KEGG ORTHOLOGY: K10611

ORTHOLOGY: K10611

Entry

K10611                      KO

Symbol

RBX2, ROC2, RNF7

Name

RING-box protein 2

Pathway

map04120

Ubiquitin mediated proteolysis

map05170

Human immunodeficiency virus 1 infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10611  RBX2, ROC2, RNF7; RING-box protein 2
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K10611  RBX2, ROC2, RNF7; RING-box protein 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10611  RBX2, ROC2, RNF7; RING-box protein 2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul5 complex
    Ring finger protein
     K10611  RBX2, ROC2, RNF7; RING-box protein 2

Genes

HSA:	9616(RNF7)

PTR:	100612089(RNF7)

PPS:	100978642(RNF7)

GGO:	101137541(RNF7)

PON:	100445667(RNF7)

PPYG:

129032626(RNF7)

NLE:	100595971(RNF7)

HMH:	116461674(RNF7)

SSYN:

129491218(RNF7)

MCC:	714961(RNF7)

MCF:	102132104(RNF7)

MTHB:

126947463

MNI:	105469987(RNF7)

CSAB:

103241565(RNF7)

CATY:

105586353(RNF7)

PANU:

101023104(RNF7)

TGE:	112619211(RNF7)

MLEU:

105555626(RNF7)

RRO:	104674058(RNF7)

RBB:	108522431(RNF7)

TFN:	117084097(RNF7) 117095109

PTEH:

111526425(RNF7)

CANG:

105523307(RNF7)

CJC:	100385536(RNF7) 103790838

SBQ:	101047556(RNF7)

CIMI:

108300819(RNF7) 108303555 108310387

ANAN:

105706613(RNF7) 105722946

CSYR:

103268593(RNF7)

MMUR:

105870045(RNF7)

LCAT:

123630107(RNF7)

PCOQ:

105812867(RNF7)

OGA:	100947344(RNF7)

MMU:	19823(Rnf7)

MCAL:

110287200

MPAH:

110328308(Rnf7)

RNO:	300948(Rnf7)

MCOC:

116073045(Rnf7)

ANU:	117693770(Rnf7)

ASYL:

127688700(Rnf7)

MUN:	110555295(Rnf7)

CGE:	100758051 103161028(Rnf7)

MAUA:

101831342(Rnf7)

PROB:

127238271(Rnf7)

PLEU:

114690975(Rnf7)

MORG:

121464388(Rnf7)

MFOT:

126510667

AAMP:

119809704(Rnf7)

NGI:	103748287(Rnf7)

HGL:	101696646(Rnf7)

CPOC:

100735307(Rnf7)

CCAN:

109699822(Rnf7)

DORD:

105995997(Rnf7)

DSP:	122095293(Rnf7)

PLOP:

125342615(Rnf7)

NCAR:

124993474

MMMA:

107143347(Rnf7)

ITI:	101974387(Rnf7)

OCU:

103350405

OPI:	101526300(RNF7)

TUP:	102492378(RNF7)

GVR:	103583982 103602290(RNF7)

CFA:	106557459(RNF7)

CLUD:

112661019(RNF7)

VVP:	112934967(RNF7)

VLG:	121479049(RNF7)

NPO:	129507307(RNF7)

AML:	100467561(RNF7)

UMR:	103681595(RNF7)

UAH:	113254010(RNF7)

UAR:	123788435(RNF7)

ELK:

111148303

LLV:

125098139

MPUF:

101675609(RNF7)

MNP:	132012178(RNF7)

MLK:	131825060(RNF7)

NVS:	122908555(RNF7)

ORO:	101367433(RNF7)

EJU:	114205690(RNF7)

ZCA:	113918755(RNF7)

MLX:	118004598(RNF7)

NSU:	110570697(RNF7)

LWW:	102736375(RNF7)

FCA:	101097835(RNF7)

PYU:	121033758(RNF7)

PCOO:

112849344(RNF7)

PBG:	122491915(RNF7)

PVIV:

125175619(RNF7)

LRUF:

124526921

LGF:	123611477(RNF7)

AJU:

106981979

PTG:	107180020(RNF7)

PPAD:

109260233(RNF7)

PUC:

125921976

PLEZ:

122198450(RNF7)

HHV:	120242665(RNF7)

BTA:	515595(RNF7)

BOM:	102271201(RNF7)

BIU:	109559651(RNF7)

BBUB:

112577612(RNF7)

BBIS:

105001780(RNF7)

CHX:	102180802(RNF7)

OAS:	101106816(RNF7)

BTAX:

128048644(RNF7)

CSUM:

138083748(RNF7)

ODA:	120858096(RNF7)

CCAD:

122445251(RNF7)

MREE:

136173365(RNF7)

OVR:	110128489(RNF7) 139033555

MBEZ:

129547032(RNF7)

SSC:	100514874(RNF7)

CFR:	102513293(RNF7)

CBAI:

105066825(RNF7)

CDK:	105086323(RNF7)

VPC:	107033403(RNF7)

BACU:

103013390(RNF7)

BMUS:

118894166 118894791(RNF7)

LVE:	103085016(RNF7)

OOR:	101277941(RNF7)

LALB:

132520893(RNF7)

DLE:	111179254(RNF7)

PCAD:

102982210(RNF7)

PSIU:

116753505(RNF7)

NASI:

112415913(RNF7)

ECB:	106781847(RNF7)

EAI:	106838121(RNF7)

MYB:	106726736(RNF7)

MMYO:

118668109(RNF7) 118676345

MDT:	132215482(RNF7) 132231230

MYUM:

139022402(RNF7)

PKL:	118715270(RNF7)

EFUS:

103302115 114226989(RNF7)

DRO:	112301284(RNF7)

SHON:

118990752(RNF7)

AJM:	119044845(RNF7)

PDIC:

114493325 114502116(RNF7)

PHAS:

123814600(RNF7)

MMF:	118633602(RNF7)

PPAM:

129087991(RNF7)

HAI:	109384569(RNF7)

RFQ:	117037322(RNF7)

PALE:

102897338(RNF7)

PGIG:

120582157(RNF7)

PVP:	105290357(RNF7)

RAY:	107509411(RNF7)

MJV:	108389889(RNF7)

TOD:	119257712(RNF7)

SFUM:

130030034(RNF7)

SETR:

126020041 126025569(RNF7)

LAV:	100662128(RNF7)

TMU:

101343724

ETF:	101649009(RNF7)

DNM:	101429475(RNF7)

MDO:	100013833(RNF7)

GAS:	123235747 123240190(RNF7)

SHR:	100931485(RNF7)

AFZ:

127552999

PCW:	110197241(RNF7)

TVP:	118848482(RNF7)

PBRV:

138174372(RNF7)

OAA:	100079008(RNF7)

TACU:

119932957(RNF7)

GGA:	424781(RNF7)

PCOC:

116230893(RNF7)

CJO:	107318089(RNF7)

TPAI:

128082300(RNF7)

LMUT:

125697595(RNF7)

NMEL:

110397748(RNF7)

APLA:

110354583(RNF7)

ACYG:

106036209(RNF7)

CATA:

118247267(RNF7)

AFUL:

116492640(RNF7)

TGU:	105759507(RNF7)

LSR:	110473945(RNF7)

SCAN:

103815421(RNF7)

PMOA:

120508567(RNF7)

OTC:	121341102(RNF7)

PRUF:

121357934(RNF7)

ATRC:

139594926(RNF7)

FAB:	101811778(RNF7)

OMA:	130256764(RNF7)

PHI:	102108340(RNF7)

PMAJ:

107208861(RNF7)

CCW:	104693496(RNF7)

CBRC:

103624867(RNF7)

ACOE:

138114522(RNF7)

ETL:	114068735(RNF7)

ZAB:	102073818(RNF7)

ZLE:	135451611(RNF7)

ACHL:

103807332

SVG:	106854174(RNF7)

MMEA:

130574006(RNF7)

HRT:	120757372(RNF7)

SATI:

136365666(RNF7)

CCIC:

134047700(RNF7)

NNT:	104410547(RNF7)

SHAB:

115612044(RNF7)

TALA:

104367187(RNF7)

ACHC:

115346980(RNF7)

HALD:

104318622

HLE:	104832248(RNF7)

AGEN:

126039318

HHAR:

128149294(RNF7)

GCL:

127020046

CSTI:

104562869(RNF7)

LDI:

104343526

MNB:

103775846

PPUS:

135186941(RNF7)

AVIT:

104273937

NNI:	104016487(RNF7)

PCRI:

104025743

PCAO:

104047886

PADL:

103917914(RNF7)

FGA:

GSTE:

MUI:

PGUU:

PLET:

EHS:	104505007(RNF7)

CMAC:

104477336

CUCA:

104063707(RNF7)

TEO:	104370570(RNF7)

BREG:

104641648

OHA:	104327211(RNF7)

CVF:	104291149(RNF7)

RTD:	128911127(RNF7)

CRID:

134517146(RNF7)

NPD:	112947940(RNF7)

TGT:	104580233(RNF7)

DNE:	112984104(RNF7)

SCAM:

104153196(RNF7)

ASN:	112550868(RNF7)

AMJ:	102559542(RNF7)

CPOO:

109308601(RNF7)

PSS:	102444285(RNF7)

CMY:	102947876(RNF7)

CCAY:

125643175(RNF7)

DCC:	119861030(RNF7)

CPIC:

101936482 101943407(RNF7)

TST:	117882791(RNF7)

CABI:

116816434(RNF7)

MRV:	120372625(RNF7)

ACS:	100557348(rnf7)

ASAO:

132770642(RNF7)

PVT:	110078457(RNF7)

SUND:

121926490(RNF7)

PBI:	103050152(RNF7)

PMUR:

107287768(RNF7)

CTIG:

120314391(RNF7)

TSR:	106541867(RNF7)

PGUT:

117678337(RNF7)

APRI:

131200865(RNF7)

PTEX:

113436864(RNF7)

NSS:	113410095(RNF7)

VKO:	123024834(RNF7)

PMUA:

114597832(RNF7)

PRAF:

128414609(RNF7)

ZVI:	118093645(RNF7)

HCG:	128350680(RNF7)

GJA:	107112355(RNF7)

STOW:

125438271(RNF7)

EMC:	129332346(RNF7)

XLA:	414491(rnf7.L)

XTR:	100135737(rnf7)

NPR:	108790154(RNF7)

RTEM:

120936454(RNF7)

BBUF:

120997624(RNF7)

BGAR:

122934582(RNF7)

PWL:	138265843(RNF7)

MUO:	115478638(RNF7)

DRE:	503534(rnf7)

SRX:	107709817 107713281

SANH:

107684626 107692028

SGH:	107557824 107563517

CCAR:

109109129(rnf7)

CAUA:

113061699 113118613

CGIB:

127934496 127976957

PTET:

122363159(rnf7)

LROH:

127180912(rnf7)

OMC:	131524274(rnf7)

PPRM:

120460024(rnf7)

RKG:	130073772(rnf7)

MAMB:

125254164(rnf7)

CIDE:

127500082

CERY:

137022577(rnf7)

MASI:

127416783 127455682

TROS:

130561175(rnf7)

TDW:	130435130(rnf7)

MANU:

129419391(rnf7)

PDAB:

135729169 135746435

IPU:	100528632(rnf7)

IFU:	128606967(rnf7)

PHYP:

113534666(rnf7)

SMEO:

124395731(rnf7)

TFD:	113652766(rnf7)

TVC:	132851404(rnf7)

CGAR:

128527415(rnf7)

NGRA:

132887854(rnf7)

TRN:	134323366(rnf7)

AMEX:

103026563(rnf7)

CMAO:

118818272(rnf7)

EEE:	113577429(rnf7)

CHAR:

105902798(rnf7)

SPIL:

134099620(rnf7)

TRU:	101064365(rnf7)

TFS:	130535516(rnf7)

TNG:	GSTEN00011291G001

LCO:	104924169(rnf7)

NCC:	104945226(rnf7)

TBEN:

117470232(rnf7)

CGOB:

115017770(rnf7)

PGEO:

117456872(rnf7)

GACU:

117557369(rnf7)

EMAC:

134879694(rnf7)

ELY:	117260197(rnf7)

EFO:	125888553(rnf7)

PLEP:

121943524(rnf7)

SLUC:

116045577(rnf7)

ECRA:

117942437(rnf7)

ESP:	116685227(rnf7)

PFLV:

114552504(rnf7)

GAT:	120824850(rnf7)

PPUG:

119211854(rnf7)

AFB:	129092293(rnf7)

PSWI:

130210736(rnf7)

CANA:

137790623(rnf7)

CVE:	137876469(rnf7)

MSAM:

119883420(rnf7) 119916750

SCHU:

122879124(rnf7)

CUD:	121515534(rnf7)

SPUL:

138597154(rnf7)

LMIX:

132980278(rnf7)

ALAT:

119012610(rnf7)

ASTR:

137596950(rnf7)

MZE:	101476463(rnf7)

ONL:	100694401(rnf7)

OAU:	116330376(rnf7)

OLA:	101175180(rnf7)

OML:	112149850(rnf7)

CSAI:

133442315(rnf7)

XMA:	102218703(rnf7)

XCO:	114133575(rnf7)

XHE:	116708227(rnf7)

PRET:

103474446(rnf7)

PFOR:

103146305(rnf7)

PLAI:

106945714(rnf7)

PMEI:

106931537(rnf7)

GAF:	122832698(rnf7)

PPRL:

129359125(rnf7)

CVG:	107083469(rnf7)

CTUL:

119771835(rnf7)

GMU:	124883930(rnf7)

NFU:	107380488(rnf7)

KMR:	108240459(rnf7)

ALIM:

106524388(rnf7)

NWH:	119410512(rnf7)

AOCE:

111586020(rnf7)

EJA:	138197192(rnf7)

BFRE:

138634834(rnf7)

MCEP:

125014069(rnf7)

CSEM:

103378578(rnf7)

POV:	109634390(rnf7)

SSEN:

122773800(rnf7)

SSOE:

131463032(rnf7)

HHIP:

117773188(rnf7)

HSP:	118106631(rnf7)

PPLT:

128439646(rnf7)

SMAU:

118299669(rnf7)

LCF:

108872411

SDU:	111224077(rnf7)

SLAL:

111649980(rnf7)

XGL:	120791471(rnf7)

HCQ:	109508678 109525535(rnf7)

SSCV:

125972771(rnf7)

SBIA:

133504806(rnf7)

PEE:	133405190(rnf7)

PTAO:

133482430(rnf7)

BPEC:

110174357(rnf7)

ENY:	140375005(rnf7)

MALB:

109970566(rnf7)

BSPL:

114868378(rnf7)

SJO:	128359779(rnf7)

SSCO:

133980517(rnf7)

GMH:	115528799(rnf7)

SASA:

100195710(rbx2) 106580882(RBX2) 106599537

STRU:

115163213 115206158

OTW:	112265317 112266904

OMY:	110503734 110507619

OGO:	123992895 124005631

ONE:	115136919 115142152

OKI:	109905581 109909027

OKE:	118383999 118397323

OMM:	135546276 135552764

OCLA:

139386349

SALP:

111949351 111949558

SNH:	120018302 120028707

CCLU:

121564635(rnf7) 121567549

ELS:	105012598(rnf7)

OEP:	134028912(rnf7)

SFM:	108926805(rnf7)

PKI:	111836651(rnf7)

AANG:

118210005(rnf7)

AROT:

135236525(rnf7)

CCOG:

133107227(rnf7)

LOC:	102693771(rnf7)

PSPA:

121323127 121327169

ARUT:

117423175(rnf7)

PSEX:

120533391(rnf7)

LCM:	102348519(RNF7)

CMK:	103178831(rnf7)

HOC:	132821413(rnf7)

LERI:

129703306(rnf7)

PMRN:

116952626(RNF7)

LRJ:	133353983(RNF7)

BFO:

BBEL:

CIN:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

DME:	Dmel_CG8998(Roc2)

DER:

6546603

DSE:

6608695

DSI:	Dsimw501_GD25891(Dsim_GD25891)

DYA:	Dyak_GE13508

DAN:

DSR:

DPO:

DPE:

DMN:	108160032 117185973

DWI:

26529403

DGR:

6560839

DMO:	Dmoj_GI21036

DNV:

108653517

DHE:

111600604

DVI:	6625102(Roc2)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119680712 119686284

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135960392(Roc2)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

ASUA:

CQU:	CpipJ_CPIJ004515 CpipJ_CPIJ004519

CPII:

BCOO:

LLL:

PPAP:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

CGIG:

SOC:

MPHA:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:	105676474(Roc2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138136078(Roc2)

DPA:

109539785

ESIM:

136408891(Roc2)

EFOR:

136345212(Roc2)

SOY:

AGRG:

CSET:

NVL:

DCOR:

135797610(Roc2)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137926790(Roc2)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110374121(roc2)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

BTAB:

DCI:	103513967 103513968 108253146

CLEC:

106669775

HHAL:

106681590(Roc2)

NLU:

111043368

HVI:

124362693

MQU:

128988683

PHU:	Phum_PHUM616000 Phum_PHUM616050

FOC:

TPAL:

SGRE:

BROR:

HAMR:

139689653(Roc2)

FCD:

110843189

DPX:	DAPPUDRAFT_326083

DMK:

116923357

DPZ:

124342155

AFRA:

136040382

PVM:	113817645(Roc2)

PJA:

122242755

PCHN:

125032735

HAME:

121866466

PCLA:

123754353(Roc2)

PTRU:

123513511

ESN:

126999445

MNZ:

135219747

MRJ:	136826597(Roc2)

PORN:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:	119442157 119442170

RSAN:

VDE:

VJA:

CSCU:

CVS:	136983227(Roc2)

PTEP:

107447083

ABRU:

129981058

UDV:

129222389

SDM:	118196216 118204398

LPOL:

106466387

PMEO:

129590874

CEL:	CELE_R10A10.2(rbx-2)

CBR:	CBG_12620(Cbr-rbx-2)

NAI:	NECAME_19393

BMY:	BM_BM5321(Bma-rbx-2)

LOA:	LOAG_09011

HRO:	HELRODRAFT_86038

LGI:	LOTGIDRAFT_231871

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111132103 111133488

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_50751

AQU:

100640523

» show all

Reference

PMID:11506706

Authors

Swaroop M, Gosink M, Sun Y

Title

SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes.

Journal

DNA Cell Biol 20:425-34 (2001)
DOI:10.1089/104454901750361488

Sequence

[hsa:9616]

Reference

PMID:15601820

Authors

Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.

Title

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

Journal

Genes Dev 18:3055-65 (2004)
DOI:10.1101/gad.1252404

Sequence

[hsa:9616]

Reference

PMID:10851089

Authors

Swaroop M, Wang Y, Miller P, Duan H, Jatkoe T, Madore SJ, Sun Y

Title

Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation.

Journal

Oncogene 19:2855-66 (2000)
DOI:10.1038/sj.onc.1203635

Sequence

[hsa:9616]

LinkDB

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