Homo sapiens (human): 2677 Help Entry 2677              CDS       T01001                                  Symbol GGCX, VKCFD1 Name (RefSeq) gamma-glutamyl carboxylase   KO K10106   vitamin K-dependent gamma-carboxylase [EC:4.1.1.90] Organism hsa  Homo sapiens (human) Pathway hsa00130   Ubiquinone and other terpenoid-quinone biosynthesis hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors Disease H00560   Pseudoxanthoma elasticum H00995   Combined deficiency of vitamin K-dependent clotting factors H01205   Coumarin resistance Drug target Anisindione:  D07457 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09108 Metabolism of cofactors and vitamins    00130 Ubiquinone and other terpenoid-quinone biosynthesis     2677 (GGCX) Enzymes [BR:hsa01000]  4. Lyases   4.1  Carbon-carbon lyases    4.1.1  Carboxy-lyases     4.1.1.90  peptidyl-glutamate 4-carboxylase      2677 (GGCX) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  HTTM VKGC_lumenal_dom Cupin_2 Ppnp Motif Other DBs NCBI-GeneID:  2677 NCBI-ProteinID:  NP_000812 OMIM:  137167 HGNC:  4247 Ensembl:  ENSG00000115486 UniProt:  P38435 Structure PDBPDBj LinkDB All DBs Position 2:complement(85544720..85561493) Genome browser AA seq 758 aa AA seqDB search MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTD PASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYT IMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYW SVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSP FKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFS YVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRH QLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRT GELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQR IFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHL ENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYM YVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFL RRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEV TYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF NT seq 2277 nt NT seq  +upstreamnt  +downstreamnt atggcggtgtctgccgggtccgcgcggacctcgcccagctcagataaagtacagaaagac aaggctgaactgatctcagggcccaggcaggacagccgaatagggaaactcttgggtttt gagtggacagatttgtccagttggcggaggctggtgaccctgctgaatcgaccaacggac cctgcaagcttagctgtctttcgttttctttttgggttcttgatggtgctagacattccc caggagcgggggctcagctctctggaccggaaataccttgatgggctggatgtgtgccgc ttccccttgctggatgccctacgcccactgccacttgactggatgtatcttgtctacacc atcatgtttctgggggcactgggcatgatgctgggcctgtgctaccggataagctgtgtg ttattcctgctgccatactggtatgtgtttctcctggacaagacatcatggaacaaccac tcctatctgtatgggttgttggcctttcagctaacattcatggatgcaaaccactactgg tctgtggacggtctgctgaatgcccataggaggaatgcccacgtgcccctttggaactat gcagtgctccgtggccagatcttcattgtgtacttcattgcgggtgtgaaaaagctggat gcagactgggttgaaggctattccatggaatatttgtcccggcactggctcttcagtccc ttcaaactgctgttgtctgaggagctgactagcctgctggtcgtgcactggggtgggctg ctgcttgacctctcagctggtttcctgctcttttttgatgtctcaagatccattggcctg ttctttgtgtcctacttccactgcatgaattcccagcttttcagcattggtatgttctcc tacgtcatgctggccagcagccctctcttctgctcccctgagtggcctcggaagctggtg tcctactgcccccgaaggttgcaacaactgttgcccctcaaggcagcccctcagcccagt gtttcctgtgtgtataagaggagccggggcaaaagtggccagaagccagggctgcgccat cagctgggagctgccttcaccctgctctacctcctggagcagctattcctgccctattct cattttctcacccagggctataacaactggacaaatgggctgtatggctattcctgggac atgatggtgcactcccgctcccaccagcacgtgaagatcacctaccgtgatggccgcact ggcgaactgggctaccttaaccctggggtatttacacagagtcggcgatggaaggatcat gcagacatgctgaagcaatatgccacttgcctgagccgcctgcttcccaagtataatgtc actgagccccagatctactttgatatttgggtctccatcaatgaccgcttccagcagagg atttttgaccctcgtgtggacatcgtgcaggccgcttggtcaccctttcagcgcacatcc tgggtgcaaccactcttgatggacctgtctccctggagggccaagttacaggaaatcaag agcagcctagacaaccacactgaggtggtcttcattgcagatttccctggactgcacttg gagaattttgtgagtgaagacctgggcaacactagcatccagctgctgcagggggaagtg actgtggagcttgtggcagaacagaagaaccagactcttcgagagggagaaaaaatgcag ttgcctgctggtgagtaccataaggtgtatacgacatcacctagcccttcttgctacatg tacgtctatgtcaacactacagagcttgcactggagcaagacctggcatatctgcaagaa ttaaaggaaaaggtggagaatggaagtgaaacagggcctctacccccagagctgcagcct ctgttggaaggggaagtaaaagggggccctgagccaacacctctggttcagacctttctt agacgccaacaaaggctccaggagattgaacgccggcgaaatactcctttccatgagcga ttcttccgcttcttgttgcgaaagctctatgtctttcgccgcagcttcctgatgacttgt atctcacttcgaaatctgatattaggccgtccttccctggagcagctggcccaggaggtg acttatgcaaacttgagaccctttgaggcagttggagaactgaatccctcaaacacggat tcttcacattctaatcctcctgagtcaaatcctgatcctgtccactcagagttctga

DBGET integrated database retrieval system