy)

SSEN:

122759251(coasy)

SSOE:

131448737(coasy)

HHIP:

117752857(coasy)

HSP:	118100290(coasy)

PPLT:

128426889(coasy)

SMAU:

118287688(coasy)

LCF:

108901723

SDU:	111220054(coasy)

SLAL:

111657115(coasy)

XGL:	120794207(coasy)

HCQ:	109513396(coasy)

SSCV:

125991157(coasy)

SBIA:

133495159(coasy)

PEE:	133417753(coasy)

PTAO:

133469057(coasy)

BPEC:

110154307(coasy)

ENY:	140368596(coasy)

MALB:

109963087(coasy)

BSPL:

114845357(coasy)

SJO:	128381269(coasy)

SSCO:

134003253(coasy)

GMH:	115531018(coasy)

SASA:

106579131(coasy)

STRU:

115161334(coasy)

OTW:	112223789(coasy)

OMY:	110491699(coasy)

OGO:	124048438(coasy)

ONE:	115106656(coasy)

OKI:	109865535(coasy)

OKE:	118365156(coasy)

OMM:	135504817(coasy)

OCLA:

139368226

SALP:

111978503(coasy)

SNH:	120046353(coasy)

CCLU:

121560416(coasy)

ELS:	105028460(coasy)

OEP:	134031244(coasy)

SFM:	108928136(coasy)

PKI:	111842569(coasy)

AANG:

118220694(coasy)

AROT:

135247760(coasy)

CCOG:

133121880(coasy)

LOC:	102694112(coasy)

PSPA:

121302015(coasy)

ARUT:

117433282(coasy)

PSEX:

120517509(coasy)

LCM:	102362220(COASY)

CMK:	103183806(coasy)

RTP:	109929557(coasy)

CPLA:

122565523(coasy)

HOC:	132830893(coasy)

LERI:

129710051(coasy)

PMRN:

116948573(COASY)

LRJ:	133349790(COASY)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115923837 579804

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG10575(Ppat-Dpck)

DER:

6544694

DSE:

6610912

DSI:	Dsimw501_GD17598(Dsim_GD17598)

DYA:	Dyak_GE20540

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16599

DAZ:

108612496

DNV:

108650367

DHE:

111595307

DVI:	6622234(Ppat-Dpck)

CCAT:

101456034

BOD:

106618490

BDR:

105224800

RZE:	108369103 108379394

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135953457(Ppat-Dpck)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

ASUA:

CQU:	CpipJ_CPIJ008826

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139108887(Ppat-dpck)

TLN:	139809509(Ppat-dpck)

HST:

DQU:

CFO:

FEX:

PMEC:

138943143(Ppat-dpck)

LHU:	105673684(Ppat-Dpck)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

NPT:	124219140(Ppat-Dpck)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

136410901(Ppat-Dpck)

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207820

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933210(Ppat-Dpck)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106687948(Ppat-Dpck)

NLU:

111053869

HVI:

124366429

MQU:

129002149

PHU:	Phum_PHUM004620

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139690062(Ppat-Dpck)

FCD:

110852486

DPX:	DAPPUDRAFT_52530

DMK:

116918433

DPZ:

124342673

AFRA:

136039166 136040335 136041209

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123770314(Ppat-Dpck)

CQD:	128703431(Ppat-Dpck)

PTRU:

123515467

ESN:

127002133

MNZ:	135202859 135202860

MRJ:	136835008(Ppat-Dpck)

PORN:

139747440(Ppat-Dpck)

HAZT:

108680749

EAF:

111707999

LSM:	121115155(Ppat-Dpck)

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136989755(Ppat-Dpck)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_Y65B4A.8(Y65B4A.8)

CBR:	CBG_18542 CBG_22156

CRQ:	GCK72_001176 GCK72_001396

NAI:	NECAME_15000

BMY:	BM_BM6972(Bm6972)

LOA:	LOAG_08818

TSP:

Tsp_08941

HRO:	HELRODRAFT_82715

LGI:	LOTGIDRAFT_173410

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_149950

SHX:	MS3_00010948

OVI:	T265_02191

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:	124439490 124453618

HMG:

100209839

HSY:

130647769

RES:

135689980

TAD:	TRIADDRAFT_55032

AQU:

105314234

DDI:	DDB_G0285525

TGO:	TGME49_230990

PSOJ:

PHYSODRAFT_320933

» show all

Reference

PMID:11923312

Authors

Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A

Title

Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.

Journal

J Biol Chem 277:21431-9 (2002)
DOI:10.1074/jbc.M201708200

Sequence

[hsa:80347]

LinkDB

DBGET integrated database retrieval system