KEGG ORTHOLOGY: K10106

ORTHOLOGY: K10106

Entry

K10106                      KO

Symbol

GGCX

Name

vitamin K-dependent gamma-carboxylase [EC:4.1.1.90]

Pathway

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01240

Biosynthesis of cofactors

Reaction

R05144

peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing)

R09991

peptidyl-glutamate 4-carboxylase (menaquinone-epoxidizing)

Disease

H00560

Pseudoxanthoma elasticum

H00995

Combined deficiency of vitamin K-dependent clotting factors

H01205

Coumarin resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K10106  GGCX; vitamin K-dependent gamma-carboxylase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.90  peptidyl-glutamate 4-carboxylase
     K10106  GGCX; vitamin K-dependent gamma-carboxylase

Other DBs

GO:

0008488

Genes

HSA:	2677(GGCX)

PTR:	459364(GGCX)

PPS:	100979139(GGCX)

GGO:	101133597(GGCX)

PON:	100171564(GGCX)

PPYG:

129030258(GGCX)

NLE:	100605566(GGCX)

HMH:	116484114(GGCX)

SSYN:

129463072(GGCX)

MCC:	695628(GGCX)

MCF:	102116153(GGCX)

MTHB:

126933385

MNI:	105465382(GGCX)

CSAB:

103219944(GGCX)

CATY:

105587647(GGCX)

PANU:

101020748(GGCX)

TGE:	112636902(GGCX)

MLEU:

105528850(GGCX)

RRO:	104677047(GGCX)

RBB:	108518115(GGCX)

TFN:	117062132(GGCX)

PTEH:

111551132(GGCX)

CANG:

105527602(GGCX)

CJC:	100412061(GGCX)

SBQ:	101035344(GGCX)

CIMI:

108295705(GGCX)

ANAN:

105731250(GGCX)

CSYR:

103250138(GGCX)

MMUR:

105876590(GGCX)

LCAT:

123637123(GGCX)

ERUF:

138400159(GGCX)

PCOQ:

105810269(GGCX)

OGA:	100953290(GGCX)

MMU:	56316(Ggcx)

MCAL:

110295983(Ggcx)

MPAH:

110315938(Ggcx)

RNO:	81716(Ggcx)

MCOC:

116099081(Ggcx)

ANU:	117714830(Ggcx)

ASYL:

127678779(Ggcx)

MUN:	110558893(Ggcx)

CGE:	100774482(Ggcx)

MAUA:

101823033(Ggcx)

PROB:

127235720(Ggcx)

PLEU:

114681594(Ggcx)

PMAV:

102908949(Ggcx)

MORG:

121441057(Ggcx)

MFOT:

126495260

AAMP:

119806379(Ggcx)

CNL:	130869674(Ggcx)

NGI:	103739792(Ggcx)

HGL:	101703456(Ggcx)

CPOC:

100730272(Ggcx)

CCAN:

109686177(Ggcx)

DORD:

106000221(Ggcx)

DSP:	122116883(Ggcx)

DMER:

138804693(Ggcx) 138825207

PLOP:

125356225(Ggcx)

NCAR:

124963392

MMMA:

107159715(Ggcx)

ITI:	101955634(Ggcx)

OCU:

100346091

OPI:	101522968(GGCX)

OCZ:	121165129(GGCX)

TUP:	102479702(GGCX)

GVR:	103594511(GGCX)

CFA:	475769(GGCX)

CLUD:

112664313(GGCX)

VVP:	112916676(GGCX)

VLG:	121491115(GGCX)

NPO:	129510836(GGCX)

AML:	100477985(GGCX)

UMR:	103671848(GGCX)

UAH:	113243151(GGCX)

UAR:	123799658(GGCX)

ELK:	111147897 111148155

LLV:

125110018

MPUF:

101674852(GGCX)

MNP:	132021398(GGCX)

MLK:	131840388(GGCX)

NVS:	122915050(GGCX)

ORO:	101380661(GGCX)

EJU:	114203728 114203729

ZCA:	113937957(GGCX)

MLX:	118007911(GGCX)

MANO:

123851112(GGCX)

NSU:	110587403(GGCX)

LWW:	102747287(GGCX)

FCA:	101085622(GGCX)

PYU:	121019159(GGCX)

PCOO:

112868883(GGCX)

PBG:	122497107(GGCX)

PVIV:

125161931(GGCX)

LRUF:

124503019

LGF:	123581049(GGCX)

AJU:

106978202

PTG:	102962433(GGCX)

PPAD:

109263806(GGCX)

PUC:

125937401

PLEZ:

122216270(GGCX)

HHV:	120220500(GGCX)

CCRU:

144221453(GGCX)

BTA:	281190(GGCX)

BOM:	102277857(GGCX)

BIU:	109566174(GGCX)

BBUB:

102393009(GGCX)

BKE:	129623187(GGCX)

BBIS:

105004558(GGCX)

CHX:	102170242(GGCX)

OAS:	443129(GGCX)

BTAX:

128055800(GGCX)

CSUM:

138082305(GGCX)

ODA:	120851488(GGCX)

CCAD:

122441738(GGCX)

MREE:

136164319(GGCX)

OVR:	110134768(GGCX)

MBEZ:

129539212(GGCX)

SSC:	100620337(GGCX)

CFR:	102506387(GGCX)

CBAI:

105072101(GGCX)

CDK:	105104153(GGCX)

VPC:	102543119(GGCX)

BACU:

103007146(GGCX)

BMUS:

118905678(GGCX)

LVE:	103089680(GGCX)

OOR:	101285440(GGCX)

LALB:

132531747(GGCX)

GMF:	115842505(GGCX)

DDP:	132435275(GGCX)

DLE:	111165448(GGCX)

PCAD:

102985096(GGCX)

PSIU:

116764387(GGCX)

PPHC:

136133484(GGCX)

NASI:

112398960(GGCX)

ECB:	100067312(GGCX)

EPZ:	103548273(GGCX)

EAI:	106838601(GGCX)

MYB:	102242720(GGCX)

MYD:	102767774(GGCX)

MMYO:

118668788(GGCX)

MLF:	102429671(GGCX)

MDT:	132213144(GGCX)

MYUM:

139020050(GGCX)

PKL:	118717610(GGCX)

EFUS:

103299046(GGCX)

MNA:	107528662(GGCX)

DRO:	112302990(GGCX)

SHON:

118982322(GGCX)

AJM:	119059873(GGCX)

PDIC:

114499213(GGCX)

PHAS:

123811894(GGCX)

MMF:	118630499(GGCX)

PPAM:

129073956(GGCX)

HAI:	109371334(GGCX)

RFQ:	117032921(GGCX)

PALE:

102898204(GGCX)

PGIG:

120594588(GGCX)

PVP:	105298516(GGCX)

RAY:	107506180(GGCX)

MJV:	108405890(GGCX)

TOD:	119259131(GGCX)

SARA:

101551669(GGCX)

SFUM:

130026023(GGCX)

SETR:

126024482(GGCX)

LAV:	100675417(GGCX)

TMU:

101340769

ETF:	101638327(GGCX)

DNM:	101415430(GGCX)

MDO:	100030057(GGCX)

GAS:	123236676(GGCX)

SHR:	116421248(GGCX)

AFZ:

127547440

PCW:	110196278(GGCX)

TVP:	118843034(GGCX)

PBRV:

138171556(GGCX)

MLAO:

141495285(GGCX)

OAA:	100077833(GGCX)

TACU:

119934445(GGCX)

PCOC:

116231292(GGCX)

MGP:

104916860

CJO:	107323599(GGCX)

LMUT:

125685279(GGCX)

NMEL:

110387173(GGCX)

APLA:

119713508(GGCX)

AACU:

137845299(GGCX)

ACYG:

125181303(GGCX)

CATA:

118259321(GGCX)

AFUL:

116499300(GGCX)

TGU:	100221126(GGCX)

LSR:	110478265(GGCX)

PMOA:

120504920(GGCX)

OTC:	121346663(GGCX)

PRUF:

121359598(GGCX)

ATRC:

139585205(GGCX)

FAB:	101818545(GGCX)

OMA:	130261855(GGCX)

PHI:	102110670(GGCX)

PMAJ:

107213872(GGCX)

CCAE:

111944157(GGCX)

CCW:	104683151(GGCX)

CBRC:

103622636(GGCX)

ACOE:

138121831(GGCX)

ZLE:	135456860(GGCX)

SVG:	106862388(GGCX)

HRT:	120763962(GGCX)

SATI:

136372630(GGCX)

CCIC:

134054622(GGCX)

SHAB:

115602933(GGCX)

TALA:

116963810(GGCX)

ACHC:

115349897(GGCX)

AGEN:

126051622

HHAR:

128149927(GGCX)

BBUT:

142038345(GGCX)

PARX:

142068177(GGCX)

CBOR:

142093550(GGCX)

CBOY:

140643794(GGCX)

MAME:

142420153(GGCX)

CNIC:

135998416(GGCX)

CUCA:

128854642(GGCX)

RTD:	128900144(GGCX)

CRID:

134526582(GGCX)

LMIC:

141733309(GGCX)

AAM:	106493802(GGCX)

AROW:

112961654(GGCX)

DNE:	112995819(GGCX)

SCAM:

104148909(GGCX)

ASN:	102383382(GGCX)

AMJ:

106737680

CPOO:

109317369(GGCX)

GGN:	109295521(GGCX)

PSS:	102449866(GGCX)

CIZ:	142004350(GGCX)

CMY:	102930896(GGCX)

CCAY:

125626506(GGCX)

LKP:	140903610(GGCX)

NDS:	141978299(GGCX)

DCC:	119848794(GGCX)

CPIC:

101940387(GGCX)

TST:	117872830(GGCX)

CABI:

116830718(GGCX)

MRV:	120398325(GGCX)

ACS:	100555036(ggcx)

ASAO:

132782304(GGCX)

PVT:	110072205(GGCX)

SUND:

121933178(GGCX)

PBI:	103064362(GGCX)

PMUR:

107283246(GGCX)

CTIG:

120299414 120320110

TSR:	106550210(GGCX)

PGUT:

117673367(GGCX)

APRI:

131203635(GGCX)

PTEX:

113445859(GGCX)

NSS:	113423356(GGCX)

VKO:	123016752(GGCX)

PMUA:

114602665(GGCX)

PRAF:

128420033(GGCX)

ZVI:	118086699(GGCX)

HCG:	128333841(GGCX)

GJA:	107120342(GGCX)

STOW:

125441520(GGCX)

EMC:	129342338(GGCX)

XLA:	444473(ggcx.L)

XTR:	100144666(ggcx)

NPR:	108786501(GGCX)

RTEM:

120933026(GGCX)

ACAT:

141133025(GGCX)

PADS:

140322597(GGCX)

BBUF:

120986144(GGCX)

BGAR:

122927405(GGCX)

DTC:	141100243(GGCX)

HSQ:	130368066(GGCX)

PCOB:

134936751(GGCX)

PWL:	138266044(GGCX)

MUO:	115469238(GGCX)

GSH:	117362366(GGCX)

DRE:	557240(ggcX)

SRX:	107713363 107744113

SANH:

107686456 107688460

SGH:	107562573 107569403

CCAR:

109052005 109052006

CAUA:

113054121(ggcx)

CGIB:

128021367

PTET:

122352884(ggcx)

LROH:

127171708(ggcx)

GRF:	141299115(ggcx)

OMC:	131548403(ggcx)

PPRM:

120481998(ggcx)

RKG:	130087107(ggcx)

MAMB:

125256553(ggcx)

CIDE:

127520621

CERY:

137028843(ggcx)

MASI:

127432741

TROS:

130545668(ggcx)

TDW:	130411670(ggcx)

MANU:

129447196(ggcx)

PDAB:

135779641(ggcx)

IPU:

108276729

IFU:	128620095(ggcx)

PHYP:

113544161(ggcx)

SMEO:

124393922(ggcx)

TFD:	113661292(ggcx)

TVC:	132863129(ggcx)

CGAR:

128545635(ggcx)

NGRA:

132873861(ggcx)

TRN:	134332139(ggcx)

AMEX:

103037933(ggcx)

CMAO:

118824259(ggcx)

EEE:	113575128(ggcx)

CHAR:

105895502(ggcx)

SPIL:

134059425(ggcx)

ASAD:

121689795(ggcx)

TRU:	101067681(ggcx)

TFS:	130516896(ggcx)

TNG:	GSTEN00017326G001

LCO:	104923320(ggcx)

NCC:	104944448(ggcx)

TBEN:

117476452(ggcx)

CGOB:

115016566(ggcx)

PGEO:

117456244(ggcx)

GACU:

117558143(ggcx)

EMAC:

134868377(ggcx)

ELY:	117269650(ggcx)

EFO:	125905640(ggcx)

PLEP:

121959554(ggcx)

SLUC:

116035102(ggcx)

ECRA:

117959301(ggcx)

PFLV:

114571490(ggcx)

GAT:	120832229(ggcx)

PPUG:

119226506(ggcx)

AFB:	129102407(ggcx)

CLUM:

117740251(ggcx)

PSWI:

130205319(ggcx)

CANA:

137783823(ggcx)

CVE:	137868995(ggcx)

MSAM:

119914441(ggcx)

SCHU:

122866046(ggcx)

EARM:

139301142(ggcx)

CUD:	121524933(ggcx)

SPUL:

138602098(ggcx)

LMIX:

132992693(ggcx)

HTC:	141805335(ggcx)

ALAT:

119030073(ggcx)

ASTR:

137608296(ggcx)

PKLU:

139219148(ggcx)

MZE:	101484617(ggcx)

ONL:	100703429(ggcx)

OAU:	116322404(ggcx)

OLA:	101172424(ggcx)

OML:	112163202(ggcx)

CSAI:

133455290(ggcx)

XMA:	102224466(ggcx)

XCO:	114149555(ggcx)

XHE:	116724289(ggcx)

PRET:

103473687(ggcx)

PFOR:

103148465(ggcx)

PLAI:

106942210(ggcx)

PMEI:

106927956(ggcx)

GAF:	122846891(ggcx)

PPRL:

129366516(ggcx)

CVG:	107092698(ggcx)

CTUL:

119771594(ggcx)

GMU:	124872326(ggcx)

NFU:	107372879(ggcx)

KMR:	108232694(ggcx)

ALIM:

106514510(ggcx)

NWH:	119425080(ggcx)

AOCE:

111568361(ggcx)

EJA:	138207182(ggcx)

BFRE:

138623266(ggcx)

MCEP:

124996587(ggcX)

CSEM:

103390489(ggcx)

POV:	109626324(ggcx)

SSEN:

122781970(ggcx)

SSOE:

131446427(ggcx)

HHIP:

117772029(ggcx)

HSP:	118125659(ggcx)

PPLT:

128425268(ggcx)

SMAU:

118284516(ggcx)

LCF:

108879865

SDU:	111234176(ggcx)

SLAL:

111668085(ggcx)

XGL:	120806113(ggcx)

HCQ:	109513153(ggcx)

SSCV:

125980049(ggcx)

SBIA:

133490654(ggcx)

PEE:	133413348(ggcx)

PTAO:

133490262(ggcx)

BPEC:

110160481(ggcx)

ENY:	140368385(ggcx)

MALB:

109963473(ggcx)

BSPL:

114866779(ggcx)

SJO:	128380723(ggcx)

SSCO:

133995712(ggcx)

TTY:	137170367(ggcx)

GMH:	115541687(ggcx)

SASA:

106563193

STRU:

115204185(ggcx)

OTW:	112231088(ggcx)

OMY:

110509897

OGO:	124007218(ggcx)

ONE:

115101259

OKI:	109873963(ggcx)

OKE:

118385197

OMM:	135544373(ggcx)

OCLA:

139387883

SALP:

111964110(ggcx)

SNH:	120021309(ggcx)

SFON:

129864033

CCLU:

121541763(ggcx)

ELS:	105014991(ggcx)

OEP:	134034110(ggcx)

SFM:	108931977(ggcx)

PKI:	111849976(ggcx)

AANG:

118213230(ggcx)

AROT:

135239159(ggcx)

CCOG:

133142158(ggcx)

LOC:	102682147(ggcx)

PSPA:

121303076(ggcx)

ARUT:

117397839(ggcx) 117969799

PSEX:

120539376(ggcx)

LCM:	102360484(GGCX)

CMK:	103187831(ggcx)

CPUN:

140459787(ggcx)

HOC:	132836951(ggcx)

SCAU:

119957436(ggcx)

LERI:

129713416(ggcx)

HAKA:

140735519(ggcx)

PMRN:

116956866(GGCX)

BFO:	118417156 118425987

BBEL:

109465908 109473717

CIN:	780874(ggcx)

SCLV:

CLEP:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG13927(GC)

DER:

6545421

DSE:

6610356

DSI:	Dsimw501_GD13462(Dsim_GD13462)

DYA:	Dyak_GE20943

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12843

DAZ:

108614065

DNV:

108652044

DHE:

111602887

DVI:	6624515(GC)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119679660 119679680

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135955361(GC)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:	110675715 5575300

AALB:

109426646

ASUA:

134214661

CQU:	CpipJ_CPIJ007343

CPII:

CBRI:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108726254(GC)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:	139820609(Gc)

TAME:

143900288(Gc)

HST:

DQU:

CFO:

FEX:

PMEC:

138938101(Gc)

LHU:	105675652(GC)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

CTYP:

141535823(Gc)

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

138130968(GC)

SOY:	115883290 115888516

RFG:	143201944(GC)

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

PPYR:

OTU:

MSEX:

DPL:	KGM_210061

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137931211(GC)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

ECLR:

140750740(GC)

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141433841(GC)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

CLEC:

HHAL:

106691853(GC)

NLU:

111051519

LDA:	142331169(GC)

HVI:

124358251

MQU:

128986236

PHU:	Phum_PHUM216730

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138691225(GC)

SGRE:

126320553

BROR:

134529100

IEL:

124160705

HAMR:

139700668(GC)

FCD:

110841759

DPX:	DAPPUDRAFT_301381

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123759075(GC)

PTRU:

SPRM:

ESN:

MNZ:

MRJ:	136835414(GC)

PORN:

139764670(GC)

OOT:	143019975 143019982

DSV:

119438165

DALB:

135909398(GC)

RSAN:

RMP:

TUT:

DPTE:

DFR:	124489784(GC)

CSCU:

111628100

CVS:	136978552(GC)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LGI:	LOTGIDRAFT_182855

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:	124278444 124281086

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:	110441576 110455778 110455786 110467012

PMAX:

117318519 117339305

AIRR:

138323228 138326189 138326259

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:	135468967 135469175

LAK:	106156062 106176385

LLON:

135483141

NVE:	5510609 5513238

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114527632 114540605

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_24664 TRIADDRAFT_30063 TRIADDRAFT_30165

PSL:

Psta_4704

PLS:	VT03_27170

» show all

Reference

PMID:21239697

Authors

Tie JK, Jin DY, Straight DL, Stafford DW

Title

Functional study of the vitamin K cycle in mammalian cells.

Journal

Blood 117:2967-74 (2011)
DOI:10.1182/blood-2010-08-304303

LinkDB

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