KEGG ORTHOLOGY: K04716

ORTHOLOGY: K04716

Entry

K04716                      KO

Symbol

SGPP1

Name

sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-]

Pathway

map00600

Sphingolipid metabolism

map01100

Metabolic pathways

map04071

Sphingolipid signaling pathway

Reaction

R06520

3-sn-phosphatidate phosphohydrolase

R06521

3-sn-phosphatidate phosphohydrolase

R06522

3-sn-phosphatidate phosphohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K04716  SGPP1; sphingosine-1-phosphate phosphatase 1
09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K04716  SGPP1; sphingosine-1-phosphate phosphatase 1

Other DBs

GO:

0042392

Genes

HSA:	81537(SGPP1)

PTR:	467479(SGPP1)

PPS:	100979353(SGPP1)

GGO:	101140990(SGPP1)

PON:	100458471(SGPP1)

PPYG:

129013308(SGPP1)

NLE:	100591437(SGPP1)

HMH:	116484788(SGPP1)

SSYN:

129487781(SGPP1)

MCC:	709364(SGPP1)

MCF:	102142274(SGPP1)

MTHB:

126959023

MNI:	105473685(SGPP1)

CSAB:

103229157(SGPP1)

CATY:

105582818(SGPP1)

PANU:

101009539(SGPP1)

TGE:	112629436(SGPP1)

MLEU:

105538458(SGPP1)

RRO:	104678442(SGPP1)

RBB:	108542435(SGPP1)

TFN:	117069489(SGPP1)

PTEH:

111555760(SGPP1)

CANG:

105526093(SGPP1)

CJC:	100414910(SGPP1)

SBQ:	101044802(SGPP1)

CIMI:

108308228(SGPP1)

ANAN:

105725169(SGPP1)

CSYR:

103268166(SGPP1)

MMUR:

105878330(SGPP1)

LCAT:

123648208(SGPP1)

PCOQ:

105819798(SGPP1)

OGA:	100943893(SGPP1)

MMU:	81535(Sgpp1)

MCAL:

110307304(Sgpp1)

MPAH:

110324488(Sgpp1)

RNO:	81536(Sgpp1)

MCOC:

116080196(Sgpp1)

ANU:	117697390(Sgpp1)

ASYL:

127687229(Sgpp1)

MUN:	110557569(Sgpp1)

CGE:	100766871(Sgpp1)

MAUA:

101831227(Sgpp1)

PROB:

127230701(Sgpp1)

PLEU:

114683641(Sgpp1)

MORG:

121452527(Sgpp1)

MFOT:

126508455

AAMP:

119819059(Sgpp1)

NGI:	103747973(Sgpp1)

HGL:	101697333 101698443 101710628(Sgpp1)

CPOC:

100715609(Sgpp1)

CCAN:

109697372(Sgpp1)

DORD:

105983794(Sgpp1)

DSP:	122110036(Sgpp1)

DMER:

138833694(Sgpp1)

PLOP:

125363184(Sgpp1)

NCAR:

124977848

MMMA:

107145970(Sgpp1)

ITI:	101973800(Sgpp1)

OCU:

108178643

OPI:	101527797(SGPP1)

TUP:	102491372(SGPP1)

CFA:	490728(SGPP1)

CLUD:

112657079(SGPP1)

VVP:	112921349(SGPP1)

VLG:	121493754(SGPP1)

NPO:	129496365(SGPP1)

AML:	109488741(SGPP1)

UMR:	121105228(SGPP1)

UAH:	113246334(SGPP1)

UAR:	123800638(SGPP1)

ELK:

111161192

LLV:

125104831

MPUF:

101673418(SGPP1)

MNP:	132000019(SGPP1)

MLK:	131836665(SGPP1)

NVS:	122892886(SGPP1)

ORO:	101379255(SGPP1)

EJU:	114206788(SGPP1)

ZCA:	113908641(SGPP1)

NSU:	110590597(SGPP1)

LWW:	102745068(SGPP1)

FCA:	101095345(SGPP1)

PYU:	121031883(SGPP1)

PCOO:

112855797(SGPP1)

PBG:	122469196(SGPP1)

PVIV:

125168860(SGPP1)

LRUF:

124512132

LGF:	123583973(SGPP1)

AJU:

106971302

PTG:	102967184(SGPP1)

PPAD:

109268345(SGPP1)

PUC:

125909442

PLEZ:

122222805(SGPP1)

HHV:	120238431(SGPP1)

BTA:	516881(SGPP1)

BOM:	102277496(SGPP1)

BIU:	109565238(SGPP1)

BBUB:

102390378(SGPP1)

BBIS:

104993515(SGPP1)

CHX:	102174749(SGPP1)

OAS:	101108492(SGPP1)

BTAX:

128054605(SGPP1)

CSUM:

138074548(SGPP1)

ODA:	120852820(SGPP1)

CCAD:

122443737(SGPP1)

MREE:

136172004(SGPP1)

OVR:	110151058(SGPP1)

MBEZ:

129562822(SGPP1)

SSC:	100626032(SGPP1)

CFR:	102505600(SGPP1)

CBAI:

105074658(SGPP1)

CDK:	105086202(SGPP1)

VPC:	102535101(SGPP1)

BACU:

103012286(SGPP1)

BMUS:

118890636(SGPP1)

LVE:	103069005(SGPP1)

OOR:	101274550(SGPP1)

LALB:

132515302(SGPP1)

GMF:	115852378(SGPP1)

DDP:	132420212(SGPP1)

DLE:	111173079(SGPP1)

PCAD:

102973214(SGPP1)

PSIU:

116749890(SGPP1)

PPHC:

136119372(SGPP1)

ECB:	100061850(SGPP1)

EPZ:	103554332(SGPP1)

EAI:	106839161(SGPP1)

MYB:	102253110(SGPP1)

MYD:	102772311(SGPP1)

MMYO:

118656325(SGPP1)

MLF:	102430160(SGPP1)

MDT:	132233384(SGPP1)

MYUM:

139012547(SGPP1)

PKL:	118716981(SGPP1)

EFUS:

103283664(SGPP1)

MNA:	107545698(SGPP1)

DRO:	112311133(SGPP1)

SHON:

118976591(SGPP1)

AJM:	119034866(SGPP1)

PDIC:

114491641(SGPP1)

PHAS:

123808935(SGPP1)

MMF:	118628276(SGPP1)

PPAM:

129065971(SGPP1)

HAI:	109375914(SGPP1)

RFQ:	117023463(SGPP1)

PALE:

102878079(SGPP1)

PGIG:

120603814(SGPP1)

PVP:	105310002(SGPP1)

RAY:	107509326(SGPP1)

MJV:	108395651(SGPP1)

TOD:	119239172(SGPP1)

SARA:

101558610(SGPP1)

SFUM:

130041860(SGPP1)

LAV:	100676598(SGPP1)

TMU:

101350524

ETF:	101643560(SGPP1)

DNM:	101413948(SGPP1)

MDO:	100027518(SGPP1)

GAS:	123237747(SGPP1)

SHR:	100918515(SGPP1)

AFZ:

127549614

PCW:	110208454(SGPP1)

TVP:	118828521(SGPP1)

PBRV:

138164322(SGPP1)

MLAO:

141522492(SGPP1)

OAA:	100080900(SGPP1)

PCOC:

116236795(SGPP1)

MGP:	100543310(SGPP1)

CJO:	107315352(SGPP1)

TPAI:

128086189(SGPP1)

LMUT:

125694876(SGPP1)

NMEL:

110401289(SGPP1)

APLA:

101801150(SGPP1)

ACYG:

106037176(SGPP1)

CATA:

118250340(SGPP1)

AFUL:

116489655(SGPP1)

TGU:	100221899(SGPP1)

LSR:	110484105(SGPP1)

SCAN:

103826857(SGPP1)

PMOA:

120513518(SGPP1)

OTC:	121332582(SGPP1)

PRUF:

121358243(SGPP1)

ATRC:

139589694(SGPP1)

GFR:	102040480(SGPP1)

FAB:	101808981(SGPP1)

OMA:	130254207(SGPP1)

PHI:	102108318(SGPP1)

PMAJ:

107206227(SGPP1)

CCAE:

111929534(SGPP1)

CCW:	104688935(SGPP1)

CBRC:

103618871(SGPP1)

ACOE:

138111931(SGPP1)

ETL:	114063206(SGPP1)

ZAB:	102072788(SGPP1)

ZLE:	135448365(SGPP1)

ACHL:

103798335(SGPP1)

SVG:	106850277(SGPP1)

MMEA:

130584858(SGPP1)

HRT:	120754654(SGPP1)

SATI:

136362798(SGPP1)

CCIC:

134045434(SGPP1)

FPG:	101912992(SGPP1)

FCH:	102059905(SGPP1)

NNT:	104405899(SGPP1)

SHAB:

115607232(SGPP1)

ACUN:

113480421(SGPP1)

TALA:

104356661(SGPP1)

ACHC:

115336220(SGPP1)

HALD:

104322139(SGPP1)

HLE:	104842090(SGPP1)

AGEN:

126050671

HHAR:

128140047(SGPP1)

GCL:

127016944

CSTI:

104553929(SGPP1)

LDI:	104340479(SGPP1)

MNB:	103769917(SGPP1)

DPUB:

104303276(SGPP1)

PPUS:

135182375(SGPP1)

AVIT:

104278959(SGPP1)

BRHI:

104491160(SGPP1)

EGZ:	104131675(SGPP1)

NNI:	104010142(SGPP1)

PCAO:

104050633(SGPP1)

PADL:

103924257(SGPP1)

AFOR:

103894074(SGPP1)

FGA:	104082035(SGPP1)

GSTE:

104261922(SGPP1)

CBOY:

140653282(SGPP1)

CLV:	102098480(SGPP1)

CNIC:

135989700(SGPP1)

MUI:	104543308(SGPP1)

PGUU:

104472005(SGPP1)

PLET:

104623680(SGPP1)

EHS:	104510193(SGPP1)

CMAC:

104481401(SGPP1)

CUCA:

104062364

TEO:	104377478(SGPP1)

BREG:

104633058(SGPP1)

OHA:	104330068(SGPP1)

ACAR:

104531814(SGPP1)

CPEA:

104391421(SGPP1)

CVF:	104291914(SGPP1)

RTD:	128909207(SGPP1)

CRID:

134515028(SGPP1)

AAM:	106483101(SGPP1)

AROW:

112976905(SGPP1)

NPD:	112959665(SGPP1)

TGT:	104575709(SGPP1)

DNE:	112991634(SGPP1)

ASN:	102377319(SGPP1)

AMJ:	102576958(SGPP1)

CPOO:

109320652(SGPP1)

GGN:	109299291(SGPP1)

CMY:	102948002(SGPP1)

CCAY:

125638565(SGPP1)

DCC:	119857212(SGPP1)

CPIC:

101941158(SGPP1)

TST:	117876194(SGPP1)

CABI:

116830007(SGPP1)

MRV:	120404350(SGPP1)

ACS:	100554530(sgpp1)

ASAO:

132761429(SGPP1)

PVT:	110087858(SGPP1)

SUND:

121914804(SGPP1)

PBI:	103050345(SGPP1)

PMUR:

107285160 107293309

CTIG:

120297182(SGPP1)

TSR:	106543021(SGPP1)

PGUT:

117675170(SGPP1)

PCAE:

139308153(SGPP1)

APRI:

131188001(SGPP1)

PTEX:

113435066(SGPP1)

NSS:	113413686(SGPP1)

VKO:	123026512(SGPP1)

PMUA:

114603505(SGPP1)

PRAF:

128422385(SGPP1)

ZVI:	118079830(SGPP1)

HCG:	128341211(SGPP1)

GJA:	107121444(SGPP1)

STOW:

125427055(SGPP1)

EMC:	129324528(SGPP1)

XLA:

101027287

XTR:	549040(sgpp1)

NPR:	108786892(SGPP1)

RTEM:

120920032(SGPP1)

ACAT:

141117354(SGPP1)

BBUF:

120981946(SGPP1)

BGAR:

122921812(SGPP1)

DTC:	141085467(SGPP1)

PWL:	138259545(SGPP1)

MUO:	115477503(SGPP1)

GSH:

117363353

DRE:	100003745(sgpp1b) 556439(sgpp1a)

SRX:	107716492 107726595 107736834(sgpp1) 107743975

SANH:

107654933(sgpp1) 107683631 107697306 107701492

SGH:	107553224 107563688 107589063 107602978

CCAR:

109073161 109082491(sgpp1b) 109101722

CAUA:

113056817 113063371 113112461 113121036

CGIB:

127938542 127970182 127984425 128025999

PTET:

122343244(sgpp1a) 122356636(sgpp1b)

LROH:

127175276(sgpp1b) 127183094(sgpp1a)

GRF:	141283523(sgpp1a) 141325197(sgpp1b)

OMC:	131552456(sgpp1b)

PPRM:

120463111(sgpp1) 120493748(si:ch211-212g7.6)

RKG:	130088231(sgpp1b) 130097560(sgpp1a)

MAMB:

125277322(sgpp1b) 125277761 125277764 125277788

CIDE:

127502370 127525072

CERY:

137018852(sgpp1a) 137020846(sgpp1b)

MASI:

127409801 127411654 127414070 127416415

TROS:

130558853(sgpp1b) 130566080(sgpp1a)

TDW:	130431387(sgpp1b) 130431390 130434352(sgpp1a)

MANU:

129415766(sgpp1b) 129430093(sgpp1a)

PDAB:

135738977(sgpp1a) 135786749(sgpp1b)

IPU:	108257884(sgpp1a) 108263245(sgpp1b)

IFU:	128601275(sgpp1a) 128605141(sgpp1b)

PHYP:

113541943(sgpp1) 113545242

SMEO:

124376660(sgpp1a) 124398703(sgpp1b)

TFD:	113644517(sgpp1a) 113656550(sgpp1b)

TVC:	132843325(sgpp1a) 132846901(sgpp1b)

CGAR:

128515215(sgpp1a) 128528906(sgpp1b)

NGRA:

132883734(sgpp1a) 132889081(sgpp1b)

TRN:	134314920(sgpp1b) 134320053(sgpp1a)

AMEX:

103033561(sgpp1a) 103043414(sgpp1b)

CMAO:

118810966(sgpp1) 118815525(si:ch211-212g7.6)

EEE:	113573005 113575535(sgpp1)

CHAR:

105890348(sgpp1b) 105897768(sgpp1a)

SPIL:

134067254(sgpp1b) 134097256(sgpp1a)

TRU:	101069308 101073941(sgpp1)

TFS:	130513129(sgpp1b) 130516441

TNG:	GSTEN00023278G001 GSTEN00030340G001

LCO:	104930364(sgpp1) 104930546

NCC:	104951070 104956487(sgpp1)

TBEN:

117492646 117494616

CGOB:

115003595 115005059

PGEO:

117439906(sgpp1a) 117467628(sgpp1b)

GACU:

117533817 117540524(sgpp1)

EMAC:

134877139 134881697

ELY:	117266618(sgpp1) 117271282

EFO:	125896703 125901195(sgpp1b)

PLEP:

121953821(sgpp1b) 121955641 121963384

SLUC:

116036777(sgpp1) 116065956

ECRA:

117935889(sgpp1) 117961121

ESP:	116670210 116706552

PFLV:

114546634 114573551

GAT:	120808106 120814132 120832846(sgpp1)

PPUG:

119194793 119227401(sgpp1b)

AFB:	129103661 129107153

CLUM:

117727564 117751193(sgpp1)

PSWI:

130201470(sgpp1b) 130202462

CANA:

137786043 137802463(sgpp1b)

CVE:	137877679 137882339

MSAM:

119909573 119919153

SCHU:

122861493(sgpp1b) 122862800

CUD:	121521592 121526083(sgpp1b)

SPUL:

138591693(sgpp1b) 138610880

LMIX:

132985022 132993608(sgpp1b)

ALAT:

119004480(sgpp1) 119012176

ASTR:

137610885(sgpp1b) 137613800(sgpp1a)

MZE:	101480011(sgpp1) 101484831

ONL:	100700490(sgpp1) 100711669

OAU:	116310692(sgpp1) 116310703

OLA:	101166766 101173595(sgpp1)

OML:	112140558 112149495(sgpp1) 112158315

CSAI:

133462433(sgpp1b) 133464391

XMA:	102217671 102236212

XCO:	114155583 114158888

XHE:	116709640 116734139

PRET:

103457586 103458086

PFOR:

103138616 103147754

PLAI:

106939204 106949072

PMEI:

106906725 106919673(sgpp1)

GAF:	122825836 122846008

PPRL:

129351222 129377422

CVG:	107082722 107084889

CTUL:

119785105 119792147

GMU:	124855645 124882539

NFU:	107377578 107391642(sgpp1)

KMR:	108242494 108251518(sgpp1)

ALIM:

106516927 106531564(sgpp1)

NWH:	119418191 119427091(sgpp1b)

AOCE:

111566662 111568813(sgpp1b)

EJA:	138193808 138200244(sgpp1b)

BFRE:

138619831 138631892(sgpp1b)

MCEP:

124999119 125023490(sgpp1b)

CSEM:

103380814 103382704(sgpp1)

POV:	109636161(sgpp1) 109648136

SSEN:

122761556 122783399(sgpp1b)

SSOE:

131444107 131444837(sgpp1b)

HHIP:

117756720(sgpp1) 117758166

HSP:	118099589 118116512(sgpp1b)

PPLT:

128450973(sgpp1b) 128460144

SMAU:

118285947(sgpp1b) 118290544

LCF:	108895644 108901642(sgpp1b)

SDU:	111225386 111239742

SLAL:

111652673 111654330

XGL:	120789376 120795346(sgpp1)

HCQ:	109520744 109524863

SSCV:

125990696(sgpp1a)

SBIA:

133496772 133501519(sgpp1b)

PEE:	133401902(sgpp1b) 133417276

PTAO:

133467950 133480104(sgpp1b)

BPEC:

110153074 110153456

ENY:	140357878(sgpp1a) 140370811

MALB:

109954458 109966615

BSPL:

114849114(sgpp1b) 114850089

SJO:	128375660(sgpp1b)

SSCO:

133997908 134001050

GMH:	115534249 115543467(sgpp1)

SASA:

106571509 106599021(sgpp1)

STRU:

115172521(sgpp1)

OTW:	112250420(sgpp1a) 112261702

OMY:	110497831 110529718(si:ch211-212g7.6)

OGO:	123990853 124001379(sgpp1b)

ONE:	115107859 115146155(sgpp1)

OKI:	109894442 109900841

OKE:	118362585 118398552(sgpp1a)

OMM:	135505864 135508132

OCLA:

139375164 139415224

SALP:

111954355 111968653(sgpp1)

SNH:	120024085(si:ch211-212g7.6) 120060345(sgpp1)

CCLU:

121539359 121544457 121552384

ELS:	105015553 105017650

OEP:	134024843 134026535(sgpp1b)

SFM:	108919425(sgpp1) 108941948

PKI:	111844461 111851059(sgpp1)

AANG:

118215330(sgpp1) 118230775(si:ch211-212g7.6)

AROT:

135248917(sgpp1b) 135257051(sgpp1a)

CCOG:

133107782(sgpp1b) 133129561(sgpp1a)

LOC:	102683932(sgpp1)

PSPA:

121324557 121330252

ARUT:

117430327 117974017

PSEX:

120518501(sgpp1)

LCM:	102367084(SGPP1)

CMK:	103185418(sgpp1b)

RTP:	109914447(sgpp1b)

CPLA:

122553448(sgpp1b)

HOC:	132818373(sgpp1b)

HAKA:

140724837(sgpp1b)

PMRN:

116947247(SGPP1)

LRJ:	133360764(SGPP1)

BFO:

118410290

BBEL:

109469942

CIN:	100182290 100182465

SCLV:

120326238 120328410

APLC:

110982172

AFIL:

140145912

SKO:	100367222 100367374

PFLL:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009138

CPII:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

MZT:

CCOA:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LBD:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

ATD:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209451

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM323580

FOC:

TPAL:

ZNE:

CSEC:

PAME:

BROR:

IEL:	124158036 124163045

HAMR:

139700078

FCD:

110843083

DPX:	DAPPUDRAFT_251767

DMK:

116928372

DPZ:	124328532 124340525

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

PORN:

EAF:

PPOI:

RMP:

DPTE:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129222939 129233221

SDM:

118180155

LPOL:

106465598

PMEO:

129584583

HRO:	HELRODRAFT_122845

LGI:	LOTGIDRAFT_140415 LOTGIDRAFT_54296

PVUL:

126807880 126820595

PCAN:

112564569 112570185

LSAX:

138951975 138982750

BGT:	106057009 106057010 106069578 106074606

GAE:	121372716 121380615 121381749

HRF:	124145460 124146650

HRJ:	124267147 124276789

HASI:

137256318 137293928

HCRA:

139442897 139470057

CRG:	105333032 105334190

CANU:

128177333

CVN:

111129840

OED:	125650000 125666804

MYI:	110441852 110446509

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:	135468409 135469179 135477459

LAK:	106165271 106181304

LLON:

135485559

NVE:	5499548 5515990

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

HMG:

RES:

TAD:	TRIADDRAFT_33901

AQU:	100639563 100641496

MBR:	MONBRDRAFT_31293

» show all

Reference

PMID:10859351

Authors

Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S

Title

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death.

Journal

Proc Natl Acad Sci U S A 97:7859-64 (2000)
DOI:10.1073/pnas.120146897

Sequence

[hsa:81537]

LinkDB

ORTHOLOGY: K04717

Entry

K04717                      KO

Symbol

SGPP2

Name

sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]

Pathway

map00600

Sphingolipid metabolism

map01100

Metabolic pathways

map04071

Sphingolipid signaling pathway

Reaction

R06520

3-sn-phosphatidate phosphohydrolase

R06521

3-sn-phosphatidate phosphohydrolase

R06522

3-sn-phosphatidate phosphohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K04717  SGPP2; sphingosine-1-phosphate phosphotase 2
09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K04717  SGPP2; sphingosine-1-phosphate phosphotase 2

Other DBs

GO:

0042392

Genes

HSA:	130367(SGPP2)

PTR:	470726(SGPP2)

PPS:	100976002(SGPP2)

GGO:	101154040(SGPP2)

PON:	100462316(SGPP2)

PPYG:

129031254(SGPP2)

NLE:	100592130(SGPP2)

HMH:	116465318 116810242(SGPP2)

SSYN:

129488496(SGPP2)

MCC:	705674(SGPP2)

MCF:	102135818(SGPP2)

MTHB:

126932847

MNI:	105481305(SGPP2)

CSAB:

103217939(SGPP2)

CATY:

105587000(SGPP2)

PANU:

101016966(SGPP2)

TGE:	112636112(SGPP2)

MLEU:

105550934(SGPP2)

RRO:	104655908(SGPP2)

RBB:	108532648(SGPP2)

TFN:	117094464(SGPP2)

PTEH:

111549088(SGPP2)

CANG:

105518783(SGPP2)

CJC:	100407081(SGPP2)

SBQ:	101051796(SGPP2)

CIMI:

108309126(SGPP2)

ANAN:

105712908(SGPP2)

CSYR:

103260071(SGPP2)

MMUR:

105858642(SGPP2)

LCAT:

123643625(SGPP2)

PCOQ:

105808772(SGPP2)

OGA:	100963481(SGPP2)

MMU:	433323(Sgpp2)

MCAL:

110291335(Sgpp2)

MPAH:

110322485(Sgpp2)

RNO:	301543(Sgpp2)

MCOC:

116089242(Sgpp2)

ANU:	117705243(Sgpp2)

ASYL:

127693038(Sgpp2)

MUN:	110549410(Sgpp2)

CGE:	100760822(Sgpp2)

MAUA:

101828898(Sgpp2)

PROB:

127226483(Sgpp2)

PLEU:

114706790(Sgpp2)

MORG:

121447305(Sgpp2)

MFOT:

126512964

AAMP:

119821637(Sgpp2)

NGI:	103727771(Sgpp2)

HGL:	101701693(Sgpp2)

CPOC:

100731261(Sgpp2)

CCAN:

109698828(Sgpp2)

DORD:

105987962(Sgpp2)

DSP:	122107414(Sgpp2)

DMER:

138823143(Sgpp2)

PLOP:

125350258(Sgpp2)

NCAR:

124981069

MMMA:

107138739(Sgpp2)

ITI:	101977472(Sgpp2)

OCU:

100357833

OPI:	101529574(SGPP2)

TUP:	102497979(SGPP2)

GVR:	103609253(SGPP2)

CFA:	610884(SGPP2)

CLUD:

112656620(SGPP2)

VVP:	112922503(SGPP2)

VLG:	121480542(SGPP2)

NPO:	129522679(SGPP2)

AML:	105234969(SGPP2)

UMR:	103662865(SGPP2)

UAH:	113250408(SGPP2)

UAR:	123778090(SGPP2)

ELK:

111138525

LLV:

125096034

MPUF:

101681375(SGPP2)

MNP:	132013592(SGPP2)

MLK:	131827399(SGPP2)

NVS:	122902353(SGPP2)

ORO:	101365224(SGPP2)

EJU:	114210860(SGPP2)

ZCA:	113920266(SGPP2)

MLX:	118012006(SGPP2)

NSU:	110592343(SGPP2)

LWW:	102743524(SGPP2)

FCA:	101083024(SGPP2)

PYU:	121014504(SGPP2)

PCOO:

112848540(SGPP2)

PBG:	122481830(SGPP2)

PVIV:

125173363(SGPP2)

LRUF:

124514772

LGF:	123599536(SGPP2)

AJU:

106975905

PTG:	107180011(SGPP2)

PPAD:

109264996(SGPP2)

PUC:

125911741

PLEZ:

122226696(SGPP2)

HHV:	120234842(SGPP2)

BTA:	100337041(SGPP2)

BOM:	102286517(SGPP2)

BIU:	109575817(SGPP2)

BBUB:

102409064(SGPP2)

BBIS:

104986515(SGPP2)

CHX:	102183470(SGPP2)

OAS:	101116130(SGPP2)

BTAX:

128067857(SGPP2)

CSUM:

138076337(SGPP2)

ODA:	120854472(SGPP2)

CCAD:

122426310(SGPP2)

MREE:

136163195(SGPP2)

OVR:	110148653(SGPP2)

MBEZ:

129538508(SGPP2)

SSC:	100524832(SGPP2)

CFR:	102506559(SGPP2)

CBAI:

105064059(SGPP2)

CDK:	105098290(SGPP2)

VPC:	102543563(SGPP2)

BACU:

102998333 102998371(SGPP2)

BMUS:

118897939(SGPP2)

LVE:	103081882(SGPP2)

OOR:	101276880(SGPP2)

LALB:

132522057(SGPP2)

GMF:	115842235(SGPP2)

DDP:	132427981(SGPP2)

DLE:	111171871(SGPP2)

PCAD:

102990066(SGPP2)

PSIU:

116756572(SGPP2)

PPHC:

136125439(SGPP2)

NASI:

112411804(SGPP2)

ECB:	100060934(SGPP2)

EPZ:	103547286(SGPP2)

EAI:	106832476(SGPP2)

MYB:	102259379(SGPP2)

MYD:	102762633(SGPP2)

MMYO:

118661275(SGPP2)

MLF:	102438562(SGPP2)

MDT:	132238284(SGPP2)

MYUM:

139015052(SGPP2)

PKL:	118709056(SGPP2)

EFUS:

103289269(SGPP2)

MNA:	107526694(SGPP2)

DRO:	112307811(SGPP2)

SHON:

118975362(SGPP2)

AJM:	119050966(SGPP2)

PDIC:

114495375(SGPP2)

PHAS:

123828190(SGPP2)

MMF:	118625850(SGPP2)

PPAM:

129080616(SGPP2)

HAI:	109396189(SGPP2)

RFQ:	117025771(SGPP2)

PALE:

102894969(SGPP2)

PGIG:

120587707(SGPP2)

PVP:	105291100(SGPP2)

RAY:	107516746(SGPP2)

MJV:	108398001(SGPP2)

TOD:	119256253(SGPP2)

SARA:

101557193(SGPP2)

SFUM:

130021064(SGPP2)

SETR:

126000985(SGPP2)

LAV:	100669348(SGPP2)

TMU:

101356122

ETF:	101644553(SGPP2)

DNM:	101419582(SGPP2)

MDO:	100022862(SGPP2)

GAS:	123240169(SGPP2)

SHR:	100920724(SGPP2)

AFZ:

127553054

PCW:	110219500(SGPP2)

TVP:	118848235(SGPP2)

PBRV:

138174326(SGPP2)

MLAO:

141490893(SGPP2)

OAA:	100074162(SGPP2)

TACU:

119930608(SGPP2)

GGA:	424813(SGPP2)

PCOC:

116230932(SGPP2)

MGP:	100550401(SGPP2)

CJO:	107318029(SGPP2)

TPAI:

128081814(SGPP2)

LMUT:

125697876(SGPP2)

NMEL:

110397785(SGPP2)

APLA:

101797259(SGPP2)

ACYG:

106036188(SGPP2)

CATA:

118247045(SGPP2)

AFUL:

116492578(SGPP2)

TGU:	100226252(SGPP2)

LSR:	110483631(SGPP2)

SCAN:

103815661(SGPP2)

PMOA:

120508563(SGPP2)

OTC:	121341164(SGPP2)

PRUF:

121357974(SGPP2)

ATRC:

139594876(SGPP2)

GFR:	102043416(SGPP2)

FAB:	101809677(SGPP2)

OMA:	130256980(SGPP2)

PHI:	102101175(SGPP2)

PMAJ:

107209013(SGPP2)

CCAE:

111933562(SGPP2)

CCW:	104693093(SGPP2)

CBRC:

103612041(SGPP2)

ACOE:

138114629(SGPP2)

ETL:	114067632(SGPP2)

ZAB:	102068032(SGPP2)

ZLE:	135451734(SGPP2)

ACHL:

103801979(SGPP2)

SVG:	106855136(SGPP2)

MMEA:

130585399(SGPP2)

HRT:	120757446(SGPP2)

SATI:

136365630(SGPP2)

CCIC:

134047888(SGPP2)

FPG:	101914913(SGPP2)

FCH:	102053072(SGPP2)

NNT:	104402664(SGPP2)

SHAB:

115612053(SGPP2)

ACUN:

113483359(SGPP2)

TALA:

104365207(SGPP2)

ACHC:

115347624(SGPP2)

HALD:

104320842(SGPP2)

HLE:	104832288(SGPP2)

AGEN:

126039893

HHAR:

128149421(SGPP2)

GCL:

127020136

CSTI:

104560326(SGPP2)

LDI:	104349562(SGPP2)

MNB:	103769926(SGPP2)

DPUB:

104297650(SGPP2)

PPUS:

135180401(SGPP2)

AVIT:

104281235(SGPP2)

BRHI:

104489353(SGPP2)

EGZ:	104135441(SGPP2)

NNI:	104012997(SGPP2)

PCRI:

104023768(SGPP2)

PCAO:

104040154(SGPP2)

PADL:

103917899

AFOR:

103896736(SGPP2)

FGA:	104078608(SGPP2)

GSTE:

104259034(SGPP2)

CBOY:

140654830(SGPP2)

CLV:	102092199(SGPP2)

CNIC:

135991454(SGPP2)

PGUU:

104467372(SGPP2)

PLET:

104613621(SGPP2)

EHS:	104506484(SGPP2)

CUCA:

104058800(SGPP2)

TEO:	104382348(SGPP2)

BREG:

104642251(SGPP2)

OHA:	104337999(SGPP2)

ACAR:

104522075(SGPP2)

CPEA:

104392269(SGPP2)

CVF:	104291012(SGPP2)

RTD:	128911525(SGPP2)

CRID:

134517472(SGPP2)

AAM:

106485849

AROW:

112969612(SGPP2)

NPD:	112947966(SGPP2)

TGT:	104569001(SGPP2)

DNE:	112988929(SGPP2)

SCAM:

104144660(SGPP2)

ASN:	102382033(SGPP2)

AMJ:	102557931(SGPP2)

CPOO:

109308643(SGPP2)

GGN:	109288203(SGPP2)

PSS:	102450918(SGPP2)

CMY:	102946621(SGPP2)

CCAY:

125642928(SGPP2)

DCC:	119861054(SGPP2)

CPIC:

101946541(SGPP2)

TST:	117883321(SGPP2)

CABI:

116838437(SGPP2)

MRV:	120372303(SGPP2)

ACS:	100566481(sgpp2)

ASAO:

132770678(SGPP2)

PVT:	110079978(SGPP2)

SUND:

121925195(SGPP2)

PBI:	103057174(SGPP2)

PMUR:

107289157(SGPP2)

CTIG:

120307590(SGPP2)

TSR:	106540099(SGPP2)

PGUT:

117678383(SGPP2)

PCAE:

139318561(SGPP2)

APRI:

131200652(SGPP2)

PTEX:

113436846(SGPP2)

NSS:	113409868(SGPP2)

VKO:	123024842(SGPP2)

PMUA:

114597792(SGPP2)

PRAF:

128414568(SGPP2)

ZVI:	118093453(SGPP2)

HCG:	128350412(SGPP2)

GJA:	107115866(SGPP2)

STOW:

125438314(SGPP2)

EMC:	129331698(SGPP2)

XLA:	100036888(sgpp2.L) 108717467(sgpp2.S)

XTR:	100489794(sgpp2)

NPR:	108796930(SGPP2)

RTEM:

120936578(SGPP2)

ACAT:

141139634(SGPP2)

BBUF:

120997730(SGPP2)

BGAR:

122935941(SGPP2)

DTC:	141095238(SGPP2)

PWL:	138265604(SGPP2)

MUO:	115479171(SGPP2)

GSH:	117367018(SGPP2)

DRE:	100330698(sgpp2)

SRX:	107705636 107722257

SANH:

107669878 107670120(sgpp2)

SGH:	107558808 107585790

CCAR:

109104165 109104170

CAUA:

113058699

CGIB:

128029044

PTET:

122358828(sgpp2)

LROH:

127177038(sgpp2)

OMC:	131520364(sgpp2)

PPRM:

120483580(sgpp2)

RKG:	130073152(sgpp2)

MAMB:

125248633(sgpp2)

CIDE:

127495916

CERY:

137004963(sgpp2)

MASI:

127422234 127429900

TROS:

130564850(sgpp2)

TDW:	130428610(sgpp2)

MANU:

129438590(sgpp2)

PDAB:

135771825(sgpp2)

IPU:	108277594 108277997

IFU:	128621488 128621685

PHYP:

113544525

SMEO:

124394586(sgpp2)

TFD:	113637873(sgpp2)

TVC:	132858016(sgpp2)

CGAR:

128533642(sgpp2)

NGRA:

132900952(sgpp2)

TRN:	134334295(sgpp2)

AMEX:

103045304(sgpp2)

CMAO:

118797997(sgpp2)

EEE:	113578720(sgpp2)

CHAR:

105890585(sgpp2)

SPIL:

134099581(sgpp2)

TRU:	101075825(sgpp2)

TFS:	130534531(sgpp2)

TNG:	GSTEN00026737G001 GSTEN00026738G001

LCO:	104934363(sgpp2)

NCC:

104948104

TBEN:

117475906(sgpp2)

CGOB:

115017976(sgpp2)

PGEO:

117457701(sgpp2)

GACU:

117540024(sgpp2)

EMAC:

134880807(sgpp2)

ELY:	117259546(sgpp2)

EFO:	125888257(sgpp2)

PLEP:

121943690(sgpp2)

SLUC:

116038901(sgpp2)

ECRA:

117939798(sgpp2)

ESP:	116673003(sgpp2)

PFLV:

114553071(sgpp2)

PPUG:

119214998(sgpp2)

AFB:	129095066(sgpp2)

CLUM:

117741548(sgpp2)

CANA:

137791020(sgpp2)

CVE:	137872050(sgpp2)

MSAM:

119882788(sgpp2)

SCHU:

122878856(sgpp2)

CUD:	121523985(sgpp2)

SPUL:

138604707(sgpp2)

LMIX:

132979813(sgpp2)

ALAT:

119008881(sgpp2)

ASTR:

137597019(sgpp2)

MZE:	101471415(sgpp2)

ONL:	100698709(sgpp2)

OAU:	116328148(sgpp2)

OLA:	101156907(sgpp2)

OML:	112149309(sgpp2)

CSAI:

133442234(sgpp2)

XMA:	102225026(sgpp2)

XCO:	114161625(sgpp2)

XHE:	116737385(sgpp2)

PRET:

103474930(sgpp2)

PFOR:

103145235(sgpp2)

PLAI:

106953862(sgpp2)

PMEI:

106920630(sgpp2)

GAF:	122832568(sgpp2)

PPRL:

129358693(sgpp2)

CVG:

107081276

CTUL:

119774559(sgpp2)

GMU:	124884485(sgpp2)

NFU:	107380792(sgpp2)

KMR:	108228397(sgpp2)

ALIM:

106523275(sgpp2)

NWH:	119429236 119429238

AOCE:

111577125(sgpp2)

EJA:	138197013(sgpp2)

BFRE:

138616954(sgpp2)

MCEP:

125013098(sgpp2)

CSEM:

103377830(sgpp2)

POV:	109634441(sgpp2)

SSEN:

122773506(sgpp2)

SSOE:

131462574(sgpp2)

HHIP:

117773456(sgpp2)

HSP:	118105667(sgpp2)

PPLT:

128440863(sgpp2)

SMAU:

118298896(sgpp2)

LCF:

108888205

SDU:	111232860(sgpp2)

SLAL:

111671281(sgpp2)

XGL:	120792150(sgpp2)

HCQ:	109510750(sgpp2)

SSCV:

125971774(sgpp2)

SBIA:

133505178(sgpp2)

PEE:	133405510(sgpp2)

PTAO:

133482746(sgpp2)

BPEC:

110154580(sgpp2)

ENY:	140371800(sgpp2)

MALB:

109951303(sgpp2)

BSPL:

114867693(sgpp2)

SJO:	128360661(sgpp2)

SSCO:

133980488(sgpp2)

GMH:	115560836(sgpp2)

SASA:

106581310(sgpp2) 106613137

STRU:

115206527

OTW:	112267254(sgpp2)

OMY:	110504111(sgpp2)

OGO:	124006527(sgpp2)

ONE:	115141962(sgpp2)

OKI:	109882821(sgpp2)

OKE:

118374414

OMM:	135546602(sgpp2)

OCLA:

139383139

SALP:

111957842(sgpp2)

SNH:	120028482(sgpp2)

CCLU:

121567705

ELS:	105017512(sgpp2)

OEP:	134028823(sgpp2)

SFM:	108932149(sgpp2)

PKI:	111860299(sgpp2)

AANG:

118208881(sgpp2)

AROT:

135236825(sgpp2)

CCOG:

133108078(sgpp2)

LOC:	102693517(sgpp2)

PSPA:

121323448 121326801(sgpp2)

ARUT:

117416540(sgpp2)

PSEX:

120531011(sgpp2)

LCM:	102359263(SGPP2)

CMK:	103176344(sgpp2)

RTP:	109914278(sgpp2) 109919317

CPLA:

122540352 122555849(sgpp2)

HOC:	132821571(sgpp2) 132833619

LERI:

129703724(sgpp2) 129711581

HAKA:

140718378 140725464(sgpp2)

PMRN:

116946847

LRJ:	133351227(SGPP2)

SPU:

LPIC:

AJJ:

APLC:

ARUN:

117287703 117296106 117299773

AAMU:

139948393 139948400 139948406

CNS:

AGRG:

LDC:

DCI:

HAZT:

DSV:

RSAN:

RMP:

DFR:

CANU:

CVN:	111111654 111111935

MMER:

RPHI:

DPOL:

MAEA:

HSY:

SRE:	PTSG_03097

DDI:	DDB_G0272260(sppA)

DPP:	DICPUDRAFT_149430

ACAN:

ACA1_369180

BAL:	BACI_c22090

BCR:	BCAH187_A2364

BNC:

BCF:

BMOB:

Reference

PMID:12411432

Authors

Ogawa C, Kihara A, Gokoh M, Igarashi Y

Title

Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2.

Journal

J Biol Chem 278:1268-72 (2003)
DOI:10.1074/jbc.M209514200

Sequence

[hsa:130367]

LinkDB

REACTION: R06522

Entry

R06522                      Reaction

Name

3-sn-phosphatidate phosphohydrolase

Definition

Ceramide 1-phosphate + H2O <=> N-Acylsphingosine + Orthophosphate

Equation

C02960 + C00001 <=> C00195 + C00009

Comment

phosphohydrolase

Reaction class

RC00017

C00195_C02960

Enzyme

3.1.3.4 3.1.3.-

Pathway

rn00600

Sphingolipid metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4
     R06522  Ceramide 1-phosphate + H2O <=> N-Acylsphingosine + Orthophosphate
    3.1.3.-
     R06522  Ceramide 1-phosphate + H2O <=> N-Acylsphingosine + Orthophosphate

Orthology

K01080

phosphatidate phosphatase [EC:3.1.3.4]

K04716

sphingosine-1-phosphate phosphatase 1 [EC:3.1.3.-]

K04717

sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]

LinkDB

DBGET integrated database retrieval system