| Entry |
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| Name |
nucleoside-triphosphate phosphatase;
nucleoside-triphosphatase;
nucleoside triphosphate phosphohydrolase;
nucleoside-5-triphosphate phosphohydrolase;
nucleoside 5-triphosphatase;
unspecific diphosphate phosphohydrolase
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| Class |
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
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| Sysname |
nucleoside-triphosphate phosphohydrolase
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| Reaction(IUBMB) |
a nucleoside triphosphate + H2O = a nucleoside diphosphate + phosphate [RN: R02319]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5].
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| History |
EC 3.6.1.15 created 1972
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| Pathway |
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| Orthology |
| K06928 | nucleoside-triphosphatase |
| K21517 | Orthopoxvirus nucleoside triphosphatase I |
| K22273 | HCV serine protease / helicase NS3 |
| K25328 | Flavivirus serine protease NS3 catalytic subunit |
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| Genes |
» show all
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| Reference |
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| Authors |
Brightwell R, Tappel AL. |
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| Title |
Lysosomal acid pyrophosphatase and acid phosphatase. |
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| Journal |
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| Reference |
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| Authors |
LEWIS M, WEISSMAN S. |
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| Title |
PROPERTIES OF A SOLUBLE NUCLEOSIDE TRIPHOSPHATASE ACTIVITY IN MAMMALIAN LIVER. |
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| Journal |
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| Reference |
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| Authors |
Matsushita S, Raacke ID. |
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| Title |
Purification of nucleoside triphosphatases from pea seedling ribosomes. |
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| Journal |
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| Reference |
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| Authors |
Tong CG, Dauwalder M, Clawson GA, Hatem CL, Roux SJ |
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| Title |
The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins. |
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| Journal |
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| Reference |
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| Authors |
Hsieh HL, Tong CG, Thomas C, Roux SJ |
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| Title |
Light-modulated abundance of an mRNA encoding a calmodulin-regulated, chromatin-associated NTPase in pea. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Klinger C, Rossbach M, Howe R, Kaufmann M |
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| Title |
Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Placzek WJ, Almeida MS, Wuthrich K |
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| Title |
NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.1.15 |
| ExPASy - ENZYME nomenclature database: | 3.6.1.15 |
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| LinkDB |
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