KEGG ORTHOLOGY: K02633

ORTHOLOGY: K02633

Entry

K02633                      KO

Symbol

PER2

Name

period circadian protein 2

Pathway

map04710

Circadian rhythm

map04711

Circadian rhythm - fly

map04713

Circadian entrainment

map05202

Transcriptional misregulation in cancer

map05221

Acute myeloid leukemia

Disease

H00688

Familial advanced sleep phase syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K02633  PER2; period circadian protein 2
   04713 Circadian entrainment
    K02633  PER2; period circadian protein 2
   04711 Circadian rhythm - fly
    K02633  PER2; period circadian protein 2
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K02633  PER2; period circadian protein 2
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K02633  PER2; period circadian protein 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K02633  PER2; period circadian protein 2
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  Check point factors
   Other check point factors
    K02633  PER2; period circadian protein 2

Genes

HSA:	8864(PER2)

PTR:	460057(PER2)

PPS:	100971888(PER2)

GGO:	101136580(PER2)

PON:	100433863(PER2)

PPYG:

129031454(PER2)

NLE:	100596712(PER2)

HMH:	116809367(PER2)

SSYN:

129488643(PER2)

MCC:	696476(PER2)

MCF:	102141183(PER2)

MTHB:

126933048

MNI:	105473817(PER2)

CSAB:

103218182(PER2)

CATY:

105577907(PER2)

PANU:

101001232(PER2)

TGE:	112636139(PER2)

MLEU:

105539844(PER2)

RRO:	104658049(PER2)

RBB:	108531921(PER2)

TFN:	117094318(PER2)

PTEH:

111553762(PER2)

CANG:

105502905(PER2)

CJC:	100410942(PER2)

SBQ:	101053996(PER2)

CIMI:

108310692(PER2)

ANAN:

105731629(PER2)

CSYR:

103260084(PER2)

MMUR:

105866415(PER2)

LCAT:

123643221(PER2)

PCOQ:

105813986(PER2)

OGA:	100950959(PER2)

MMU:	18627(Per2)

MCAL:

110291004(Per2)

MPAH:

110321613(Per2)

RNO:	63840(Per2)

MCOC:

116088770(Per2)

ANU:	117722427(Per2)

MUN:	110554310(Per2)

CGE:	100772001(Per2)

MAUA:

101834497(Per2)

PROB:

127226695(Per2)

PLEU:

114700680(Per2)

MORG:

121447197(Per2)

MFOT:

126514246

AAMP:

119820492(Per2)

NGI:	103733610(Per2)

HGL:	101724066(Per2)

CPOC:

100713579(Per2)

CCAN:

109693286(Per2)

DORD:

105980672(Per2)

DSP:	122128040(Per2)

PLOP:

125350142(Per2)

NCAR:

124979613

MMMA:

107138849(Per2)

OCU:

100349720

OPI:	101516229(PER2)

TUP:	102476055(PER2)

GVR:	103601506(PER2)

CFA:	486180(PER2)

CLUD:

112669991(PER2)

VVP:	112908777(PER2)

VLG:	121496731(PER2)

NPO:	129523451(PER2)

AML:	100468132(PER2)

UMR:	103662618(PER2)

UAH:	113249994(PER2)

UAR:	123790014(PER2)

ELK:

111145278

LLV:

125095411

MPUF:

101690138(PER2)

MNP:	132013696(PER2)

MLK:	131827274(PER2)

NVS:	122902460(PER2)

ORO:	101368281(PER2)

EJU:	114210826(PER2)

ZCA:	113920792(PER2)

MLX:	118011886(PER2)

NSU:	110570901(PER2)

LWW:	102737351(PER2)

FCA:	101088352(PER2)

PYU:	121014355(PER2)

PCOO:

112867632(PER2)

PBG:	122481974(PER2)

PVIV:

125158901(PER2)

LRUF:

124516348

PTG:	102964143(PER2)

PPAD:

109264827(PER2)

PUC:

125911012

AJU:

106967109

HHV:	120229541(PER2)

BTA:	512237(PER2)

BOM:	102272325(PER2)

BIU:	109556582(PER2)

BBUB:

102407269(PER2)

BBIS:

105004442(PER2)

CHX:	102178971(PER2)

OAS:	443259(PER2)

BTAX:

128044387(PER2)

ODA:	120856512(PER2)

CCAD:

122437311(PER2)

MBEZ:

129540600(PER2)

SSC:	100154609(PER2)

CFR:	102523986(PER2)

CBAI:

105063545(PER2)

CDK:	105105762(PER2)

VPC:	102528788(PER2)

BACU:

103004245(PER2)

BMUS:

118898194(PER2)

LVE:	103089690(PER2)

OOR:	101270576(PER2)

DLE:	111171985(PER2)

PCAD:

102989201(PER2)

PSIU:

116756885(PER2)

NASI:

112404689(PER2)

ECB:	100034167(PER2)

EPZ:	103559632(PER2)

EAI:	106832196(PER2)

MYB:	102239673(PER2)

MYD:	102759182(PER2)

MMYO:

118661280(PER2)

MLF:	102433851(PER2)

MDT:	132238413(PER2)

PKL:	118709891(PER2)

EFUS:

103283235(PER2)

MNA:	107530033(PER2)

DRO:	112307826(PER2)

SHON:

119003050(PER2)

AJM:	119061056(PER2)

PDIC:

114494660(PER2)

PHAS:

123823156(PER2)

MMF:	118625851(PER2)

PPAM:

129068600(PER2)

HAI:	109375021(PER2)

RFQ:	117026146(PER2)

PALE:

102896517(PER2)

PGIG:

120601708(PER2)

PVP:	105305112(PER2)

RAY:	107510593(PER2)

MJV:	108407247(PER2)

LAV:	100676638(PER2)

TMU:

101346172

ETF:	101639723(PER2)

DNM:	101423767(PER2)

MDO:	100022127(PER2)

GAS:	123246883(PER2)

SHR:	100918743(PER2)

AFZ:

127563159

PCW:	110198036(PER2)

TVP:	118858496(PER2)

OAA:	100074740(PER2)

GGA:	374116(PER2)

PCOC:

116230948(PER2)

MGP:	100008571(PER2) 104912585

CJO:	107317944(PER2)

TPAI:

128082640(PER2)

LMUT:

125697730(PER2)

NMEL:

110397251(PER2)

APLA:

101801476(PER2)

ACYG:

106040317(PER2)

CATA:

118246932(PER2)

AFUL:

116492380(PER2)

TGU:	100221513(PER2)

LSR:	110484830(PER2)

SCAN:

103824200(PER2)

PMOA:

120511198(PER2)

OTC:	121342064(PER2)

PRUF:

121363995(PER2)

GFR:

102041010

FAB:	101821464(PER2)

OMA:	130256544(PER2)

PHI:	102106828(PER2)

PMAJ:

107208758(PER2)

CCAE:

111945056(PER2)

CCW:	104693043(PER2)

CBRC:

103611984(PER2)

ETL:	114057701(PER2)

ZAB:	102064588(PER2)

ZLE:	135451553(PER2)

ACHL:

103803495

SVG:	106849579(PER2)

MMEA:

130580155(PER2)

HRT:	120756952(PER2)

SATI:

136365498(PER2)

FPG:	101916123(PER2)

FCH:	102054285(PER2)

CCRI:

104164536(PER2)

NNT:	104405975(PER2)

SHAB:

115611417(PER2)

ACUN:

113483272(PER2)

TALA:

104359342(PER2)

ACHC:

115347132(PER2)

HALD:

104318806(PER2)

HLE:	104832205(PER2)

AGEN:

126039266

GCL:

127019915

CSTI:

104550204(PER2)

LDI:	104340330(PER2)

MNB:	103778428(PER2)

DPUB:

104304087(PER2)

AVIT:

104267112(PER2)

BRHI:

104498546(PER2)

EGZ:	104135482(PER2)

NNI:	104023670(PER2)

PCRI:

104024496(PER2)

PCAO:

104050678

PADL:

103917839

AFOR:

103894033

FGA:	104074650(PER2)

GSTE:

104250926

CLV:	102098771(PER2)

MUI:	104543637(PER2)

PGUU:

104458230(PER2)

PLET:

104623063(PER2)

EHS:	104502518(PER2)

CMAC:

104473770

CUCA:

104066359(PER2)

TEO:	104378533(PER2)

BREG:

104629780(PER2)

OHA:	104335408(PER2)

ACAR:

104523942(PER2)

CPEA:

104395384(PER2)

CVF:	104282649(PER1)

RTD:	128911026(PER2)

AAM:	106496184(PER2)

AROW:

112972894(PER2)

NPD:	112947858(PER2)

TGT:	104572110(PER2)

DNE:	112988854(PER2)

SCAM:

104143547(PER2)

ASN:

102372737

AMJ:	102558725(PER2)

CPOO:

109308658(PER2)

GGN:	109288218(PER2)

PSS:	102461167(PER2)

CMY:	102936723(PER2)

CCAY:

125642445(PER2)

DCC:	119860991(PER2)

CPIC:

101938410(PER2)

TST:	117883303(PER2)

CABI:

116819464(PER2)

MRV:	120371692(PER2)

ACS:	100556699(per2)

ASAO:

132770696(PER2)

PVT:	110078726(PER2)

SUND:

121925307(PER2)

PBI:	103048182(PER2)

PMUR:

107293320

CTIG:

120308506

TSR:	106538751(PER2)

PGUT:

117678409(PER2)

APRI:

131201238(PER2)

PTEX:

113436834(PER2)

NSS:	113409704(PER2)

VKO:	123024741(PER2)

PMUA:

114597772(PER2)

PRAF:

128414548(PER2)

ZVI:	118093807(PER2)

HCG:	128351447(PER2)

GJA:	107110475(PER2)

STOW:

125437724

EMC:	129332121(PER2)

XLA:	394381(per2.L)

XTR:	100151702(per2)

NPR:	108796662(PER2)

RTEM:

120936562

BBUF:

120997647(PER2)

BGAR:

122935589(PER2)

MUO:	115478344(PER2)

GSH:	117366917(PER2)

DRE:	140633(per2)

SRX:	107726111 107728390 107737392

SANH:

107655301 107698490

SGH:	107569272 107572994

CCAR:

109057293 109057329

CAUA:

113045318 113113592

CGIB:

127935330 127950842

PTET:

122327352 122328819(per2) 122359034

LROH:

127175509(per2) 127177089

OMC:	131523098(per2) 131554320

PPRM:

120464710 120482434(per2)

RKG:	130087235(per2)

MAMB:

125248347 125250636(per2)

CIDE:

127496215 127500547

CERY:

137003466(per2) 137004123

MASI:

127422251 127429483 127441544 127442059

TROS:

130553951(per2) 130565055

TDW:	130417615(per2) 130428570

MANU:

129437442 129443196(per2)

IPU:	108280269 108280459(per2)

IFU:	128623862(per2) 128624188

PHYP:

113533218 113543344

SMEO:

124403031(per2) 124403080

TFD:	113640397 113640651(per2)

TVC:	132846747(per2) 132847653

TRN:	134302173 134302685(per2)

AMEX:

103027946 103039742(per2)

CMAO:

118796671(per2) 118796683

EEE:	113578961 113590464

CHAR:

105893790(per2)

TRU:	101061913 101074942(per2) 115246449

TFS:	130535428 130539524(per2)

TNG:	GSTEN00026769G001 GSTEN00028368G001

LCO:	104918281 104919392

NCC:	104941262(per2)

TBEN:

117488560(per2)

CGOB:

115021969

PGEO:

117461743(per2)

GACU:

117558380(per2)

EMAC:

134866405(per2) 134880574

ELY:	117259648 117263230(per2)

EFO:	125888243 125901776(per2)

PLEP:

121942800 121950903(per2)

SLUC:

116038944 116046083(per2)

ECRA:

117941823 117954226(per2)

ESP:	116680760 116698680

PFLV:

114551733(per2) 114565312

GAT:	120815910(per2) 120834641

PPUG:

119209697(per2) 119218880

AFB:	129111598(per2) 129115514

CLUM:

117741627 117746958(per2)

PSWI:

130197536 130210720

MSAM:

119883089 119902095(per2)

SCHU:

122878475 122886663(per2)

CUD:	121519718(per2) 121526424

ALAT:

119004642 119010517(per2)

ASTR:

137596325 137612084(per2)

MZE:	101465886(per2) 101485591

ONL:	100689707 100692129

OAU:	116316958(per2) 116321631

OLA:	101158624(per2) 101161338

OML:	112136440 112147051(per2)

CSAI:

133441576 133452724(per2)

XMA:	102220757 102222074(per2)

XCO:	114146573 114161687(per2)

XHE:	116721702 116737600

PRET:

103474948(per2) 103479643

PFOR:

103130355 103140706 103143047

PLAI:

106941719 106941729 106956786

PMEI:

106906541 106908653 106930547

GAF:	122832693 122840946(per2)

PPRL:

129359270 129361857(per2)

CVG:	107082679(per2) 107083335

CTUL:

119786181(per2) 119786917

GMU:	124870188(per2) 124884193

NFU:	107383961 107388065

KMR:	108239359 108239667(per2)

ALIM:

106522144 106534467

NWH:	119410499 119415117(per2)

AOCE:

111569711 111578789

MCEP:

125010538(per2) 125013199

CSEM:

103378226(per2) 103396076

POV:	109634507 109639905

SSEN:

122762696 122767790(per2)

HHIP:

117772850 117777637(per2)

HSP:	118106568 118118163(per2)

PPLT:

128439741 128454121(per2)

SMAU:

118299893 118311342(per2)

LCF:	108883459(per2) 108888223

SDU:	111232799 111238968

SLAL:

111653530 111668886

XGL:	120791715 120799452(per2)

HCQ:	109510843 109521251

SSCV:

125972529 125984518(per2)

SBIA:

133504716 133510769(per2)

PEE:	133404902 133411132

PTAO:

133482307 133489049(per2)

BPEC:

110153604 110158280

MALB:

109951961 109957699

BSPL:

114844717(per2) 114868056

SJO:	128360699 128369288(per2)

SASA:

100301980(per2) 106581343 106599551

STRU:

115156851 115169848

OTW:	112227009 112260395

OMY:	110508801 110530223

OGO:	124009961 124041933

ONE:	115103159 115114331

OKI:	109872060 109874463

OKE:	118395197 118402188

SALP:

111957278 111979352

SNH:	120020410 120056300

CCLU:

121535146(per2) 121580854

ELS:	105018507 105029130

SFM:	108932436 108935214

PKI:	111847548 111860664

AANG:

118210320 118229573(per2)

LOC:	102694501(per2)

PSPA:

121322552 121326350

ARUT:

117416452 117422898

PSEX:

120530875(per2)

LCM:	102353441(PER2)

CMK:	103175145(per2)

RTP:	109919168(per2)

CPLA:

122555832(per2)

HOC:	132821579(per2)

LERI:

129703742

PMRN:

116946838(PER1)

LRJ:	133351202(PER1)

BBEL:

109479609

DME:	Dmel_CG2647(per)

DER:

6550757

DSE:

6616175

DSI:	Dsimw501_GD26889(Dsim_GD26889)

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16295(Dmoj_per)

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:	101890180 131801868

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007193

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:	406112(Per)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105668944(per)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

MDL:

CGLO:

FAS:

CCIN:

AROA:

TCA:	659015(Per)

DPA:

109539844

SOY:	115879660 115891578

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

692522(Per)

BMAN:

114246916

MSEX:

115455052

DPL:	KGM_203908

BANY:

PMAC:

PPOT:

PXU:

PRAP:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

LGLY:

API:	100328916(per)

DNX:

AGS:

RMD:

CLEC:

HHAL:

106686423(per)

PHU:	Phum_PHUM247270

FOC:

TPAL:

ZNE:

CSEC:

BROR:

DPX:	DAPPUDRAFT_322497(PER)

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

MRJ:	136854052(per)

HAZT:

EAF:

DSV:

RSAN:

RMP:

CVS:	136975376(per)

PTEP:

BGT:

HRF:

HRJ:

CRG:

OSN:

Reference

PMID:11232563

Authors

Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptacek LJ, Fu YH

Title

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.

Journal

Science 291:1040-3 (2001)
DOI:10.1126/science.1057499

Sequence

[hsa:8864]

LinkDB

DBGET integrated database retrieval system