KEGG   ORTHOLOGY: K03146
Entry
K03146                      KO                                     
Symbol
THI4, THI1
Name
cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60]
Pathway
map00730  Thiamine metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00897  Thiamine biosynthesis, plants, AIR (+ NAD+) => TMP/thiamine/TPP
M00898  Thiamine biosynthesis, pyridoxal-5P => TMP/thiamine/TPP
Reaction
R10685  NAD+:glycine ADP-D-ribosyltransferase (dehydroalanine-producing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K03146  THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.60  cysteine-dependent adenosine diphosphate thiazole synthase
     K03146  THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase
Other DBs
COG: COG1635
Genes
ATH: AT5G54770(THI1)
ALY: 9300430
CRB: 17876896
CSAT: 104726000 104731059 104763460
EUS: EUTSA_v10013978mg
BRP: 103844930 103851941 103857026
BNA: 106346007 106347311 106366413 106371241 106402237 106420919 125601255
BOE: 106318832 106327201 106335239
RSZ: 108836615 108837050 108844151 130501203
THJ: 104817652
CPAP: 110810965
CIT: 102626594(thi) 102629135
PVY: 116123427
EGR: 104450213
APRC: 113872364
TPRA: 123882686
PSAT: 127097128
PPER: 18780719
PMUM: 103342510
PDUL: 117623858
MNT: 21395127
CSAV: 115717421
CSV: 101211553
CMO: 103501605
BHJ: 120091480
RCU: 8280736
MEAN: 126670687
JCU: 105632894
HBR: 110647144
VVI: 100260728(THI1-1) 100265774(THI1-2)
SLY: 101257192
SPEN: 107025837
SOT: 102598996
SSTN: 125856795
SDUL: 129892560
CANN: 107856341
LBB: 132620419
NTA: 107797059(ThiI) 107798781
NSY: 104224143
NTO: 104087540
NAU: 109232136
SMIL: 130985758
SOE: 110795721
ATRI: 130818300
MOF: 131145521
NNU: 104604883
TSS: 122640918
OSA: 4343443
OBR: 102709384
OGL: 127779938
BDI: 100841709
ATS: 109771029
TUA: 125525971
PHAI: 112889419
DCT: 110108175
PEQ: 110031149
NCOL: 116249223
ATR: 18435056
APRO: F751_1708
SCE: YGR144W(THI4)
SEUB: DI49_2107
ERC: Ecym_6012
KMX: KLMA_40625(THI4)
CGR: 2891165(GVI51_M01067)
NCS: NCAS_0D01750(NCAS0D01750)
NDI: NDAI_0C02860(NDAI0C02860)
TPF: TPHA_0A04790(TPHA0A04790)
TBL: TBLA_0B09390(TBLA0B09390) TBLA_0H00760(TBLA0H00760)
TDL: TDEL_0H00200(TDEL0H00200)
KNG: KNAG_0E03150(KNAG0E03150)
LEL: PVL30_003709(THI4)
LBG: 92208508(LODBEIA_P33120)
CAL: CAALFM_C305130CA(THI4)
BNN: FOA43_001955(STI35)
BBRX: BRETT_001261(THI4)
YLI: 2905790(YALI2_A00151g)
SLB: AWJ20_4223(THI4)
NCR: NCU06110
NTE: NEUTE1DRAFT95662(NEUTE1DRAFT_95662)
SMP: 10802063(SMAC4_06409)
PBEL: QC761_508470(THI4)
PPSD: QC762_508470(THI4)
PPSP: QC763_508470(THI4)
PPSA: QC764_508470(THI4)
MGR: MGG_03098
PGRI: PgNI_10244
SSCK: SPSK_07738
FPOA: FPOAC1_002586(STI35)
FMU: J7337_005314(STI35)
TRE: TRIREDRAFT_68608(thi4)
TATV: 25781467(TrAtP1_003045)
TASP: 36616857(TrAFT101_006760)
MAW: 19245497(THI4_1)
MAJ: MAA_05549
MBRN: 26238893(sti35)
CMT: CCM_01639
PLJ: 28891457(PLICBS_010469)
PTKZ: JDV02_002359(THI4)
CDET: 87942727(CDEST_06224)
BFU: BCIN_07g06010(Bcthi4)
MBE: MBM_01288
ANI: ANIA_03928(thiF)
ALUC: AKAW2_80142S(THI4)
ACHE: ACHE_80625S(THI4)
APUU: APUU_40431S(THI4)
ABE: ARB_07940
TVE: TRV_04098
PTE: PTT_08482
PTRR: 6343353(PtrM4_121390)
SPO: 2540526(thi2)
SOM: SOMG_00517(thi2)
ABP: AGABI1DRAFT40074(AGABI1DRAFT_40074)
ABV: AGABI2DRAFT72787(AGABI2DRAFT_72787)
SCM: SCHCO_02490971(SCHCODRAFT_02490971)
WSE: WALSEDRAFT_32181(CYPBP37)
MGL: MGL_1314
PTRC: PtA15_7A55
SPAR: SPRG_04526
 » show all
Reference
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
  Sequence
[sce:YGR144W]
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