KEGG   ORTHOLOGY: K07438
Entry
K07438                      KO                                     

Name
CYP27B1
Definition
calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map04928  Parathyroid hormone synthesis, secretion and action
map05152  Tuberculosis
Module
M00103  Cholecalciferol biosynthesis
Disease
H00408  Type 1 diabetes mellitus
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.18  calcidiol 1-monooxygenase
     K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Other DBs
RN: R03610 R11324
GO: 0004498
Genes
HSA: 1594(CYP27B1)
PTR: 452027(CYP27B1)
PPS: 100974264
GGO: 101146696
PON: 100443915
NLE: 100594622
MCC: 715747(CYP27B1)
MCF: 102117707
CSAB: 103238591(CYP27B1)
CATY: 105587234
PANU: 101009903
RRO: 104682342
RBB: 108524407
TFN: 117089857
PTEH: 111541786
CJC: 100388588(CYP27B1)
SBQ: 101042462
MMUR: 105877998
MMU: 13115(Cyp27b1)
MCAL: 110303958
MPAH: 110327080
RNO: 114700(Cyp27b1)
MCOC: 116075946
MUN: 110561784
CGE: 100760414
PLEU: 114704779
NGI: 103742896
HGL: 101700851
CCAN: 109686086
OCU: 100341053
TUP: 102492875
CFA: 481133(CYP27B1)
VVP: 112922328
VLG: 121491053
AML: 100481484
UMR: 103656705
UAH: 113256358
ORO: 101363421
ELK: 111160181
MPUF: 101674682
EJU: 114215050
MLX: 118008655
FCA: 100750221(CYP27B1)
PTG: 102971063
PPAD: 109270394
AJU: 106975877
HHV: 120248015
BTA: 539630(CYP27B1)
BOM: 102278257
BIU: 109559305
BBUB: 102414554
CHX: 102170758
OAS: 101116039
ODA: 120857512
SSC: 397055(CYP27B1)
CFR: 102522811
CDK: 105100328
BACU: 103001013
LVE: 103084276
OOR: 101284262
DLE: 111173817
PCAD: 102984886
ECB: 100034100(CYP27B1)
EPZ: 103553643
EAI: 106833020
MYB: 102262846
MYD: 102757775
MMYO: 118649575
MNA: 107546167
HAI: 109390756
DRO: 112319168
SHON: 118975885
AJM: 119065237
MMF: 118623548
PALE: 102894468
RAY: 107501490
MJV: 108387803
TOD: 119248104
LAV: 100657886
TMU: 101355020
MDO: 100031497
SHR: 100913970
PCW: 110210991
OAA: 114814717
LSR: 110473893
SCAN: 103824978
PMOA: 120499536
FAB: 101816678
PHI: 102103763
PMAJ: 107199279
ASN: 102386966
AMJ: 102574984
CPOO: 109324487
PSS: 102443605
CMY: 102946801
CPIC: 101954100
TST: 117888845
CABI: 116828443
ACS: 100559713
PVT: 110074451
PBI: 103060795
PMUR: 107291644
TSR: 106552999
PGUT: 117662682
PMUA: 114593032
ZVI: 118078986
GJA: 107119675
XLA: 108708601(cyp27b1.L) 108709871(cyp27b1.S)
XTR: 448754(cyp27b1)
NPR: 108791588
DRE: 793309(cyp27b1)
SRX: 107747831
SANH: 107684010
SGH: 107561793
CCAR: 109089182
CAUA: 113068164
IPU: 108254794
AMEX: 103035224
EEE: 113572450
TRU: 101062641
LCO: 109142364
NCC: 104955571
ELY: 117257290
PLEP: 121956007
SLUC: 116066246
ECRA: 117942881
PFLV: 114554512
GAT: 120835315
MSAM: 119886596
CUD: 121528681
MZE: 101476393
ONL: 100706100
OAU: 116326616
OLA: 101172325
OML: 112145670
XMA: 102222483
XCO: 114134887
XHE: 116709734
PRET: 103465325
CVG: 107082096
CTUL: 119795482
NFU: 107385653
KMR: 108235620
ALIM: 106518084
AOCE: 111587639
CSEM: 103386049
POV: 109628943
LCF: 108898968
SDU: 111221905
SLAL: 111667688
XGL: 120806983
HCQ: 109522134
BPEC: 110171326
MALB: 109956137
ELS: 105017033
PKI: 111854850
LOC: 102685924
PSPA: 121308962
LCM: 102346327
CMK: 103191415
RTP: 109925523
PPOT: 106099942
BGT: 106053581
GAE: 121389521
 » show all
Reference
  Authors
Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R
  Title
Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.
  Journal
Mol Cancer Res 1:56-67 (2002)
  Sequence
[hsa:1594]
Reference
PMID:9344864
  Authors
Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T
  Title
Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.
  Journal
Biochem Biophys Res Commun 239:527-33 (1997)
DOI:10.1006/bbrc.1997.7508
  Sequence
[hsa:1594]
Reference
  Authors
Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K
  Title
Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli.
  Journal
Eur J Biochem 265:950-6 (1999)
DOI:10.1046/j.1432-1327.1999.00794.x
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