KEGG   ORTHOLOGY: K09590
Entry
K09590                      KO                                     
Symbol
CYP85A1, BR6OX1
Name
brassinosteroid 6-oxygenase [EC:1.14.14.179]
Pathway
map00905  Brassinosteroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00371  Castasterone biosynthesis, plants, campesterol => castasterone
Reaction
R07450  6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (6alpha-hydroxylating)
R07451  6alpha-hydroxy-castasterone,NADPH---hemoprotein reductase:oxygen 6-oxidoreductase
R07455  6-deoxoteasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (teasterone-forming)
R07457  3-dehydro-6-deoxoteasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (3-dehydroteasterone-forming)
R07458  6-deoxotyphasterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (typhasterol-forming)
R10669  6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (castasterone-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00905 Brassinosteroid biosynthesis
    K09590  CYP85A1, BR6OX1; brassinosteroid 6-oxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K09590  CYP85A1, BR6OX1; brassinosteroid 6-oxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.179  brassinosteroid 6-oxygenase
     K09590  CYP85A1, BR6OX1; brassinosteroid 6-oxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP85 family
   K09590  CYP85A1, BR6OX1; brassinosteroid 6-oxygenase
Genes
ATH: AT5G38970(BR6OX1)
ALY: 9306879
CRB: 17880458
CSAT: 104719559 104724260 104732939
EUS: EUTSA_v10027742mg
BRP: 103864167
BNA: 106449738 125575048 125599608
BOE: 106339725
RSZ: 108837548
THJ: 104823884
CPAP: 110820131 110823995
CIT: 102613870 102627864
CIC: CICLE_v10011662mg CICLE_v10031449mg
PVY: 116109710 116132910
MINC: 123198264 123213958 123216775 123226215
TCC: 18601740 18610219
GRA: 105781807 105789387 105801672
GHI: 107894854 107910165 107919617 107954898 121219372 121232120
GAB: 108453607 108463311 108482799
HSYR: 120113986 120127048 120130453 120130527 120152241 120153181 120153818 120164120 120170916 120171060
DZI: 111283830 111306268 111313564 111317590
EGR: 104419439 104422041 104422043 104422045
RARG: 115753477 115755529
GMX: 100779967 100785414 100805958 100818004 100818290
GSJ: 114372680 114381879 114395015 114399240 114423881
PVU: 137805771 137825481 137837022
VRA: 106753400 106758156 106779292
VAR: 108326910 108335521 108344744
VUN: 114166182 114181354 114183716
VUM: 124819671 124832523 124839185
CCAJ: 109796264 109797613 109813276 109818989
APRC: 113861763 113867653 113869100 113869572
MTR: 11422367 25495426 25497603
TPRA: 123893063 123908660
CAM: 101509866 101510185 101510551
PSAT: 127115423 127115432 127120958 127128705
VVO: 131598744 131598753 131628644 131629940 131630104
LJA: 130728647 130735695 130735696 130739472
ADU: 107471377 107486576
AIP: 107623811 107637361
AHF: 112716544 112716545 112744628 112784627 112784628 112797930
LANG: 109330371 109335133 109347392 109359433 109359685 109360156
PCIN: 129289879 129306523 129311025 129311028
QSA: O6P43_004380 O6P43_009190 O6P43_032891
FVE: 101313910
AANS: 126799249
RCN: 112190949
PPER: 18782277
PMUM: 103329572
PAVI: 110759051
PDUL: 117623030
MDM: 103404651 103442442
MSYL: 126583959(LOC126583959) 126612490(LOC126612490)
PXB: 103926586 103962743
PCOX: 137707948 137739718
ZJU: 125421869
MNT: 21401153 21409111
CSAV: 115698729
HLP: 133817848
CSV: 101204494 101206858
CMO: 103495886 103498545
BHJ: 120079745
MCHA: 111006661
CMAX: 111487713 111489110
CMOS: 111445417 111455792
CPEP: 111788371 111808466
RCU: 8277307
MEAN: 126679480
JCU: 105630569 105646746
HBR: 110648160 110655288 110672384 110672390
MESC: 110609099 110615056 110619853
POP: 18107339 7468141 7480593
PEU: 105113937 105119329 105123253
PALZ: 118042705 118043350 118055061
PNZ: 133670623 133696644 133698949
JRE: 108987930 108989489
CILL: 122303021 122306104
CAVE: 132179667 132181229
AGLU: 133858764 133860886
QSU: 112004759 112006726
QLO: 115976259 115981444 115981445
CSAA: 142608806 142629248 142629249
TWL: 119993370 120011335 120017232
VVI: 100232983(BR6OX1) 100257818 100262943
VRI: 117923784 117925175 117929660
SLY: 100037489(CYP85A1)
SPEN: 107009077
SOT: 102603315
SSTN: 125849224
SDUL: 129875118
SVER: 125810749
CANN: 107860427
LBB: 132621167
NTA: 107760973 107776096 107780292 107789559
NSY: 104211653 104214321
NTO: 104092995 104103228
NAU: 109212730 109222927
INI: 109153620 109173064 109180625 109189067
ITR: 115999955 116013189 116013963 116019775
SIND: 105156751 105177542
OEU: 111374568 111381944 111409964
EGT: 105952596 105971548
SSPL: 121754265 121755396 121767430 121770076
SMIL: 130987156 130989766
SHIS: 125208620 125220261 125224420
APAN: 127244512 127258238 127263988
HPUM: 140864307 140887368
PHUA: 140963502 140969153 140970819 140974421
PEBU: 140806228 140816553 140821705 140826485 140837016
PTAB: 142506253 142533495 142546682 142549404 142549754
CARB: 113700162 113702447 113715687 113718612
HAN: 110911035 110921448
BHW: 143532084 143534581 143561359 143567298
ECAD: 122579005 122589730
LSV: 111876869(LOC111876869)
CCAV: 112513235(LOC112513235) 112515661(LOC112515661)
DCR: 108193941 108194607 108213230
AGRV: 141661669 141721131
CSIN: 114256381 114306437
RVL: 131301037 131304513 131336204
AEW: 130751052 130768177 130778234 130778892
DLT: 127803232 127810104
CFLO: 132284682 132302175 132316008
BVG: 104906946(LOC104906946)
SOE: 110793171
CQI: 110703563 110705784
CALB: 145556521(LOC145556521) 145592859(LOC145592859) 145594479(LOC145594479)
ATRI: 130802184 130803910
SLAF: 141612529 141629399
MOF: 131154317 131160507
NNU: 104597895 104599689 104609612
MING: 122075756 122078986
TSS: 122655820 122663736
PSOM: 113275767 113281843
OSA: 4333399(CYP85A1)
DOSA: Os03g0602300
OBR: 102700319
OGL: 127767630
BDI: 100837653
ATS: 109777766 109777767 109777768 109777769 109777770
TDC: 119352698 119352699 119358574 119358575 119360155 119361707 119361709 119366782 119366783
TAES: 123038724 123039915 123043102 123043103 123048178 123048179 123050998 123051000 123051001 123184190 123186954 123186955 123186956
TUA: 125534977 125540566 125540569 125540570
HVG: 123431500 123431503
LPER: 127333421
LRD: 124674413
SBI: 8062533
ZMA: 100193331
MFLO: 136520504 136523016 136523027 136531007
SITA: 101770408
SVS: 117838234
PVIR: 120650403 120692586
PHAI: 112875680
PAUA: 133912852 133915872 133920596
TANG: 140761987 140779778
CROT: 144572294
PDA: 103696100 103704209 103704493 103722877
EGU: 105046675 105056073 105057148 105058109
MUS: 135583353 135611339 135614115 135620035
ZOF: 121975689 122012212 122017716 122034502 122039599 122049062
DCT: 110095594 110112633
PEQ: 110030284 110033615 110034826 110039402
AOF: 109822473 109825906 109845117 109846361
MSIN: 131219410 131229521
ACAK: 137951923 137953250
NCOL: 116258091 116258773
ATR: 18446218 18446219
CJF: 131029741 131029742 131054376
PPP: 112292180
 » show all
Reference
PMID:11402205
  Authors
Shimada Y, Fujioka S, Miyauchi N, Kushiro M, Takatsuto S, Nomura T, Yokota T, Kamiya Y, Bishop GJ, Yoshida S
  Title
Brassinosteroid-6-oxidases from Arabidopsis and tomato catalyze multiple C-6 oxidations in brassinosteroid biosynthesis.
  Journal
Plant Physiol 126:770-9 (2001)
DOI:10.1104/pp.126.2.770
  Sequence
[ath:AT5G38970]
LinkDB

KEGG   ORTHOLOGY: K12640
Entry
K12640                      KO                                     
Symbol
CYP85A2, BR6OX2
Name
brassinosteroid 6-oxygenase / brassinolide synthase [EC:1.14.14.179 1.14.14.180]
Pathway
map00905  Brassinosteroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00371  Castasterone biosynthesis, plants, campesterol => castasterone
Reaction
R07450  6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (6alpha-hydroxylating)
R07451  6alpha-hydroxy-castasterone,NADPH---hemoprotein reductase:oxygen 6-oxidoreductase
R07455  6-deoxoteasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (teasterone-forming)
R07457  3-dehydro-6-deoxoteasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (3-dehydroteasterone-forming)
R07458  6-deoxotyphasterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (typhasterol-forming)
R07471  castasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (lactonizing, brassinolide-forming)
R08840  teasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (lactonizing, 7-oxateasterone-forming)
R08841  typhasterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (lactonizing, 7-oxatyphasterol-forming)
R10669  6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (castasterone-forming)
R10682  6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (brassinolide-forming)
R10683  6-deoxotyphasterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (7-oxatyphasterol-forming)
R10684  6-deoxoteasterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (7-oxateasterone-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00905 Brassinosteroid biosynthesis
    K12640  CYP85A2, BR6OX2; brassinosteroid 6-oxygenase / brassinolide synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12640  CYP85A2, BR6OX2; brassinosteroid 6-oxygenase / brassinolide synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.179  brassinosteroid 6-oxygenase
     K12640  CYP85A2, BR6OX2; brassinosteroid 6-oxygenase / brassinolide synthase
    1.14.14.180  brassinolide synthase
     K12640  CYP85A2, BR6OX2; brassinosteroid 6-oxygenase / brassinolide synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP85 family
   K12640  CYP85A2, BR6OX2; brassinosteroid 6-oxygenase / brassinolide synthase
Genes
ATH: AT3G30180(BR6OX2)
ALY: 9311596
CRB: 17885676
CSAT: 104710811 104780197 104790595
EUS: EUTSA_v10004156mg
BRP: 103837220 103854484 103875063
BNA: 106349108 106363995 106397123 106400040 106410433
BOE: 106301844 106316572
RSZ: 108807315 108825972 108849348
THJ: 104805522 104822777
Reference
PMID:12529536
  Authors
Shimada Y, Goda H, Nakamura A, Takatsuto S, Fujioka S, Yoshida S.
  Title
Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis.
  Journal
Plant Physiol 131:287-97 (2003)
DOI:10.1104/pp.013029
  Sequence
[ath:AT3G30180]
Reference
PMID:18685225
  Authors
Katsumata T, Hasegawa A, Fujiwara T, Komatsu T, Notomi M, Abe H, Natsume M, Kawaide H
  Title
Arabidopsis CYP85A2 catalyzes lactonization reactions in the biosynthesis of 2-deoxy-7-oxalactone brassinosteroids.
  Journal
Biosci Biotechnol Biochem 72:2110-7 (2008)
DOI:10.1271/bbb.80192
  Sequence
[ath:AT3G30180]
LinkDB

KEGG   ENZYME: 1.14.14.179
Entry
EC 1.14.14.179              Enzyme                                 
Name
brassinosteroid 6-oxygenase;
CYP85A1 (gene name);
CYP85A2 (gene name);
brassinosteroid 6-oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
6-deoxocastasterone,NADPH---hemoprotein reductase:oxygen 6-oxidoreductase (castasterone-forming)
Reaction(IUBMB)
6-deoxocastasterone + 2 O2 + 2 [reduced NADPH---hemoprotein reductase] = castasterone + 3 H2O + 2 [oxidized NADPH---hemoprotein reductase] (overall reaction) [RN:R10669];
(1a) 6-deoxocastasterone + O2 + [reduced NADPH---hemoprotein reductase] = 6alpha-hydroxy-6-deoxocastasterone + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R07450];
(1b) 6alpha-hydroxy-6-deoxocastasterone + O2 + [reduced NADPH---hemoprotein reductase] = castasterone + 2 H2O + [oxidized NADPH---hemoprotein reductase] [RN:R07451]
Reaction(KEGG)
R07450 R07451 R10669;
(other) R07455 R07457 R07458
Substrate
6-deoxocastasterone [CPD:C15802];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
6alpha-hydroxy-6-deoxocastasterone
Product
castasterone [CPD:C15794];
H2O [CPD:C00001];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
6alpha-hydroxy-6-deoxocastasterone
Comment
This cytochrome P-450 (heme thiolate) plant enzyme catalyses the C-6 hydoxylation of several brassinosteroid biosynthesis intermediates, and the further oxidation of the hydroxyl group to an oxo group. Substrates include 6-deoxocastasterone, 6-deoxotyphasterol, 3-dehydro-6-deoxoteasterone, and 6-deoxoteasterone. The CYP85A2 isozyme of Arabidopsis thaliana (but not the CYP85A1 isozyme) also catalyses the activity of EC 1.14.14.180, brassinolide synthase.
History
EC 1.14.14.179 created 2022
Pathway
ec00905  Brassinosteroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09590  brassinosteroid 6-oxygenase
K12640  brassinosteroid 6-oxygenase / brassinolide synthase
K25959  brassinosteroid 6-oxygenase / brassinolide synthase
Genes
ATH: AT3G30180(BR6OX2) AT5G38970(BR6OX1)
ALY: 9306879 9311596
CRB: 17880458 17885676
CSAT: 104710811 104719559 104724260 104732939 104780197 104790595
EUS: EUTSA_v10004156mg EUTSA_v10027742mg
BRP: 103837220 103854484 103864167 103875063
BNA: 106349108 106363995 106397123 106400040 106410433 106449738 125575048 125599608
BOE: 106301844 106316572 106339725
RSZ: 108807315 108825972 108837548 108849348
THJ: 104805522 104822777 104823884
CPAP: 110820131 110823995
CIT: 102613870 102627864
CIC: CICLE_v10011662mg CICLE_v10031449mg
PVY: 116109710 116132910
MINC: 123198264 123213958 123216775 123226215
TCC: 18601740 18610219
GRA: 105781807 105789387 105801672
GHI: 107894854 107910165 107919617 107954898 121219372 121232120
GAB: 108453607 108463311 108482799
HSYR: 120113986 120127048 120130453 120130527 120152241 120153181 120153818 120164120 120170916 120171060
DZI: 111283830 111306268 111313564 111317590
EGR: 104419439 104422041 104422043 104422045
RARG: 115753477 115755529
GMX: 100779967 100785414 100805958 100818004 100818290
GSJ: 114372680 114381879 114395015 114399240 114423881
PVU: 137805771 137825481 137837022
VRA: 106753400 106758156 106779292
VAR: 108326910 108335521 108344744
VUN: 114166182 114181354 114183716
VUM: 124819671 124832523 124839185
CCAJ: 109796264 109797613 109813276 109818989
APRC: 113861763 113867653 113869100 113869572
MTR: 11422367 25495426 25497603
TPRA: 123893063 123908660
CAM: 101509866 101510185 101510551
PSAT: 127115423 127115432 127120958 127128705
VVO: 131598744 131598753 131628644 131629940 131630104
LJA: 130728647 130735695 130735696 130739472
ADU: 107471377 107486576
AIP: 107623811 107637361
AHF: 112716544 112716545 112744628 112784627 112784628 112797930
LANG: 109330371 109335133 109347392 109359433 109359685 109360156
PCIN: 129289879 129306523 129311025 129311028
QSA: O6P43_004380 O6P43_009190 O6P43_032891
FVE: 101313910
AANS: 126799249
RCN: 112190949
PPER: 18782277
PMUM: 103329572
PAVI: 110759051
PDUL: 117623030
MDM: 103404651 103442442
MSYL: 126583959(LOC126583959) 126612490(LOC126612490)
PXB: 103926586 103962743
PCOX: 137707948 137739718
ZJU: 125421869
MNT: 21401153 21409111
CSAV: 115698729
HLP: 133817848
CSV: 101204494 101206858
CMO: 103495886 103498545
BHJ: 120079745
MCHA: 111006661
CMAX: 111487713 111489110
CMOS: 111445417 111455792
CPEP: 111788371 111808466
RCU: 8277307
MEAN: 126679480
JCU: 105630569 105646746
HBR: 110648160 110655288 110672384 110672390
MESC: 110609099 110615056 110619853
POP: 18107339 7468141 7480593
PEU: 105113937 105119329 105123253
PALZ: 118042705 118043350 118055061
PNZ: 133670623 133696644 133698949
JRE: 108987930 108989489
CILL: 122303021 122306104
CAVE: 132179667 132181229
AGLU: 133858764 133860886
QSU: 112004759 112006726
QLO: 115976259 115981444 115981445
CSAA: 142608806 142629248 142629249
TWL: 119993370 120011335 120017232
VVI: 100232983(BR6OX1) 100257818 100262943
VRI: 117923784 117925175 117929660
SLY: 100037489(CYP85A1) 100136888(CYP85A3)
SPEN: 107009077 107010718
SOT: 102599687 102603315
SSTN: 125848344 125849224
SDUL: 129874522 129875118
SVER: 125810749
CANN: 107860427 107861006
LBB: 132621167
NTA: 107760973 107776096 107780292 107789559
NSY: 104211653 104214321
NTO: 104092995 104103228
NAU: 109212730 109222927
INI: 109153620 109173064 109180625 109189067
ITR: 115999955 116013189 116013963 116019775
SIND: 105156751 105177542
OEU: 111374568 111381944 111409964
EGT: 105952596 105971548
SSPL: 121754265 121755396 121767430 121770076
SMIL: 130987156 130989766
SHIS: 125208620 125220261 125224420
APAN: 127244512 127258238 127263988
HPUM: 140864307 140887368
PHUA: 140963502 140969153 140970819 140974421
PEBU: 140806228 140816553 140821705 140826485 140837016
PTAB: 142506253 142533495 142546682 142549404 142549754
CARB: 113700162 113702447 113715687 113718612
HAN: 110911035 110921448
BHW: 143532084 143534581 143561359 143567298
ECAD: 122579005 122589730
LSV: 111876869(LOC111876869)
CCAV: 112513235(LOC112513235) 112515661(LOC112515661)
DCR: 108193941 108194607 108213230
AGRV: 141661669 141721131
CSIN: 114256381 114306437
RVL: 131301037 131304513 131336204
AEW: 130751052 130768177 130778234 130778892
DLT: 127803232 127810104
CFLO: 132284682 132302175 132316008
BVG: 104906946(LOC104906946)
SOE: 110793171
CQI: 110703563 110705784
CALB: 145556521(LOC145556521) 145592859(LOC145592859) 145594479(LOC145594479)
ATRI: 130802184 130803910
SLAF: 141612529 141629399
MOF: 131154317 131160507
NNU: 104597895 104599689 104609612
MING: 122075756 122078986
TSS: 122655820 122663736
PSOM: 113275767 113281843
OSA: 4333399(CYP85A1)
DOSA: Os03g0602300
OBR: 102700319
OGL: 127767630
BDI: 100837653
ATS: 109777766 109777767 109777768 109777769 109777770
TDC: 119352698 119352699 119358574 119358575 119360155 119361707 119361709 119366782 119366783
TAES: 123038724 123039915 123043102 123043103 123048178 123048179 123050998 123051000 123051001 123184190 123186954 123186955 123186956
TUA: 125534977 125540566 125540569 125540570
HVG: 123431500 123431503
LPER: 127333421
LRD: 124674413
SBI: 8062533
ZMA: 100193331
MFLO: 136520504 136523016 136523027 136531007
SITA: 101770408
SVS: 117838234
PVIR: 120650403 120692586
PHAI: 112875680
PAUA: 133912852 133915872 133920596
TANG: 140761987 140779778
CROT: 144572294
PDA: 103696100 103704209 103704493 103722877
EGU: 105046675 105056073 105057148 105058109
MUS: 135583353 135611339 135614115 135620035
ZOF: 121975689 122012212 122017716 122034502 122039599 122049062
DCT: 110095594 110112633
PEQ: 110030284 110033615 110034826 110039402
AOF: 109822473 109825906 109845117 109846361
MSIN: 131219410 131229521
ACAK: 137951923 137953250
NCOL: 116258091 116258773
ATR: 18446218 18446219
CJF: 131029741 131029742 131054376
PPP: 112292180
 » show all
Reference
1  [PMID:11402205]
  Authors
Shimada Y, Fujioka S, Miyauchi N, Kushiro M, Takatsuto S, Nomura T, Yokota T, Kamiya Y, Bishop GJ, Yoshida S
  Title
Brassinosteroid-6-oxidases from Arabidopsis and tomato catalyze multiple C-6 oxidations in brassinosteroid biosynthesis.
  Journal
Plant Physiol 126:770-9 (2001)
DOI:10.1104/pp.126.2.770
  Sequence
[ath:AT5G38970] [sly:100037489]
Reference
2  [PMID:21364326]
  Authors
Perez-Espana VH, Sanchez-Leon N, Vielle-Calzada JP.
  Title
CYP85A1 is required for the initiation of female gametogenesis in Arabidopsis thaliana.
  Journal
Plant Signal Behav 6:321-6 (2011)
DOI:10.4161/psb.6.3.13206
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.179
IUBMB Enzyme Nomenclature: 1.14.14.179
ExPASy - ENZYME nomenclature database: 1.14.14.179
BRENDA, the Enzyme Database: 1.14.14.179
LinkDB

KEGG   REACTION: R07458
Entry
R07458                      Reaction                               
Name
6-deoxotyphasterol,NADPH---hemoprotein reductase:oxygen oxidoreductase (typhasterol-forming)
Definition
6-Deoxotyphasterol + 2 Oxygen + 2 [Reduced NADPH---hemoprotein reductase] <=> Typhasterol + 3 H2O + 2 [Oxidized NADPH---hemoprotein reductase]
Equation
C15801 + 2 C00007 + 2 C03024 <=> C15793 + 3 C00001 + 2 C03161
Comment
possibly two-step reaction (similar to R10669, R07450+R07451)
Reaction class
RC02079  C15793_C15801
Enzyme
1.14.14.179
Pathway
rn00905  Brassinosteroid biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.179
     R07458  6-Deoxotyphasterol + 2 Oxygen + 2 [Reduced NADPH---hemoprotein reductase] <=> Typhasterol + 3 H2O + 2 [Oxidized NADPH---hemoprotein reductase]
Orthology
K09590  brassinosteroid 6-oxygenase [EC:1.14.14.179]
K12640  brassinosteroid 6-oxygenase / brassinolide synthase [EC:1.14.14.179 1.14.14.180]
Other DBs
RHEA: 70038
LinkDB

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