KEGG ORTHOLOGY: K07363

ORTHOLOGY: K07363

Entry

K07363                      KO

Symbol

ITK

Name

IL2-inducible T-cell kinase [EC:2.7.10.2]

Pathway

map04062

Chemokine signaling pathway

map04660

T cell receptor signaling pathway

map04670

Leukocyte transendothelial migration

Disease

H00107

Other well-defined immunodeficiency syndromes

H01970

Lymphoproliferative syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K07363  ITK; IL2-inducible T-cell kinase
   04670 Leukocyte transendothelial migration
    K07363  ITK; IL2-inducible T-cell kinase
   04062 Chemokine signaling pathway
    K07363  ITK; IL2-inducible T-cell kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07363  ITK; IL2-inducible T-cell kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K07363  ITK; IL2-inducible T-cell kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  TEC family
   K07363  ITK; IL2-inducible T-cell kinase

Other DBs

GO:

0004715

Genes

HSA:

3702(ITK)

PTR:	735556(ITK)

PPS:	100981091(ITK)

GGO:	101128821(ITK)

PON:	100459632(ITK)

PPYG:

129037423(ITK)

NLE:	100599482(ITK)

HMH:	116471767(ITK)

SSYN:

129485692(ITK)

MCC:	715471(ITK)

MCF:	102142892(ITK)

MTHB:

126956727

MNI:	105482374(ITK)

CSAB:

103244862(ITK)

CATY:

105581557(ITK)

PANU:

101015366(ITK)

TGE:	112626391(ITK)

MLEU:

105529541(ITK)

RRO:	104662403(ITK)

RBB:	108516778(ITK)

TFN:	117065560(ITK)

PTEH:

111547160(ITK)

CANG:

105515765(ITK)

CJC:	100386478(ITK)

SBQ:	101029382(ITK)

CIMI:

108295057(ITK)

ANAN:

105719509(ITK)

CSYR:

103257754(ITK)

MMUR:

105880501(ITK)

LCAT:

123638024(ITK)

PCOQ:

105815233(ITK)

OGA:	100966188(ITK)

MMU:	16428(Itk)

MCAL:

110304731(Itk)

MPAH:

110331447(Itk)

RNO:	363577(Itk)

MCOC:

116076825(Itk)

ANU:	117711057(Itk)

ASYL:

127693709(Itk)

MUN:	110554048(Itk)

CGE:	100770087(Itk)

MAUA:

101838481(Itk)

PROB:

127219389(Itk)

PLEU:

114689818(Itk)

MORG:

121463768(Itk)

MFOT:

126499457

AAMP:

119812250(Itk)

NGI:	103745463(Itk)

HGL:	101710258(Itk)

CPOC:

100722647(Itk)

CCAN:

109679288(Itk)

DORD:

105996792(Itk)

DSP:	122101061(Itk)

PLOP:

125342098(Itk)

NCAR:

124987174

MMMA:

107148077(Itk)

ITI:	101977647(Itk)

OCU:

100351986

OPI:	101531899(ITK)

TUP:	102489750(ITK)

GVR:	103591883(ITK)

CFA:	489159(ITK)

CLUD:

112651612(ITK)

VVP:	112928658(ITK)

VLG:	121486266(ITK)

NPO:	129509629(ITK)

AML:	100475688(ITK)

UMR:	103664542(ITK)

UAH:	113264017(ITK)

UAR:	123788538(ITK)

ELK:

111140995

LLV:

125100819

MPUF:

101682037(ITK)

MNP:	132028359(ITK)

MLK:	131831830(ITK)

NVS:	122902010(ITK)

ORO:	101378358(ITK)

EJU:	114211992(ITK)

ZCA:	113929341(ITK)

MLX:	118015977(ITK)

NSU:	110587242(ITK)

LWW:	102738058(ITK)

FCA:	101100785(ITK)

PYU:	121009837(ITK)

PCOO:

112860351(ITK)

PBG:	122493180(ITK)

PVIV:

125170445(ITK)

LRUF:

124520860

LGF:	123611580(ITK)

AJU:

106967681

PTG:	102955674(ITK)

PPAD:

109276017(ITK)

PUC:

125934499

PLEZ:

122225502(ITK)

HHV:	120243339(ITK)

BTA:	522311(ITK)

BOM:	102287219(ITK)

BIU:	109562249(ITK)

BBUB:

102396554(ITK)

BBIS:

104999721(ITK)

CHX:	102176528(ITK)

OAS:	101112899(ITK)

BTAX:

128050842(ITK)

CSUM:

138085706(ITK)

ODA:	120864388(ITK)

CCAD:

122439634(ITK)

MREE:

136156324(ITK)

OVR:	110137187(ITK)

MBEZ:

129559389(ITK)

SSC:	100523474(ITK)

CFR:	102507570(ITK)

CBAI:

105080927(ITK)

CDK:	105095141(ITK)

VPC:	102540749(ITK)

BACU:

103010220(ITK)

BMUS:

118892733(ITK)

LVE:	103068755(ITK)

OOR:	101282766(ITK)

LALB:

132518547(ITK)

DLE:	111183154(ITK)

PCAD:

102994407(ITK)

PSIU:

116751629(ITK)

NASI:

112409812(ITK)

ECB:	100071232(ITK)

EPZ:	103547637(ITK)

EAI:	106832127(ITK)

MYB:	102245625(ITK)

MYD:	102770972(ITK)

MMYO:

118657691(ITK)

MLF:	102440593(ITK)

MDT:	132235904(ITK)

MYUM:

139010279(ITK)

PKL:	118711428(ITK)

EFUS:

103291607(ITK)

MNA:	107534429(ITK)

DRO:	112319647(ITK)

SHON:

118986110(ITK)

AJM:	119054369(ITK)

PDIC:

114509639(ITK)

PHAS:

123813227(ITK)

MMF:	118615153(ITK)

PPAM:

129066364(ITK)

HAI:	109388902(ITK)

RFQ:	117016411(ITK)

PALE:

102880728(ITK)

PGIG:

120613855(ITK)

PVP:	105289957(ITK)

RAY:	107521926(ITK)

MJV:	108386690(ITK)

TOD:	119235500(ITK)

SARA:

101544431(ITK)

SFUM:

130022146(ITK)

SETR:

126011949(ITK)

LAV:	100674289(ITK)

TMU:

101347980

ETF:	101647469(ITK)

DNM:	101440230(ITK)

MDO:	100030005(ITK)

GAS:	123235580(ITK)

SHR:	100930926(ITK)

AFZ:

127550133

PCW:	110199718(ITK)

TVP:	118845003(ITK)

PBRV:

138172553(ITK)

OAA:	100075949(ITK)

TACU:

119919457(ITK)

GGA:	416247(ITK)

PCOC:

116232109(ITK)

MGP:	100544879(ITK)

CJO:	107320457(ITK)

TPAI:

128081427(ITK)

LMUT:

125700346(ITK)

NMEL:

110405195(ITK)

APLA:

101801229(ITK)

ACYG:

106032857(ITK)

CATA:

118254448(ITK)

AFUL:

116494848(ITK)

TGU:	100229084(ITK)

LSR:	110470843(ITK)

SCAN:

103817335(ITK)

PMOA:

120498743(ITK)

OTC:	121332325(ITK)

PRUF:

121361357(ITK)

ATRC:

139597768(ITK)

GFR:	102036579(ITK)

FAB:	101821472(ITK)

OMA:	130258862(ITK)

PHI:	102103491(ITK)

PMAJ:

107210762(ITK)

CCAE:

111935494(ITK)

CCW:	104689548(ITK)

CBRC:

103611434(ITK)

ACOE:

138117988(ITK)

ETL:	114058340(ITK)

ZAB:	102066774(ITK)

ZLE:	135453622(ITK)

ACHL:

103803747(ITK)

SVG:	106853002(ITK)

MMEA:

130581356(ITK)

HRT:	120759214(ITK)

SATI:

136367529(ITK)

CCIC:

134049449(ITK)

FPG:	101923516(ITK)

FCH:	102052480(ITK)

CCRI:

104154714(ITK)

NNT:	104411640(ITK)

SHAB:

115616043(ITK)

ACUN:

113485171(ITK)

TALA:

104355597(ITK)

ACHC:

115334047(ITK)

HALD:

104313582(ITK)

HLE:	104838937(ITK)

AGEN:

126051062

HHAR:

128134395(ITK)

GCL:

127021941

CSTI:

104555528(ITK)

LDI:	104350882(ITK)

MNB:	103774651(ITK)

DPUB:

104303907(ITK)

PPUS:

135185322(ITK)

AVIT:

104267609

BRHI:

104495162(ITK)

EGZ:	104122559(ITK)

NNI:	104014226(ITK)

PCRI:

104031022(ITK)

PCAO:

104039752(ITK)

PADL:

103924912(ITK)

AFOR:

103904350(ITK)

FGA:	104077231(ITK)

GSTE:

104250522(ITK)

CLV:	102088979(ITK)

MUI:	104536473(ITK)

PGUU:

104457420(ITK)

PLET:

104613738(ITK)

EHS:	104516424(ITK)

CMAC:

104486574(ITK)

CUCA:

104063084(ITK)

TEO:	104380468(ITK)

BREG:

104636387(ITK)

OHA:	104336744(ITK)

ACAR:

104523638(ITK)

CPEA:

104392586(ITK)

CVF:	104293595(ITK)

RTD:	128916260(ITK)

CRID:

134522081(ITK)

AAM:	106493597(ITK)

AROW:

112964817(ITK)

NPD:	112954351(ITK)

TGT:	104573199(ITK)

DNE:	112994296(ITK)

SCAM:

104151078(ITK)

ASN:	102374726(ITK)

AMJ:	102573379(ITK)

CPOO:

109310206(ITK)

GGN:	109289846(ITK)

PSS:	102453567(ITK)

CMY:	102946851(ITK)

CCAY:

125641695(ITK)

CPIC:

101952342(ITK)

TST:	117882179(ITK)

CABI:

116836700(ITK)

MRV:	120370838(ITK)

ACS:	100554114(itk)

ASAO:

132769000(ITK)

PVT:	110090007(ITK)

SUND:

121922559(ITK)

PBI:	103049642(ITK)

PMUR:

107299982 107302950(ITK)

CTIG:

120318156(ITK)

TSR:	106543528(ITK)

PGUT:

117654768(ITK)

APRI:

131191191(ITK)

PTEX:

113433523(ITK)

NSS:	113421643(ITK)

VKO:	123034013(ITK)

PMUA:

114591396(ITK)

PRAF:

128408008(ITK)

ZVI:	118080461(ITK)

HCG:	128341730(ITK)

GJA:	107124803(ITK)

STOW:

125429286(ITK)

EMC:	129329021(ITK)

XLA:	108710759(itk.L)

XTR:	100492561(itk)

NPR:	108802025(ITK)

RTEM:

120932588(ITK)

BBUF:

121007779(ITK)

BGAR:

122926521(ITK)

PWL:	138245760(ITK)

MUO:	115475773(ITK)

GSH:	117351904(ITK)

DRE:	798906(itk)

SRX:	107744567 107752064(itk)

SANH:

107664330 107669068

SGH:	107550750 107561417

CCAR:

109102261(itk) 109102276

CAUA:

113057730 113113909

CGIB:

127971343 128027662

PTET:

122357268(itk)

LROH:

127175967(itk)

OMC:	131553584(itk)

PPRM:

120474374(itk)

RKG:	130090922(itk)

MAMB:

125259315(itk)

CIDE:

127494648

CERY:

137021295(itk)

MASI:

127412876 127417692

TROS:

130564116(itk)

TDW:	130438522(itk)

MANU:

129422203(itk)

PDAB:

135757484(itk)

IPU:

108269212

IFU:	128611540(itk)

PHYP:

113529348(itk)

SMEO:

124386588(itk)

TFD:	113636061(itk)

TVC:	132856072(itk)

CGAR:

128532309(itk)

NGRA:

132890637(itk)

TRN:	134318906(itk)

AMEX:

103036744(itk)

CMAO:

118807139(itk)

EEE:	113586131(itk)

CHAR:

105902870(itk)

SPIL:

134068865(itk)

TRU:	101071372(itk)

TFS:	130531733(itk)

TNG:	GSTEN00004811G001

LCO:	104923894(itk)

NCC:	104943063(itk)

TBEN:

117475073(itk)

CGOB:

115014528(itk)

PGEO:

117454457(itk)

GACU:

117545199(itk)

EMAC:

134859457(itk)

ELY:	117260616(itk)

EFO:	125894853(itk)

PLEP:

121948301(itk)

SLUC:

116052073(itk)

ECRA:

117951328(itk)

ESP:	116697372(itk)

PFLV:

114562563(itk)

GAT:	120818469(itk)

PPUG:

119211643(itk)

AFB:	129090018(itk)

CLUM:

117737812(itk)

PSWI:

130209592(itk)

CANA:

137791167(itk)

CVE:	137875293(itk)

MSAM:

119889299(itk)

SCHU:

122880875(itk)

CUD:	121516692(itk)

SPUL:

138598322(itk)

LMIX:

132982457(itk)

ALAT:

119008076(itk)

ASTR:

137602594(itk)

MZE:	101468250(itk)

ONL:	100705059(itk)

OAU:	116315159(itk)

OLA:	101172000(itk)

OML:	112153432(itk)

CSAI:

133447660(itk)

XMA:	102238272(itk)

XCO:	114139597(itk)

XHE:	116714263(itk)

PRET:

103470898(itk)

PFOR:

103155889(itk)

PLAI:

106935085(itk)

PMEI:

106928222(itk)

GAF:	122837572(itk)

PPRL:

129362929(itk)

CVG:

107086328

CTUL:

119771971(itk)

GMU:	124859817(itk)

NFU:	107383707(itk)

KMR:	108237934(itk)

ALIM:

106519086(itk)

NWH:	119409109(itk)

AOCE:

111588043(itk)

EJA:	138211715(itk)

BFRE:

138619990(itk)

MCEP:

125007650(itk)

CSEM:

103391413(itk)

POV:	109628724(itk)

SSEN:

122778140(itk)

SSOE:

131473108(itk)

HHIP:

117769617(itk)

HSP:	118112261(itk)

PPLT:

128445759(itk)

SMAU:

118319293(itk)

LCF:

108882785

SDU:	111226600(itk)

SLAL:

111664667(itk)

XGL:	120785117(itk)

HCQ:

109524354

SSCV:

125994001(itk)

SBIA:

133508575(itk)

PEE:	133407896(itk)

PTAO:

133485013(itk)

BPEC:

110162323

ENY:	140354665(itk)

MALB:

109956578(itk)

BSPL:

114864218(itk)

SJO:	128362652(itk)

SSCO:

133985693(itk)

GMH:	115552132(itk)

SASA:

106604351 106612055 106612060

STRU:

115205605(itk)

OTW:	112239105(itk)

OMY:	110504383(itk)

OGO:	124010369(itk)

OKI:	109878951(itk)

OKE:	118380942(itk)

OMM:	135545565(itk)

OCLA:

139390648

SALP:

111965532 112072854

SNH:	120046920(itk) 120062415

CCLU:

121533207(itk) 121555530

ELS:	105007074(itk)

OEP:	134032919(itk)

SFM:	108936752(itk)

PKI:	111848924(itk)

AANG:

118223585(itk)

AROT:

135249752(itk)

CCOG:

133124446(itk)

LOC:	102688164(itk)

PSPA:

121296884(itk)

ARUT:

117412870 117431104

PSEX:

120542592(itk)

LCM:	102355202(ITK)

CMK:

RTP:

CPLA:

HOC:

LERI:

Reference

PMID:20206686

Authors

Bradshaw JM

Title

The Src, Syk, and Tec family kinases: distinct types of molecular switches.

Journal

Cell Signal 22:1175-84 (2010)
DOI:10.1016/j.cellsig.2010.03.001

LinkDB

DBGET integrated database retrieval system