KEGG   ORTHOLOGY: K04450
Entry
K04450                      KO                                     
Symbol
ATF2, CREBP1
Name
cyclic AMP-dependent transcription factor ATF-2
Pathway
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04022  cGMP-PKG signaling pathway
map04151  PI3K-Akt signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04624  Toll and Imd signaling pathway
map04668  TNF signaling pathway
map04714  Thermogenesis
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04013 MAPK signaling pathway - fly
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04668 TNF signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04022 cGMP-PKG signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04151 PI3K-Akt signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09152 Endocrine system
   04911 Insulin secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04922 Glucagon signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04915 Estrogen signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04926 Relaxin signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04935 Growth hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04918 Thyroid hormone synthesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04928 Parathyroid hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04925 Aldosterone synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04927 Cortisol synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09156 Nervous system
   04728 Dopaminergic synapse
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09149 Aging
   04211 Longevity regulating pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05203 Viral carcinogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05161 Hepatitis B
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05163 Human cytomegalovirus infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09164 Neurodegenerative disease
   05020 Prion disease
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09165 Substance dependence
   05030 Cocaine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05031 Amphetamine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05034 Alcoholism
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Other DBs
GO: 0035497
Genes
HSA: 1386(ATF2)
PTR: 101059354(ATF2)
PPS: 100985706(ATF2)
GGO: 101135003(ATF2)
PON: 100450554(ATF2)
NLE: 100582751(ATF2)
MCC: 699072(ATF2)
MCF: 101925838(ATF2)
CSAB: 103217363(ATF2)
CATY: 105579833(ATF2)
PANU: 101011350(ATF2)
TGE: 112636593(ATF2)
RRO: 104672399(ATF2)
RBB: 108527163(ATF2)
TFN: 117094833(ATF2)
PTEH: 111542753(ATF2)
CJC: 100414156(ATF2)
SBQ: 101035834(ATF2)
CSYR: 103264952(ATF2)
MMUR: 105865052(ATF2)
OGA: 100966891(ATF2)
MMU: 11909(Atf2)
MCAL: 110286367(Atf2)
MPAH: 110317821(Atf2)
RNO: 81647(Atf2)
MCOC: 116091666(Atf2)
MUN: 110556579(Atf2)
CGE: 100754663(Atf2)
PLEU: 114700827(Atf2)
NGI: 103751761(Atf2)
HGL: 101717365(Atf2)
CPOC: 100726889(Atf2)
CCAN: 109689841(Atf2)
DORD: 105995552(Atf2)
DSP: 122120051(Atf2)
NCAR: 124979831
OCU: 100355367(ATF2)
OPI: 101526116(ATF2)
TUP: 102473406(ATF2)
CFA: 478806(ATF2)
VVP: 112916383(ATF2)
VLG: 121501564(ATF2)
AML: 100474135(ATF2)
UMR: 103659593(ATF2)
UAH: 113250749(ATF2)
UAR: 123794100(ATF2)
ELK: 111142901
LLV: 125095761
MPUF: 101690544(ATF2)
ORO: 101374034(ATF2)
EJU: 114224124(ATF2)
ZCA: 113919173(ATF2)
MLX: 118012308(ATF2)
FCA: 101090884(ATF2)
PYU: 121030728(ATF2)
PBG: 122481480(ATF2)
PTG: 102954603(ATF2)
PPAD: 109273371(ATF2)
AJU: 106988085(ATF2)
HHV: 120243894(ATF2)
BTA: 509827(ATF2)
BOM: 102283891(ATF2)
BIU: 109566270(ATF2)
BBUB: 102410577(ATF2)
CHX: 102180634(ATF2)
OAS: 101108548(ATF2)
ODA: 120854293(ATF2)
CCAD: 122453548(ATF2)
SSC: 100513441(ATF2)
CFR: 102512476(ATF2)
CBAI: 105073454(ATF2)
CDK: 105097571(ATF2)
VPC: 102542128(ATF2)
BACU: 102999133(ATF2)
LVE: 103089070(ATF2)
OOR: 101276923(ATF2)
DLE: 111172890(ATF2)
PCAD: 102974369(ATF2)
PSIU: 116756632(ATF2)
ECB: 100053304(ATF2)
EPZ: 103553756(ATF2)
EAI: 106837905(ATF2)
MYB: 102241887(ATF2)
MYD: 102761389(ATF2)
MMYO: 118661230(ATF2)
MLF: 102418405(ATF2)
MNA: 107532468(ATF2)
PKL: 118709956(ATF2)
HAI: 109388738(ATF2)
DRO: 112305718(ATF2)
SHON: 118985682(ATF2)
AJM: 119057201(ATF2)
PDIC: 114495679(ATF2)
PHAS: 123808666(ATF2)
MMF: 118625175(ATF2)
RFQ: 117025773(ATF2)
PALE: 102889014(ATF2)
PGIG: 120597156(ATF2)
PVP: 105290195(ATF2)
RAY: 107504977(ATF2)
MJV: 108407377
TOD: 119255950(ATF2)
SARA: 101539734(ATF2)
LAV: 100657989(ATF2)
TMU: 101359884
DNM: 101414225(ATF2)
MDO: 100025939(ATF2)
GAS: 123242200(ATF2)
SHR: 100914193(ATF2)
PCW: 110211588(ATF2)
OAA: 100077942(ATF2)
GGA: 395727(ATF2)
PCOC: 116232833(ATF2)
MGP: 100549420(ATF2)
CJO: 107316660(ATF2)
NMEL: 110399453(ATF2)
APLA: 101800932(ATF2)
ACYG: 106030015(ATF2)
AFUL: 116490508(ATF2)
TGU: 100226584(ATF2)
LSR: 110482896(ATF2)
SCAN: 103814449(ATF2)
PMOA: 120500700(ATF2)
OTC: 121335296(ATF2)
PRUF: 121356463(ATF2)
GFR: 102034606(ATF2)
FAB: 101812575(ATF2)
PHI: 102105113(ATF2)
PMAJ: 107207532(ATF2)
CCAE: 111932059(ATF2)
CCW: 104693853(ATF2)
ETL: 114054885(ATF2)
ZAB: 102072645(ATF2)
FPG: 101912040(ATF2)
FCH: 102052727(ATF2)
CLV: 102084432(ATF2)
EGZ: 104128067(ATF2)
NNI: 104010014(ATF2)
ACUN: 113482190(ATF2)
TALA: 104364997(ATF2)
PADL: 103924112(ATF2)
ACHC: 115342678(ATF2)
AAM: 106499205(ATF2)
AROW: 112970626(ATF2)
NPD: 112958230(ATF2)
DNE: 112978957(ATF2)
ASN: 102387336(ATF2)
AMJ: 102572172(ATF2)
CPOO: 109322848(ATF2)
GGN: 109301712(ATF2)
PSS: 102460331(ATF2)
CMY: 102939131(ATF2)
CPIC: 101945668(ATF2)
TST: 117884769(ATF2)
CABI: 116827201(ATF2)
MRV: 120375150(ATF2)
ACS: 100557710(atf2)
PVT: 110085213(ATF2)
SUND: 121932133(ATF2)
PBI: 103053462(ATF2)
PMUR: 107301365(ATF2)
TSR: 106548735(ATF2)
PGUT: 117671729(ATF2)
VKO: 123021813(ATF2)
PMUA: 114606668(ATF2) 114606722
ZVI: 118094461(ATF2)
GJA: 107123397(ATF2)
XLA: 108701386(atf2.L) 108703012
XTR: 100485532(atf2)
NPR: 108800395(ATF2)
RTEM: 120943988(ATF2)
BBUF: 121007592(ATF2)
BGAR: 122944878(ATF2)
DRE: 100006516(atf2)
SGH: 107600703
CAUA: 113053545 113109105(atf2)
PPRM: 120459863(atf2)
IPU: 108266715(atf2)
PHYP: 113525280(atf2)
SMEO: 124382881(atf2)
TFD: 113654398(atf2)
AMEX: 103028069(atf2)
EEE: 113582331(atf2)
TRU: 101063333(atf2)
LCO: 104924439(atf2)
NCC: 104965544(atf2)
CGOB: 115026508(atf2)
ELY: 117251515(atf2)
PLEP: 121949234(atf2)
SLUC: 116048273(atf2)
ECRA: 117952621(atf2)
PFLV: 114564663(atf2)
GAT: 120833901(atf2)
PPUG: 119229099(atf2)
MSAM: 119904115(atf2)
CUD: 121523045(atf2)
MZE: 101463949(atf2)
ONL: 100699389(atf2)
OAU: 116322969(atf2)
OLA: 101161843(atf2)
OML: 112155414(atf2)
XMA: 102234028(atf2)
XCO: 114148083(atf2)
XHE: 116723009(atf2)
PRET: 103458305(atf2)
PFOR: 103134309(atf2)
PLAI: 106957443(atf2)
PMEI: 106924454(atf2)
GAF: 122840186(atf2)
CVG: 107085739(atf2)
CTUL: 119797535(atf2)
GMU: 124871553(atf2)
NFU: 107390001(atf2)
KMR: 108239783(atf2)
ALIM: 106512883(atf2)
NWH: 119419612(atf2)
AOCE: 111577835(atf2)
CSEM: 103391862 107988055(atf2)
POV: 109631016(atf2)
SSEN: 122759712(atf2)
HHIP: 117754585(atf2)
LCF: 108882968(atf2)
SDU: 111218870(atf2)
SLAL: 111654625(atf2)
XGL: 120801815(atf2)
HCQ: 109507870(atf2)
BPEC: 110166549(atf2)
MALB: 109958112(atf2)
SASA: 106582491 106586246(atf2)
OTW: 112236821(atf2)
OMY: 110501941 110520124(atf2)
OGO: 124043875(atf2)
ONE: 115109253(atf2)
SALP: 111959522 111975332(atf2)
SNH: 120058257(atf2)
ELS: 105016218(atf2)
SFM: 108920372(atf2) 108928057
PKI: 111838634(atf2)
AANG: 118214264 118224160(atf2)
LOC: 102687984(atf2)
ARUT: 117409383 117426833(atf2)
LCM: 102366239(ATF2) 106703183
CMK: 103176469(atf2)
RTP: 109914907 109929477(atf2)
BFO: 118403115
BBEL: 109464068
SPU: 577426
APLC: 110984186
DME: Dmel_CG44246(Atf-2)
DER: 6548433
DSE: 6618893
DSI: Dsimw501_GD11905(Dsim_GD11905)
DAN: 6496187
DSR: 110184110
DPE: 6592285
DWI: 6640182
DAZ: 108617045
DNV: 108654709
DHE: 111593910
DVI: 6627255
CCAT: 101461123
BOD: 106621609
MDE: 101890809
SCAC: 106094051
LCQ: 111685726
ACOZ: 120957666
AARA: 120899786
AAG: 5577542
CPII: 120415596
CNS: 116349554
AME: 100576527
ACER: 107998814
ALAB: 122714345
BIM: 100749459
BBIF: 117216530
BVK: 117231694
BVAN: 117154781
BTER: 100649707
BPYO: 122574306
CCAL: 108632989
OBB: 114879534
MGEN: 117222605
NMEA: 116432713
CGIG: 122403408
SOC: 105202168
MPHA: 105839911
AEC: 105145677
ACEP: 105627948
PBAR: 105426825
VEM: 105565082
HST: 105192642
DQU: 106742046
CFO: 105249521
LHU: 105677106
PGC: 109858507
PCF: 106791946
PFUC: 122518840
VPS: 122627367
NVI: 100119270
CSOL: 105361172
MDL: 103576287
CGLO: 123264457
FAS: 105269492
DAM: 107048578
AGIF: 122853254
CCIN: 107265952
TCA: 663103
DPA: 109539767
ATD: 109608283
AGB: 108907836
LDC: 111512904
NVL: 108569504
PPYR: 116172949
BMOR: 100862750
BMAN: 114250244
BANY: 112043820
PMAC: 106715142
PPOT: 106107463
PXU: 106124939
PRAP: 110993434
ZCE: 119836510
HAW: 110369623
TNL: 113499958
SLIU: 111350089
OFU: 114351755
PXY: 105390395
BTAB: 109041413
DCI: 103505653
CLEC: 106663685
NLU: 111051786
FOC: 113208974
ZNE: 110833127
CSEC: 111864946
FCD: 110852191
DMK: 116916298
PVM: 113822147
PCLA: 123772298
PTRU: 123502978
EAF: 111696387
DSV: 119456025
RSAN: 119394757
RMP: 119172692
VJA: 111268659
CSCU: 111619050
PTEP: 107440184
SDM: 118182201
PCAN: 112556639
BGT: 106070610
GAE: 121385639
HRF: 124150803
CRG: 105323178
MYI: 110446621
PMAX: 117322365
MMER: 123559510
OBI: 106878431
OSN: 115220882
LAK: 106161773
NVE: 5514292
EPA: 110232304
ATEN: 116293486
ADF: 107348901
AMIL: 114967441
PDAM: 113668572
SPIS: 111331051
DGT: 114523073
XEN: 124439886
HMG: 100213904
AQU: 100632529
APRO: F751_3120
MAW: MAC_08741
MAJ: MAA_01331
CMT: CCM_09413
 » show all
Reference
PMID:2529117
  Authors
Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M, Ishii S
  Title
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.
  Journal
EMBO J 8:2023-8 (1989)
DOI:10.1002/j.1460-2075.1989.tb03610.x
  Sequence
[hsa:1386]
Reference
  Authors
Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, Yokoyama KK
  Title
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
  Journal
Nature 405:195-200 (2000)
DOI:10.1038/35012097
  Sequence
[hsa:1386]
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