KEGG ORTHOLOGY: K09189

ORTHOLOGY: K09189

Entry

K09189                      KO

Symbol

MLL5

Name

[histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H02803

Neurodevelopmental disorder with histone modification defect

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5

Other DBs

GO:

0042800

Genes

HSA:	55904(KMT2E)

PTR:	463640(KMT2E)

PPS:	100982828(KMT2E)

GGO:	101144971(KMT2E)

PON:	100173903(KMT2E)

PPYG:

129040576(KMT2E)

NLE:	100600051(KMT2E)

HMH:	116814204(KMT2E)

SSYN:

129484853(KMT2E)

MCC:	697233(KMT2E)

MCF:	101926094(KMT2E)

MTHB:

126949835

MNI:	105475332(KMT2E)

CSAB:

103226692(KMT2E)

CATY:

105583166(KMT2E)

PANU:

101010195(KMT2E)

TGE:	112621770(KMT2E)

MLEU:

105554094(KMT2E)

RRO:	104675848(KMT2E)

RBB:	108531292(KMT2E)

TFN:	117073230(KMT2E)

PTEH:

111526693(KMT2E)

CANG:

105501710(KMT2E)

CJC:	100389921(KMT2E)

SBQ:	101033099(KMT2E)

CIMI:

108287696(KMT2E)

ANAN:

105720043(KMT2E)

CSYR:

103274301(KMT2E)

MMUR:

105861339(KMT2E)

LCAT:

123647293(KMT2E)

PCOQ:

105815198(KMT2E)

OGA:	100954551(KMT2E)

MMU:	69188(Kmt2e)

MCAL:

110294014(Kmt2e)

MPAH:

110313856(Kmt2e)

RNO:	311968(Kmt2e)

MCOC:

116097528(Kmt2e)

ANU:	117720383(Kmt2e)

ASYL:

127678256(Kmt2e)

MUN:	110552814(Kmt2e)

CGE:	100756731(Kmt2e)

MAUA:

101824199(Kmt2e)

PROB:

127214400(Kmt2e)

PLEU:

114681829(Kmt2e)

MORG:

121434635 121459125(Kmt2e)

MFOT:

126500117

AAMP:

119803796(Kmt2e)

NGI:	103732191(Kmt2e)

HGL:	101712321(Kmt2e)

CPOC:

100722538(Kmt2e)

CCAN:

109684282(Kmt2e)

DORD:

105999650(Kmt2e)

DSP:	122111781(Kmt2e)

PLOP:

125346903(Kmt2e)

NCAR:

124990995

MMMA:

107144560(Kmt2e)

ITI:	101955747(Kmt2e)

OCU:

100353840

OPI:	101518647(KMT2E)

TUP:	102483069(KMT2E)

GVR:	103586689(KMT2E)

CFA:	475895(KMT2E)

CLUD:

112661448(KMT2E)

VVP:	112925373(KMT2E)

VLG:	121471496(KMT2E)

NPO:	129494321(KMT2E)

AML:	100468393(KMT2E)

UMR:	103674714(KMT2E)

UAH:	113258804(KMT2E)

UAR:	123789383(KMT2E)

ELK:

111155211

LLV:

125081229

MPUF:

101688015(KMT2E)

MNP:	132016019(KMT2E)

MLK:	131829267(KMT2E)

NVS:	122904727(KMT2E)

ORO:	101362332(KMT2E)

EJU:	114221922(KMT2E)

ZCA:	113911901(KMT2E)

MLX:	118020644(KMT2E)

NSU:	110574278(KMT2E)

LWW:	102736062(KMT2E)

FCA:	101084945(KMT2E)

PYU:	121028858(KMT2E)

PCOO:

112867066(KMT2E)

PBG:	122487770(KMT2E)

PVIV:

125147999(KMT2E)

LRUF:

124524290

LGF:	123606327(KMT2E)

AJU:

106978485

PTG:	102949117(KMT2E)

PPAD:

109268101(KMT2E)

PUC:

125930780

PLEZ:

122206438(KMT2E)

HHV:	120243583(KMT2E)

BTA:	539121(KMT2E)

BOM:	102281278(KMT2E)

BIU:	109557366(KMT2E)

BBUB:

102398212(KMT2E)

BBIS:

104989687(KMT2E)

CHX:	102169548(KMT2E)

OAS:	101121766(KMT2E)

BTAX:

128046444(KMT2E)

CSUM:

138079821(KMT2E)

ODA:	120878163(KMT2E)

CCAD:

122438292(KMT2E)

MREE:

136170414(KMT2E)

OVR:	110146572(KMT2E)

MBEZ:

129552374(KMT2E)

SSC:	100628131(KMT2E)

CFR:	102514543(KMT2E)

CBAI:

105062412(KMT2E)

CDK:	105093021(KMT2E)

VPC:	102536134(KMT2E)

BACU:

103002011(KMT2E)

BMUS:

118900473(KMT2E)

LVE:	103074842(KMT2E)

OOR:	101285642(KMT2E)

LALB:

132524813(KMT2E)

DLE:	111164613(KMT2E)

PCAD:

102980726(KMT2E)

PSIU:

116759805(KMT2E)

NASI:

112407436(KMT2E)

ECB:	100058928(KMT2E)

EPZ:	103560579(KMT2E)

EAI:	106825187(KMT2E)

MYB:	102246410(KMT2E)

MYD:	102758785(KMT2E)

MMYO:

118666018(KMT2E)

MLF:	102420403(KMT2E)

MDT:	132243133(KMT2E)

MYUM:

139016496(KMT2E)

PKL:	118714393(KMT2E)

EFUS:

103293529(KMT2E)

MNA:	107542284(KMT2E)

DRO:	112303206(KMT2E)

SHON:

118994425(KMT2E)

AJM:	119063552(KMT2E)

PDIC:

114507268(KMT2E)

PHAS:

123811826(KMT2E)

MMF:	118620490(KMT2E)

PPAM:

129063476(KMT2E)

HAI:	109392049(KMT2E)

RFQ:	117012250(KMT2E)

PALE:

102888384(KMT2E)

PGIG:

120591655(KMT2E)

PVP:	105300340(KMT2E)

RAY:	107511501(KMT2E)

MJV:	108398623(KMT2E)

TOD:	119245069(KMT2E)

SARA:

101541405(KMT2E)

SFUM:

130027512(KMT2E)

SETR:

126022074(KMT2E)

LAV:	100671071(KMT2E)

TMU:

101357397

ETF:	101651153(KMT2E)

DNM:	101443711(KMT2E)

MDO:	100018480(KMT2E)

GAS:	123249354(KMT2E)

SHR:	100922144(KMT2E)

AFZ:

127538133

PCW:	110206991(KMT2E)

TVP:	118849930(KMT2E)

PBRV:

138175907 138176057

OAA:	100077208(KMT2E)

TACU:

119920774(KMT2E)

GGA:	417712(KMT2E)

PCOC:

116230863(KMT2E)

MGP:	100545555(KMT2E)

CJO:	107325180(KMT2E)

TPAI:

128079545(KMT2E)

LMUT:

125692210(KMT2E)

NMEL:

110392363(KMT2E)

APLA:

101805084(KMT2E)

ACYG:

106043274(KMT2E)

CATA:

118249529(KMT2E)

AFUL:

116501490(KMT2E)

TGU:	100226399(KMT2E)

LSR:	110472726(KMT2E)

SCAN:

103813524(KMT2E)

PMOA:

120509257(KMT2E)

OTC:	121336375(KMT2E)

PRUF:

121357414(KMT2E)

ATRC:

139588495(KMT2E)

GFR:	102045471(KMT2E)

FAB:	101812878(KMT2E)

OMA:	130248653(KMT2E)

PHI:	102108338(KMT2E)

PMAJ:

107204272(KMT2E)

CCAE:

111923252(KMT2E)

CCW:	104686872(KMT2E)

CBRC:

103623419(KMT2E)

ACOE:

138098166(KMT2E)

ETL:	114060528(KMT2E)

ZAB:	102066708(KMT2E)

ZLE:	135442735(KMT2E)

ACHL:

103805653(KMT2E)

SVG:	106848840(KMT2E)

MMEA:

130572663(KMT2E)

HRT:	120751397(KMT2E)

SATI:

136361034(KMT2E)

CCIC:

134043401(KMT2E)

FPG:	101919912(KMT2E)

FCH:	102047542(KMT2E)

CCRI:

104168454(KMT2E)

SHAB:

115605050(KMT2E)

ACUN:

113490163(KMT2E)

TALA:

104361303(KMT2E)

ACHC:

115341062(KMT2E)

HALD:

104319785(KMT2E)

HLE:	104840156(KMT2E)

AGEN:

126044473

HHAR:

128143644(KMT2E)

GCL:

127026814

CSTI:

104558096(KMT2E)

LDI:	104343329(KMT2E)

MNB:	103770762(KMT2E)

DPUB:

104307867(KMT2E)

PPUS:

135187339(KMT2E)

AVIT:

104273424(KMT2E)

BRHI:

104490852(KMT2E)

EGZ:	104128583(KMT2E)

NNI:	104010731(KMT2E)

PCRI:

104034948(KMT2E)

PCAO:

104047173(KMT2E)

PADL:

103920580(KMT2E)

AFOR:

103906976(KMT2E)

FGA:	104080339(KMT2E)

GSTE:

104263967

CLV:	102088903(KMT2E)

MUI:	104537048(KMT2E)

PGUU:

104461520(KMT2E)

PLET:

104626408(KMT2E)

EHS:	104505919(KMT2E)

CMAC:

104478959(KMT2E)

CUCA:

104056073(KMT2E)

TEO:	104372793(KMT2E)

OHA:	104328750(KMT2E)

ACAR:

104518615(KMT2E)

CPEA:

104394278(KMT2E)

CVF:	104285138(KMT2E)

RTD:	128904181(KMT2E)

CRID:

134510317(KMT2E)

AAM:	106485892(KMT2E)

AROW:

112962650(KMT2E)

NPD:	112953335(KMT2E)

TGT:

104570786

DNE:	112981749(KMT2E)

SCAM:

104140582(KMT2E)

ASN:	102375642(KMT2E)

AMJ:	102560388(KMT2E)

CPOO:

109315734(KMT2E)

GGN:	109292146(KMT2E)

PSS:	102454598(KMT2E)

CMY:	102933355(KMT2E)

CCAY:

125630438(KMT2E)

DCC:	119855274(KMT2E)

CPIC:

101935009(KMT2E)

TST:	117875197(KMT2E)

CABI:

116828853(KMT2E)

MRV:	120392458(KMT2E)

ACS:	100553183(kmt2e)

ASAO:

132776559(KMT2E)

PVT:	110080953(KMT2E)

SUND:

121931651(KMT2E)

PBI:	103051962(KMT2E)

PMUR:

107298635(KMT2E)

CTIG:

120313722(KMT2E)

TSR:	106543655(KMT2E)

PGUT:

117675207(KMT2E)

APRI:

131201678(KMT2E)

PTEX:

113436879(KMT2E)

NSS:	113418372(KMT2E)

VKO:	123019961(KMT2E)

PMUA:

114605818(KMT2E)

PRAF:

128422350(KMT2E)

ZVI:	118091298(KMT2E)

HCG:	128327966(KMT2E)

GJA:	107113725(KMT2E)

STOW:

125434309(KMT2E)

EMC:	129335378(KMT2E)

XLA:	108711190(kmt2e.L) 108713071(kmt2e.S)

XTR:	779539(kmt2e)

NPR:	108795231(KMT2E)

RTEM:

120931759(KMT2E)

BBUF:

120982437(KMT2E)

BGAR:

122927872(KMT2E)

PWL:	138288338(KMT2E)

MUO:	115478814(KMT2E)

GSH:	117367034(KMT2E)

DRE:	325395(kmt2e)

SRX:	107710662 107755882

SANH:

107680023(kmt2e) 107694189

SGH:	107590817 107590964

CCAR:

109066408 109066409

CAUA:

113048205 113061806

CGIB:

127956623 127973055

PTET:

122343261(kmt2e)

LROH:

127163812(kmt2e)

OMC:	131538635(kmt2e)

PPRM:

120476920(kmt2e)

RKG:	130082666(kmt2e)

MAMB:

125245495(kmt2e)

CIDE:

127510796

CERY:

137024550(kmt2e)

MASI:

127435394 127436493

TROS:

130547852(kmt2e)

TDW:	130421504(kmt2e)

MANU:

129432309(kmt2e)

PDAB:

135749954 135750568

IPU:

108279641

IFU:	128622996(kmt2e)

PHYP:

113523882(kmt2e)

SMEO:

124401164(kmt2e)

TFD:	113651867(kmt2e)

TVC:	132858628(kmt2e)

CGAR:

128534142(kmt2e)

NGRA:

132870206(kmt2e)

TRN:	134316603(kmt2e)

AMEX:

103038810(kmt2e)

CMAO:

118812318(kmt2e)

EEE:	113569424(kmt2e)

CHAR:

105909605(kmt2e) 116224043

SPIL:

134061782(kmt2e)

TRU:	101076756(kmt2e)

TFS:	130519095(kmt2e)

TNG:	GSTEN00021508G001

LCO:	104925314(kmt2e)

NCC:	104950113(kmt2e)

TBEN:

117484886(kmt2e)

CGOB:

115028240(kmt2e)

PGEO:

117468384(kmt2e)

GACU:

117559172(kmt2e)

EMAC:

134879091(kmt2e)

ELY:	117249611(kmt2e)

EFO:	125882665(kmt2e)

PLEP:

121961373(kmt2e)

SLUC:

116060181(kmt2e)

ECRA:

117938968(kmt2e)

ESP:	116673276(kmt2e)

PFLV:

114550568(kmt2e)

GAT:	120818322(kmt2e)

PPUG:

119210331(kmt2e)

AFB:	129112782(kmt2e)

CLUM:

117725970(kmt2e)

PSWI:

130200813(kmt2e)

CANA:

137791256(kmt2e)

CVE:	137877405(kmt2e)

MSAM:

119918232(kmt2e)

SCHU:

122871308(kmt2e)

CUD:	121505652(kmt2e)

SPUL:

138599332(kmt2e)

LMIX:

132956625(kmt2e)

ALAT:

119032432(kmt2e)

ASTR:

137589102(kmt2e)

MZE:	101483461(kmt2e)

ONL:	100699588(kmt2e)

OAU:	116334675(kmt2e)

OLA:	101162568(kmt2e)

OML:	112155842(kmt2e)

CSAI:

133424477(kmt2e)

XMA:	102233159(kmt2e)

XCO:	114160652(kmt2e)

XHE:	116736574(kmt2e)

PRET:

103459296(kmt2e)

PFOR:

103140276(kmt2e)

PLAI:

106957544(kmt2e)

PMEI:

106924679(kmt2e)

GAF:	122826612(kmt2e)

PPRL:

129351546(kmt2e)

CVG:	107095902(kmt2e)

CTUL:

119791153(kmt2e)

GMU:	124882897(kmt2e)

NFU:	107386366(kmt2e)

KMR:	108233216(kmt2e)

ALIM:

106514822(kmt2e)

NWH:	119428195(kmt2e)

AOCE:

111569065(kmt2e)

EJA:	138207473(kmt2e)

BFRE:

138628183(kmt2e)

MCEP:

125000051(kmt2e)

CSEM:

103382716(kmt2e)

POV:	109643621(kmt2e)

SSEN:

122766654(kmt2e)

SSOE:

131456938(kmt2e)

HHIP:

117757178(kmt2e)

HSP:	118101325(kmt2e)

PPLT:

128428856(kmt2e)

SMAU:

118286000(kmt2e)

LCF:

108886201

SDU:	111224728(kmt2e)

SLAL:

111660020(kmt2e)

XGL:	120799113(kmt2e)

HCQ:	109530075(kmt2e)

SSCV:

125992144(kmt2e)

SBIA:

133493738(kmt2e)

PEE:	133396899(kmt2e)

PTAO:

133471831(kmt2e)

BPEC:

110161381(kmt2e)

ENY:	140368204(kmt2e)

MALB:

109969716(kmt2e)

BSPL:

114861452(kmt2e)

SJO:	128385260(kmt2e)

SSCO:

134004722(kmt2e)

GMH:	115532350(kmt2e)

SASA:

106576014 106609379

STRU:

115180212(kmt2e) 115197978

OTW:	112217205(kmt2e) 112267824

OMY:	110490479(kmt2e) 110501025

OGO:	123994441 124014611

ONE:

115132988

OKI:	109864517 109885967

OKE:	118377779 118380705

OMM:	135515010 135515788

OCLA:

139378514 139393264

SNH:	120031905(kmt2e) 120049120

CCLU:

121579219(kmt2e)

ELS:	105023447(kmt2e)

OEP:	134038091(kmt2e)

SFM:	108918760 108931426

PKI:	111851208(kmt2e) 111857810

AANG:

118218848 118231711(kmt2e)

AROT:

135245878 135259033(kmt2e)

CCOG:

133118848 133135301(kmt2e)

LOC:	102694752(kmt2e)

PSPA:

121317956 121319159

ARUT:

117415540 117419831(kmt2e)

PSEX:

120539610(kmt2e)

LCM:	102349988(KMT2E)

CMK:	103176975(kmt2e)

RTP:	109916977(kmt2e)

CPLA:

122561751(kmt2e)

HOC:	132826706(kmt2e)

LERI:

129707817(kmt2e)

PMRN:

116942478(KMT2E)

LRJ:	133349350(KMT2E)

BFO:

BBEL:

CIN:

SPU:

LPIC:

APLC:

ARUN:

AAMU:

PFLL:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ005719

CPII:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139109620(Upset)

TLN:	139816559(Upset)

HST:

DQU:

CFO:

FEX:

PMEC:

138936306(Upset)

LHU:	105669787(upSET)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

TMOL:

138126551(upSET)

DPA:

109539550

ESIM:

136410767(upSET)

EFOR:

136349520(upSET)

SOY:

CSET:

HAXR:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209930

BANY:

PMAC:

PPOT:

PXU:

BPHI:

137931243(upSET)

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

LGLY:

CSTB:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

106683585(upSET)

NLU:

111049998

PHU:	Phum_PHUM494030

FOC:

TPAL:

ZNE:

DMK:

PVM:	113821425(upSET)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123771933(upSET)

PTRU:

HAZT:

EAF:

LSM:

PPOI:

RSAN:

VDE:

VJA:

LOA:	LOAG_17683

TSP:

Tsp_08530

HRO:	HELRODRAFT_182558

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

SMM:	Smp_161010

SHX:	MS3_00007773

OVI:	T265_13393

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

AQU:

Reference

PMID:14718661

Authors

Deng LW, Chiu I, Strominger JL

Title

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.

Journal

Proc Natl Acad Sci U S A 101:757-62 (2004)
DOI:10.1073/pnas.2036345100

Sequence

[hsa:55904]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

LinkDB

DBGET integrated database retrieval system