KEGG ORTHOLOGY: K05726

ORTHOLOGY: K05726

Entry

K05726                      KO

Symbol

BCAR1, CAS

Name

breast cancer anti-estrogen resistance 1

Pathway

map04015

Rap1 signaling pathway

map04062

Chemokine signaling pathway

map04148

Efferocytosis

map04510

Focal adhesion

map04517

IgSF CAM signaling

map04670

Leukocyte transendothelial migration

map04810

Regulation of actin cytoskeleton

map04935

Growth hormone synthesis, secretion and action

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

map05135

Yersinia infection

map05163

Human cytomegalovirus infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
   04062 Chemokine signaling pathway
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
09160 Human Diseases
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
   05135 Yersinia infection
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
   05100 Bacterial invasion of epithelial cells
    K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1

Genes

HSA:	9564(BCAR1)

PTR:	454246(BCAR1)

PPS:	100980143(BCAR1)

GGO:	101132653(BCAR1)

PON:	103889518(BCAR1)

PPYG:

129015476(BCAR1)

NLE:	100598535(BCAR1)

HMH:	116470814(BCAR1)

SSYN:

129493388(BCAR1)

MCC:	713965(BCAR1)

MCF:	102114845(BCAR1)

MTHB:

126943713

MNI:	105491272(BCAR1)

CSAB:

103233309(BCAR1)

CATY:

105572979(BCAR1)

PANU:

101013590(BCAR1)

TGE:	112613778(BCAR1)

MLEU:

105537242(BCAR1)

RRO:	104677838(BCAR1)

RBB:	108527422(BCAR1)

TFN:	117088057(BCAR1)

PTEH:

111536154(BCAR1)

CANG:

105514570(BCAR1)

CJC:	100391559(BCAR1)

SBQ:	101041293(BCAR1)

CIMI:

108305732(BCAR1)

ANAN:

105706748(BCAR1)

CSYR:

103251606(BCAR1)

MMUR:

105875451(BCAR1)

LCAT:

123625428(BCAR1)

ERUF:

138373924(BCAR1)

PCOQ:

105808008(BCAR1)

OGA:	100955552(BCAR1)

MMU:	12927(Bcar1)

MCAL:

110299902(Bcar1)

MPAH:

110337447(Bcar1)

RNO:	25414(Bcar1)

MCOC:

116070207(Bcar1)

ANU:	117723039(Bcar1)

ASYL:

127671795(Bcar1)

MUN:	110554744(Bcar1)

CGE:	100768861(Bcar1)

MAUA:

101826097(Bcar1)

PROB:

127234668(Bcar1)

PLEU:

114709099(Bcar1)

PMAV:

102924920(Bcar1)

MORG:

121446990(Bcar1)

MFOT:

126502806

AAMP:

119802091(Bcar1)

CNL:	130863656(Bcar1)

NGI:	103725688(Bcar1)

HGL:	101709701(Bcar1)

CPOC:

100713475(Bcar1)

CCAN:

109684025(Bcar1)

DORD:

105983092(Bcar1)

DSP:	122126159(Bcar1)

DMER:

138825107 138826704

PLOP:

125358177(Bcar1)

NCAR:

124967218

MMMA:

107150899(Bcar1)

ITI:	101964713(Bcar1)

OCU:

100350323

OPI:	101522546(BCAR1)

OCZ:	121157908(BCAR1)

TUP:	102488824(BCAR1)

CFA:	479648(BCAR1)

CLUD:

112646654(BCAR1)

VVP:	112915672(BCAR1)

VLG:	121499705(BCAR1)

NPO:	129497226(BCAR1)

AML:	100479448(BCAR1)

UMR:	103662115(BCAR1)

UAH:	113252495(BCAR1)

UAR:	123791314(BCAR1)

ELK:

111152853

LLV:

125089499

MPUF:

101691130(BCAR1)

MNP:	132005689(BCAR1)

MLK:	131817944(BCAR1)

NVS:	122911232(BCAR1)

ORO:	101364349(BCAR1)

EJU:	114202711(BCAR1)

ZCA:	113936040(BCAR1)

MLX:	118023562(BCAR1)

NSU:	110591950(BCAR1)

LWW:

102726881

FCA:	101096625(BCAR1)

PYU:	121009797(BCAR1)

PCOO:

112857231(BCAR1)

PBG:	122494471(BCAR1)

PVIV:

125153269(BCAR1)

LRUF:

124511865

LGF:	123579458(BCAR1)

AJU:

106989704

PTG:	102961947(BCAR1)

PPAD:

109245694(BCAR1)

PUC:

125916426

PLEZ:

122208320(BCAR1)

HHV:	120248194(BCAR1)

BTA:	527550(BCAR1)

BOM:	102286652(BCAR1)

BIU:	109572528(BCAR1)

BBUB:

102391781(BCAR1)

BKE:	129631019(BCAR1)

BBIS:

104996481(BCAR1)

CHX:	102176451(BCAR1)

OAS:	101117693(BCAR1)

BTAX:

128062963(BCAR1)

CSUM:

138095932(BCAR1)

ODA:	120872852(BCAR1)

CCAD:

122421110(BCAR1)

MREE:

136160845(BCAR1)

OVR:	110131398(BCAR1)

MBEZ:

129547261(BCAR1)

SSC:	100621541(BCAR1)

CFR:	102522119(BCAR1)

CBAI:

105078652(BCAR1)

CDK:	105085072(BCAR1)

VPC:	102533924(BCAR1)

BACU:

102999909(BCAR1)

BMUS:

118885184(BCAR1)

LVE:	103077564(BCAR1)

OOR:	101286283(BCAR1)

LALB:

132509403(BCAR1)

GMF:	115856806(BCAR1)

DDP:	132416656(BCAR1)

DLE:	111179506(BCAR1)

PCAD:

102974736(BCAR1)

PSIU:

116744074(BCAR1)

PPHC:

136140431(BCAR1)

NASI:

112393343(BCAR1)

ECB:	100068908(BCAR1)

EPZ:	103553038(BCAR1)

EAI:	106835699(BCAR1)

MYB:	102256265(BCAR1)

MYD:	102751761(BCAR1)

MMYO:

118674128(BCAR1)

MLF:	102431239(BCAR1)

MDT:	132217325(BCAR1)

MYUM:

138996775(BCAR1)

PKL:	118720505(BCAR1)

EFUS:

103284373(BCAR1)

MNA:	107524660(BCAR1)

DRO:	112300743(BCAR1)

SHON:

118999214(BCAR1)

AJM:	119048924(BCAR1)

PDIC:

114488127(BCAR1)

PHAS:

123805863(BCAR1)

MMF:	118639462(BCAR1)

PPAM:

129075188(BCAR1)

HAI:	109384807(BCAR1)

RFQ:	117034639(BCAR1)

PALE:

102897097(BCAR1)

PGIG:

120617366(BCAR1)

PVP:	105305354(BCAR1)

RAY:	107502656(BCAR1)

MJV:	108396170(BCAR1)

TOD:	119249084(BCAR1)

SARA:

101557104(BCAR1)

SFUM:

130044103(BCAR1)

SETR:

126027351(BCAR1)

LAV:	100675124(BCAR1)

TMU:

101346861

ETF:	101642973(BCAR1)

DNM:	101444214(BCAR1)

GAS:

123255869

SHR:	116420956(BCAR1)

AFZ:

127547693

PCW:	110192462(BCAR1)

TVP:	118843761(BCAR1)

PBRV:

138160860(BCAR1) 138163037

MLAO:

141497023(BCAR1)

OAA:	100085802(BCAR1)

TACU:

119934200(BCAR1)

GGA:	415691(BCAR1)

PCOC:

116243714(BCAR1)

MGP:	100543321 104913032(BCAR1)

CJO:	107319194(BCAR1)

TPAI:

128081724(BCAR1)

LMUT:

125699064(BCAR1)

NMEL:

110404454(BCAR1)

APLA:

101792603(BCAR1)

AACU:

137861682(BCAR1)

ACYG:

106043124(BCAR1)

CATA:

118246530(BCAR1)

AFUL:

116494114(BCAR1)

TGU:	100231478(BCAR1)

LSR:	110472998(BCAR1)

SCAN:

103816661(BCAR1)

PMOA:

120507998(BCAR1)

OTC:	121333870(BCAR1)

PRUF:

121348806(BCAR1)

ATRC:

139596323(BCAR1)

GFR:	102041223(BCAR1)

FAB:	101822200(BCAR1)

OMA:	130257874(BCAR1)

PHI:	102099890(BCAR1)

PMAJ:

107209875(BCAR1)

CCAE:

111934540(BCAR1)

CCW:	104687562(BCAR1)

CBRC:

103620292(BCAR1)

ACOE:

138116832(BCAR1)

ETL:	114069815(BCAR1)

ZAB:	102072898(BCAR1)

ZLE:	135452676(BCAR1)

ACHL:

103798443

SVG:	106855836(BCAR1)

MMEA:

130572693(BCAR1)

HRT:	120757726(BCAR1)

SATI:

136366595(BCAR1)

CFAI:

136295781(BCAR1)

CCIC:

134048265(BCAR1)

FPG:	101919872(BCAR1)

FCH:	102047594(BCAR1)

NNT:

104408939

SHAB:

115601091(BCAR1) 115619013

ACUN:

113484549(BCAR1)

SURA:

141948816(BCAR1)

TALA:

116965967(BCAR1)

ACHC:

115345831(BCAR1)

HLE:	104842161(BCAR1)

AGEN:

126041069

HHAR:

128146319(BCAR1)

BBUT:

142036783(BCAR1)

GCL:

127021089

LDI:	104353499(BCAR1)

DPUB:

104299017(BCAR1)

PPUS:

135184589(BCAR1)

BRHI:

104498303(BCAR1)

EGZ:	104130282(BCAR1)

NNI:	104016382(BCAR1)

PCRI:

104036011(BCAR1)

PARX:

142061130(BCAR1)

AFOR:

103896885(BCAR1)

CBOR:

142087005(BCAR1)

CBOY:

140656660(BCAR1)

MAME:

142413859(BCAR1)

CLV:	102090770(BCAR1)

CNIC:

135991998(BCAR1)

PLET:

104617596(BCAR1)

CUCA:

104055946(BCAR1)

TEO:	104380097(BCAR1)

GAME:

129212500(BCAR1)

CPEA:

104386318(BCAR1)

CVF:	104293456(BCAR1)

RTD:	128909361(BCAR1)

CRID:

134515335(BCAR1)

LMIC:

141741975(BCAR1)

NARQ:

141467162(BCAR1)

AAM:	106490061(BCAR1)

AROW:

112978255(BCAR1)

NPD:	112943196(BCAR1)

TGT:	104573906(BCAR1)

DNE:	112987467(BCAR1)

SCAM:

104149530

ASN:	102387422(BCAR1)

AMJ:	102565268(BCAR1)

CPOO:

109310330(BCAR1)

GGN:	109289657(BCAR1)

CIZ:	142020755(BCAR1)

CMY:	102938416(BCAR1)

CCAY:

125620869(BCAR1)

LKP:	140896053(BCAR1)

NDS:	141996380(BCAR1)

DCC:	119841327(BCAR1)

CPIC:

101937536(BCAR1)

CABI:

116831920(BCAR1)

MRV:	120384673(BCAR1)

ASAO:

132782949(BCAR1)

PVT:	110081315(BCAR1)

SUND:

121937506(BCAR1)

PBI:	103054416(BCAR1)

PMUR:

107287376(BCAR1)

CTIG:

120312673(BCAR1)

TSR:	106539030(BCAR1)

PGUT:

117670420(BCAR1)

PCAE:

139323486(BCAR1)

APRI:

131184042(BCAR1)

PTEX:

113445305(BCAR1)

NSS:	113420290(BCAR1)

VKO:	123025466(BCAR1)

PMUA:

114601800(BCAR1)

PRAF:

128419019(BCAR1)

ZVI:	118086452(BCAR1)

HCG:	128334566(BCAR1)

GJA:	107107898(BCAR1)

STOW:

125443644(BCAR1)

EMC:	129344103(BCAR1)

XLA:	108715363(bcar1.S) 398756(bcar1.L)

XTR:	447979(bcar1)

NPR:	108796559(BCAR1)

RTEM:

120917637(BCAR1)

ACAT:

141112524(BCAR1)

PADS:

140338612(BCAR1)

BBUF:

120980274(BCAR1)

BGAR:

122920389(BCAR1)

DTC:	141089719(BCAR1)

HSQ:	130276693(BCAR1)

PWL:	138268227(BCAR1)

MUO:	115470478(BCAR1)

GSH:	117359328(BCAR1)

DRE:	568309(bcar1)

SRX:	107726155(bcar1)

SANH:

107694928 107701029

SGH:	107583722 107596915

CCAR:

109108845 109109428

CAUA:

113061593 113118411

CGIB:

127934435 127977038

PTET:

122362867(bcar1)

LROH:

127180490(bcar1)

GRF:	141345525(bcar1)

OMC:	131524147(bcar1)

PPRM:

120487727(bcar1)

RKG:	130088453(bcar1)

MAMB:

125254581(bcar1)

CIDE:

127499634

CERY:

137023396(bcar1)

MASI:

127417139 127455954

TROS:

130562897(bcar1)

TDW:	130435456(bcar1)

MANU:

129418917(bcar1)

PDAB:

135769639(bcar1)

IPU:

108264615

IFU:	128606779(bcar1)

PHYP:

113534477(bcar1)

SMEO:

124395692(bcar1)

TFD:	113652577(bcar1)

TVC:	132851182(bcar1)

CGAR:

128527875(bcar1)

NGRA:

132888047(bcar1)

TRN:	134322767(bcar1)

AMEX:

103028804(bcar1)

CMAO:

118801340(bcar1)

EEE:	113573599(bcar1)

CHAR:

105904514(bcar1)

SPIL:

134094690(bcar1)

ASAD:

121723235(bcar1)

TFS:	130536031(bcar1)

TNG:	GSTEN00005088G001

LCO:	104939488(bcar1)

NCC:

104967430

TBEN:

117491646(bcar1)

CGOB:

115009962

PGEO:

117448018(bcar1)

GACU:

117532770(bcar1)

EMAC:

134882406(bcar1)

ELY:	117262291(bcar1)

EFO:	125887527(bcar1)

PLEP:

121939291

SLUC:

116040233(bcar1)

ECRA:

117948743(bcar1)

ESP:	116694598(bcar1)

PFLV:

114560766(bcar1)

AFB:	129108682(bcar1)

CLUM:

117732825(bcar1)

PSWI:

130194904(bcar1)

CANA:

137804254(bcar1)

CVE:	137881120(bcar1)

MSAM:

119894442(bcar1)

SCHU:

122874521(bcar1)

EARM:

139286801(bcar1)

CUD:	121514840(bcar1)

SPUL:

138612882(bcar1)

LMIX:

132972290(bcar1)

HTC:	141795972(bcar1)

ALAT:

119024324(bcar1)

ASTR:

137593441(bcar1)

PKLU:

139201909(bcar1)

MZE:	101473839(bcar1)

ONL:	100705076(bcar1)

OAU:	116330994(bcar1)

OLA:	101167688(bcar1)

OML:	112151935(bcar1)

CSAI:

133444082(bcar1)

XMA:	102230743(bcar1)

XCO:	114157230(bcar1)

XHE:	116708852(bcar1)

PRET:

103465773(bcar1)

PFOR:

103132472(bcar1)

PLAI:

106943028(bcar1)

PMEI:

106912250(bcar1)

GAF:	122835222(bcar1)

PPRL:

129361215(bcar1)

CVG:	107096741(bcar1)

CTUL:

119789784(bcar1)

GMU:	124877544(bcar1)

NFU:	107389510(bcar1)

KMR:	108246391(bcar1)

ALIM:

106510812

NWH:	119415890(bcar1)

AOCE:

111566681(bcar1)

EJA:	138205913(bcar1)

BFRE:

138632785(bcar1)

MCEP:

125014911(bcar1)

CSEM:

103379847(bcar1)

POV:

109642993

SSEN:

122764718(bcar1)

SSOE:

131470134(bcar1)

HHIP:

117762747(bcar1)

HSP:	118110097(bcar1)

PPLT:

128444320(bcar1)

SMAU:

118314880(bcar1)

LCF:

108884593

SDU:	111234832(bcar1)

SLAL:

111647742(bcar1)

XGL:	120793057(bcar1)

HCQ:

109520705

SSCV:

125970399(bcar1)

SBIA:

133502724(bcar1)

PEE:	133402900(bcar1)

PTAO:

133477987(bcar1)

BPEC:

110169470(bcar1)

ENY:	140348642(bcar1)

MALB:

109967267(bcar1)

BSPL:

114857897(bcar1)

SJO:	128359219(bcar1)

SSCO:

133981503(bcar1)

TTY:	137182458(bcar1)

GMH:

115550628

SASA:

106560839 106573733

STRU:

115151950 115196808

OTW:	112218531 112252351(bcar1)

OMY:	110494902 110520323

OGO:	124000508 124037227

ONE:	115109374 115134292

OKI:	109867161 109889323

OKE:	118396663 118400852

OMM:	135509394 135524431(bcar1)

OCLA:

139371292 139396469

SALP:

111952497 111962362

SNH:	120053907 120066244

SFON:

129862514 129867104

CCLU:

121531861(bcar1) 121576652

ELS:	105018442(bcar1)

OEP:	134020983(bcar1)

SFM:	108918978(bcar1) 108933991

PKI:	111851927(bcar1) 111859378

AANG:

118227845(bcar1)

AROT:

135254853(bcar1)

CCOG:

133130873(bcar1)

LOC:	102692374(bcar1)

PSPA:

121296232(bcar1) 121325511

ARUT:

117424712 117425067

PSEX:

120535285(bcar1)

LCM:	102355909 102362517(BCAR1)

CMK:

103176114

RTP:	109925586(bcar1)

CPLA:

122558450(bcar1)

CPUN:

140453054(bcar1)

HOC:	132823971(bcar1)

SCAU:

119971350(bcar1)

LERI:

129705071(bcar1)

HAKA:

140740620(bcar1)

BFO:

BBEL:

LVG:

AJJ:

AAMU:

AFIL:

SKO:

PFLL:

DALB:

135906673(p130CAS)

BARL:

143286129 143300141

YBA:

132556589

» show all

Reference

PMID:17038317

Authors

Modzelewska K, Newman LP, Desai R, Keely PJ

Title

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

Journal

J Biol Chem 281:37527-35 (2006)
DOI:10.1074/jbc.M604342200

Sequence

[hsa:9564]

Reference

PMID:10639512

Authors

Brinkman A, van der Flier S, Kok EM, Dorssers LC

Title

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.

Journal

J Natl Cancer Inst 92:112-20 (2000)
DOI:10.1093/jnci/92.2.112

Sequence

[hsa:9564]

LinkDB

DBGET integrated database retrieval system