KEGG ORTHOLOGY: K05070

ORTHOLOGY: K05070

Entry

K05070                      KO

Symbol

IL2RG, CD132

Name

interleukin 2 receptor gamma

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05321

Inflammatory bowel disease

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04151 PI3K-Akt signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04659 Th17 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05162 Measles
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05340 Primary immunodeficiency
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04090 CD molecules
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05070  IL2RG, CD132; interleukin 2 receptor gamma
CD molecules [BR:ko04090]
Proteins
  K05070  CD132, IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency)

Other DBs

GO:

0004911

Genes

HSA:	3561(IL2RG)

PTR:	101059843(IL2RG)

PPS:	100986679(IL2RG)

GGO:	129529998(IL2RG)

PON:	100454903(IL2RG)

PPYG:

129023894(IL2RG)

NLE:	100585758(IL2RG)

HMH:	116464897(IL2RG)

SSYN:

129476031(IL2RG)

MCC:	641338(IL2RG)

MCF:	102144912(IL2RG)

MTHB:

126946182

MNI:	105476651(IL2RG)

CSAB:

103232148(IL2RG)

CATY:

105586122(IL2RG)

PANU:

101008968(IL2RG)

TGE:	112615453(IL2RG)

MLEU:

105548157(IL2RG)

RRO:	104656782(IL2RG)

RBB:	108532108(IL2RG)

TFN:	117077624(IL2RG)

PTEH:

111533635(IL2RG)

CANG:

105512612(IL2RG)

CJC:	100388189(IL2RG)

SBQ:	101047979(IL2RG)

CIMI:

108294787(IL2RG)

ANAN:

105732794(IL2RG)

CSYR:

103250262(IL2RG)

MMUR:

105855320(IL2RG)

LCAT:

123628744(IL2RG)

PCOQ:

105809985(IL2RG)

OGA:	100961176(IL2RG)

MMU:	16186(Il2rg)

MCAL:

110286942(Il2rg)

MPAH:

110313918(Il2rg)

RNO:	140924(Il2rg)

MCOC:

116087170(Il2rg)

ANU:	117694639(Il2rg)

MUN:	110564656(Il2rg)

CGE:	100756284(Il2rg)

MAUA:

101824015(Il2rg)

PROB:

127218462(Il2rg)

PLEU:

114708654(Il2rg)

MORG:

121443322 121444965

MFOT:

126487061

AAMP:

119804964(Il2rg)

NGI:	103751955(Il2rg)

HGL:	101715243(Il2rg)

CPOC:

100713379(Il2rg)

CCAN:

109673990(Il2rg)

DORD:

105997296(Il2rg)

DSP:	122120620(Il2rg)

PLOP:

125343243(Il2rg)

NCAR:

124972015

MMMA:

107155679(Il2rg)

OCU:

103351862

OPI:	101536616(IL2RG)

TUP:	102476004(IL2RG)

GVR:	103586318(IL2RG)

CFA:	403851(IL2RG)

CLUD:

112671816(IL2RG)

VVP:	112907637(IL2RG)

VLG:	121483086(IL2RG)

NPO:	129518467(IL2RG)

AML:	100468126(IL2RG)

UMR:	103682591(IL2RG)

UAH:	113245610(IL2RG)

ELK:

111161041

LLV:

125092325

MPUF:

101678968(IL2RG)

MNP:	132007353(IL2RG)

MLK:	131821377(IL2RG)

NVS:	122896347(IL2RG)

ORO:	101374379(IL2RG)

EJU:	114203171 114203175

ZCA:	113930805(IL2RG)

MLX:	118025926(IL2RG)

NSU:	110572174(IL2RG)

LWW:	102741990(IL2RG)

FCA:	101090239(IL2RG)

PYU:	121025256(IL2RG)

PCOO:

112871236(IL2RG)

PBG:	122477318(IL2RG)

PVIV:

125157955(IL2RG)

LRUF:

124521570

PTG:	102966580(IL2RG)

PPAD:

109254610(IL2RG)

PUC:

125931753

AJU:

106982399

HHV:	120246070(IL2RG)

BTA:	281862(IL2RG)

BOM:	102266681(IL2RG)

BIU:	109555190(IL2RG)

BBUB:

102402566(IL2RG)

CHX:	102169656(IL2RG)

OAS:	101103538(IL2RG)

BTAX:

128070243(IL2RG)

ODA:	120882006(IL2RG)

CCAD:

122434652(IL2RG)

MBEZ:

129564419(IL2RG)

SSC:	397156(IL2RG)

CBAI:

105083690(IL2RG)

CDK:	105087982(IL2RG)

VPC:	102526609(IL2RG)

BACU:

103016442(IL2RG)

BMUS:

118888758(IL2RG)

LVE:	103087530(IL2RG)

OOR:	101286718(IL2RG)

DLE:	111167807(IL2RG)

PCAD:

102979617(IL2RG)

PSIU:

116747462(IL2RG)

NASI:

112408519(IL2RG)

ECB:	100055911(IL2RG)

EPZ:	103544610(IL2RG)

EAI:	106828880(IL2RG)

MYB:	102241164(IL2RG)

MYD:	102757155(IL2RG)

MMYO:

118654549(IL2RG) 118661694(METTL8)

MLF:	102441989(IL2RG)

MDT:	132224060(IL2RG)

PKL:	118704153(IL2RG) 118709172(METTL8)

EFUS:

103283323(METTL8) 103304360(IL2RG)

MNA:	107532895(IL2RG)

DRO:	112300079(IL2RG)

AJM:	119035395(IL2RG)

PDIC:

114504996(IL2RG)

PHAS:

123824325(IL2RG)

MMF:	118635917(IL2RG)

PPAM:

129071133(IL2RG)

HAI:	109385585(IL2RG)

RFQ:	117024055(IL2RG)

PALE:

102888070(IL2RG)

PGIG:

120585387(IL2RG)

PVP:	105299605(IL2RG)

RAY:	107513773(IL2RG)

MJV:	108403309(IL2RG)

TOD:	119246676(IL2RG)

SARA:

101545374(IL2RG)

SETR:

125999240(IL2RG)

LAV:	100664834(IL2RG)

TMU:

101359472

ETF:	101657280(IL2RG)

DNM:	101437298(IL2RG)

MDO:	100619507(IL2RG)

GAS:	123254760(IL2RG)

SHR:	100929781(IL2RG)

AFZ:

127542639

PCW:	110201024(IL2RG)

OAA:	114812802(IL2RG)

GGA:	395199(IL2RG)

PCOC:

116229598(IL2RG)

MGP:	104912104(IL2RG)

CJO:	107312576(IL2RG)

TPAI:

128076089(IL2RG)

LMUT:

125699677(IL2RG)

NMEL:

110403135(IL2RG)

APLA:

101794194(IL2RG)

ACYG:

106037383(IL2RG)

CATA:

118245587(IL2RG)

AFUL:

116494466(IL2RG)

TGU:	100226174(IL2RG)

LSR:	110472683(IL2RG)

SCAN:

103824248(IL2RG)

PMOA:

120506133(IL2RG)

OTC:	121331697(IL2RG)

PRUF:

121363036(IL2RG)

GFR:	102043888(IL2RG)

FAB:	107603321(IL2RG)

OMA:	130253047(IL2RG)

PHI:	102112500(IL2RG)

PMAJ:

107203656(IL2RG)

CCAE:

111929372(IL2RG)

CCW:	104691748(IL2RG)

CBRC:

103617890(IL2RG)

ETL:	114067449(IL2RG)

ZAB:	102065939(IL2RG)

ZLE:	135447939(IL2RG)

ACHL:

103797625(IL2RG)

SVG:	106853684(IL2RG)

MMEA:

130577338(IL2RG)

HRT:	120762058(IL2RG)

SATI:

136370547(IL2RG)

FPG:	101923008(IL2RG)

FCH:	102052025(IL2RG)

CCRI:

104169538

NNT:

104412205

SHAB:

115603092(IL2RG)

ACUN:

113479902(IL2RG)

TALA:

104369148(IL2RG)

ACHC:

115333600(IL2RG)

HALD:

104315844(IL2RG)

HLE:	104830423(IL2RG)

AGEN:

126050273

GCL:

127019612

CSTI:

104563317(IL2RG)

LDI:

104339820

MNB:

103770051

DPUB:

104296345(IL2RG)

AVIT:

104267159

BRHI:

104493368

EGZ:	104124289(IL2RG)

NNI:	104012899(IL2RG)

PCRI:

104037364

PCAO:

104051643

PADL:

103923348(IL2RG)

AFOR:

103905836(IL2RG)

FGA:	104081348(IL2RG)

CLV:	102094834(IL2RG)

MUI:	104533161(IL2RG)

PGUU:

104470831

PLET:

104628689(IL2RG)

CMAC:

104487058

CUCA:

104069038(IL2RG)

TEO:

104373241

BREG:

104629114(IL2RG)

OHA:	104335752(IL2RG)

ACAR:

104522005

CPEA:

104388320(IL2RG)

CVF:	104283545(IL2RG)

RTD:	128915316(IL2RG)

AROW:

112966349(IL2RG)

NPD:	112948661(IL2RG)

DNE:	112989719(IL2RG)

ASN:	102379602(IL2RG)

AMJ:	102575498(IL2RG)

GGN:	109300562(IL2RG)

PSS:	102443813(IL2RG)

CMY:	102933244(IL2RG)

CCAY:

125642589(IL2RG)

DCC:	119861160(IL2RG)

CPIC:

101931356(IL2RG)

TST:	117883178(IL2RG)

CABI:

116833382(IL2RG)

MRV:	120372096(IL2RG)

ACS:	103281066(il2rg)

ASAO:

132762891(IL2RG)

PVT:	110080214(IL2RG)

SUND:

121937400(IL2RG)

PBI:	103061889(IL2RG)

PMUR:

107303211(IL2RG)

PGUT:

117679627(IL2RG)

APRI:

131205123(IL2RG)

PTEX:

113446829(IL2RG)

NSS:	113423068(IL2RG)

VKO:	123034956(IL2RG)

PMUA:

114589433(IL2RG)

PRAF:

128406648(IL2RG)

ZVI:	118078798(IL2RG)

HCG:	128335534(IL2RG)

GJA:	107108490(IL2RG)

STOW:

125442884(IL2RG)

EMC:	129340874(IL2RG)

XLA:	100036958(il2rg.L)

XTR:	100492995(il2rg)

NPR:	108800627(IL2RG)

RTEM:

120921918(IL2RG)

BBUF:

120977619(IL2RG)

BGAR:

122919489(IL2RG)

MUO:	115474690(IL2RG)

GSH:	117361218(IL2RG)

DRE:	100144554(il2rgb) 796604(il2rga)

SRX:	107728855 107734452 107752048

SANH:

107658077 107661390 107686149 107691671

SGH:	107560888 107577653 107589463 107601097

CCAR:

109097914 109102144

CAUA:

113054431 113057950 113078587 113098710 113109907 113109945

CGIB:

127966456 127987755 127987757 128021068 128026960

PTET:

122352820(il2rga) 122357181(il2rgb)

LROH:

127153297 127153303 127172529(il2rga) 127176610(il2rgb)

OMC:	131548538(il2rga) 131553603(il2rgb)

PPRM:

120475010(il2rgb) 120482795(il2rga)

RKG:	130078719(il2rgb) 130105529 130105531

MAMB:

125259092(il2rgb) 125262226 125262227(il2rga)

CIDE:

127494333 127520018

CERY:

137020602(il2rgb) 137028679

MASI:

127413094 127432535 127433946

TROS:

130545695(il2rga) 130564184(il2rgb)

TDW:	130412252(il2rga) 130437774(il2rgb)

MANU:

129422472(il2rgb) 129446805(il2rga)

IPU:	108269358(il2rgb) 108276805(il2rga)

IFU:	128611749(il2rgb) 128620732(il2rga)

PHYP:

113529255 113538165

SMEO:

124385987(il2rgb) 124393103(il2rga)

TFD:	113636124(il2rgb) 113650230(il2rga)

TVC:	132856064(il2rgb) 132862930(il2rga)

TRN:	134319668(il2rgb) 134332250(il2rga)

AMEX:

103023433(il2rgb) 103037129(il2rga)

CMAO:

118807216(il2rgb) 118824265(il2rga) 118824266

EEE:	113575423 113579244

CHAR:

105890468(il2rga) 116217993(il2rgb)

TRU:	100190946(il2rg)

TFS:

130538136

TNG:	GSTEN00033798G001

LCO:

104938889

NCC:

104967331

TBEN:

117490338 117490339 117493938

CGOB:

115018623

GACU:

117540123

EMAC:

134871732

ELY:	117263382 117266025

EFO:	125893357 125898685

PLEP:

121946054 121953003

SLUC:

116037024

ECRA:

117956151

ESP:	116699939(il2rg)

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101473695 101474000

OAU:	116319686 116319720 120442159

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:	124875956 124876950

NFU:

107386732

KMR:	108238920 108238928

ALIM:

106527375 106527376

NWH:	119420844 119420846

AOCE:

111573091

MCEP:

125021858

CSEM:

103395485(il2rg)

POV:

109635689

SSEN:

122779628

HHIP:

117773898 117773908

HSP:	118121975 118121976

PPLT:

128457111 128457112

SMAU:

118301277

LCF:	108893180 108893209

SDU:	111217233(il2rg)

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:	128361859 128370872 128371460

SASA:

106563690 106563704

STRU:

115204456 115204470

OTW:	112231157 112231168

OMY:	100136033 101268908(il2rc2)

OGO:	124006721 124006885

ONE:	115101458 115146950

OKI:	109873647 109874333

OKE:	118384975 118385627

SALP:

111964368

SNH:	120021469 120021532 120021552

CCLU:

121541304 121541305

ELS:	105010007 105024667 114828756

SFM:	108923155 108923156 108928942

PKI:	111834615 111836318 111836422

AANG:

118222620 118236490

LOC:	102686346 107077891

PSPA:

121295824 121318888 121318889

ARUT:

117411877 117412087 117430222 117430325

LCM:	102356230(IL2RG)

CMK:	103179046 103179080

RTP:

109930496

CPLA:

122551079 122557372 122557517

HOC:	132820129 132820130

LERI:

129702355

» show all

Reference

PMID:1631559

Authors

Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K

Title

Cloning of the gamma chain of the human IL-2 receptor.

Journal

Science 257:379-82 (1992)
DOI:10.1126/science.1631559

Sequence

[hsa:3561]

Reference

PMID:8476561

Authors

Minami Y, Kono T, Miyazaki T, Taniguchi T

Title

The IL-2 receptor complex: its structure, function, and target genes.

Journal

Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333

Reference

PMID:21715655

Authors

Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M

Title

IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.

Journal

Proc Natl Acad Sci U S A 108:11977-82 (2011)
DOI:10.1073/pnas.1100319108

Sequence

[hsa:3561]

LinkDB

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