KEGG ORTHOLOGY: K10138

ORTHOLOGY: K10138

Entry

K10138                      KO

Symbol

IGFBP3

Name

insulin-like growth factor-binding protein 3

Pathway

map04115

p53 signaling pathway

map04218

Cellular senescence

map04935

Growth hormone synthesis, secretion and action

map05202

Transcriptional misregulation in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
   04218 Cellular senescence
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
Membrane trafficking [BR:ko04131]
Endocytosis
  Others
   Insulin-like growth factor-binding proteins
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other cancer cells
   K10138  IGFBP3; insulin-like growth factor-binding protein 3

Other DBs

GO:

0005520

Genes

HSA:	3486(IGFBP3)

PTR:	463396(IGFBP3)

PPS:	100970241(IGFBP3)

GGO:	101129439(IGFBP3)

PPYG:

129040357(IGFBP3)

NLE:	100603785(IGFBP3)

HMH:	116812466(IGFBP3)

SSYN:

129489942(IGFBP3)

MCC:	696868(IGFBP3)

MCF:	102144139(IGFBP3)

MTHB:

126950174

MNI:	105494236(IGFBP3)

CSAB:

103226113(IGFBP3)

CATY:

105588318(IGFBP3)

PANU:

101026054(IGFBP3)

TGE:	112620335(IGFBP3)

RRO:	104671167(IGFBP3)

RBB:	108534795(IGFBP3)

TFN:	117073335(IGFBP3)

PTEH:

111552313(IGFBP3)

CANG:

105515089(IGFBP3)

CJC:	100393906(IGFBP3)

CIMI:

108301430(IGFBP3)

ANAN:

105721491(IGFBP3)

MMUR:

105870670(IGFBP3)

LCAT:

123647498(IGFBP3)

PCOQ:

105812488(IGFBP3)

OGA:	100949697(IGFBP3)

MMU:	16009(Igfbp3)

MCAL:

110305209(Igfbp3)

MPAH:

110330706(Igfbp3)

RNO:	24484(Igfbp3)

MCOC:

116070218(Igfbp3)

ANU:	117713128(Igfbp3)

ASYL:

127696205(Igfbp3)

MUN:	110555170(Igfbp3)

CGE:	100764858(Igfbp3)

MAUA:

101838522(Igfbp3) 101839104

PROB:

127233858(Igfbp3)

PLEU:

114693961(Igfbp3)

MORG:

121459914(Igfbp3)

MFOT:

126500794

AAMP:

119803267(Igfbp3)

NGI:	103741431(Igfbp3)

HGL:	101710997(Igfbp3) 101721052

CPOC:

100714097(Igfbp3)

CCAN:

109694875(Igfbp3)

DORD:

105998267(Igfbp3) 106002924

DSP:	122100040 122100935 122108733 122121599 122127665 122128073(Igfbp3)

PLOP:

125346639(Igfbp3)

NCAR:

124991742

MMMA:

107146075(Igfbp3)

ITI:	101965685(Igfbp3)

OCU:

127485419

OPI:	101533087(IGFBP3)

TUP:	102477021(IGFBP3)

GVR:	103599614(IGFBP3)

CFA:	100855619(IGFBP3)

CLUD:

112650981(IGFBP3)

VLG:	121490105(IGFBP3)

NPO:	129516210(IGFBP3)

AML:	105239315(IGFBP3)

UMR:	103674673(IGFBP3)

UAH:	113257692(IGFBP3)

UAR:	123789482(IGFBP3)

ELK:

111157077

LLV:

125081186

MPUF:

101679105(IGFBP3)

MNP:	132016090(IGFBP3)

MLK:	131829177(IGFBP3)

NVS:	122904660(IGFBP3)

ORO:	101376941(IGFBP3)

EJU:	114213702(IGFBP3)

ZCA:	113911843(IGFBP3)

FCA:	101080442(IGFBP3)

PYU:	121016980(IGFBP3)

PCOO:

112859777(IGFBP3)

PBG:	122487652(IGFBP3)

PVIV:

125161071(IGFBP3)

LRUF:

124522960

LGF:	123606173(IGFBP3)

AJU:

106968195

PTG:	102961146(IGFBP3)

PPAD:

109267951(IGFBP3)

PUC:

125930397

PLEZ:

122205284(IGFBP3)

HHV:	120238887(IGFBP3)

BTA:	282261(IGFBP3)

BOM:	102288361(IGFBP3)

BIU:	109557914(IGFBP3)

BBUB:

102395071(IGFBP3)

BBIS:

104980413(IGFBP3)

CHX:	102174541(IGFBP3)

OAS:	100286737(IGFBP3)

BTAX:

128046632(IGFBP3)

CSUM:

138079830(IGFBP3)

ODA:	120877471(IGFBP3)

CCAD:

122438512(IGFBP3)

MREE:

136170824(IGFBP3)

OVR:	110151949(IGFBP3)

MBEZ:

129552547(IGFBP3)

SSC:	448812(IGFBP3)

CFR:	102520723(IGFBP3)

CDK:	116150633(IGFBP3)

BACU:

102998097(IGFBP3)

BMUS:

118900960(IGFBP3)

LVE:	103082081(IGFBP3)

OOR:	101272404(IGFBP3)

LALB:

132524886(IGFBP3)

DLE:	111184577(IGFBP3)

PCAD:

102973604(IGFBP3)

PSIU:

116759438(IGFBP3)

ECB:	100034155(IGFBP3)

EPZ:	103550432(IGFBP3)

EAI:	123289215(IGFBP3)

MYB:	102257375(IGFBP3)

MYD:	102760273(IGFBP3)

MMYO:

118665885(IGFBP3)

MLF:	106696100(IGFBP3)

MDT:	132211220(IGFBP3)

MYUM:

139016596(IGFBP3)

PKL:	118727846(IGFBP3)

EFUS:

103303614(IGFBP3)

MNA:	107526006(IGFBP3)

SHON:

118983487(IGFBP3)

AJM:	119057336(IGFBP3)

PDIC:

114490249(IGFBP3)

PHAS:

123812162(IGFBP3)

MMF:	118620088(IGFBP3)

PPAM:

129068926(IGFBP3)

HAI:	109373013(IGFBP3)

RFQ:	117012511(IGFBP3)

PALE:

102891216(IGFBP3)

PGIG:

120589582(IGFBP3)

PVP:	105308301 105311774

RAY:	107512409(IGFBP3)

MJV:	108403510(IGFBP3)

TOD:	119231497(IGFBP3)

SARA:

101554973(IGFBP3)

SFUM:

130017596(IGFBP3)

SETR:

126031385(IGFBP3)

LAV:	100674990(IGFBP3)

TMU:

101355131

ETF:	101660698(IGFBP3)

DNM:	101412435(IGFBP3)

MDO:	100618843(IGFBP3)

GAS:	123243797(IGFBP3)

SHR:	100921412(IGFBP3)

AFZ:

127553634

PCW:	110197536(IGFBP3)

TVP:	118831497(IGFBP3)

PBRV:

138166974(IGFBP3)

OAA:	100076387(IGFBP3)

TACU:

119940014(IGFBP3)

GGA:	420790(IGFBP3)

PCOC:

116228272(IGFBP3)

MGP:	100539598(IGFBP3)

CJO:	107309787(IGFBP3)

TPAI:

128087793(IGFBP3)

LMUT:

125690892(IGFBP3)

NMEL:

110390830(IGFBP3)

APLA:

101803685(IGFBP3)

ACYG:

106046458(IGFBP3)

CATA:

118249661(IGFBP3)

AFUL:

116486000(IGFBP3)

TGU:	100220315(IGFBP3)

LSR:	110477392(IGFBP3)

SCAN:

103819376(IGFBP3)

PMOA:

120503534(IGFBP3)

OTC:	121333303(IGFBP3)

PRUF:

121356123(IGFBP3)

ATRC:

139591316(IGFBP3)

GFR:	102040735(IGFBP3)

FAB:	101814335(IGFBP3)

OMA:	130249929(IGFBP3)

PHI:	102109965(IGFBP3)

PMAJ:

107200870(IGFBP3)

CCAE:

111923695(IGFBP3)

CCW:	104689253(IGFBP3)

CBRC:

103622007

ACOE:

138106734(IGFBP3)

ETL:	114068393(IGFBP3)

ZAB:	102074776(IGFBP3)

ZLE:	135444020(IGFBP3)

ACHL:

103799654(IGFBP3)

SVG:	106853831(IGFBP3)

MMEA:

130574314(IGFBP3)

HRT:	120763034(IGFBP3)

SATI:

136363689(IGFBP3)

CCIC:

134047271(IGFBP3)

FPG:	101914410(IGFBP3)

FCH:	102056357(IGFBP3)

CCRI:

104166433(IGFBP3)

NNT:	104399198(IGFBP3)

SHAB:

115613560(IGFBP3)

ACUN:

113477277(IGFBP3)

TALA:

104356179(IGFBP3)

ACHC:

115353110(IGFBP3)

HLE:	104837757(IGFBP3)

AGEN:

126048596

HHAR:

128144901(IGFBP3)

GCL:

127013042

CSTI:

104549465(IGFBP3)

LDI:	104345759(IGFBP3)

MNB:	103773714(IGFBP3)

DPUB:

104298310(IGFBP3)

PPUS:

135189485(IGFBP3)

AVIT:

104267604

BRHI:

104488023(IGFBP3)

EGZ:	104125967(IGFBP3)

NNI:	104015392(IGFBP3)

PCRI:

104024281(IGFBP3)

PCAO:

104043690(IGFBP3)

PADL:

103916268(IGFBP3)

AFOR:

103904018(IGFBP3)

FGA:	104081576(IGFBP3)

GSTE:

104262179(IGFBP3)

CLV:	102098854(IGFBP3)

MUI:	104533880(IGFBP3)

PGUU:

104470206(IGFBP3)

PLET:

104618421(IGFBP3)

EHS:	104503136(IGFBP3)

CMAC:

104473157(IGFBP3)

CUCA:

104065927(IGFBP3)

TEO:	104382733(IGFBP3)

BREG:

104635724(IGFBP3)

OHA:	104334083(IGFBP3)

ACAR:

104519057(IGFBP3)

CPEA:

104392182(IGFBP3)

CVF:	104295317(IGFBP3)

RTD:	128906038(IGFBP3)

CRID:

134511545(IGFBP3)

AAM:	106492834(IGFBP3)

AROW:

112965168(IGFBP3)

NPD:	112942701(IGFBP3)

TGT:	104573628(IGFBP3)

DNE:	112997508(IGFBP3)

SCAM:

104150332(IGFBP3)

ASN:	102372891(IGFBP3)

AMJ:	102573354(IGFBP3)

CPOO:

109313100(IGFBP3)

GGN:	109291656(IGFBP3)

PSS:	102445995(IGFBP3)

CMY:	102936213(IGFBP3)

CCAY:

125631859(IGFBP3)

DCC:	119851932(IGFBP3)

CPIC:

101934995(IGFBP3)

TST:	117872637(IGFBP3)

CABI:

116834613(IGFBP3)

MRV:	120399123(IGFBP3)

ACS:	100565907(igfbp3)

ASAO:

132778509(IGFBP3)

PVT:	110088740(IGFBP3)

PBI:	103052169(IGFBP3)

PMUR:

107295282(IGFBP3)

TSR:	106551681(IGFBP3)

PGUT:

117664956(IGFBP3)

APRI:

131197789(IGFBP3)

PTEX:

113437372(IGFBP3)

NSS:	113421049(IGFBP3)

VKO:	123035469(IGFBP3)

PMUA:

114607066

PRAF:

128398539(IGFBP3)

ZVI:	118077661(IGFBP3)

HCG:	128331974(IGFBP3)

GJA:	107105599(IGFBP3)

STOW:

125441337(IGFBP3)

EMC:	129337560(IGFBP3)

BBUF:

121001966(IGFBP3)

BGAR:

122938679(IGFBP3)

PWL:	138267319(IGFBP3)

MUO:	115470307(IGFBP3)

GSH:	117353887(IGFBP3)

DRE:	403079(igfbp3)

SRX:	107712886 107755684

SANH:

107687177 107697441

SGH:	107559743 107581452

CCAR:

109113390 109113391

CAUA:

113063281 113121088

CGIB:

127938457 127983874

PTET:

122325179(igfbp3)

LROH:

127183434(igfbp3)

OMC:	131527755(igfbp3)

PPRM:

120493735(igfbp3)

RKG:	130096164(igfbp3)

MAMB:

125279130(igfbp3)

CIDE:

127502180

CERY:

137019403(igfbp3)

MASI:

127410401 127416443

TROS:

130566291(igfbp3)

TDW:	130434452(igfbp3)

MANU:

129429463(igfbp3)

PDAB:

135739040(igfbp3)

IPU:	100305016(igfbp3) 108268023

IFU:	128601050(igfbp3) 128610435

PHYP:

113545296 113547291

SMEO:

124377352(igfbp3) 124387769

TFD:	113662305 113664019(igfbp3)

TVC:	132843369(igfbp3) 132849007

CGAR:

128514947(igfbp3) 128522647

NGRA:

132881529 132882961(igfbp3)

TRN:	134312446 134320661(igfbp3)

AMEX:

103027084(igfbp3) 111194341

CMAO:

118815471(igfbp3)

EEE:	113582983 113588642(igfbp3)

CHAR:

105898458 105910822(igfbp3)

SPIL:

134099600 134102500(igfbp3)

TRU:	101075107(igfbp3) 115247245 115247338

TFS:	130528769 130538680(igfbp3)

TNG:	GSTEN00004782G001 GSTEN00012277G001

LCO:	104927720(igfbp3) 104929330

NCC:	104950566 104960607

TBEN:

117488867 117495959(igfbp3)

CGOB:

115007374 115022759

PGEO:

117445467(igfbp3) 117462513

GACU:

117558466 117560551(igfbp3)

EMAC:

134865994 134869792(igfbp3)

ELY:	117254459(igfbp3) 117272377

EFO:	125895337 125902035

PLEP:

121941129(igfbp3) 121951737

SLUC:

116038224(igfbp3) 116046041

ECRA:

117951099 117954819

ESP:	116695248 116699487

PFLV:

114561819 114565527

GAT:	120816582 120824119(igfbp3)

PPUG:

119209202 119217194(igfbp3)

AFB:	129088934 129094584(igfbp3)

CLUM:

117729588(igfbp3)

PSWI:

130193636(igfbp3) 130197938

CANA:

137782011 137793437

CVE:	137883489 137892842

MSAM:

119900263 119902051

SCHU:

122878309(igfbp3) 122887422

CUD:	121512269(igfbp3) 121520437

SPUL:

138607077(igfbp3) 138611713

LMIX:

132968461(igfbp3) 132979192

ALAT:

119010995 119028604(igfbp3)

ASTR:

137599200(igfbp3) 137612025

MZE:	101465250 101475198

ONL:	100702310 102082028

OAU:	116314525(igfbp3) 116318660

OLA:	101162674 101166253

OML:	112147859 112150763

CSAI:

133452759(igfbp3)

XMA:	102226624 102227338(igfbp3)

XCO:	114147198 114151072

XHE:	116722303 116725969(igfbp3)

PRET:

103463405(igfbp3) 103479557

PFOR:

103129638 103143000

PLAI:

106936141 106948623

PMEI:

106914435(igfbp6) 106925935

GAF:	122838014(igfbp3) 122841231

PPRL:

129362303 129376855(igfbp3)

CVG:	107083028 107092413

CTUL:

119787606(igfbp3) 119795715

GMU:	124870254 124874155

NFU:	107383917 107393047

KMR:	108239579 108248361(igfbp3)

ALIM:

106526014 106533982

NWH:	119407634(igfbp3) 119414206

AOCE:

111568688 111569879(igfbp3)

EJA:	138200355(igfbp3) 138202995

BFRE:

138617260 138631701(igfbp3)

MCEP:

125009199(igfbp3) 125011472

CSEM:

103396287 103399857

POV:	109639207 109641634 109643988

SSEN:

122777543 122780781

SSOE:

131463963 131466234

HHIP:

117760194(igfbp3) 117778085

HSP:	118118138 118120960

PPLT:

128455055(igfbp3)

SMAU:

118310527 118317720

LCF:	108879542(igfbp3) 108883419

SDU:	111227515 111231074

SLAL:

111670503 111671736

XGL:	120790603(igfbp3) 120799102

HCQ:	109521219 109524696

SSCV:

125970133 125985326

SBIA:

133503301 133510824

PEE:	133406700(igfbp3) 133411193

PTAO:

133480794(igfbp3) 133489519

BPEC:

110158832 110172249

ENY:	140353863 140356545

MALB:

109957706 109961275

BSPL:

114845183 114854703

SJO:	128361512 128369211

SSCO:

133984553 133990578

GMH:	115549529 115556122

SASA:

101448060(igfbp-3a1) 101448063(igfbp-3a2) 101448066(igfbp-3b1) 101448067(igfbp-3b2)

STRU:

115157128 115158654 115169642 115192277

OTW:	112226459 112248249 112251323(igfbp3) 112260576

OMY:	110508632 110521771 110524670(igfbp3) 110530431

OGO:	123996815(igfbp3) 124009764 124037163 124040909

ONE:	115101771 115114519 115145418

OKI:	109872345 109898102 116353052

OKE:	118372076 118381503(igfbp3) 118395122 118402010

OMM:	135512990 135513114(igfbp3) 135556216 135558793

OCLA:

139376143 139386638 139406783 139409429

SALP:

111956369 111971187 111979022 112070217

SNH:	120020194 120051896 120054303 120055572

CCLU:

121533870(igfbp3) 121535310 121540035 121581004

ELS:	105011949 105018684

OEP:	134012684 134036973

SFM:	108937708 108939070(igfbp3)

PKI:	111845974(igfbp3) 111850180

AANG:

118225902(igfbp3) 118233164

AROT:

135253966(igfbp3) 135260769

CCOG:

133126309(igfbp3) 133137553

LOC:	102688916(igfbp3)

PSPA:

121313143 121314512

ARUT:

117394456 117399925

PSEX:

120529516(igfbp3)

LCM:	102347870(IGFBP3)

CMK:	103190034(igfbp3)

RTP:	109910480(igfbp3)

CPLA:

122549911(igfbp3)

HOC:	132815736(igfbp3)

LERI:

129710303(igfbp3)

PMRN:

LRJ:

BBEL:

VDE:

VJA:

XEN:

Reference

PMID:12067807

Authors

Furstenberger G, Senn HJ

Title

Insulin-like growth factors and cancer.

Journal

Lancet Oncol 3:298-302 (2002)
DOI:10.1016/S1470-2045(02)00731-3

Reference

PMID:2464130

Authors

Wood WI, Cachianes G, Henzel WJ, Winslow GA, Spencer SA, Hellmiss R, Martin JL, Baxter RC

Title

Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.

Journal

Mol Endocrinol 2:1176-85 (1988)
DOI:10.1210/mend-2-12-1176

Sequence

[hsa:3486]

LinkDB

DBGET integrated database retrieval system