KEGG   DISEASE: Coumarin resistance
Entry
H01205                      Disease                                

Name
Coumarin resistance;
Warfarin resistance
Description
Warfarin is widely prescribed anticoagulant for the prevention of thromboembolic diseases. However, its use is made difficult by the wide interindividual variation in dose required to achieve a therapeutic effect, the narrow therapeutic range, and the risk of serious bleeding. Warfarin dose requirement is influenced by factors such as intake of vitamin K, ethnicity, age, gender, and genetic factors. Warfarin acts through interference with the recycling of vitamin K in the liver. It has been reported that mutations in VKORC1, CYP2C9, and GGCX cause warfarin resistance.
Category
Inherited metabolic disease
Brite
Human diseases [BR:br08402]
 Congenital disorders of metabolism
  Other congenital disorders of metabolism
   H01205  Coumarin resistance
Pathway
hsa00982  Drug metabolism - cytochrome P450
Gene
VKORC1 [HSA:79001] [KO:K05357]
CYP2A6 [HSA:1548] [KO:K17683]
CYP2C9 [HSA:1559] [KO:K17719]
GGCX [HSA:2677] [KO:K10106]
Other DBs
MeSH: C563039
OMIM: 122700
Reference
  Authors
Osinbowale O, Al Malki M, Schade A, Bartholomew JR
  Title
An algorithm for managing warfarin resistance.
  Journal
Cleve Clin J Med 76:724-30 (2009)
DOI:10.3949/ccjm.76a.09062
Reference
  Authors
Wadelius M, Chen LY, Eriksson N, Bumpstead S, Ghori J, Wadelius C, Bentley D, McGinnis R, Deloukas P
  Title
Association of warfarin dose with genes involved in its action and metabolism.
  Journal
Hum Genet 121:23-34 (2007)
DOI:10.1007/s00439-006-0260-8
Reference
  Authors
Pelkonen O, Rautio A, Raunio H, Pasanen M
  Title
CYP2A6: a human coumarin 7-hydroxylase.
  Journal
Toxicology 144:139-47 (2000)
DOI:10.1016/S0300-483X(99)00200-0
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