KEGG   ORTHOLOGY: K10251
Entry
K10251                      KO                                     
Symbol
HSD17B12, KAR, IFA38
Name
17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
Pathway
map00062  Fatty acid elongation
map00140  Steroid hormone biosynthesis
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01212  Fatty acid metabolism
Module
M00415  Fatty acid elongation in endoplasmic reticulum
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   00140 Steroid hormone biosynthesis
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   01040 Biosynthesis of unsaturated fatty acids
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
    1.1.1.330  very-long-chain 3-oxoacyl-CoA reductase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Other DBs
RN: R02352 R02353 R04681 R04682 R07759 R08945 R08980 R10826
COG: COG0300
GO: 0004303
Genes
HSA: 51144(HSD17B12)
PTR: 741010(HSD17B12)
PPS: 100971612(HSD17B12)
GGO: 101126579(HSD17B12)
PON: 100439025(HSD17B12)
NLE: 100600308(HSD17B12)
MCC: 106993263(HSD17B12)
MCF: 101867269(HSD17B12)
CSAB: 103237147(HSD17B12)
CATY: 105586834(HSD17B12)
PANU: 101021809(HSD17B12)
TGE: 112607175(HSD17B12)
RRO: 104673891(HSD17B12)
RBB: 108519261(HSD17B12)
TFN: 117081598(HSD17B12)
PTEH: 111544940(HSD17B12)
CJC: 100399351(HSD17B12)
SBQ: 101037623(HSD17B12)
CSYR: 103268187(HSD17B12)
MMUR: 105885553(HSD17B12)
OGA: 100948449(HSD17B12)
MMU: 56348(Hsd17b12)
MCAL: 110306681(Hsd17b12)
MPAH: 110318386(Hsd17b12)
RNO: 84013(Hsd17b12)
MCOC: 116090525(Hsd17b12)
MUN: 110540580(Hsd17b12)
CGE: 100751291(Hsd17b12)
MAUA: 101841032(Hsd17b12) 121138620
PLEU: 114699733(Hsd17b12)
MORG: 121440572(Hsd17b12)
NGI: 103746669(Hsd17b12)
HGL: 101706276 101717552(Hsd17b12)
CPOC: 100730531(Hsd17b12)
CCAN: 109700741(Hsd17b12)
DORD: 105993803 105996070(Hsd17b12)
DSP: 122100741(Hsd17b12)
NCAR: 124958518
OCU: 100346603(HSD17B12) 103347152
OPI: 101516180(HSD17B12)
TUP: 102495234(HSD17B12)
CFA: 475939(HSD17B12)
VVP: 112914444(HSD17B12)
VLG: 121471458(HSD17B12)
AML: 100484147(HSD17B12)
UMR: 103672348(HSD17B12)
UAH: 113265017(HSD17B12)
UAR: 123799601(HSD17B12)
ELK: 111149694
MPUF: 101675135(HSD17B12)
ORO: 101367938(HSD17B12)
EJU: 114215274(HSD17B12)
ZCA: 113913485(HSD17B12) 113920142
MLX: 118015780(HSD17B12)
FCA: 101082595(HSD17B12)
PYU: 121043519(HSD17B12)
PBG: 122483721(HSD17B12)
PTG: 102963001(HSD17B12)
PPAD: 109279204(HSD17B12)
AJU: 106978054(HSD17B12)
HHV: 120228431(HSD17B12)
BTA: 508455 789567(HSD17B12)
BOM: 102274407(HSD17B12) 102278627
BIU: 109569664(HSD17B12) 109572870
BBUB: 102394606 102395741(HSD17B12)
CHX: 102169696 102186887(HSD17B12)
OAS: 101110086(HSD17B12) 101112590 114109406
ODA: 120872318 120876903(HSD17B12)
CCAD: 122421629 122450094(HSD17B12)
SSC: 100312972(HSD17B12)
CFR: 102505228 102515430(HSD17B12)
CBAI: 105062508 105076771(HSD17B12)
CDK: 105095461 105106832(HSD17B12)
VPC: 102543324(HSD17B12)
BACU: 102998439(HSD17B12)
LVE: 103068441(HSD17B12)
OOR: 101273198 101279942(HSD17B12)
DLE: 111180753 111184015(HSD17B12)
PCAD: 102977062(HSD17B12) 102995699
PSIU: 116757883(HSD17B12)
ECB: 100050075(HSD17B12) 100070719
EPZ: 103556451(HSD17B12) 103566841
EAI: 106843965(HSD17B12) 106848436
MYB: 102263289 102263627(HSD17B12)
MYD: 102758451 102766960(HSD17B12)
MMYO: 118665112(HSD17B12) 118674807
MLF: 102423611(HSD17B12)
MNA: 107525487(HSD17B12) 107536738
PKL: 118706806 118713576(HSD17B12)
HAI: 109391968(HSD17B12)
DRO: 112303253(HSD17B12) 112312939
SHON: 118996351 119002958(HSD17B12)
AJM: 119064415(HSD17B12)
PDIC: 114499782(HSD17B12)
PHAS: 123810137(HSD17B12)
MMF: 118627767(HSD17B12)
RFQ: 117030394(HSD17B12)
PALE: 102889386(HSD17B12)
PGIG: 120606234(HSD17B12)
PVP: 105289991(HSD17B12)
RAY: 107511892(HSD17B12)
MJV: 108391004 108402895(HSD17B12)
TOD: 119239560 119255346(HSD17B12)
SARA: 101545744(HSD17B12)
LAV: 100656306(HSD17B12) 111749606
DNM: 101417351 101443284(HSD17B12)
MDO: 100013277(HSD17B12)
GAS: 123251995(HSD17B12)
SHR: 100917982(HSD17B12) 100923950
OAA: 100079057(HSD17B12)
GGA: 769787(HSD17B12)
PCOC: 116229126(HSD17B12)
MGP: 104911119(HSD17B12) 104911129
CJO: 107314810(HSD17B12)
NMEL: 110402080(HSD17B12)
APLA: 101803586(HSD17B12)
ACYG: 106044159(HSD17B12)
AFUL: 116489718(HSD17B12)
TGU: 100223843(HSD17B12)
LSR: 110472034(HSD17B12)
SCAN: 103827003(HSD17B12)
PMOA: 120512557(HSD17B12)
OTC: 121332687(HSD17B12)
PRUF: 121349510(HSD17B12)
GFR: 102039695(HSD17B12)
FAB: 101807632(HSD17B12)
PHI: 102106801(HSD17B12)
PMAJ: 107206004(HSD17B12)
CCAE: 111930136(HSD17B12)
CCW: 104688088(HSD17B12)
ETL: 114062366(HSD17B12)
ZAB: 102062927(HSD17B12)
FPG: 101917180(HSD17B12)
FCH: 102056639(HSD17B12)
CLV: 102085015(HSD17B12)
EGZ: 104134096(HSD17B12)
NNI: 104019569(HSD17B12)
ACUN: 113481381(HSD17B12)
TALA: 116965826(HSD17B12)
PADL: 103921723(HSD17B12)
ACHC: 115334079(HSD17B12)
AAM: 106498375(HSD17B12)
AROW: 112978372(HSD17B12)
NPD: 112943478(HSD17B12)
DNE: 112979236(HSD17B12)
ASN: 102368497 102381002(HSD17B12)
AMJ: 102559362(HSD17B12)
CPOO: 109321171(HSD17B12)
GGN: 109298939(HSD17B12)
PSS: 102445815(HSD17B12) 112544543
CMY: 102938030(HSD17B12) 102939820
CPIC: 101950937(HSD17B12)
TST: 117876490(HSD17B12)
CABI: 116830761(HSD17B12)
MRV: 120388126 120404380(HSD17B12)
PVT: 110081502(HSD17B12)
SUND: 121915202 121927711(HSD17B12)
PBI: 103049647(HSD17B12)
PMUR: 107289668(HSD17B12)
TSR: 106550332(HSD17B12)
PGUT: 117665486(HSD17B12)
VKO: 123026754(HSD17B12)
PMUA: 114596283(HSD17B12)
ZVI: 118085419(HSD17B12)
GJA: 107119118(HSD17B12) 107120158
STOW: 125425892(HSD17B12) 125435522
XLA: 108711776 379747(hsd17b12.S) 444506(XB5863530.L) 495218(hsd17b12.L)
XTR: 100497556 549988(hsd17b12)
NPR: 108785839(HSD17B12) 108794729 108800692
DRE: 322626(hsd17b12b) 327417(hsd17b12a) 368367(hsd20b2)
PPRM: 120464879(hsd17b12b) 120469251(hsd17b12a) 120469553(hsd20b2)
MAMB: 125247486(hsd17b12a) 125265113(hsd17b12b) 125266957(hsd20b2)
IPU: 100528251(hsd17b12b) 108259770(hsd20b2) 108275383(hsd17b12a)
PHYP: 113529736(hsd17b12) 113531207 113540909
SMEO: 124379010(hsd20b2) 124379869(hsd17b12b) 124392550(hsd17b12a)
TFD: 113636775(hsd17b12b) 113641504(hsd20b2) 113653866(hsd17b12a)
AMEX: 103024613 103027081(hsd17b12) 103033448
LCO: 104922399(hsd17b12) 104925842 104937328
CGOB: 115010283(hsd17b12) 115018701 115026948
ELY: 117254100(hsd17b12b) 117262158(hsd17b12a) 117272257(hsd20b2)
PLEP: 121946227(hsd17b12b) 121950239(hsd17b12a) 121952986(hsd20b2)
SLUC: 116043441(hsd17b12b) 116046803(hsd17b12a) 116064965(hsd20b2)
ECRA: 117945771(hsd17b12b) 117948977(hsd17b12a) 117955933(hsd20b2)
GAT: 120809367(hsd17b12a) 120810802(hsd17b12b) 120812780 120821946(hsd20b2)
PPUG: 119196546(hsd17b12a) 119215073(hsd20b2) 119228980(hsd17b12b)
MSAM: 119890035(hsd17b12b) 119894170(hsd17b12a) 119895729(hsd20b2)
CUD: 121511685(hsd17b12b) 121514582(hsd17b12a) 121518339(hsd20b2)
ALAT: 119018355(hsd17b12b) 119024424(hsd17b12a) 119031475(hsd20b2)
MZE: 101464359 101469758 101474165(hsd17b12)
ONL: 100534526(hsd17b12) 100698702(hsd17b12) 100703825
OAU: 116313953(hsd17b12a) 116329463(hsd17b12b) 116330254(hsd20b2)
OML: 112142757(hsd20b2) 112151954(hsd17b12a) 112161173(hsd17b12b)
PLAI: 106938924 106951467 106964816(hsd17b12)
PMEI: 106904443 106904793 106905847(hsd17b12)
GAF: 122825317(hsd17b12b) 122835863(hsd17b12a) 122845150 122845151
CVG: 107092201(hsd17b12) 107094051 107102295
CTUL: 119773587(hsd17b12b) 119779138(hsd20b2) 119798189(hsd17b12a)
GMU: 124860273(hsd17b12a) 124866985(hsd17b12b) 124876678(hsd20b2)
KMR: 108234813(hsd17b12b) 108245742(hsd17b12a) 108248270(hsd20b2)
NWH: 119415413(hsd17b12a) 119420296(hsd20b2) 119430244(hsd17b12b)
CSEM: 103378812 103379805(hsd17b12) 103395421
SSEN: 122772712(hsd17b12b) 122776505(hsd17b12a) 122779464(hsd20b2)
HHIP: 117754480(hsd17b12b) 117763680(hsd17b12a) 117774157(hsd20b2)
HSP: 118110078(hsd17b12a) 118112338(hsd17b12b) 118122511(hsd20b2)
SDU: 111223976 111229620(hsd17b12) 111234380
SLAL: 111644335 111650479(hsd17b12) 111654023
XGL: 120793269(hsd17b12b) 120793271(hsd17b12a) 120802596(hsd20b2)
MALB: 109959449 109965090 109973524(hsd17b12)
BSPL: 114852315(hsd17b12b) 114856970(hsd17b12a) 114869756(hsd20b2)
OTW: 112218279(hsd17b12a) 112221313 112228610 112228629(hsd20b2) 112263883(hsd17b12b)
OMY: 110492095(hsd17b12a) 110506214 110506981 110521254 110533703(hsd20b2)
SALP: 111950141 111962105(hsd17b12) 111972052
SNH: 120049888(hsd17b12b) 120057113(hsd20b2) 120066617(hsd17b12a)
ELS: 105006117(hsd17b12) 105023923 105025310
SFM: 108918746 108934676 108942280(hsd17b12)
PKI: 111841056 111859443(hsd17b12) 111860853
AANG: 118215391(hsd17b12a) 118235687(hsd20b2)
LOC: 102689373 102698923(hsd17b12)
PSPA: 121294460 121305577(hsd20b2) 121329764
LCM: 102348665 102362094(HSD17B12)
CMK: 103174968(hsd17b12a)
APLC: 110981629
DME: Dmel_CG1444(spidey)
DSE: 6620253
DSI: Dsimw501_GD16868(Dsim_GD16868) Dsimw501_GD21890(Dsim_GD21890) Dsimw501_GD21891(Dsim_GD21891) Dsimw501_GD29058(Dsim_GD29058)
DAN: 6503875
DGR: 6565541
CCAT: 101463440
BOD: 106621918
SCAC: 106095761
LSQ: 119607342
HIS: 119657766
ASTE: 118506151
CNS: 116341934
ACER: 107999730
NMEA: 116430374
CGLO: 123258842
FAS: 105272920
DAM: 107047628
SOY: 115882363
AGB: 108909742
LDC: 111507140
PPYR: 116165914
OTU: 111425324
BMAN: 114251904
MSEX: 115448088
BANY: 112053126
PRAP: 110993240
SLIU: 111360103
OFU: 114353050
DCI: 103504954
HHAL: 106680388
FOC: 113204642
TPAL: 117639400
CSEC: 111871100
FCD: 110850806
PCHN: 125036143
HAME: 121857081
PCLA: 123768224
PTRU: 123509194
HAZT: 108671318
DSV: 119464487
RSAN: 119402257
RMP: 119163881
VDE: 111245920
VJA: 111263446
CEL: CELE_C06B3.4(stdh-1) CELE_C06B3.5(stdh-3) CELE_C56G2.6(let-767) CELE_F11A5.12(stdh-2) CELE_F25G6.5(stdh-4)
CBR: CBG_11441(Cbr-stdh-1) CBG_11442 CBG_19695(Cbr-let-767)
BMY: BM_BM18110(Bm18110) BM_BM2004(Bm2004)
TSP: Tsp_02573
PCAN: 112558929
BGT: 106073897
GAE: 121381176
HRF: 124151312
HRJ: 124267001
CRG: 105341564
MYI: 110454786
PMAX: 117335529
MMER: 123535666
OBI: 106880401
OSN: 115218478
LAK: 106169616
ATEN: 116298883
ADF: 107343948
XEN: 124452735
ATH: AT1G24470(KCR2) AT1G67730(KCR1)
LJA: Lj0g3v0295429.1(Lj0g3v0295429.1) Lj4g3v2717040.1(Lj4g3v2717040.1) Lj6g3v0585170.1(Lj6g3v0585170.1)
JCU: 105644725
CANN: 107860712
NTO: 104087941
DOSA: Os04t0116600-01(Os04g0116600) Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299100-01(Os06g0299100) Os06t0300200-00(Os06g0300200)
AOF: 109823841
PPP: 112290473
APRO: F751_1671
SCE: YBR159W(IFA38)
SEUB: DI49_1186
ERC: Ecym_2565
NCS: NCAS_0B02360(NCAS0B02360)
NDI: NDAI_0C05330(NDAI0C05330)
TPF: TPHA_0L01460(TPHA0L01460)
TBL: TBLA_0H03430(TBLA0H03430)
TDL: TDEL_0B01260(TDEL0B01260)
KAF: KAFR_0E03020(KAFR0E03020)
KNG: KNAG_0A03910(KNAG0A03910)
PIC: PICST_79198(YBO9)
CAL: CAALFM_CR06070WA(CaO19.3859)
SLB: AWJ20_1871(IFA38)
NCR: NCU04462
NTE: NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
MBE: MBM_06633
ANI: AN5861.2
ANG: ANI_1_488024(An02g03570)
CIM: CIMG_08188 CIMG_11390(CIMG04755)
PTE: PTT_14300
CNE: CNI00690
CNB: CNBH0660
TASA: A1Q1_07306
ABP: AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: AGABI2DRAFT192460(AGABI2DRAFT_192460)
MGL: MGL_1839
MRT: MRET_1973
DFA: DFA_11026
EHI: EHI_118210(18.t00033) EHI_163540(256.t00010) EHI_165070(127.t00009)
PCB: PCHAS_052260(PC000268.05.0)
CPV: cgd3_2370
SPAR: SPRG_04210
TCR: 506219.40
BCEN: DM39_5665
BMK: DM80_3022
FLN: FLA_0019
 » show all
Reference
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM.
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
DOI:10.1074/jbc.M205620200
  Sequence
[sce:YBR159W]
Reference
  Authors
Luu-The V, Tremblay P, Labrie F
  Title
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
  Journal
Mol Endocrinol 20:437-43 (2006)
DOI:10.1210/me.2005-0058
  Sequence
[hsa:51144]
Reference
  Authors
Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L
  Title
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
  Journal
Plant Physiol 150:1174-91 (2009)
DOI:10.1104/pp.109.137497
  Sequence
[ath:AT1G67730]
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