KEGG ORTHOLOGY: K04541

ORTHOLOGY: K04541

Entry

K04541                      KO

Symbol

GNG4

Name

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04151

PI3K-Akt signaling pathway

map04371

Apelin signaling pathway

map04713

Circadian entrainment

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04926

Relaxin signaling pathway

map05032

Morphine addiction

map05034

Alcoholism

map05163

Human cytomegalovirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04371 Apelin signaling pathway
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04151 PI3K-Akt signaling pathway
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  09156 Nervous system
   04724 Glutamatergic synapse
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04727 GABAergic synapse
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04725 Cholinergic synapse
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04728 Dopaminergic synapse
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04726 Serotonergic synapse
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   04723 Retrograde endocannabinoid signaling
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   05163 Human cytomegalovirus infection
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  09165 Substance dependence
   05032 Morphine addiction
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
   05034 Alcoholism
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
GTP-binding proteins [BR:ko04031]
Heterotrimeric G-proteins
  Gamma Subunits
   Gamma [OT]
    K04541  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Genes

HSA:	2786(GNG4)

PTR:	743331(GNG4)

PPS:	100980807(GNG4)

GGO:	101141949(GNG4)

PON:	100190818(GNG4)

NLE:	100591313(GNG4)

HMH:	116457634(GNG4)

MCC:	718223(GNG4)

MCF:	102146209(GNG4)

MTHB:

126942604

MNI:	105474606(GNG4)

PANU:

101024158(GNG4)

TGE:	112627501(GNG4)

RRO:	104679173(GNG4)

RBB:	108522231(GNG4)

TFN:	117075268(GNG4)

PTEH:

113224997(GNG4)

CJC:	100411028(GNG4)

SBQ:	101030348(GNG4)

CIMI:

108302840(GNG4)

CSYR:

103254833(GNG4)

MMUR:

105856485(GNG4)

LCAT:

123627584(GNG4)

PCOQ:

105823098(GNG4)

OGA:	100967014(GNG4)

MMU:	14706(Gng4)

MCAL:

110308267(Gng4)

MPAH:

110333990(Gng4)

RNO:	114118(Gng4)

MCOC:

116082206(Gng4)

ANU:	117713460(Gng4)

MUN:	110558140(Gng4)

CGE:	100767992(Gng4)

MAUA:

101830234(Gng4)

PROB:

127229769(Gng4)

PLEU:

114685202(Gng4)

MORG:

121432656 121432753(Gng4)

MFOT:

126501666

AAMP:

119817037(Gng4)

NGI:	103745125(Gng4)

HGL:	101696772(Gng4)

CPOC:

100728440(Gng4)

CCAN:

109692616(Gng4)

DORD:

105984475(Gng4)

DSP:	122113060(Gng4)

PLOP:

125367180(Gng4)

NCAR:

124961969

MMMA:

107157965(Gng4)

OCU:

103350926

OPI:	101531710(GNG4)

TUP:	102493758(GNG4)

CFA:	607513(GNG4)

CLUD:

112660832(GNG4)

VVP:	112927368(GNG4)

VLG:	121486114(GNG4)

NPO:	129499161(GNG4)

AML:	100468197(GNG4)

UMR:	103661898(GNG4)

UAH:	113258997(GNG4)

UAR:	123783123(GNG4)

ELK:

111160502

LLV:

125084842

MPUF:

101688079(GNG4)

MNP:	132016147(GNG4)

MLK:	131829051(GNG4)

NVS:	122898876(GNG4)

ORO:	101369684(GNG4)

EJU:	114210371(GNG4)

ZCA:	113923917(GNG4)

MLX:	118012933(GNG4)

NSU:	110586041(GNG4)

LWW:	102747228(GNG4)

FCA:	101081928(GNG4)

PYU:	121023145(GNG4)

PCOO:

112851564(GNG4)

PVIV:

125148085(GNG4)

LRUF:

124518716

PTG:	102953604(GNG4)

PPAD:

109248876(GNG4)

PUC:

125932581

AJU:

106982557

HHV:	120241831(GNG4)

BTA:	100125276(GNG4)

BOM:	102279686(GNG4)

BIU:	109553666(GNG4)

BBUB:

102405602(GNG4)

BBIS:

105003123(GNG4)

CHX:	102170665(GNG4)

OAS:	101114927(GNG4)

BTAX:

128048580(GNG4)

ODA:	120860493 120865418

CCAD:

122446614(GNG4)

MBEZ:

129555099(GNG4)

SSC:	102167388(GNG4)

CFR:	116660433 116667292(GNG4)

CBAI:

105069319 105075111(GNG4)

CDK:	105088827(GNG4) 116156024

VPC:	102545167(GNG4)

BACU:

103019275(GNG4)

BMUS:

118882268(GNG4)

LVE:	103082839(GNG4)

OOR:	101271265(GNG4)

DLE:	111163963(GNG4)

PCAD:

102976421(GNG4)

PSIU:

116742043(GNG4)

NASI:

112410724(GNG4)

ECB:	100058605(GNG4)

EPZ:	103547680(GNG4)

EAI:	106834701(GNG4)

MYB:	102259768(GNG4)

MYD:	107182728(GNG4)

MMYO:

118678724(GNG4)

PKL:	118727686(GNG4)

EFUS:

103293513(GNG4)

MNA:	107527185(GNG4)

DRO:	112306067(GNG4)

SHON:

118980656(GNG4)

AJM:	119044222(GNG4)

PDIC:

114512408(GNG4)

PHAS:

123804859(GNG4)

MMF:	118640651(GNG4)

PPAM:

129072091(GNG4)

HAI:	109387705(GNG4)

RFQ:	117018688(GNG4)

PALE:

102889599(GNG4)

PGIG:

120592628(GNG4)

PVP:	105302718(GNG4)

RAY:	107520069(GNG4)

MJV:	108394280(GNG4)

TOD:	119245241(GNG4)

SETR:

126030791(GNG4)

LAV:	100664179(GNG4)

TMU:

101357541

ETF:	101643112(GNG4)

DNM:	101428860(GNG4)

MDO:	100021132(GNG4)

GAS:	123245546(GNG4)

SHR:	100917856(GNG4)

AFZ:

127559635

PCW:	110217882(GNG4)

OAA:	114805646(GNG4)

GGA:	771582(GNG4)

PCOC:

116228330(GNG4)

MGP:	100551249(GNG4)

CJO:	107311376(GNG4)

TPAI:

128075309(GNG4)

LMUT:

125690214(GNG4)

NMEL:

110396440(GNG4)

APLA:

101801725(GNG4)

ACYG:

106048830(GNG4)

CATA:

118254269(GNG4)

AFUL:

116487577(GNG4)

TGU:	100229848(GNG4)

LSR:	110468927(GNG4)

SCAN:

103818520(GNG4)

PMOA:

120501475(GNG4)

OTC:	121340984(GNG4)

PRUF:

121363294(GNG4)

GFR:	102035797(GNG4)

FAB:	101813022(GNG4)

OMA:	130251524(GNG4)

PHI:	102112912(GNG4)

CCAE:

111926852(GNG4)

CCW:	104684286(GNG4)

CBRC:

103624082(GNG4)

ETL:	114066555(GNG4)

ZAB:	102066784(GNG4)

ACHL:

103810117(GNG4)

SVG:	106851970 106852257

MMEA:

130588787(GNG4)

HRT:	120750402(GNG4)

FPG:	101910999(GNG4)

FCH:	102046189(GNG4)

CLV:	102094738(GNG4)

EGZ:	104131015(GNG4)

NNI:	104019870(GNG4)

PCRI:

104035548(GNG4)

PLET:

104613582

EHS:	104502466(GNG4)

PCAO:

104039321

ACUN:

113478536(GNG4)

TALA:

104368610(GNG4)

PADL:

103921232(GNG4)

AFOR:

103900991(GNG4)

ACHC:

115350350(GNG4)

HALD:

104310368(GNG4)

HLE:	104828734(GNG4)

AGEN:

126051832

GCL:

127014795

CCRI:

104154832

CSTI:

104561362(GNG4)

CMAC:

104476079

MUI:	104533143(GNG4)

BREG:

104633549

FGA:	104069081(GNG4)

GSTE:

104258818(GNG4)

LDI:	104339705(GNG4)

MNB:	103772049(GNG4)

OHA:	104328289(GNG4)

NNT:	104406344(GNG4)

SHAB:

115613816(GNG4)

DPUB:

104305330(GNG4)

PGUU:

104461844(GNG4)

ACAR:

104532112

CPEA:

104388691(GNG4)

AVIT:

104266975(GNG4)

CVF:	104287253(GNG4)

RTD:	128907162(GNG4)

CUCA:

104060348(GNG4)

TEO:	104369610(GNG4)

BRHI:

104497871(GNG4)

AAM:	106486782(GNG4)

AROW:

112964548(GNG4)

NPD:	112951980(GNG4)

TGT:	104573815(GNG4)

DNE:	112989003(GNG4)

SCAM:

104147890(GNG4)

ASN:	102374121(GNG4)

AMJ:	102561211(GNG4)

CPOO:

109319967(GNG4)

GGN:	109304726(GNG4)

PSS:	102460105(GNG4)

CMY:	102935631(GNG4)

CCAY:

125633875(GNG4)

DCC:	119853183(GNG4)

CPIC:

101933136(GNG4)

TST:	117874689(GNG4)

CABI:

116835081(GNG4)

MRV:	120402126(GNG4)

ACS:	100564764(gng4)

ASAO:

132761201(GNG4)

PVT:	110075633(GNG4)

SUND:

121920003(GNG4)

PBI:	103056915(GNG4)

PMUR:

107288313(GNG4)

CTIG:

120312351(GNG4)

TSR:	106538197(GNG4)

PGUT:

117671971(GNG4)

APRI:

131189754(GNG4)

PTEX:

113439371(GNG4)

NSS:	113413292(GNG4)

VKO:	123018174(GNG4)

PMUA:

114594413(GNG4)

PRAF:

128410838(GNG4)

ZVI:	118081864(GNG4)

HCG:	128346487(GNG4)

GJA:	107117696(GNG4)

STOW:

125426921(GNG4)

EMC:	129331568(GNG4)

XLA:	108716733 446597(gng4.S)

XTR:	779661(gng4)

NPR:	108787993(GNG4)

RTEM:

120937423(GNG4)

DRE:	101883928(gng4)

SRX:	107728325 107730380

SANH:

107691205(gng4)

SGH:	107557730(gng4)

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

AMEX:

103030837(gng4)

CMAO:

118810723

EEE:	113577746(gng4)

CHAR:

105902302

TRU:	115249594(gng4) 115249611

TFS:

130534002

TNG:	GSTEN00030874G001

LCO:	104934547(gng4)

NCC:	104960298(gng4)

TBEN:

117499440

CGOB:

115020445(gng4)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116705451(gng4)

PFLV:

114572073(gng4)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101477020(gng4)

ONL:	100696068(gng4)

OAU:

116318512

OLA:	101169806(gng4)

OML:

112161467

CSAI:

133463316

XMA:	102231914(gng4)

XCO:	114138288(gng4)

XHE:	116713463(gng4)

PRET:

103477260(gng4)

PFOR:

103137662(gng4)

PLAI:

106949763(gng4)

PMEI:

106930332(gng4)

GAF:

122842583

PPRL:

129360008

CVG:	107087806(gng4)

CTUL:

119782944

GMU:

124859567

NFU:	107375430(gng4)

KMR:

108240657

ALIM:

106515874(gng4)

NWH:

119417654

AOCE:

111573728(gng4)

MCEP:

125018971

CSEM:

103387615(gng4)

POV:	109642024(gng4)

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:	111220606(gng4)

SLAL:

111658902(gng4)

XGL:

120796966

HCQ:	109516271(gng4)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110157143(gng4)

MALB:

109962013(gng4)

BSPL:

114842011

SJO:

128372835

SASA:

106578768(gng4)

STRU:

115155336(gng4) 115200873

OTW:

112236097

OMY:	110491205 118942079

OGO:

124048032

ONE:	115125227(gng4)

OKI:	109866053(gng4) 116357482

OKE:	118382553 127911276

SALP:

112071949(gng4) 112072672

SNH:	120036088 120045397

CCLU:

121580567

ELS:	105006089(gng4)

SFM:	108933658(gng4)

PKI:	111856362(gng4)

AANG:

LOC:

PSPA:

ARUT:

PSEX:

CMK:

RTP:

CPLA:

HOC:

LERI:

RPHI:

Reference

PMID:7665596

Authors

Ray K, Kunsch C, Bonner LM, Robishaw JD

Title

Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.

Journal

J Biol Chem 270:21765-71 (1995)
DOI:10.1074/jbc.270.37.21765

Sequence

[hsa:2786]

LinkDB

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