KEGG   ORTHOLOGY: K02861
Entry
K02861                      KO                                     
Symbol
RIPK1, RIP1
Name
receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
Pathway
map04064  NF-kappa B signaling pathway
map04210  Apoptosis
map04217  Necroptosis
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04668  TNF signaling pathway
map04936  Alcoholic liver disease
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
Disease
H02525  Disorders of innate immunity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04668 TNF signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04217 Necroptosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04621 NOD-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04622 RIG-I-like receptor signaling pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   04623 Cytosolic DNA-sensing pathway
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05160 Hepatitis C
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05163 Human cytomegalovirus infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05169 Epstein-Barr virus infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05132 Salmonella infection
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
   05131 Shigellosis
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RIPK family [OT]
   K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1
Genes
HSA: 8737(RIPK1)
PTR: 462397(RIPK1)
PPS: 100991521(RIPK1)
GGO: 101153833(RIPK1)
PON: 100449028(RIPK1)
NLE: 100599272(RIPK1)
MCC: 708013(RIPK1)
MCF: 101926590(RIPK1)
CSAB: 103222283(RIPK1)
CATY: 105596428(RIPK1)
PANU: 101011511(RIPK1)
TGE: 112622229(RIPK1)
RRO: 104661228(RIPK1)
RBB: 108514229(RIPK1)
TFN: 117086621(RIPK1)
PTEH: 111548565(RIPK1)
CJC: 100415562(RIPK1)
SBQ: 101047042(RIPK1)
CSYR: 103272007(RIPK1)
MMUR: 105873484(RIPK1)
OGA: 100949124(RIPK1)
MMU: 19766(Ripk1)
MCAL: 110307946(Ripk1)
MPAH: 110333762(Ripk1)
RNO: 306886(Ripk1)
MCOC: 116082569(Ripk1)
MUN: 110561376(Ripk1)
CGE: 100761116(Ripk1)
MAUA: 101835042(Ripk1)
PLEU: 114701254(Ripk1)
MORG: 121433918(Ripk1)
NGI: 103732937(Ripk1)
HGL: 101696605(Ripk1)
CPOC: 100727211(Ripk1)
CCAN: 109695449(Ripk1)
DORD: 105985992(Ripk1)
DSP: 122108407(Ripk1)
NCAR: 124989445
OCU: 100352965(RIPK1)
OPI: 101525469(RIPK1)
TUP: 102502622(RIPK1)
CFA: 102152063(RIPK1)
VVP: 112907423(RIPK1)
VLG: 121500447(RIPK1)
AML: 100469872(RIPK1)
UMR: 103664964(RIPK1)
UAH: 113264397(RIPK1)
UAR: 123801512(RIPK1)
ELK: 111156712
LLV: 125103136
MPUF: 101685502(RIPK1)
ORO: 101363053(RIPK1)
EJU: 114223902(RIPK1)
ZCA: 113927116(RIPK1)
MLX: 118027395(RIPK1)
FCA: 101087663(RIPK1)
PYU: 121020589(RIPK1)
PBG: 122489292(RIPK1)
PTG: 102964459(RIPK1)
PPAD: 109249466(RIPK1)
AJU: 106976163(RIPK1)
HHV: 120241444(RIPK1)
BTA: 504727(RIPK1)
BOM: 102279783(RIPK1)
BIU: 109577264(RIPK1)
BBUB: 102399138(RIPK1)
CHX: 102178407(RIPK1)
OAS: 101110186(RIPK1)
ODA: 120869963(RIPK1)
CCAD: 122429455(RIPK1)
SSC: 100524751(RIPK1)
CFR: 102516401(RIPK1)
CBAI: 105079771(RIPK1)
CDK: 105087344(RIPK1)
VPC: 102534952(RIPK1)
BACU: 103004292(RIPK1)
LVE: 103079935(RIPK1)
OOR: 101289751(RIPK1)
DLE: 111181305(RIPK1)
PCAD: 102985812(RIPK1)
PSIU: 116762851(RIPK1)
ECB: 100058015(RIPK1)
EPZ: 103556321(RIPK1)
EAI: 106847888(RIPK1)
MYB: 102245425(RIPK1)
MYD: 102770973(RIPK1)
MMYO: 118675368(RIPK1)
MLF: 102425101(RIPK1)
MNA: 107542939(RIPK1)
PKL: 118724462(RIPK1)
HAI: 109396595(RIPK1)
DRO: 112297551(RIPK1)
SHON: 118986453(RIPK1)
AJM: 119051788(RIPK1)
PDIC: 114497608(RIPK1)
PHAS: 123820769(RIPK1)
MMF: 118616944 118626388(RIPK1)
RFQ: 117027041(RIPK1)
PALE: 102885162(RIPK1)
PGIG: 120607712(RIPK1)
PVP: 105296778(RIPK1)
RAY: 107521720(RIPK1)
MJV: 108393592(RIPK1)
TOD: 119251060(RIPK1)
SARA: 101537410(RIPK1)
LAV: 100666489(RIPK1)
TMU: 101341436
DNM: 101427202(RIPK1)
MDO: 100028597(RIPK1)
GAS: 123240537(RIPK1)
SHR: 100914177(RIPK1)
PCW: 110201152(RIPK1)
OAA: 100079746(RIPK1) 114805391
GGA: 378921(RIPK1)
PCOC: 116226413(RIPK1)
MGP: 100542115(RIPK1)
CJO: 107309664(RIPK1)
NMEL: 110392996(RIPK1)
APLA: 101801990(RIPK1)
ACYG: 106043847(RIPK1)
AFUL: 116486694(RIPK1)
TGU: 100230522(RIPK1)
LSR: 110478243(RIPK1)
SCAN: 103817591(RIPK1)
PMOA: 120497257(RIPK1)
OTC: 121340487(RIPK1)
PRUF: 121357820(RIPK1)
GFR: 102038584(RIPK1)
FAB: 101806351(RIPK1)
PHI: 102112432(RIPK1)
PMAJ: 107199939(RIPK1)
CCAE: 111923828(RIPK1)
CCW: 120409663(RIPK1)
ETL: 114062379(RIPK1)
ZAB: 102066640(RIPK1)
FPG: 101913441(RIPK1)
FCH: 102058820(RIPK1)
CLV: 102093314(RIPK1)
EGZ: 104122827(RIPK1)
NNI: 104021840(RIPK1)
ACUN: 113477033(RIPK1)
TALA: 104360980(RIPK1)
PADL: 103919013(RIPK1)
ACHC: 115353096(RIPK1)
AAM: 106483966(RIPK1)
AROW: 112968039(RIPK1)
NPD: 112947649(RIPK1)
DNE: 112992029(RIPK1)
ASN: 102367941(RIPK1)
AMJ: 102572936(RIPK1)
CPOO: 109315078(RIPK1)
GGN: 109301070(RIPK1)
PSS: 102455858
CMY: 102944603(RIPK1)
CPIC: 101949964(RIPK1)
TST: 117873157(RIPK1)
CABI: 116835506(RIPK1)
MRV: 120396472(RIPK1)
ACS: 100556206(ripk1)
PVT: 110077096(RIPK1)
SUND: 121929823(RIPK1)
PBI: 103062047(RIPK1)
PMUR: 107285792(RIPK1)
TSR: 106553353(RIPK1)
PGUT: 117672432(RIPK1)
VKO: 123020633(RIPK1)
PMUA: 114600956(RIPK1)
ZVI: 118090528(RIPK1)
GJA: 107123834(RIPK1)
STOW: 125439120(RIPK1)
XLA: 108720077(ripk1.S) 734234(ripk1.L)
XTR: 779958(ripk1)
NPR: 108793401(RIPK1)
RTEM: 120940660(RIPK1)
BBUF: 121001072(RIPK1)
BGAR: 122938217(RIPK1)
DRE: 567460(ripk1l)
PPRM: 120470021(ripk1l)
MAMB: 125250625(ripk1l)
IPU: 108267903(ripk1l)
PHYP: 113547223(ripk1)
SMEO: 124387540(ripk1l)
TFD: 113662308(ripk1l)
AMEX: 103045920(ripk1)
EEE: 113582984(ripk1)
TRU: 101073092(ripk1)
LCO: 104931522(ripk1)
NCC: 104943381(ripk1)
CGOB: 115023129(ripk1)
ELY: 117272378(ripk1l)
PLEP: 121951905(ripk1l)
SLUC: 116046027(ripk1l)
ECRA: 117954180(ripk1l)
PFLV: 114565733(ripk1)
GAT: 120815607(ripk1l)
PPUG: 119209169(ripk1l)
MSAM: 119902043(ripk1l)
CUD: 121520732(ripk1l)
ALAT: 119011508(ripk1l)
MZE: 101477700(ripk1)
ONL: 100705112(ripk1)
OAU: 116318688(ripk1l)
OLA: 101167739(ripk1)
OML: 112147068(ripk1l)
XMA: 102226461(ripk1)
XCO: 114146782(ripk1)
XHE: 116721949(ripk1)
PRET: 103479635
PFOR: 103135809(ripk1)
PLAI: 106948613(ripk1)
PMEI: 106925927(ripk1)
GAF: 122841239(ripk1l)
CVG: 107090042(ripk1)
CTUL: 119795720(ripk1l)
GMU: 124870569(ripk1l)
NFU: 107383909(ripk1)
KMR: 108239582(ripk1l)
ALIM: 106533899(ripk1)
NWH: 119414197(ripk1l)
AOCE: 111568701(ripk1)
CSEM: 103396277(ripk1)
POV: 109645932(ripk1)
SSEN: 122777872(ripk1l)
HHIP: 117778363(ripk1l)
HSP: 118117970(ripk1l)
LCF: 108883409(ripk1)
SDU: 111231266(ripk1)
SLAL: 111670509(ripk1)
XGL: 120799349(ripk1l)
HCQ: 109521234(ripk1)
BPEC: 110158624(ripk1)
MALB: 109957635(ripk1)
BSPL: 114845086(ripk1l)
SASA: 106569156(ripk1) 106599735
ELS: 105018575(ripk1)
SFM: 108937518 108939327(ripk1)
PKI: 111845914(ripk1)
AANG: 118226129 118234395(ripk1l)
LOC: 102691146(ripk1)
PSPA: 121314593(ripk1l)
ARUT: 117394623(ripk1l)
LCM: 102363596(RIPK1)
CMK: 103176210(ripk1l)
BFO: 118418091
APLC: 110987573
TPAL: 117649048
GAE: 121388632
HRF: 124148256
HRJ: 124272674
CRG: 117682406
PMAX: 117337254
ATEN: 116287675
 » show all
Reference
  Authors
Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK
  Title
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
  Journal
Cell 137:1112-23 (2009)
DOI:10.1016/j.cell.2009.05.037
Reference
PMID:8612133
  Authors
Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV
  Title
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.
  Journal
Immunity 4:387-96 (1996)
DOI:10.1016/S1074-7613(00)80252-6
  Sequence
[hsa:8737]
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