| Entry |
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| Name |
Attention deficit hyperactivity disorder (ADHD) |
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| Description |
Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder first diagnosed in childhood and frequently persistent throughout adult life. The disorder is classically characterized by symptoms of inattention, impulsivity, and hyperactivity. Many children with ADHD go on to have problems related to education, social functioning, and/or other mental illness as adolescents and young adults. Although heritability estimates are consistently high, ADHD is a genetically complex disorder characterized by multifactorial inheritance involving numerous genes of moderate effect. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD. And interaction between the dopamine and serotonin systems has been implicated in both the pathophysiology of ADHD and the mechanism of action of widely used stimulant compounds.
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| Category |
Mental and behavioural disorder
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| Brite |
Human diseases [BR:br08402]
Other diseases
Mental and behavioural disorders
H01895 Attention deficit hyperactivity disorder (ADHD)
Human diseases in ICD-11 classification [BR:br08403]
06 Mental, behavioural or neurodevelopmental disorders
Neurodevelopmental disorders
6A05 Attention deficit hyperactivity disorder
H01895 Attention deficit hyperactivity disorder (ADHD)
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Related
pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Gene |
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| Drug |
Guanfacine hydrochloride [DR: D00606]
Viloxazine hydrochloride [DR: D02572]
Amfetamine [DR: D07445]
Amphetamine sulfate [DR: D02074]
Dextroamphetamine sulfate [DR: D02078]
Methamphetamine hydrochloride [DR: D02242]
Methylphenidate [DR: D04999]
Methylphenidate hydrochloride [DR: D01296]
Atomoxetine hydrochloride [DR: D02574]
Dexmethylphenidate hydrochloride [DR: D03721]
Lisdexamfetamine dimesylate [DR: D04747]
Amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate and dextroamphetamine sulfate [DR: D11624]
Serdexmethylphenidate and dexmethylphenidate [DR: D11989]
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| Other DBs |
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| Reference |
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| Authors |
Matthews M, Nigg JT, Fair DA |
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| Title |
Attention deficit hyperactivity disorder. |
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| Journal |
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| Reference |
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| Authors |
Kustanovich V, Ishii J, Crawford L, Yang M, McGough JJ, McCracken JT, Smalley SL, Nelson SF |
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| Title |
Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. |
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| Journal |
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| Reference |
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| Authors |
Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer Ch, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Knolker U, Friedel S, Schafer H, Gross C, Hebebrand J, Warnke A, Lesch KP |
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| Title |
Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. |
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| Journal |
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| Reference |
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| Authors |
Roskell NS, Setyawan J, Zimovetz EA, Hodgkins P |
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| Title |
Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine. |
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| Journal |
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| Reference |
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| Authors |
Bello NT |
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| Title |
Clinical utility of guanfacine extended release in the treatment of ADHD in children and adolescents. |
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| Journal |
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| LinkDB |
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