KEGG ORTHOLOGY: K04147

ORTHOLOGY: K04147

Entry

K04147                      KO

Symbol

DRD4

Name

dopamine receptor D4

Pathway

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04082

Neuroactive ligand signaling

map04728

Dopaminergic synapse

Disease

H01895

Attention deficit hyperactivity disorder (ADHD)

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04147  DRD4; dopamine receptor D4
   04082 Neuroactive ligand signaling
    K04147  DRD4; dopamine receptor D4
   04081 Hormone signaling
    K04147  DRD4; dopamine receptor D4
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K04147  DRD4; dopamine receptor D4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04147  DRD4; dopamine receptor D4
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Biogenic amine
   Dopamine
    K04147  DRD4; dopamine receptor D4

Other DBs

GO:

0001591

Genes

HSA:	1815(DRD4)

PTR:	449578(DRD4)

PPS:	100975028(DRD4)

GGO:	129525428(DRD4)

PON:	100462264(DRD4)

PPYG:

129007185(DRD4)

NLE:	100605969(DRD4)

HMH:	116466583(DRD4)

SSYN:

129471474(DRD4)

MCC:	699697(DRD4)

MCF:	102129091(DRD4)

MTHB:

126935840

MNI:	105494142(DRD4)

CSAB:

103231255(DRD4)

CATY:

105577204(DRD4)

PANU:

101006821(DRD4)

TGE:	112606858(DRD4)

RRO:	104656265(DRD4)

RBB:	108519717(DRD4)

TFN:	117079844(DRD4)

PTEH:

111533362(DRD4)

CANG:

105503278(DRD4)

CJC:	100410254(DRD4)

CIMI:

108288782(DRD4)

ANAN:

105719802(DRD4)

CSYR:

103252076(DRD4)

MMUR:

105874043(DRD4)

LCAT:

123641926(DRD4)

PCOQ:

105816504(DRD4)

OGA:	100942161(DRD4)

MMU:	13491(Drd4)

MCAL:

110299106(Drd4)

MPAH:

110336331(Drd4)

RNO:	25432(Drd4)

MCOC:

116100971(Drd4)

ANU:	117721041(Drd4)

ASYL:

127678608(Drd4)

MUN:	110553893(Drd4)

CGE:	100751093(Drd4)

MAUA:

101837477(Drd4)

PROB:

127227737(Drd4)

PLEU:

114695121(Drd4)

MORG:

121458134(Drd4)

MFOT:

126498200

AAMP:

119805682(Drd4)

NGI:	103751110(Drd4)

HGL:	101708437(Drd4)

CPOC:

100733356(Drd4)

CCAN:

109698036(Drd4)

DSP:	122102583(Drd4)

PLOP:

125361203(Drd4)

NCAR:

124960292

MMMA:

107156915(Drd4)

ITI:	101969444(Drd4)

CFA:	119864199(DRD4)

CLUD:

112663528(DRD4)

VVP:	112914608(DRD4)

VLG:	121472190(DRD4)

NPO:	129494047(DRD4)

AML:	105242158(DRD4)

UMR:	121104724(DRD4)

UAH:	113248798(DRD4)

UAR:	123775549(DRD4)

ELK:

111149948

LLV:

125078588

MPUF:

106004514(DRD4)

MNP:	132016443(DRD4)

MLK:	131822745(DRD4)

NVS:	122914580(DRD4)

ORO:	101374603(DRD4)

EJU:	114201511(DRD4)

ZCA:	113915198(DRD4)

MLX:	118015661(DRD4)

NSU:	110582245(DRD4)

LWW:	102742999(DRD4)

FCA:	111556768(DRD4)

PYU:	121022811(DRD4)

PBG:	122484168(DRD4)

PVIV:

125176906(DRD4)

LRUF:

124527531

LGF:	123602133(DRD4)

AJU:

113596787

PPAD:

109259826(DRD4)

PUC:

125937386

PLEZ:

122200632(DRD4)

HHV:	120223421(DRD4)

BTA:	101906668(DRD4)

BOM:	138984623(DRD4)

CHX:	108634223(DRD4)

OAS:	114110137(DRD4)

BTAX:

128069248(DRD4)

CSUM:

138084570(DRD4)

ODA:	120859780(DRD4)

CCAD:

122430586(DRD4)

MREE:

136169572(DRD4)

OVR:	110149587(DRD4)

MBEZ:

129548404(DRD4)

SSC:	100512329(DRD4)

CFR:	102505709(DRD4)

CBAI:

105069987(DRD4)

CDK:	105105453(DRD4)

VPC:	102527132(DRD4)

BACU:

102998943(DRD4)

BMUS:

118899812(DRD4)

LVE:	103077762(DRD4)

OOR:	101276710(DRD4)

LALB:

132526576(DRD4)

DLE:	111170290(DRD4)

PCAD:

102979303(DRD4)

PSIU:

116758686(DRD4)

ECB:	100147552(DRD4)

EPZ:	139074428(DRD4)

EAI:	123277790(DRD4)

MMYO:

118649020(DRD4)

MDT:	132241821(DRD4)

MYUM:

139018593(DRD4)

PKL:	118717953(DRD4)

EFUS:

129151286(DRD4)

MNA:	107542323(DRD4)

SHON:

118982257(DRD4)

AJM:	119062182(DRD4)

PDIC:

114499190(DRD4)

PHAS:

123807355(DRD4)

MMF:	118643168(DRD4)

PPAM:

129073109(DRD4)

HAI:	109375622(DRD4)

RFQ:	117030456(DRD4)

PGIG:

120584668(DRD4)

RAY:	107507163(DRD4)

MJV:	118971154(DRD4)

SARA:

101545829(DRD4)

SFUM:

130039727(DRD4)

SETR:

126018830(DRD4)

LAV:	100655981(DRD4)

TMU:

101352591

ETF:	101648333(DRD4)

MDO:	100618204(DRD4)

SHR:	116420079(DRD4)

AFZ:

127541738

PCW:	110202979(DRD4)

TVP:	118855253(DRD4)

PBRV:

138176995(DRD4)

OAA:	114810299(DRD4)

TACU:

119944159(DRD4)

GGA:	423016(DRD4)

PCOC:

116237805(DRD4)

MGP:	100546496(DRD4)

CJO:	107314165(DRD4)

TPAI:

128086642(DRD4)

LMUT:

125695211(DRD4)

NMEL:

110401919(DRD4)

APLA:

101797742(DRD4)

ACYG:

106047027(DRD4)

CATA:

118244697(DRD4)

AFUL:

116490135(DRD4)

TGU:	100228686(DRD4)

LSR:	110467571(DRD4)

SCAN:

103822310(DRD4)

PMOA:

120500962(DRD4)

OTC:	121337724(DRD4)

PRUF:

121357309(DRD4)

ATRC:

139590453(DRD4)

GFR:	102034185(DRD4)

FAB:	101816830(DRD4)

OMA:	130254469(DRD4)

PHI:	102106131(DRD4)

PMAJ:

107205240(DRD4)

CCAE:

111930366(DRD4)

CCW:	120410159(DRD4)

CBRC:

103613051(DRD4)

ACOE:

138112080(DRD4)

ETL:	114067952(DRD4)

ZAB:	102066929(DRD4)

ZLE:	135448447(DRD4)

ACHL:

103809898(DRD4)

SVG:	106854726(DRD4)

MMEA:

130581682(DRD4)

HRT:	120753743(DRD4)

SATI:

136362274(DRD4)

CCIC:

134045277(DRD4)

FPG:	101923143(DRD4)

FCH:	102047285(DRD4)

CCRI:

104166681(DRD4)

NNT:	104412238(DRD4)

SHAB:

115607020(DRD4)

ACUN:

113481035(DRD4)

TALA:

104364574(DRD4)

ACHC:

115352022(DRD4)

HALD:

104313536(DRD4)

HLE:	104829829(DRD4)

AGEN:

126047521

HHAR:

128152810(DRD4)

GCL:

127016976

LDI:	104346722(DRD4)

DPUB:

104299769(DRD4)

PPUS:

135185973(DRD4)

AVIT:

104272268(DRD4)

EGZ:	104131370(DRD4)

NNI:	104020528(DRD4)

PCRI:

104037332(DRD4)

PADL:

103925149(DRD4)

AFOR:

103902622(DRD4)

FGA:	104070893(DRD4)

GSTE:

104261022(DRD4)

CLV:	102096088(DRD4)

MUI:	104546493(DRD4)

PGUU:

104468117(DRD4)

PLET:

104616514(DRD4)

CMAC:

104483889(DRD4)

CUCA:

104064429(DRD4)

TEO:	104379034(DRD4)

BREG:

104637078(DRD4)

OHA:	104333302(DRD4)

CPEA:

104385140(DRD4)

CVF:	104292995(DRD4)

RTD:	128908475(DRD4)

CRID:

134514497(DRD4)

AAM:	106486729(DRD4)

AROW:

112969684(DRD4)

NPD:	112952065(DRD4)

TGT:	104580069(DRD4)

DNE:	112989506(DRD4)

SCAM:

104141485(DRD4)

ASN:	102382464(DRD4)

AMJ:	102563488(DRD4)

CPOO:

109318210(DRD4)

GGN:	109299217(DRD4)

PSS:	102459870(DRD4)

CMY:	102929688(DRD4)

CCAY:

125637605(DRD4)

DCC:	119857461 119858059(DRD4)

CPIC:

101932676(DRD4)

TST:	117876638(DRD4)

CABI:

116838806(DRD4)

MRV:	120403000(DRD4)

ACS:	100565088(drd4)

ASAO:

132771418(DRD4)

PVT:	110074195(DRD4)

SUND:

121916972(DRD4)

PBI:	103051517(DRD4)

PMUR:

107283884(DRD4)

CTIG:

120298379(DRD4)

TSR:	106553964(DRD4)

PGUT:

117665186(DRD4)

APRI:

131185036(DRD4)

PTEX:

113440243(DRD4)

NSS:	113412471(DRD4)

VKO:	123021364(DRD4)

PMUA:

114599668(DRD4)

PRAF:

128416932(DRD4)

ZVI:	118089409(DRD4)

HCG:	128340769(DRD4)

GJA:	107112901(DRD4)

STOW:

125427230(DRD4)

EMC:	129323470(DRD4)

XLA:	108713876(drd4.L) 108715168(drd4.S)

XTR:	100486482(drd4)

NPR:	108786698(DRD4)

RTEM:

120917373(DRD4)

BBUF:

120980632(DRD4)

BGAR:

122921042(DRD4)

PWL:	138284379(DRD4) 138288130

MUO:	115478783(DRD4)

GSH:	117366872(DRD4)

DRE:	503564(drd4a) 503565(drd4b) 503566(drd4-rs)

SRX:	107712616 107726856 107730172 107732971 107738833 107754372

SANH:

107655149 107663015 107674856 107686879 107694151 107699035 107699039

SGH:	107551439 107557292 107561186 107561434 107591318 107600352

CCAR:

109067421 109073213(drd4a) 109082994 109091546 109094269 122140029(drd4-rs)

CAUA:

113042899 113043031 113048621 113062541 113085976 113105314

CGIB:

127947342 127956300 127961115 127974354 128014175 128016297

PTET:

122330671(drd4a) 122343517(drd4-rs) 122348293(drd4b)

LROH:

127156359(drd4a) 127164603(drd4-rs) 127168489(drd4b)

OMC:	131534941(drd4a) 131539109(drd4-rs) 131544267(drd4b)

PPRM:

120476541(drd4-rs) 120492597(drd4b)

RKG:	130072310(drd4-rs) 130100338(drd4b) 130106508(drd4a)

MAMB:

125245979(drd4-rs) 125247823(drd4a) 125265821(drd4b)

CIDE:

127507668 127511435 127516671

CERY:

137014878(drd4a) 137023947(drd4-rs) 137030977(drd4b)

MASI:

127410268 127435386 127436046 127436768 127437270 127442998

TROS:

130547754(drd4-rs) 130551799(drd4a) 130558226(drd4b)

TDW:	130413977(drd4a) 130420892(drd4-rs) 130428588(drd4b)

MANU:

129431733(drd4-rs) 129434046(drd4a) 129451650(drd4b)

PDAB:

135743754(drd4b) 135749800 135750446 135768265(drd4a)

IPU:	108270559(drd4b) 108274555(drd4a)

IFU:	128614175(drd4b) 128618647(drd4a)

PHYP:

113529991(drd4) 113536780

SMEO:

124391731(drd4b) 124391919(drd4a)

TFD:	113646739(drd4b) 113653925(drd4a)

TVC:	132842612(drd4b) 132856975(drd4a)

CGAR:

128543206(drd4b) 128544259(drd4a)

NGRA:

132873160(drd4a) 132898754(drd4b)

TRN:	134321673(drd4a) 134331850(drd4b)

AMEX:

103025686(drd4-rs) 103032612(drd4a) 103044336(drd4b)

CMAO:

118811328(drd4a) 118811344(drd4-rs) 118819016(drd4b)

EEE:	113578778 113579982 113584503

CHAR:

105892359(drd4a) 105892881(drd4b) 105904090(drd4-rs)

SPIL:

134062306(drd4-rs) 134093486(drd4a) 134095661(drd4b)

TRU:	101074860(drd4) 101078250

TFS:	130518774(drd4b) 130535747

TNG:	GSTEN00012495G001 GSTEN00016052G001

LCO:	104935131 104938444 109138022

NCC:	104954599 104966378(drd4)

TBEN:

117470765 117471709(drd4b)

CGOB:

115028220

PGEO:

117448405 117462018(drd4b)

GACU:

117533643(drd4b) 117534493

EMAC:

134863083(drd4b) 134877533

ELY:	117249428(drd4-rs) 117250345 117252208(drd4b) 117262030(drd4a)

EFO:	125881073(drd4b) 125882734(drd4-rs) 125886752(drd4a)

PLEP:

121939267 121950530

SLUC:

116036286(drd4a) 116065893(drd4-rs) 116067285(drd4b)

ECRA:

117939695(drd4b) 117949746

ESP:	116687174 116693766

PFLV:

114555756 114560537

GAT:

120809248

PPUG:

119196202 119224960(drd4b)

AFB:	129103172(drd4b) 129108013 129112672(drd4-rs)

CLUM:

117725320(drd4b) 117731945(drd4a)

PSWI:

130193027(drd4b)

CANA:

137786181(drd4b) 137804248

CVE:	137882223(drd4b) 137886146 137889964(drd4-rs)

MSAM:

119890599(drd4b) 119893082 119895521(drd4-rs)

SCHU:

122871508(drd4-rs) 122874666 122880372(drd4b)

CUD:	121505165(drd4-rs) 121513523(drd4b) 121515249

SPUL:

138599795(drd4-rs) 138606828(drd4b) 138613191(drd4a)

LMIX:

132956718(drd4-rs) 132972945(drd4a) 132974895(drd4b)

ALAT:

119017917(drd4b) 119024021(drd4a) 119032236(drd4-rs)

ASTR:

137589358(drd4-rs) 137594265 137595585(drd4b)

MZE:	101473075 101473958 101486227

ONL:	100693279 100704531 102079696

OAU:	116313811(drd4-rs) 116317509 116334296(drd4b)

OLA:	101164385 101173120 101173126

OML:	112139228(drd4a) 112141983(drd4b) 112157078(drd4-rs)

CSAI:

133424576(drd4-rs) 133443691(drd4a) 133458643

XMA:	102227358 102227899

XCO:	114142522 114161223

XHE:	116719273 116736570

PRET:

103459826(drd4) 103463031

PFOR:

103129965 103155219(drd4)

PLAI:

106935070 106949359(drd4)

PMEI:

106924555(drd4) 106931758

GAF:	122824605(drd4b) 122826481(drd4-rs)

PPRL:

129351951(drd4-rs) 129356386 129356654

CVG:	107082767 107092979

CTUL:

119778957(drd4-rs) 119780589(drd4b)

GMU:	124867248(drd4b) 124882737(drd4-rs)

NFU:	107382056 107396082(drd4)

KMR:	108229721(drd4-rs) 108249900(drd4a) 112449904(drd4b)

ALIM:

106513125 106530946(drd4)

NWH:	119415370(drd4a)

AOCE:

111567783(drd4-rs) 111575966 111582546(drd4b)

EJA:	138192307(drd4b) 138195794(drd4-rs) 138206251(drd4a)

BFRE:

138636225(drd4-rs) 138636527(drd4b)

MCEP:

125005005(drd4b) 125015014

CSEM:

103378863(drd4) 103379532 103384452

POV:	109624109 109646117

SSEN:

122772392(drd4b) 122776235

SSOE:

131459422(drd4b) 131470221

HHIP:

117759157(drd4b) 117763555

HSP:	118109068(drd4a) 118109213(drd4b)

PPLT:

128437046(drd4b) 128444660(drd4a)

SMAU:

118291077(drd4-rs) 118315351(drd4a) 124850865

LCF:	108892411(drd4-rs) 108893793 108894166

SDU:	111223087 111235997 111238877

SLAL:

111656652 111665067(drd4) 111670436

XGL:	120792454(drd4b) 120792711 120801219(drd4-rs)

HCQ:	109514277 109522924(drd4)

SSCV:

125967089(drd4b) 125970305

SBIA:

133502102

PEE:	133402860 133414951(drd4b)

PTAO:

133473345(drd4b) 133477664

BPEC:

110161856 110163789(drd4)

MALB:

109956462(drd4) 109967751 109971561

BSPL:

114851851(drd4b) 114857032

SJO:	128358825(drd4a) 128364542 128385153(drd4-rs)

SSCO:

133976930(drd4-rs) 133979019(drd4b) 133981667(drd4a)

GMH:	115543132 115550354(drd4) 115558195

SASA:

106561126 106562687 106576100 106584511 106587966 106595330 106609138

STRU:

115166720 115180425 115192719 115197014 115198681 115203602

OTW:	112214397 112216807(drd4-rs) 112219080 112222030(drd4a) 112240898(drd4b)

OMY:	110490201(drd4-rs) 110492890 110500258 110521350(drd4a) 118944527 118964984(drd4b)

OGO:	123994706 124009896 124013629 124019856 124019884 124037602(drd4a)

ONE:	115106245 115133219 115134464 115144801(drd4)

OKI:	109864936 109867632 109876805 109877259 109896403 109897456

OKE:	118359299 118366170 118375397 118392286 118396473

OMM:	135508851 135514597 135515442 135536996 135556605

OCLA:

139379361 139381513 139384874 139392894 139397791 139398306 139407577

SALP:

111950911 111951363 111962180 111971660

SNH:	120031782 120037911 120037912 120049067 120051793 120066589

CCLU:

121531297 121539962(drd4a) 121543713 121546287 121583049(drd4b)

ELS:	105007372 105020169 105028893

SFM:	108934547 108936381 108942227

PKI:	111833243 111840434 111859430

AANG:

118214763 118219065 118227217 118231183(drd4-rs)

AROT:

135242173 135245657 135255643 135259126(drd4-rs)

CCOG:

133111956 133119236 133131321 133134868(drd4-rs)

LOC:	102686099(drd4) 102691939

PSPA:

121295035 121319048 121320262(drd4-rs) 121329492

ARUT:

117415356 117432453 117434428

PSEX:

120519700(drd4a) 120534122(drd4-rs)

LCM:	102349281(DRD4) 102352528

CMK:

103189088

RTP:	109928816 109932153(drd4-rs)

CPLA:

122557749 122561503(drd4-rs)

HOC:	132824225 132826875(drd4-rs)

LERI:

129705542 129708026(drd4-rs)

PMRN:

116940053 116945601

LRJ:	133350156 133351421

BFO:

BBEL:

ARUN:

AAMU:

ACER:

MGEN:

MSEX:

Reference

PMID:1840645

Authors

Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O

Title

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.

Journal

Nature 350:610-4 (1991)
DOI:10.1038/350610a0

Sequence

[hsa:1815]

LinkDB

DBGET integrated database retrieval system