KEGG   ORTHOLOGY: K08846
Entry
K08846                      KO                                     
Symbol
RIPK2
Name
receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
Pathway
map04621  NOD-like receptor signaling pathway
map04722  Neurotrophin signaling pathway
map05131  Shigellosis
map05132  Salmonella infection
map05152  Tuberculosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
   05131 Shigellosis
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
   05152 Tuberculosis
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RIPK family [OT]
   K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Genes
HSA: 8767(RIPK2)
PTR: 464277(RIPK2)
PPS: 100986683(RIPK2)
GGO: 101124865(RIPK2)
PON: 100448203(RIPK2)
NLE: 100584725(RIPK2)
MCC: 695567(RIPK2)
MCF: 102141511(RIPK2)
CSAB: 103237096(RIPK2)
CATY: 105572870(RIPK2)
PANU: 101006774(RIPK2)
TGE: 112630634(RIPK2)
RRO: 104654652(RIPK2)
RBB: 108526904(RIPK2)
TFN: 117079637(RIPK2)
PTEH: 111549683(RIPK2)
CJC: 100404956(RIPK2)
SBQ: 101030587(RIPK2)
CSYR: 103262889(RIPK2)
MMUR: 105860682(RIPK2)
OGA: 100954549(RIPK2)
MMU: 192656(Ripk2)
MCAL: 110292783(Ripk2)
MPAH: 110338775(Ripk2)
RNO: 362491(Ripk2)
MCOC: 116088041(Ripk2)
MUN: 110545065(Ripk2)
CGE: 100751944(Ripk2)
PLEU: 114694604(Ripk2)
NGI: 103729531(Ripk2)
HGL: 101709696(Ripk2)
CPOC: 100716133(Ripk2)
CCAN: 109690126(Ripk2)
DORD: 105982876(Ripk2)
DSP: 122102463(Ripk2)
NCAR: 124985002
OCU: 100351901(RIPK2)
OPI: 101519724(RIPK2)
TUP: 102473610(RIPK2)
CFA: 477936(RIPK2)
VVP: 112930867(RIPK2)
VLG: 121499089(RIPK2)
AML: 100480506(RIPK2)
UMR: 103661470(RIPK2)
UAH: 113252964(RIPK2)
UAR: 123797904(RIPK2)
ELK: 111146577
LLV: 125098185
MPUF: 101685462(RIPK2)
ORO: 101374574(RIPK2)
EJU: 114216066(RIPK2)
ZCA: 113909698(RIPK2)
MLX: 118014994(RIPK2)
FCA: 101086783(RIPK2)
PYU: 121042668(RIPK2)
PBG: 122495568(RIPK2)
PTG: 102957311(RIPK2)
PPAD: 109269456(RIPK2)
AJU: 106984785(RIPK2)
HHV: 120237347(RIPK2)
BTA: 534407(RIPK2)
BOM: 102269037(RIPK2)
BIU: 109568588(RIPK2)
BBUB: 102407215(RIPK2)
CHX: 102169397(RIPK2)
OAS: 101115883(RIPK2)
ODA: 120878516(RIPK2)
CCAD: 122451134(RIPK2)
SSC: 100518835(RIPK2)
CFR: 102507090(RIPK2)
CBAI: 105064730(RIPK2)
CDK: 105087544(RIPK2)
VPC: 102529559(RIPK2)
BACU: 103016338(RIPK2)
LVE: 103089725(RIPK2)
OOR: 101273094(RIPK2)
DLE: 111180441(RIPK2)
PCAD: 102989713(RIPK2)
PSIU: 116742527(RIPK2)
ECB: 100051086(RIPK2)
EPZ: 103564122(RIPK2)
EAI: 106838970(RIPK2)
MYB: 102240596(RIPK2)
MYD: 102771269(RIPK2)
MMYO: 118670470(RIPK2)
MLF: 102434661(RIPK2)
MNA: 107526473(RIPK2)
PKL: 118718487(RIPK2)
HAI: 109387588(RIPK2)
DRO: 112310313(RIPK2)
SHON: 118989283(RIPK2)
AJM: 119047894(RIPK2)
PDIC: 114502006(RIPK2)
PHAS: 123820979(RIPK2)
MMF: 118631733(RIPK2)
RFQ: 117024046 117034136(RIPK2)
PALE: 102897241(RIPK2)
PGIG: 120614242(RIPK2)
PVP: 105304146(RIPK2)
RAY: 107507555(RIPK2)
MJV: 108395321(RIPK2)
TOD: 119239952(RIPK2)
SARA: 101548727(RIPK2)
LAV: 100663221(RIPK2)
TMU: 101347391
DNM: 101422988(RIPK2)
MDO: 100029371(RIPK2)
GAS: 123254942(RIPK2)
SHR: 100920956(RIPK2)
PCW: 110196727(RIPK2)
OAA: 100074957(RIPK2) 103166279
GGA: 415708(RIPK3) 420215(RIPK2)
PCOC: 116227588(RIPK2)
MGP: 100541245(RIPK2)
CJO: 107310368(RIPK2)
NMEL: 110394065(RIPK2) 110404370
APLA: 101797616 101801807(RIPK2)
ACYG: 106030539(RIPK2) 106043112
AFUL: 116486248(RIPK2) 116494199
TGU: 100223072(RIPK2) 115496886
LSR: 110477423(RIPK2)
SCAN: 103813399(RIPK2) 103816814
PMOA: 120495773(RIPK2) 120508095
OTC: 121333980 121340149(RIPK2)
PRUF: 121349010 121351936(RIPK2)
GFR: 102039354 102039478(RIPK2)
FAB: 101810818 101819872(RIPK2)
PHI: 102101204(RIPK2) 102105196
PMAJ: 107200811(RIPK2) 107209761
CCAE: 111924776(RIPK2) 111934565
CCW: 104687489 104692763(RIPK2)
ETL: 114061736(RIPK2) 114071257
ZAB: 102061284 102063107(RIPK2)
FPG: 101916675(RIPK2) 101922525
FCH: 102049954(RIPK2) 102054177
CLV: 102083897(RIPK2) 102087693
EGZ: 104125840(RIPK2) 104130220
NNI: 104016365 104016403(RIPK2)
ACUN: 113476158(RIPK2) 113484502
TALA: 104361359(RIPK2) 104367582
PADL: 103914195 103917314(RIPK2)
ACHC: 115340281(RIPK2) 115346445
AAM: 106483330 106496319(RIPK2)
AROW: 112961084 112964082(RIPK2)
NPD: 112950571 112960327(RIPK2)
DNE: 112982958(RIPK2) 112984287
ASN: 102374298 102380156(RIPK2)
AMJ: 102565156 102572630(RIPK2)
CPOO: 109320195(RIPK2)
GGN: 109305018(RIPK2)
PSS: 102461132(RIPK2)
CMY: 102940358(RIPK2) 102941377
CPIC: 101944477(RIPK2) 101946154
TST: 117873640(RIPK2) 117886605
CABI: 116817534 116829434(RIPK2)
MRV: 120384459 120399286(RIPK2)
ACS: 100557554(ripk2) 103279342
PVT: 110085504 110090233(RIPK2)
SUND: 121914514 121928539(RIPK2)
PBI: 103051915 103067943(RIPK2)
PMUR: 107285743(RIPK2) 107295258
TSR: 106541579 106545514(RIPK2)
PGUT: 117668484(RIPK2) 117670372
VKO: 123020585(RIPK2) 123025465
PMUA: 114600449(RIPK2) 114601914
ZVI: 118087093 118089949(RIPK2)
STOW: 125439533(RIPK2) 125443257
XLA: 108695377(ripk2.S) 108719325(ripk2.L)
XTR: 100496958(ripk2)
NPR: 108795169 108804489(RIPK2)
RTEM: 120941273(RIPK2)
BBUF: 121001280(RIPK2)
BGAR: 122938946(RIPK2)
DRE: 373874(ripk2)
PPRM: 120471438(ripk2)
MAMB: 125251519
IPU: 108267689 108271158(si:dkey-181f22.4)
PHYP: 113536411 113540487(ripk2)
SMEO: 124387093(ripk2)
TFD: 113644082
AMEX: 103022466(ripk2)
EEE: 113570106(ripk2) 113586917
TRU: 101073996(ripk2)
LCO: 104920921(ripk2)
NCC: 104949100(ripk2)
CGOB: 115022478(ripk2)
ELY: 117272546
PLEP: 121951391
SLUC: 116046139
ECRA: 117954221
PFLV: 114565798(ripk2)
GAT: 120815847
PPUG: 119209529(ripk2)
MSAM: 119902315
CUD: 121520054
ALAT: 119010724
MZE: 101478382(ripk2)
ONL: 100704387(ripk2)
OAU: 116320422(ripk2)
OLA: 101161336(ripk2)
OML: 112147518
XMA: 102234179(ripk2)
XCO: 114146519(ripk2)
XHE: 116721580(ripk2)
PRET: 103479078(ripk2)
PFOR: 103139959(ripk2)
PLAI: 106961897(ripk2)
PMEI: 106920595(ripk2)
GAF: 122840600
CVG: 107096457(ripk2)
CTUL: 119796370(ripk2)
GMU: 124870240
NFU: 107396213(ripk2)
KMR: 108238203
ALIM: 106530176(ripk2)
NWH: 119414525
AOCE: 111581478(ripk2)
CSEM: 103396134(ripk2)
POV: 109639366(ripk2)
SSEN: 122774301
HHIP: 117778891
LCF: 108883753(ripk2)
SDU: 111228763(ripk2)
SLAL: 111661295(ripk2)
XGL: 120799207
HCQ: 109520486(ripk2)
BPEC: 110173454(ripk2)
MALB: 109951958(ripk2)
BSPL: 114845064
ELS: 105017200 105030385(ripk2)
SFM: 108937842 108938332(ripk2)
PKI: 111846146
AANG: 118225470(ripk2)
LOC: 102695929(ripk2)
PSPA: 121296577(si:dkey-181f22.4) 121312705 121314155 121325584
ARUT: 117399479 117424414(si:dkey-181f22.4) 117425474 117435339
LCM: 102348796 102354731(RIPK2)
CMK: 103184934(ripk2) 103185913(si:dkey-181f22.4) 103185937
RTP: 109911129(ripk2) 109911619
CIN: 100181177
SCLV: 120337127
 » show all
Reference
  Authors
Tigno-Aranjuez JT, Asara JM, Abbott DW
  Title
Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.
  Journal
Genes Dev 24:2666-77 (2010)
DOI:10.1101/gad.1964410
Reference
PMID:9642260
  Authors
McCarthy JV, Ni J, Dixit VM
  Title
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
  Journal
J Biol Chem 273:16968-75 (1998)
DOI:10.1074/jbc.273.27.16968
  Sequence
[hsa:8767]
LinkDB

DBGET integrated database retrieval system