KEGG ORTHOLOGY: K08846

ORTHOLOGY: K08846

Entry

K08846                      KO

Symbol

RIPK2

Name

receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]

Pathway

map04621

NOD-like receptor signaling pathway

map04722

Neurotrophin signaling pathway

map05131

Shigellosis

map05132

Salmonella infection

map05152

Tuberculosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
   05131 Shigellosis
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
   05152 Tuberculosis
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  RIPK family [OT]
   K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2

Genes

HSA:	8767(RIPK2)

PTR:	464277(RIPK2)

PPS:	100986683(RIPK2)

GGO:	101124865(RIPK2)

PON:	100448203(RIPK2)

PPYG:

129042388(RIPK2)

NLE:	100584725(RIPK2)

HMH:	116813394(RIPK2)

SSYN:

129486587(RIPK2)

MCC:	695567(RIPK2)

MCF:	102141511(RIPK2)

MTHB:

126960539

MNI:	105497286(RIPK2)

CSAB:

103237096(RIPK2)

CATY:

105572870(RIPK2)

PANU:

101006774(RIPK2)

TGE:	112630634(RIPK2)

MLEU:

105541531(RIPK2)

RRO:	104654652(RIPK2)

RBB:	108526904(RIPK2)

TFN:	117079637(RIPK2)

PTEH:

111549683(RIPK2)

CANG:

105508241(RIPK2)

CJC:	100404956(RIPK2)

SBQ:	101030587(RIPK2)

CIMI:

108310867(RIPK2)

ANAN:

105725875(RIPK2)

CSYR:

103262889(RIPK2)

MMUR:

105860682(RIPK2)

LCAT:

123645000(RIPK2)

ERUF:

138381766(RIPK2)

PCOQ:

105809800(RIPK2)

OGA:	100954549(RIPK2)

MMU:	192656(Ripk2)

MCAL:

110292783(Ripk2)

MPAH:

110338775(Ripk2)

RNO:	362491(Ripk2)

MCOC:

116088041(Ripk2)

ANU:	143438503(Ripk2)

ASYL:

127680576(Ripk2)

MUN:	110545065(Ripk2)

CGE:	100751944(Ripk2)

MAUA:

101824238(Ripk2)

PROB:

127232481(Ripk2)

PLEU:

114694604(Ripk2)

PMAV:

102918587(Ripk2)

MORG:

121452007(Ripk2)

MFOT:

126515611

AAMP:

119826831(Ripk2)

CNL:	130887907(Ripk2)

NGI:	103729531(Ripk2)

HGL:	101709696(Ripk2)

CPOC:

100716133(Ripk2)

CCAN:

109690126(Ripk2)

DORD:

105982876(Ripk2)

DSP:	122102463(Ripk2)

DMER:

138805837(Ripk2)

PLOP:

125360718(Ripk2)

NCAR:

124985002

MMMA:

107142305(Ripk2)

ITI:	101955004(Ripk2)

OCU:

100351901

OPI:	101519724(RIPK2)

OCZ:	121165093(RIPK2)

TUP:	102473610(RIPK2)

GVR:	103603842(RIPK2)

CFA:	477936(RIPK2)

CLUD:

112650841(RIPK2)

VVP:	112930867(RIPK2)

VLG:	121499089(RIPK2)

NPO:	129495745(RIPK2)

AML:	100480506(RIPK2)

UMR:	103661470(RIPK2)

UAH:	113252964(RIPK2)

UAR:	123797904(RIPK2)

ELK:

111146577

LLV:

125098185

MPUF:

101685462(RIPK2)

MNP:	132014142(RIPK2) 132026122

MLK:	131814629 131826627(RIPK2)

NVS:	122904462(RIPK2)

ORO:	101374574(RIPK2)

EJU:	114216066(RIPK2)

ZCA:	113909698(RIPK2)

MLX:	118014994(RIPK2)

MANO:

123858915(RIPK2)

NSU:	110578687(RIPK2)

LWW:	102746338(RIPK2)

FCA:	101086783(RIPK2)

PYU:	121042668(RIPK2)

PCOO:

112859385(RIPK2)

PBG:	122495568(RIPK2)

PVIV:

125156513(RIPK2)

LRUF:

124519021

LGF:	123585829(RIPK2)

AJU:

106984785

PTG:	102957311(RIPK2)

PPAD:

109269456(RIPK2)

PUC:

125924562

PLEZ:

122211171(RIPK2)

HHV:	120237347(RIPK2)

CCRU:

144237655(RIPK2)

BTA:	534407(RIPK2)

BOM:	102269037(RIPK2)

BIU:	109568588(RIPK2)

BJV:	133260747(RIPK2)

BBUB:

102407215(RIPK2)

BKE:	129627097(RIPK2)

BBIS:

105004581(RIPK2)

CHX:	102169397(RIPK2)

OAS:	101115883(RIPK2)

OCAN:

138445983(RIPK2)

BTAX:

128059425(RIPK2)

CSUM:

138088498(RIPK2)

ODA:	120878516(RIPK2)

CCAD:

122451134(RIPK2)

MREE:

136144954(RIPK2)

OVR:	110122502(RIPK2)

MBEZ:

129559967(RIPK2)

SSC:	100518835(RIPK2)

CFR:	102507090(RIPK2)

CBAI:

105064730(RIPK2)

CDK:	105087544(RIPK2)

VPC:	102529559(RIPK2)

BACU:

103016338(RIPK2)

BMUS:

118883502(RIPK2)

LVE:	103089725(RIPK2)

OOR:	101273094(RIPK2)

LALB:

132507996(RIPK2) 132508201

GMF:

115856511

DDP:	132413113(RIPK2) 138414320

DLE:	111180441(RIPK2)

PCAD:

102989713(RIPK2)

PSIU:

116742527(RIPK2)

PPHC:

136136894 136137093

NASI:

112406863(RIPK2)

ECB:	100051086(RIPK2)

EPZ:	103564122(RIPK2)

EAI:	106838970(RIPK2)

MYB:	102240596(RIPK2)

MYD:	102771269(RIPK2)

MMYO:

118670470(RIPK2)

MLF:	102434661(RIPK2)

MDT:	132220040(RIPK2)

MYUM:

138993514(RIPK2)

PKL:	118718487(RIPK2)

EFUS:

103301859(RIPK2)

MNA:	107526473(RIPK2)

DRO:	112310313(RIPK2)

SHON:

118989283(RIPK2)

AJM:	119047894(RIPK2)

PDIC:

114502006(RIPK2)

PHAS:

123820979(RIPK2)

MMF:	118631733(RIPK2)

PPAM:

129088416(RIPK2)

HAI:	109387588(RIPK2)

RFQ:	117024046 117034136(RIPK2)

PALE:

102897241(RIPK2)

PGIG:

120614242(RIPK2)

PVP:	105304146(RIPK2)

RAY:	107507555(RIPK2)

MJV:	108395321(RIPK2)

TOD:	119239952(RIPK2)

SARA:

101548727(RIPK2)

SFUM:

130019370(RIPK2)

SETR:

126020842(RIPK2)

LAV:	100663221(RIPK2)

TMU:

101347391

ETF:	101659564(RIPK2)

DNM:	101422988(RIPK2)

MDO:	100029371(RIPK2)

GAS:	123254942(RIPK2)

SHR:	100920956(RIPK2)

AFZ:

127544264

PCW:	110196727(RIPK2)

TVP:	118834441(RIPK2)

PBRV:

138160142(RIPK2)

MLAO:

141497265(RIPK2)

OAA:	100074957(RIPK2) 103166279

TACU:

119919844 119927105(RIPK2)

GGA:	415708(RIPK3) 420215(RIPK2)

PCOC:

116227588(RIPK2)

MGP:	100541245(RIPK2)

CJO:	107310368(RIPK2)

TPAI:

128090777(RIPK2)

LMUT:

125690619(RIPK2) 125699214

NMEL:

110394065(RIPK2) 110404370

APLA:

101797616 101801807(RIPK2)

AACU:

137851265(RIPK2) 137861902

OJA:	118162456(RIPK2)

ACYG:

106030539(RIPK2) 106043112

CATA:

118246392 118247865(RIPK2)

AFUL:

116486248(RIPK2) 116494199

TGU:	100223072(RIPK2) 115496886

LSR:	110477423(RIPK2)

VMC:	128808191(RIPK2)

VCHA:

128789422(RIPK2)

AIB:	137471240(RIPK2)

SCAN:

103813399(RIPK2) 103816814

PMOA:

120495773(RIPK2) 120508095

OTC:	121333980 121340149(RIPK2)

PRUF:

121349010 121351936(RIPK2)

ATRC:

139587374(RIPK2) 139596295

MATE:

118684382(RIPK2)

MAEN:

136555357(RIPK2)

GFR:	102039354 102039478(RIPK2)

FAB:	101810818 101819872(RIPK2)

OMA:	130249264(RIPK2) 130258053

PHI:	102101204(RIPK2) 102105196

PMAJ:

107200811(RIPK2) 107209761

CCAE:

111924776(RIPK2) 111934565

CCW:	104687489 104692763(RIPK2)

CBRC:

103613441(RIPK2) 103620177

ACOE:

138105284(RIPK2) 138117069

ETL:	114061736(RIPK2) 114071257

ZAB:	102061284 102063107(RIPK2)

ZLE:	135444610(RIPK2) 135452977

ACHL:

103807619 103809312(RIPK2)

SVG:	106849860(RIPK2) 106855833

MMEA:

130572716 130576428(RIPK2)

HRT:	120755475(RIPK2) 120757555

SATI:

136366618 136369973(RIPK2)

CFAI:

136286970(RIPK2)

CCIC:

134048502 134050004(RIPK2)

FPG:	101916675(RIPK2) 101922525

FCH:	102049954(RIPK2) 102054177

FRS:	119145127(RIPK2)

CCRI:

104158863(RIPK2) 104161923

NNT:	104401235 104404382

SHAB:

115610198(RIPK2) 115619627

POCC:

134156492(RIPK2)

ACUN:

113476158(RIPK2) 113484502

ANOC:

141956817(RIPK2)

SURA:

141954510(RIPK2)

TALA:

104361359(RIPK2) 104367582

ACHC:

115340281(RIPK2) 115346445

HALD:

104312500 104320409(RIPK2)

HLE:	104828369(RIPK2) 104842357

AGEN:

126040706 126046588

HHAR:

128141762(RIPK2) 128146063

BBUT:

142029158(RIPK2) 142036763

GCL:	127013250 127021294

CSTI:

104556619 104560879(RIPK2)

LDI:	104340976 104343361

MNB:

103769879

DPUB:

104297204(RIPK2) 104299028

PPUS:

135181082(RIPK2) 135184235

IIN:	128970365(RIPK2)

AVIT:

104277715 104279135

BRHI:

104490207(RIPK2) 104496480

EGZ:	104125840(RIPK2) 104130220

NNI:	104016365 104016403(RIPK2)

PCRI:

104028352 104035174(RIPK2)

PCAO:

104051864

PARX:

142053550(RIPK2) 142061100

PADL:

103914195 103917314(RIPK2)

AFOR:

103895748(RIPK2) 103896832

FGA:	104070825(RIPK2) 104079004

CBOR:

142078658(RIPK2) 142087168

GSTE:

104253189 104259807(RIPK2)

CBOY:

140647529(RIPK2) 140656921

MAME:

142406254(RIPK2) 142413887

CLV:	102083897(RIPK2) 102087693

CNIC:

135985586(RIPK2) 135992233

MUI:	104535310 104539630(RIPK2) 104545071

PGUU:

104470802 104471636

PLET:

104620539(RIPK2) 104621495

EHS:	104510095(RIPK2) 104510842

CMAC:

104475306 104486708(RIPK2)

CUCA:

104055928

PCUR:

138719247(RIPK2)

TEO:

104376228

BREG:

104640084(RIPK2) 104644152

GAME:

129203763(RIPK2)

OHA:	104335244 104337551(RIPK2)

ACAR:

104520456(RIPK2) 104531910

CPEA:

104394790 104396565(RIPK2)

CVF:	104287734 104292469(RIPK2)

RTD:	128905642(RIPK2) 128909377

CRID:

134512101(RIPK2) 134515376

LMIC:

141739669(RIPK2) 141741955

NARQ:

141463166(RIPK2)

AAM:	106483330 106496319(RIPK2)

AROW:

112961084 112964082(RIPK2)

NPD:	112950571 112960327(RIPK2)

TGT:	104568340(RIPK2) 104575537

DNE:	112982958(RIPK2) 112984287

SCAM:

104143941(RIPK2) 104146298

ASN:	102374298 102380156(RIPK2)

AMJ:	102565156 102572630(RIPK2)

CPOO:

109320195(RIPK2)

GGN:	109305018(RIPK2)

PSS:	102461132(RIPK2)

CIZ:	142009234(RIPK2) 142020675

CMY:	102940358(RIPK2) 102941377

CCAY:

125620784 125632634(RIPK2)

LKP:	140896189 140906539(RIPK2)

NDS:	141982251(RIPK2) 141996813

DCC:	119841007 119852259(RIPK2)

CPIC:

101944477(RIPK2) 101946154

TST:	117873640(RIPK2) 117886605

CABI:

116817534 116829434(RIPK2)

MRV:	120384459 120399286(RIPK2)

EMQ:	137155464 137159780(RIPK2)

ACS:	100557554(ripk2) 103279342

ASAO:

132774966(RIPK2) 132783158

PVT:	110085504 110090233(RIPK2)

SUND:

121914514 121928539(RIPK2)

PBI:	103051915 103067943(RIPK2)

PMUR:

107285743(RIPK2) 107295258

CTIG:

120309463(RIPK2) 120312719

TSR:	106541579 106545514(RIPK2)

PGUT:

117668484(RIPK2) 117670372

PCAE:

139314684(RIPK2) 139323512

APRI:

131184378 131194474(RIPK2)

PTEX:

113439927(RIPK2) 113445136

NSS:	113426019 113428568(RIPK2)

VKO:	123020585(RIPK2) 123025465

PMUA:

114600449(RIPK2) 114601914

PRAF:

128417268(RIPK2) 128419129

ZVI:	118087093 118089949(RIPK2)

HCG:	128323550(RIPK2) 128334139

GJA:	107111703 107121846(RIPK2) 107126194

STOW:

125439533(RIPK2) 125443257

EMC:	129333328(RIPK2) 129344328

XLA:	108695377(ripk2.S) 108719325(ripk2.L)

XTR:	100496958(ripk2)

NPR:	108795169 108804489(RIPK2)

RTEM:

120941273(RIPK2)

ACAT:

141145335(RIPK2)

PADS:

140330656(RIPK2)

BBUF:

121001280(RIPK2)

BGAR:

122938946(RIPK2)

DTC:	141053171(RIPK2)

PWL:	138267965 138282646(RIPK2)

MUO:	115478731(RIPK2)

GSH:	117355651(RIPK2)

DRE:	373874(ripk2)

DAES:

130240541

SRX:	107715521 107722215 107750646 107754657

SANH:

107674432 107681812 107700600 107701343

SGH:	107568621 107593863

CCAR:

109052942(si:dkey-181f22.4) 109057485 109085372

CAUA:

113038373 113046020 113049481

CGIB:

127939462 127950817 128021969

PTET:

122360624(ripk2)

LROH:

127181464(ripk2)

GRF:

141345012

OMC:	131521218(ripk2)

PPRM:

120471438(ripk2)

RKG:	130097217(ripk2)

MAMB:

CIDE:

CERY:

MASI:

TROS:

130554266(ripk2)

TDW:	130417280(ripk2)

MANU:

129442634(ripk2)

PDAB:

135750418

IPU:

108267689

IFU:	128609699(ripk2)

PHYP:

113540487(ripk2)

SMEO:

124387093(ripk2)

TFD:

113644082

TVC:	132848276(ripk2)

CGAR:

128514685(ripk2)

NGRA:

132891542(ripk2)

TRN:

134312123

AMEX:

103022466(ripk2)

CMAO:

118826197

EEE:	113570106(ripk2)

CHAR:

105889504(ripk2)

SPIL:

134074843(ripk2)

ASAD:

121707715(ripk2)

TRU:	101073996(ripk2)

TFS:

130538819

TNG:	GSTEN00014972G001

LCO:	104920921(ripk2)

NCC:	104949100(ripk2)

TBEN:

117488828(ripk2)

CGOB:

115022478(ripk2)

PGEO:

117462151(ripk2)

GACU:

117545636(ripk2)

EMAC:

134865454(ripk2)

ELY:	117272546(ripk2)

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114565798(ripk2)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

122886258(ripk2)

EARM:

CUD:

SPUL:

LMIX:

HTC:	141804571(ripk2)

ALAT:

119010724

ASTR:

137612000

PKLU:

139213995

MZE:	101478382(ripk2)

ONL:	100704387(ripk2)

OAU:	116320422(ripk2)

OLA:	101161336(ripk2)

OML:

112147518

CSAI:

133453032

XMA:	102234179(ripk2)

XCO:	114146519(ripk2)

XHE:	116721580(ripk2)

PRET:

103479078(ripk2)

PFOR:

103139959(ripk2)

PLAI:

106961897(ripk2)

PMEI:

106920595(ripk2)

GAF:

122840600

PPRL:

129361810

CVG:	107096457(ripk2)

CTUL:

119796370(ripk2)

GMU:

124870240

NFU:	107396213(ripk2)

KMR:

108238203

ALIM:

106530176(ripk2)

NWH:

LTU:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103396134(ripk2)

POV:	109639366(ripk2)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

118310960(ripk2)

LCF:

108883753

SDU:	111228763(ripk2)

SLAL:

111661295(ripk2)

XGL:

120799207

HCQ:	109520486(ripk2)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110173454(ripk2)

ENY:

140356347

MALB:

109951958(ripk2)

BSPL:

114845064

SJO:

128368809

SSCO:

133990777(ripk2)

TTY:

137193905

GMH:	115548502(ripk2)

SASA:

106562048 106568754 106587145 106598827

STRU:

115156667 115170051

OTW:	112227135 112249052 112260196 112263564

OMY:	110506391 110508995 110526239 110530062

OGO:	124010027 124042075

ONE:	115103310 115114150

OKI:	109872027 109875399

OKE:	118394444 118401722

OMM:	135517201 135558449

OCLA:

139375881 139387006

SALP:

111956958 111969277 111973687 111978984

SNH:	120020573 120025385 120025388 120046062(si:dkey-181f22.4) 120056262

SFON:

129814373(ripk2) 129823775

CCLU:

121534977 121580702

ELS:	105017200 105030385(ripk2)

OEP:

134035964

SFM:	108937842 108938332(ripk2)

PKI:

111846146

AANG:

118225470(ripk2)

AROT:

135253855(ripk2)

CCOG:

133126831

LOC:	102695929(ripk2)

PSPA:

121296577(si:dkey-181f22.4) 121312705 121314155 121325584

ARUT:

117399479 117424414(si:dkey-181f22.4) 117425474 117435339

PSEX:

120530115(ripk2)

LCM:	102348796 102354731(RIPK2)

CMK:	103184934(ripk2) 103185913(si:dkey-181f22.4) 103185937

RTP:

109911129

CPLA:

122549011

CPUN:

140477069(ripk2)

HOC:	132815016(ripk2)

SCAU:

119971419 119972428(ripk2)

LERI:

129696135(ripk2) 129705150

HAKA:

140727146(ripk2)

PMRN:

116944190(RIPK2)

LRJ:

133350895

BFO:	118408279 118408549 118408554 118408562 118408570 118408571

BBEL:

109471764 109473874 109480245

CIN:

CLEP:

LAK:

CCLM:

Reference

PMID:21123652

Authors

Tigno-Aranjuez JT, Asara JM, Abbott DW

Title

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

Journal

Genes Dev 24:2666-77 (2010)
DOI:10.1101/gad.1964410

Reference

PMID:9642260

Authors

McCarthy JV, Ni J, Dixit VM

Title

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

Journal

J Biol Chem 273:16968-75 (1998)
DOI:10.1074/jbc.273.27.16968

Sequence

[hsa:8767]

LinkDB

DBGET integrated database retrieval system