KEGG   ORTHOLOGY: K05947
Entry
K05947                      KO                                     
Symbol
E2.4.1.217
Name
mannosyl-3-phosphoglycerate synthase [EC:2.4.1.217]
Pathway
map00051  Fructose and mannose metabolism
map01100  Metabolic pathways
Reaction
R05768  GDP-mannose:3-phosphoglycerate 3-a-D-mannosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.217  mannosyl-3-phosphoglycerate synthase
     K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
Glycosyltransferases [BR:ko01003]
 Others
  Glycosylglycerate
   K05947  E2.4.1.217; mannosyl-3-phosphoglycerate synthase
Other DBs
GO: 0050504
Genes
NCR: NCU05700
NTE: NEUTE1DRAFT100267(NEUTE1DRAFT_100267)
SMP: 10807906(SMAC4_02065)
PAN: PODANSg2537
PBEL: QC761_700490
PPSD: QC762_700490
PPSP: QC763_700490
PPSA: QC764_700490
TTT: THITE_2120465
MTM: MYCTH_2303166
CTHR: CTHT_0072260
PPEI: PpBr36_05480
PGRI: PgNI_02833
TMN: UCRPA7_732
CFJ: CFIO01_04083
CLUP: CLUP02_12643
ELA: UCREL1_10936
PNO: SNOG_14776
PTE: PTT_11203
PTRR: 6341735(PtrM4_098340)
ARAB: EKO05_0010263
SLOM: PXH66_02990(mpgS)
AAQW: K1X11_020565(mpgS)
PPHT: GA004_05175(mpgS)
CLIT: OQ292_03145(mpgS)
PRHO: PZB74_17250(mpgS)
TPEL: P0M28_29720(mpgS)
RSR: T7867_17300(mpgS)
RMR: Rmar_0502
RMG: Rhom172_0500
RLO: GQ464_016260(mpgS)
ACTN: L083_6965
ACTR: Asp14428_60620
AFS: AFR_36880
PLAB: C6361_25375
PLAT: C6W10_13480
PFLA: Pflav_085120
PSUU: Psuf_048030
PRY: Prubr_39070
NHY: JQS43_18785
CCAZ: COUCH_07620(mpgS)
DET: DET1363(mpgSP)
DEH: cbdbA1314
DEB: DehaBAV1_1174
DEV: DhcVS_1144
DMC: btf_1241
DMD: dcmb_1222
DMG: GY50_1201(mngA)
DMX: X792_06380
DMY: X793_06240
DMZ: X794_05800
DUC: UCH007_11250
DLY: Dehly_0877
DEW: DGWBC_0701
DFO: Dform_01049
DETH: HX448_06860
DLF: V8247_00245
TTH: TT_C0588
TTJ: TTHA0954(TTHA0954)
TTS: Ththe16_0950
TTL: TtJL18_1098
MHD: Marky_0082
MTEE: MTTB_02910
MFV: Mfer_0544
APO: Arcpr_0588
AVE: Arcve_0995 Arcve_1326
PFU: PF0591
PFI: PFC_02085
PHO: PH0927(PH0927)
PAB: PAB0816
PYN: PNA2_1454
PYA: PYCH_06950
PYS: Py04_0855
PYC: TQ32_02365
TGA: TGAM_0817
TSI: TSIB_0251
TBA: TERMP_00005
THA: TAM4_785
TLT: OCC_09696
THS: TES1_0131
TNU: BD01_0152
THV: ADU37_CDS01910
TCH: CHITON_0969
TCE: A3L02_00525
TBS: A3L01_01795
THH: CDI07_01770
TTD: A3L14_03245
TRL: A3L10_04690
THY: A3L12_01820
THEI: K1720_04380(mpgS)
PPAC: PAP_01435
MJK: N2V74_02575(mpgS) N2V74_03285(mpgS)
APE: APE_0889.1(mpgs)
ACJ: ACAM_0578(mpgs)
SMR: Smar_0498
SHC: Shell_0304
PDL: Pyrde_0369
PABI: PABY_00960(mpgS)
NGA: Ngar_c16030(mngA1) Ngar_c27190(mngA2)
NVN: NVIE_006110(mngA)
NEV: NTE_01978
TAA: NMY3_00972 NMY3_02751
NFN: NFRAN_0350(mngA) NFRAN_1965(mngA)
NCV: NCAV_1295(mngA)
 » show all
Reference
PMID:11562374
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J Biol Chem 276:43580-8 (2001)
DOI:10.1074/jbc.M108054200
  Sequence
[pho:PH0927]
LinkDB

KEGG   ENZYME: 2.4.1.217
Entry
EC 2.4.1.217                Enzyme                                 
Name
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
Reaction(KEGG)
R05768
Substrate
GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]
Product
GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]
Comment
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
History
EC 2.4.1.217 created 2002
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K05947  mannosyl-3-phosphoglycerate synthase
Genes
NCR: NCU05700
NTE: NEUTE1DRAFT100267(NEUTE1DRAFT_100267)
SMP: 10807906(SMAC4_02065)
PAN: PODANSg2537
PBEL: QC761_700490
PPSD: QC762_700490
PPSP: QC763_700490
PPSA: QC764_700490
TTT: THITE_2120465
MTM: MYCTH_2303166
CTHR: CTHT_0072260
PPEI: PpBr36_05480
PGRI: PgNI_02833
TMN: UCRPA7_732
CFJ: CFIO01_04083
CLUP: CLUP02_12643
ELA: UCREL1_10936
PNO: SNOG_14776
PTE: PTT_11203
PTRR: 6341735(PtrM4_098340)
ARAB: EKO05_0010263
SLOM: PXH66_02990(mpgS)
AAQW: K1X11_020565(mpgS)
PPHT: GA004_05175(mpgS)
CLIT: OQ292_03145(mpgS)
PRHO: PZB74_17250(mpgS)
TPEL: P0M28_29720(mpgS)
RSR: T7867_17300(mpgS)
RMR: Rmar_0502
RMG: Rhom172_0500
RLO: GQ464_016260(mpgS)
ACTN: L083_6965
ACTR: Asp14428_60620
AFS: AFR_36880
PLAB: C6361_25375
PLAT: C6W10_13480
PFLA: Pflav_085120
PSUU: Psuf_048030
PRY: Prubr_39070
NHY: JQS43_18785
CCAZ: COUCH_07620(mpgS)
DET: DET1363(mpgSP)
DEH: cbdbA1314
DEB: DehaBAV1_1174
DEV: DhcVS_1144
DMC: btf_1241
DMD: dcmb_1222
DMG: GY50_1201(mngA)
DMX: X792_06380
DMY: X793_06240
DMZ: X794_05800
DUC: UCH007_11250
DLY: Dehly_0877
DEW: DGWBC_0701
DFO: Dform_01049
DETH: HX448_06860
DLF: V8247_00245
TTH: TT_C0588
TTJ: TTHA0954(TTHA0954)
TTS: Ththe16_0950
TTL: TtJL18_1098
MHD: Marky_0082
MTEE: MTTB_02910
MFV: Mfer_0544
APO: Arcpr_0588
AVE: Arcve_0995 Arcve_1326
PFU: PF0591
PFI: PFC_02085
PHO: PH0927(PH0927)
PAB: PAB0816
PYN: PNA2_1454
PYA: PYCH_06950
PYS: Py04_0855
PYC: TQ32_02365
TGA: TGAM_0817
TSI: TSIB_0251
TBA: TERMP_00005
THA: TAM4_785
TLT: OCC_09696
THS: TES1_0131
TNU: BD01_0152
THV: ADU37_CDS01910
TCH: CHITON_0969
TCE: A3L02_00525
TBS: A3L01_01795
THH: CDI07_01770
TTD: A3L14_03245
TRL: A3L10_04690
THY: A3L12_01820
THEI: K1720_04380(mpgS)
PPAC: PAP_01435
MJK: N2V74_02575(mpgS) N2V74_03285(mpgS)
APE: APE_0889.1(mpgs)
ACJ: ACAM_0578(mpgs)
SMR: Smar_0498
SHC: Shell_0304
PDL: Pyrde_0369
PABI: PABY_00960(mpgS)
NGA: Ngar_c16030(mngA1) Ngar_c27190(mngA2)
NVN: NVIE_006110(mngA)
NEV: NTE_01978
TAA: NMY3_00972 NMY3_02751
NFN: NFRAN_0350(mngA) NFRAN_1965(mngA)
NCV: NCAV_1295(mngA)
 » show all
Reference
1  [PMID:11562374]
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J Biol Chem 276:43580-8 (2001)
DOI:10.1074/jbc.M108054200
  Sequence
[pho:PH0927]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.217
IUBMB Enzyme Nomenclature: 2.4.1.217
ExPASy - ENZYME nomenclature database: 2.4.1.217
BRENDA, the Enzyme Database: 2.4.1.217
CAS: 393512-63-5
LinkDB

KEGG   REACTION: R05768
Entry
R05768                      Reaction                               
Name
GDP-mannose:3-phosphoglycerate 3-a-D-mannosyltransferase
Definition
GDP-mannose + 3-Phospho-D-glycerate <=> GDP + 2-(alpha-D-Mannosyl)-3-phosphoglycerate
Equation
C00096 + C00197 <=> C00035 + C11516
Reaction class
RC00005  C00035_C00096
RC00397  C00197_C11516
RC02748  C00096_C11516
Enzyme
2.4.1.217
Pathway
rn00051  Fructose and mannose metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.217
     R05768  GDP-mannose + 3-Phospho-D-glycerate <=> GDP + 2-(alpha-D-Mannosyl)-3-phosphoglycerate
Glycosyltransferase reactions [BR:br08203]
 Mannosyltransferase reactions
  R05768  Man a1-2 PGA
Orthology
K05947  mannosyl-3-phosphoglycerate synthase [EC:2.4.1.217]
Other DBs
RHEA: 13540
LinkDB

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