KEGG ORTHOLOGY: K09234

ORTHOLOGY: K09234

Entry

K09234                      KO

Symbol

WT1

Name

Wilms tumor protein 1

Pathway

map05202

Transcriptional misregulation in cancer

Disease

H00607

46,XY gonadal dysgenesis

H01657

Nephrotic syndrome

H01985

Desmoplastic small round cell tumor

H02301

Nephroblastoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09234  WT1; Wilms tumor protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09234  WT1; Wilms tumor protein 1
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys2His2 SP/KLF family and related proteins
    K09234  WT1; Wilms tumor protein 1

Genes

HSA:

7490(WT1)

PTR:	737987(WT1)

PPS:	100974201(WT1)

GGO:	101151613(WT1)

PON:	100437305(WT1)

PPYG:

129008994(WT1)

NLE:	100603690(WT1)

HMH:	116477276(WT1)

SSYN:

129484278(WT1)

MCC:	696061(WT1)

MCF:	102131274(WT1)

MTHB:

126936349

MNI:	105471510(WT1)

CSAB:

103238102(WT1)

CATY:

105586768(WT1)

PANU:

101023585(WT1)

TGE:	112606192(WT1)

MLEU:

105528718(WT1)

RRO:	104658375(WT1)

RBB:	108513839(WT1)

TFN:	117080428(WT1)

PTEH:

111554699(WT1)

CANG:

105507732(WT1)

CJC:	100399350(WT1)

SBQ:	101027475(WT1)

CIMI:

108293074(WT1)

ANAN:

105717246(WT1)

CSYR:

103276289(WT1)

MMUR:

105857490(WT1)

LCAT:

123642557(WT1)

PCOQ:

105814567(WT1)

OGA:	100963873(WT1)

MMU:	22431(Wt1)

MCAL:

110284108(Wt1)

MPAH:

110319022(Wt1)

RNO:	24883(Wt1)

MCOC:

116090592(Wt1)

ANU:	117703756(Wt1)

ASYL:

127685694(Wt1)

MUN:	110554034(Wt1)

CGE:	100767732(Wt1)

MAUA:

101841503(Wt1)

PROB:

127222163(Wt1)

PLEU:

114698984(Wt1)

MORG:

121465700(Wt1)

MFOT:

126504585

AAMP:

119814738(Wt1)

NGI:	103748712(Wt1)

HGL:	101714640(Wt1)

CPOC:

100716139(Wt1)

CCAN:

109676429(Wt1)

DORD:

105988076(Wt1)

DSP:	122117828(Wt1)

PLOP:

125361232(Wt1)

NCAR:

124958847

MMMA:

107158492(Wt1)

ITI:	101968244(Wt1)

OCU:

100346776

OPI:	101523928(WT1)

TUP:	102488718(WT1)

GVR:	103586659(WT1)

CFA:	609253(WT1)

CLUD:

112663429(WT1)

VVP:	112930596(WT1)

VLG:	121472240(WT1)

NPO:	129494218(WT1)

AML:	100479572(WT1)

UMR:	103659346(WT1)

UAH:	113265070(WT1)

UAR:	123799448(WT1)

ELK:

111149985

LLV:

125079622

MPUF:

101670628(WT1)

MNP:

132011297

MLK:

131810972

NVS:	122912819(WT1)

ORO:	101380701(WT1)

EJU:	114196927(WT1)

ZCA:	113914135(WT1)

MLX:	118015556(WT1)

NSU:	110575714(WT1)

LWW:	102732140(WT1)

FCA:	101088518(WT1)

PYU:	121043597(WT1)

PCOO:

112865604(WT1)

PBG:	122483665(WT1)

PVIV:

125177244(WT1)

LRUF:

124506227

LGF:	123601545(WT1)

AJU:

106970264

PTG:	102968959(WT1)

PPAD:

109271306(WT1)

PLEZ:

122199340(WT1)

HHV:	120232569(WT1)

BTA:	782183(WT1)

BOM:	102275862(WT1)

BIU:	109569932(WT1)

BBUB:

102392350(WT1)

CHX:	102180242(WT1)

OAS:	100101227(WT1)

BTAX:

128060467(WT1)

CSUM:

138092487(WT1)

ODA:	120876846(WT1)

CCAD:

122450189(WT1)

MREE:

136174244(WT1)

OVR:	110148980(WT1)

MBEZ:

129554725(WT1)

SSC:	397338(WT1)

CFR:	102507153(WT1)

CBAI:

105076534(WT1)

CDK:	105106916(WT1)

VPC:	102527261(WT1)

BACU:

103011643(WT1)

BMUS:

118898735(WT1)

LVE:	103069849(WT1)

OOR:	101288273(WT1)

LALB:

132525196(WT1)

DLE:	111179735(WT1)

PCAD:

102984207(WT1)

PSIU:

116757605(WT1)

NASI:

112404589(WT1)

ECB:	100072704(WT1)

EPZ:	103554490(WT1)

EAI:	106845261(WT1)

MYB:	102248003(WT1)

MYD:	102765339(WT1)

MMYO:

118664963(WT1)

MLF:	102422689(WT1)

MDT:	132241097(WT1)

MYUM:

139018986(WT1)

PKL:	118713347(WT1)

EFUS:

103292685(WT1)

MNA:	107531929(WT1)

DRO:	112303411(WT1)

SHON:

118983141(WT1)

AJM:	119036446(WT1)

PDIC:

114501003(WT1)

PHAS:

123810138(WT1)

MMF:	118628279(WT1)

PPAM:

129080734(WT1)

HAI:	109381159(WT1)

RFQ:	117030486(WT1)

PALE:

102878723(WT1)

PGIG:

120605532(WT1)

PVP:	105293703(WT1)

RAY:	107512013(WT1)

MJV:

118972613

TOD:	119255388(WT1)

SARA:

101558423(WT1)

SFUM:

130043959(WT1)

SETR:

126018587(WT1)

LAV:	100675763(WT1)

TMU:

101356687

ETF:	101644471(WT1)

DNM:	101434045(WT1)

MDO:	100031140(WT1)

GAS:	123251425(WT1)

SHR:	100917886(WT1)

AFZ:

127541531

PCW:	110192617(WT1)

TVP:	118854053(WT1)

PBRV:

138163419(WT1)

OAA:	100075190(WT1)

TACU:

119943979(WT1)

GGA:	101747322(WT1)

PCOC:

116237812(WT1)

MGP:	100545785(WT1)

CJO:	107314356(WT1)

TPAI:

128085300(WT1)

LMUT:

125695547(WT1)

NMEL:

110401164(WT1)

APLA:

101799253(WT1)

ACYG:

106033899(WT1)

CATA:

118249790(WT1)

AFUL:

116490192(WT1)

TGU:	100222371(WT1)

LSR:	110482319(WT1)

SCAN:

103822096(WT1)

PMOA:

120509917(WT1)

OTC:	121345930(WT1)

PRUF:

121350431(WT1)

ATRC:

139604203(WT1)

GFR:	102040840(WT1)

FAB:	101809124(WT1)

OMA:	130254348(WT1)

PHI:	102101293(WT1)

PMAJ:

107206258(WT1)

CCAE:

111930454(WT1)

ACOE:

138111189(WT1)

ETL:	114066784(WT1)

ZAB:	102071781(WT1)

ZLE:	135449106(WT1)

SVG:	106858113(WT1)

MMEA:

130581722(WT1)

HRT:	120754317(WT1)

SATI:

136362182(WT1)

CCIC:

134044902(WT1)

FPG:	101922515(WT1)

FCH:	102051128(WT1)

CCRI:

104158570

SHAB:

115607635(WT1)

ACUN:

113481234(WT1)

TALA:

116965091(WT1)

ACHC:

115351989(WT1)

HALD:

104325038

HLE:	104829480(WT1)

AGEN:

126046953

HHAR:

128152777(WT1)

GCL:

127016884

MNB:

103780272

DPUB:

104296689(WT1)

PPUS:

135186241(WT1)

AVIT:

104280291

EGZ:	104133518(WT1)

NNI:	104009509(WT1)

PADL:

103925805(WT1)

CBOY:

140652923(WT1)

CLV:	102086762(WT1)

PLET:

104618441

CMAC:

104485547

CUCA:

104060315(WT1)

OHA:	104331821(WT1)

CPEA:

104394648(WT1)

CVF:	104293212(WT1)

RTD:	128908675(WT1)

CRID:

134514748(WT1)

AAM:

106498269

AROW:

112976435(WT1)

NPD:	112948847(WT1)

TGT:	104574218(WT1)

DNE:	112996470(WT1)

SCAM:

104146436(WT1)

ASN:	102381580(WT1)

AMJ:	102563352(WT1)

CPOO:

109321137(WT1)

GGN:	109299044(WT1)

PSS:	102461242(WT1)

CMY:	102937751(WT1)

CCAY:

125638470(WT1)

DCC:	119856661(WT1)

CPIC:

101950000

TST:	117877119(WT1)

CABI:

116836126(WT1)

MRV:	120404222(WT1)

ACS:	100556165(wt1)

ASAO:

132761079(WT1)

PVT:	110080052(WT1)

SUND:

121919897(WT1)

PBI:	103066534(WT1)

PMUR:

107298605 107300822(WT1)

CTIG:

120313750(WT1)

TSR:	106555553(WT1)

PGUT:

117665379(WT1)

APRI:

131195495(WT1)

PTEX:

113438836(WT1)

NSS:	113410193(WT1)

VKO:	123021405(WT1)

PMUA:

114597420(WT1)

PRAF:

128414633(WT1)

ZVI:	118088359(WT1)

HCG:	128341097(WT1)

GJA:	107109060(WT1)

EMC:	129324323(WT1)

XLA:	373588(wt1.S) 378664(wt1.L)

XTR:	100216184(wt1)

NPR:	108796326(WT1)

RTEM:

120917197(WT1)

BBUF:

120980857(WT1)

BGAR:

122921020(WT1)

PWL:	138284578(WT1)

MUO:	115468729(WT1)

GSH:	117352176(WT1)

DRE:	30245(wt1a) 568416(wt1b)

SRX:	107707426 107717629 107739799 107758040

SANH:

107670615 107673204 107674952 107686651(wt1)

SGH:	107573023 107575657 107589215(wt1) 107602104

CCAR:

109069415(wt1b) 109070572 109087437(wt1a) 109103929

CAUA:

113043049 113043132 113061714 113070199 113118661

CGIB:

127934358 127946962 127976928 128014276

PTET:

122330282(wt1a) 122362887(wt1b)

LROH:

127156857(wt1a) 127180411(wt1b)

OMC:	131524345(wt1b) 131534171(wt1a)

PPRM:

120459926(wt1b) 120460387(wt1a)

RKG:	130070030(wt1b) 130085253(wt1a)

MAMB:

125247532(wt1a) 125254311(wt1b)

CIDE:

127500160 127507198

CERY:

137015440(wt1a) 137023073(wt1b)

MASI:

127416960 127435631 127437574 127455761

TROS:

130551880(wt1a) 130562448(wt1b)

TDW:	130414228(wt1a) 130435404(wt1b)

MANU:

129419677(wt1b) 129433787(wt1a)

PDAB:

135741693 135758822 135773327 135781286

IPU:	108264570(wt1b) 108268387(wt1a)

IFU:	128606533(wt1b) 128611667(wt1a)

PHYP:

113526949 113546516(wt1)

SMEO:

124386037(wt1a) 124396026(wt1b)

TFD:	113635888(wt1a) 113639373(wt1b)

TVC:	132850989(wt1b) 132855689(wt1a)

CGAR:

128527713(wt1b) 128531509(wt1a)

NGRA:

132887396(wt1b) 132890256(wt1a)

TRN:	134319123(wt1a) 134323578(wt1b)

AMEX:

103045853(wt1a) 107197440(wt1b)

CMAO:

118806622(wt1a) 118818166(wt1b)

EEE:	113586682(wt1) 113587597

CHAR:

105889153(wt1b) 105910434(wt1a)

SPIL:

134094045(wt1a) 134095152(wt1b)

TRU:	101068345 101074610(wt1)

TFS:	130521704(wt1b) 130536431(wt1a)

TNG:	GSTEN00014905G001 GSTEN00025819G001

LCO:	104927739(wt1) 104938374

NCC:	104946642 104967373

TBEN:

117471577(wt1b) 117491688(wt1a)

CGOB:

115009859 115026697

PGEO:

117441274(wt1b) 117448298(wt1a)

GACU:

117536462(wt1b) 117561365(wt1a)

EMAC:

134858518(wt1a) 134862575(wt1b)

ELY:	117262834(wt1a) 117272754(wt1b)

EFO:	125887075(wt1a) 125903922(wt1b)

PLEP:

121942645(wt1b) 121950163(wt1a)

SLUC:

116057740 116060676(wt1b)

ECRA:

117943882(wt1b) 117949284

ESP:	116687424(wt1) 116694193

PFLV:

114553487(wt1) 114560273

GAT:	120809601 120812669(wt1b) 120812804

PPUG:

119196687(wt1a) 119198042(wt1b)

AFB:	129102526(wt1b) 129108044(wt1a)

CLUM:

117732285(wt1a) 117750803(wt1b)

PSWI:

130192553(wt1b) 130195158

CANA:

137783002(wt1b) 137804150(wt1a)

CVE:	137873392(wt1a) 137887683(wt1b)

MSAM:

119890258(wt1b) 119893280(wt1a)

SCHU:

122875251(wt1a) 122882221(wt1b)

CUD:	121508310(wt1b) 121515668(wt1a)

SPUL:

138611050(wt1b) 138612587(wt1a)

LMIX:

132973371(wt1a) 132977190(wt1b)

ALAT:

119018140(wt1b) 119024892(wt1a)

ASTR:

137592910(wt1b) 137593685

MZE:	101472020 101482946(wt1)

ONL:	100694473 100701078

OAU:	116330529(wt1a) 116333709(wt1b)

OLA:	100049268(wt1) 100125521(wt1)

OML:	112152632 112161268(wt1b)

CSAI:

133421074(wt1b) 133444643(wt1a)

XMA:	102219497(wt1) 102235611

XCO:	114142441(wt1) 114150221

XHE:	116711657 116718086(wt1)

PRET:

103462859(wt1) 103466359

PFOR:

103136535(wt1) 103142524

PLAI:

106950350(wt1) 106961822

PMEI:

106924253(wt1) 106931238

GAF:	122835802(wt1a) 122842746(wt1b)

PPRL:

129364433(wt1b) 129365239(wt1a)

CVG:	107084212(wt1) 107098481

CTUL:

119796843(wt1a) 119797568(wt1b)

GMU:	124861438(wt1a) 124867461(wt1b)

NFU:	107382066 107389222

KMR:	108246890 108250745(wt1b)

ALIM:

106513175 106520212

NWH:	119415490(wt1a) 119430041(wt1b)

AOCE:

111576960(wt1b) 111588765

EJA:	138206103(wt1a) 138213003(wt1b)

BFRE:

138617987(wt1b) 138630702(wt1a)

MCEP:

125004927(wt1b) 125015461(wt1a)

CSEM:

103379141(wt1)

POV:	109636727(wt1) 109641039

SSEN:

122772019(wt1b) 122776353

SSOE:

131460099(wt1b) 131470427

HHIP:

117759557(wt1b) 117763589(wt1a)

HSP:	118101010(wt1b) 118109028(wt1a)

PPLT:

128443628(wt1b) 128444370(wt1a)

SMAU:

118302494(wt1b) 118315164(wt1a)

LCF:	108877831(wt1b) 108902295

SDU:	111218254(wt1) 111222481

SLAL:

111645907 111655561

XGL:	120793062(wt1a) 120794050(wt1b)

HCQ:	109520029 109531578(wt1)

SSCV:

125967766(wt1b) 125970723(wt1a)

SBIA:

133497948(wt1b) 133501918(wt1a)

PEE:	133396400(wt1b) 133402965(wt1a)

PTAO:

133474371(wt1b) 133478174(wt1a)

BPEC:

110169439 110175506(wt1)

ENY:	140349002 140381371(wt1b)

MALB:

109962597 109969035

BSPL:

114852742(wt1b) 114857845(wt1a)

SJO:	128358425(wt1a) 128361746(wt1b)

SSCO:

133981541(wt1a) 133982907(wt1b)

GMH:	115551350 115558695(wt1)

SASA:

100380493(wt1) 106573231(wt1) 106587831

STRU:

115152274 115167455 115203486

OTW:	112218818(wt1a) 112238474(wt1b) 112240153 112252612

OMY:	100135951(wt-t1a) 100135952(wt-t1b) 100136619(wt1b) 118936274

OGO:	124003539 124025634 124034030

ONE:	115109626 115134018

OKI:	109867408(wt1) 109880379 109889594

OKE:	118401007(wt1a) 127929276(wt1b)

OMM:	135509097 135524155 135533836 135555677(wt1b)

OCLA:

139382741 139411715 139416322

SALP:

111953055 111962669(wt1) 112077430

SNH:	120049586(wt1b) 120054134 120066316

CCLU:

121532140(wt1a) 121548212 121576909

ELS:	105014200 105030317

OEP:	134020652(wt1a) 134028329(wt1b)

SFM:	108941307(wt1)

PKI:	111847525(wt1)

AANG:

118228526(wt1a)

AROT:

135242607 135255258(wt1a)

CCOG:

133111351(wt1a) 133130683

LOC:	102696228(wt1)

PSPA:

121294346(wt1a) 121329521

ARUT:

117432063 117434596

PSEX:

120526467

LCM:	102355188(WT1)

CMK:	103175043(wt1b)

RTP:	109911691(wt1b)

CPLA:

122557695(wt1b)

HOC:

132824245

LERI:

129705615(wt1b)

PMRN:

116939910

LRJ:	133350313(WT1)

BFO:

BBEL:

PCHN:

PCLA:

HRF:

AQU:

Reference

PMID:19123921

Authors

Weiss TC, Romaniuk PJ

Title

Contribution of individual amino acids to the RNA binding activity of the Wilms' tumor suppressor protein WT1.

Journal

Biochemistry 48:148-55 (2009)
DOI:10.1021/bi801586a

Sequence

[hsa:7490]

Reference

PMID:19416806

Authors

Rivera MN, Kim WJ, Wells J, Stone A, Burger A, Coffman EJ, Zhang J, Haber DA

Title

The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity.

Journal

Proc Natl Acad Sci U S A 106:8338-43 (2009)
DOI:10.1073/pnas.0811349106

Sequence

[hsa:7490]

LinkDB

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