Homo sapiens (human): 3991
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Entry
3991 CDS
T01001
Symbol
LIPE, AOMS4, FPLD6, HSL, LHS, REH
Name
(RefSeq) lipase E, hormone sensitive type
KO
K07188
hormone-sensitive lipase [EC:
3.1.1.79
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04024
cAMP signaling pathway
hsa04152
AMPK signaling pathway
hsa04371
Apelin signaling pathway
hsa04714
Thermogenesis
hsa04910
Insulin signaling pathway
hsa04923
Regulation of lipolysis in adipocytes
hsa04925
Aldosterone synthesis and secretion
Disease
H00420
Familial partial lipodystrophy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
3991 (LIPE)
04024 cAMP signaling pathway
3991 (LIPE)
04152 AMPK signaling pathway
3991 (LIPE)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
3991 (LIPE)
04923 Regulation of lipolysis in adipocytes
3991 (LIPE)
04925 Aldosterone synthesis and secretion
3991 (LIPE)
09159 Environmental adaptation
04714 Thermogenesis
3991 (LIPE)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.79 hormone-sensitive lipase
3991 (LIPE)
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Gene cluster
GFIT
Motif
Pfam:
HSL_N
Abhydrolase_3
BD-FAE
Say1_Mug180
DUF3459
PRP4
Motif
Other DBs
NCBI-GeneID:
3991
NCBI-ProteinID:
NP_005348
OMIM:
151750
HGNC:
6621
Ensembl:
ENSG00000079435
UniProt:
Q05469
A8K8W7
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Position
19:complement(42401514..42427388)
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AA seq
1076 aa
AA seq
DB search
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
NT seq
3231 nt
NT seq
+upstream
nt +downstream
nt
atggagccaggttctaagtcagtgtctaggtcagactggcaacctgaaccacaccagagg
cctataaccccgctagagcctgggccagaaaagacacccatagcccagccagaatcgaag
actctgcagggatccaatacccaacagaagcctgcttcaaaccaaagacccctcacccag
caggagacccctgcacaacatgatgctgaatcccagaaggaacctagagcccaacaaaaa
tctgcttcacaagaggaatttcttgccccacagaagcccgcaccacagcaatcaccttac
atccaaagggtgctgctcactcaacaggaagctgcctcccagcagggacctgggctagga
aaagaatctataactcaacaggagccagcattgagacaaagacatgtagcccagccaggg
cctgggccaggagagccacctccagctcaacaagaagctgaatcaacacctgcggcccag
gctaaacctggagccaaaagggagccatctgccccgactgaatctacgtcccaagagaca
cctgaacagtcagacaagcaaacaacgccagtccagggagccaaatccaagcagggatct
ttgacagagctgggatttctaacaaaacttcaggaactatccatacagcgatcagcccta
gagtggaaggcactttctgagtgggtcacagattctgagtcagaatcagatgtgggatca
tcttcagacacagattctccagccacgatgggtggaatggtggcccagggagtgaagcta
ggcttcaaaggaaaatctggttataaagtgatgtcaggatacagtgggacgtcgccacat
gagaaaaccagtgctcggaatcacagacactaccaggatacagcctcaaggctcatccac
aacatggacctgcgcacaatgacacagtcgctggtgactctggcggaggacaacatagcc
ttcttctcgagccagggtcctggggaaacggcccagcggctgtcaggcgtttttgccggt
gtacgggagcaggcgctggggctggagccggccctgggccgcctgctgggtgtggcgcac
ctctttgacctggacccagagacaccggccaacgggtaccgcagcctagtgcacacagcc
cgctgctgcctggcgcacctcctgcacaaatcccgctatgtggcctccaaccgccgcagc
atcttcttccgcaccagccacaacctggccgagctggaggcctacctggctgccctcacc
cagctccgcgctctggtctactacgcccagcgcctgctggttaccaatcggccgggggta
ctcttctttgagggcgacgaggggctcaccgccgacttcctccgggagtatgtcacgctg
cataagggatgcttctatggccgctgcctgggcttccagttcacgcctgccatccggcca
ttcctgcagaccatctccattgggctggtgtccttcggggagcactacaaacgcaacgag
acaggcctcagtgtggccgccagctctctcttcaccagcggccgctttgccatcgacccc
gagctgcgtggggctgagtttgagcggatcacacagaacctggacgtgcacttctggaaa
gccttctggaacatcaccgagatggaagtgctatcgtctctggccaacatggcatcggcc
accgtgagggtaagccgcctgctcagcctgccacccgaagcctttgagatgccactgact
gccgaccccacgctcacggtcaccatctcacccccactggcccacacaggccctgggccc
gtcctcgtcaggctcatctcctatgacctgcgtgaaggacaggacagtgaggagctcagc
agcctgataaagtccaacggccaacggagcctggagctgtggccgcgcccccagcaggca
ccccgctcgcggtccctgatagtgcacttccacggcggtggctttgtggcccagacctcc
agatcccacgagccctacctcaagagctgggcccaggagctgggcgcccccatcatctcc
atcgactactccctggcccctgaggcccccttcccccgtgcgctggaggagtgcttcttc
gcctactgctgggccatcaagcactgcgccctccttggctcaacaggggaacgaatctgc
cttgcgggggacagtgcaggcgggaacctctgcttcaccgtggctcttcgggcagcagcc
tacggggtgcgggtgccagatggcatcatggcagcctacccggccacaatgctgcagcct
gccgcctctccctcccgcctgctgagcctcatggaccccttgctgcccctcagtgtgctc
tccaagtgtgtcagcgcctatgctggtgcaaagacggaggaccactccaactcagaccag
aaagccctcggcatgatggggctggtgcggcgggacacagccctgctcctccgagacttc
cgcctgggtgcctcctcatggctcaactccttcctggagttaagtgggcgcaagtcccag
aagatgtcggagcccatagcagagccgatgcgccgcagtgtgtctgaagcagcactggcc
cagccccagggcccactgggcacggattccctcaagaacctgaccctgagggacttgagc
ctgaggggaaactccgagacgtcgtcggacacccccgagatgtcgctgtcagctgagaca
cttagcccctccacaccctccgatgtcaacttcttattaccacctgaggatgcaggggaa
gaggctgaggccaaaaatgagctgagccccatggacagaggcctgggcgtccgtgccgcc
ttccccgagggtttccacccccgacgctccagccagggtgccacacagatgcccctctac
tcctcacccatagtcaagaaccccttcatgtcgccgctgctggcacccgacagcatgctc
aagagcctgccacctgtgcacatcgtggcgtgcgcgctggaccccatgctggacgactcg
gtcatgctcgcgcggcgactgcgcaacctgggccagccggtgacgctgcgcgtggtggag
gacctgccgcacggcttcctgaccctagcggcgctgtgccgcgagacgcgccaggccgca
gagctgtgcgtggagcgcatccgcctcgtcctcactcctcccgccggagccgggccgagc
ggggagacgggggctgcgggggtagacgggggctgcggggggcgacactaa
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