KEGG ORTHOLOGY: K10684

ORTHOLOGY: K10684

Entry

K10684                      KO

Symbol

UBLE1A, SAE1

Name

ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]

Pathway

map04120

Ubiquitin mediated proteolysis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10684  UBLE1A, SAE1; ubiquitin-like 1-activating enzyme E1 A
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10684  UBLE1A, SAE1; ubiquitin-like 1-activating enzyme E1 A
Enzymes [BR:ko01000]
6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.45  E1 ubiquitin-activating enzyme
     K10684  UBLE1A, SAE1; ubiquitin-like 1-activating enzyme E1 A
Ubiquitin system [BR:ko04121]
Ubiquitin-activating enzymes (E1)
  UBL-activating enzymes
   K10684  UBLE1A, SAE1; ubiquitin-like 1-activating enzyme E1 A

Genes

HSA:	10055(SAE1)

PTR:	456159(SAE1)

PPS:	100984788(SAE1)

GGO:	101124599(SAE1)

PON:	100173973(SAE1)

NLE:	100605617(SAE1)

MCC:	717918(SAE1)

MCF:	101865932(SAE1)

CSAB:

103235523(SAE1)

CATY:

105595199(SAE1)

PANU:

101022313(SAE1)

TGE:	112611833(SAE1)

RRO:	104673393(SAE1)

RBB:	108540359(SAE1)

TFN:	117091463(SAE1)

PTEH:

111519931(SAE1) 111520808

CJC:	100387239(SAE1)

SBQ:	101033646(SAE1)

MMUR:

105869583(SAE1)

LCAT:

123623904(SAE1)

OGA:	100941811(SAE1)

MMU:	56459(Sae1)

MCAL:

110297391(Sae1)

MPAH:

110336445(Sae1)

RNO:	308384(Sae1)

MCOC:

116101683(Sae1)

MUN:	110561314(Sae1)

CGE:	100767400(Sae1)

MAUA:

101827208(Sae1)

PLEU:

114681410(Sae1)

MORG:

121450149(Sae1)

AAMP:

119820947(Sae1)

NGI:	103724859(Sae1)

HGL:	101716133(Sae1)

CPOC:

100718649(Sae1)

CCAN:

109697532(Sae1)

DORD:

105997979(Sae1)

DSP:	122125752(Sae1)

NCAR:

124967136

OCU:	100357447(SAE1)

OPI:	101520382(SAE1)

TUP:	102501324(SAE1)

CFA:	476425(SAE1)

VVP:	112931526(SAE1)

VLG:	121485402(SAE1)

AML:	100470369(SAE1)

UMR:	103657075(SAE1)

UAH:	113243381(SAE1)

UAR:	123776261(SAE1)

ELK:

111160800

LLV:

125089220

MPUF:

101693808(SAE1)

ORO:	101367153(SAE1)

EJU:	114197138(SAE1)

ZCA:	113936547(SAE1)

MLX:	117998191(SAE1)

FCA:	101089061(SAE1)

PYU:	121018677(SAE1)

PBG:	122493880(SAE1)

PTG:	102955177(SAE1)

PPAD:

109253177(SAE1)

AJU:	106973569(SAE1)

HHV:	120242754(SAE1)

BTA:	505512(SAE1)

BOM:	102279751(SAE1)

BIU:	109572653(SAE1)

BBUB:

102416048(SAE1)

CHX:	108633205(SAE1)

OAS:	101117867(SAE1)

ODA:	120872236(SAE1)

CCAD:

122420495(SAE1)

SSC:	100515263(SAE1)

CFR:	102511420(SAE1)

CBAI:

105062558(SAE1)

CDK:	105104048(SAE1)

VPC:	102530984(SAE1)

BACU:

103000036(SAE1)

LVE:	103087564(SAE1)

OOR:	101275927(SAE1)

DLE:	111180694(SAE1)

PCAD:

102991632

PSIU:

116744339(SAE1)

ECB:	100071215(SAE1)

EPZ:	103560718(SAE1)

EAI:	106845163(SAE1)

MYB:	102246586(SAE1)

MYD:	102774894(SAE1)

MMYO:

118652771(SAE1)

MLF:	102431130(SAE1)

MNA:	107540054(SAE1)

PKL:	118706785(SAE1)

HAI:	109372231(SAE1)

DRO:	112312814(SAE1)

SHON:

118996115(SAE1)

AJM:	119056626(SAE1)

PDIC:

114510989(SAE1)

PHAS:

123823003(SAE1)

MMF:	118639051(SAE1)

RFQ:	117035127(SAE1)

PALE:

102878398(SAE1)

PGIG:

120617899(SAE1)

PVP:	105297390(SAE1)

RAY:	107516009(SAE1)

MJV:	108398869(SAE1)

TOD:	119249483(SAE1)

SARA:

101554304(SAE1)

LAV:	100670978(SAE1)

TMU:

101340994

DNM:	101434601(SAE1)

MDO:	100016572(SAE1)

GAS:	123239996(SAE1)

SHR:	100934254(SAE1)

PCW:	110202358(SAE1)

OAA:	100093563(SAE1)

GGA:	101750090(SAE1)

PCOC:

116237794(SAE1)

CJO:

107307797

NMEL:

110400512(SAE1)

PHI:	102104856(SAE1)

FPG:	101917655(SAE1)

FCH:	102053213(SAE1)

CLV:	102085425(SAE1)

NNI:	104011812(SAE1)

PLET:

104618035(SAE1)

TALA:

104365926(SAE1)

ACHC:

115337665 115337670

AAM:	106492579(SAE1)

AROW:

112977454(SAE1)

NPD:	112959428(SAE1)

DNE:	112994712(SAE1)

ASN:	102372491(SAE1)

PSS:

102444060

CMY:	102932538(SAE1)

CPIC:

101949449(SAE1)

CABI:

116819209(SAE1)

MRV:	120388717(SAE1)

ACS:	100563027(sae1)

PVT:	110075721(SAE1)

SUND:

121915331(SAE1)

PBI:	103056408(SAE1)

PMUR:

107285683(SAE1)

TSR:	106541111(SAE1)

PGUT:

117677859(SAE1)

VKO:	123023259(SAE1)

PMUA:

114603057(SAE1)

ZVI:	118086645(SAE1)

GJA:	107106905(SAE1)

STOW:

125430719(SAE1)

XLA:	443558(sae1.L)

XTR:	549624(sae1)

NPR:	108792244(SAE1)

RTEM:

120913547(SAE1)

BBUF:

120977474(SAE1)

BGAR:

122919440(SAE1)

DRE:	415148(sae1)

SRX:	107718284 107743692

SANH:

107683835 107690439

SGH:	107585558 107601738

CCAR:

109087847 109087849(sae1)

CAUA:

113058455 113115058

PPRM:

120478978(sae1)

MAMB:

125249183(sae1)

IPU:	108277980(sae1)

PHYP:

113532550(sae1)

SMEO:

124394808(sae1)

TFD:	113643486(sae1)

AMEX:

103042876

EEE:	113569680(sae1)

TRU:	101077717(sae1)

TNG:	GSTEN00025133G001

LCO:	104931221(sae1)

NCC:	104952952(sae1)

CGOB:

115018271(sae1)

ELY:	117259141(sae1)

SLUC:

116053213(sae1)

ECRA:

117942009(sae1)

PFLV:

114552583(sae1)

GAT:	120818158(sae1)

PPUG:

119218296(sae1)

MSAM:

119882556(sae1)

CUD:	121523136(sae1)

ALAT:

119031789(sae1)

MZE:	101464385(sae1)

ONL:	100707755(sae1)

OAU:	116320377(sae1)

OLA:	101162772(sae1)

OML:	112149759(sae1)

XMA:	102226867(sae1)

XCO:	114133524(sae1)

XHE:	116707524(sae1)

PRET:

103475206(sae1)

PFOR:

103138316(sae1)

PLAI:

106964043(sae1)

PMEI:

106933682(sae1)

GAF:	122832895(sae1)

CVG:	107100752(sae1)

CTUL:

119796659(sae1)

GMU:	124884580(sae1)

NFU:

107379944

KMR:	108247878(sae1)

ALIM:

106535362(sae1)

NWH:	119411407(sae1)

AOCE:

111580587(sae1)

CSEM:

103377913(sae1)

POV:	109640118(sae1)

SSEN:

122773990(sae1)

HHIP:

117773312(sae1)

HSP:	118106663(sae1)

LCF:	108876225(sae1)

SDU:	111216937(sae1)

SLAL:

111665659(sae1)

XGL:	120791496(sae1)

HCQ:	109529360(sae1)

BPEC:

110172734(sae1)

MALB:

109973544(sae1)

BSPL:

114868481(sae1)

SASA:

100286575(sae1) 106612594

OTW:	112265299 112266886

OMY:	110503717 110507599(sae1)

OGO:	123992902 124006413

ONE:	115136928 115141668

SALP:

111949508 111949519

SNH:	120018789 120028739

ELS:	105012732(sae1)

SFM:	108928643(sae1)

PKI:	111844021(sae1)

AANG:

118210412(sae1)

LOC:	102690317(sae1)

PSPA:

121304824(sae1)

ARUT:

117394604(sae1)

LCM:	102355638(SAE1)

CMK:	103191308(sae1)

RTP:	109913819(sae1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115919077 590262

APLC:

110976742

SKO:

100375688

DME:	Dmel_CG12276(Aos1)

DER:

6553698

DSE:

6606662

DSI:	Dsimw501_GD20565(Dsim_GD20565)

DYA:	Dyak_GE24516

DSR:

110189013

DPO:	Dpse_GA11527

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10362

DAZ:

108621159

DNV:

108649063

DHE:	111602798 115483791

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

HIS:

AGA:	AgaP_AGAP004459

ACOZ:

AARA:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ013962

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210473

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

TNL:

SLIU:

OFU:

API:

DNX:

AGS:

RMD:	113552927 113559375

BTAB:

109039152

DCI:	103515578 103515582

CLEC:

106673399

HHAL:

106680708

NLU:

111058847

PHU:	Phum_PHUM428030

FOC:

TPAL:

ZNE:

CSEC:

FCD:

DPX:	DAPPUDRAFT_210457

DMK:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

PPOI:

ISC:	IscW_ISCW012441

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_C08B6.9(aos-1)

CBR:	CBG_09526(Cbr-aos-1)

BMY:	BM_BM13930(Bma-aos-1)

LOA:	LOAG_02750

NAI:	NECAME_08049

TSP:

Tsp_00060

HRO:	HELRODRAFT_184875

LGI:	LOTGIDRAFT_182121

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

SMM:	Smp_048760.1

OVI:	T265_12510

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:	114517656 114543521

XEN:

124453181

HMG:

100209365

TAD:	TRIADDRAFT_51819

AQU:

100635272

ATH:	AT4G24940(SAE1A) AT5G50580(SAE1B) AT5G50680(SAE1B)

ALY:	9301893 9305770

CRB:	17876401 17877487

CSAT:

104717779 104722486 104725570 104730950 104761052

EUS:	EUTSA_v10025730mg

BRP:

103862724

BNA:	106375803 106442433

BOE:

106325250

RSZ:	108822518 108860303

THJ:

104806080

CPAP:

110812854

CIT:

102621643

CIC:	CICLE_v10032114mg

PVY:

116106904

MINC:

123215644 123222677

TCC:

18605127

GRA:	105764798 105788661

GHI:	107886222 107913433 107949610 121211076

GAB:	108459357 108479462

DZI:

111313957

EGR:

104426142

GMX:	100807922 100809607

GSJ:	114413342 114421156

PVU:	PHAVU_002G2859000

VRA:

106769370

VAR:

108332438

VUN:	114170005 114179844

CCAJ:

109816436

APRC:

113854071

MTR:	MTR_8g096740

CAM:

101507423

LJA:	Lj4g3v0523520.1(Lj4g3v0523520.1)

ADU:

107492119

AIP:

107645892

AHF:	112695518 112758137

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103409644 103454985

PXB:	103936163 103949990 103964034

ZJU:

MNT:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110656195 110671900

MESC:

110599814 110617765

POP:	7454574 7454734

PEU:	105125290 105139395

PALZ:

118044696 118057546

JRE:

108994426

QSU:	111990790 112006469 112007867

QLO:

TWL:

VVI:

VRI:

SLY:	101249529 543732

SPEN:

107012363 107021642

SOT:	102600049 102602368

CANN:

107862763 107864823 107875859

NTA:	107767527 107772135 107776804 107818108 107831548 107832306

NSY:	104229403 104230276

NTO:	104091268 104100107 104116247

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

BVG:

SOE:

CQI:	110696292 110710154

NNU:

104592847

MING:

122070832 122080657

TSS:	122654548 122671538

PSOM:

113271650 113281027

NCOL:

116248498

OSA:

4350554

DOSA:

Os11t0497000-01(Os11g0497000)

OBR:

102717102

BDI:

100842795

ATS:	109740445 109779518

TDC:	119329451 119336755

TAES:

123060252 123147950 123156320 123164518

TUA:

SBI:

ZMA:

SITA:

SVS:

PVIR:

120644377 120683315 120685555

PHAI:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_113369

PPP:

112274556

VCN:	VOLCADRAFT_95199

CSL:	COCSUDRAFT_15636

CVR:	CHLNCDRAFT_134704

APRO:

F751_3840

OLU:	OSTLU_89603

OTA:	OT_ostta20g00890

BPG:	Bathy15g00010

MIS:	MICPUN_99249

MPP:	MICPUCDRAFT_58541

CME:	CYME_CMC124C

GSL:	Gasu_43840

CCP:	CHC_T00003230001

SCE:	YPR180W(AOS1)

SEUB:

DI49_5624

SPAO:

SPAR_P04220

AGO:	AGOS_AEL271C

KLA:	KLLA0_E04863g

KMX:	KLMA_20499(AOS1)

LTH:	KLTH0A00836g

VPO:	Kpol_1050p106

ZRO:	ZYRO0D01078g

CGR:	CAGL0G09889g

NCS:	NCAS_0A15190(NCAS0A15190)

NDI:	NDAI_0J00350(NDAI0J00350)

TPF:	TPHA_0G00300(TPHA0G00300)

TBL:	TBLA_0B04900(TBLA0B04900)

TDL:	TDEL_0H00350(TDEL0H00350)

TGB:	HG536_0F00390

KAF:	KAFR_0B00350(KAFR0B00350)

KNG:	KNAG_0F03910(KNAG0F03910)

ZMK:	HG535_0C06150

PPA:	PAS_chr2-2_0425

DHA:	DEHA2E02354g

PIC:	PICST_51192

PGU:	PGUG_00106

SPAA:

SPAPADRAFT_59120

LEL:	LELG_05312

CAL:	CAALFM_CR02770CA(CaO19.2835)

CTP:	CTRG_05902

COT:	CORT_0D01120

CDU:	CD36_27820

CTEN:

CANTEDRAFT_133230

YLI:	YALI0E28182g

CLU:	CLUG_00777

CLUS:

A9F13_10g00396

CAUR:

CJI97_001656

SLB:	AWJ20_522(AOS1)

PKZ:	C5L36_0B10810

BNN:	FOA43_002480

BBRX:

BRETT_000029

OPA:	HPODL_00144

SLUD:

SCDLUD_000024

NCR:

NCU09006

NTE:	NEUTE1DRAFT122516(NEUTE1DRAFT_122516)

SMP:	SMAC_01961

PAN:	PODANSg5155

TTT:	THITE_2118599

MTM:	MYCTH_2304880

CTHR:

CTHT_0025850

MGR:

MGG_01669

PPEI:

PpBr36_01182

TMN:	UCRPA7_6338

SSCK:

SPSK_05237

FGR:	FGSG_05561

FPU:	FPSE_06152

FVR:	FVEG_06934

FOX:	FOXG_09330

NHE:	NECHADRAFT_46968

TRE:	TRIREDRAFT_37833

TRR:	M419DRAFT_86996

MAW:

MAC_05013

MAJ:

MAA_03516

CMT:

CCM_07372

PLJ:	VFPFJ_01316

VAL:	VDBG_08745

VDA:	VDAG_06406

CFJ:	CFIO01_08554

CHIG:

CH63R_02706

SAPO:

SAPIO_CDS2941

ELA:	UCREL1_2191

PFY:	PFICI_11900

SSL:	SS1G_07470

BFU:	BCIN_10g00930(Bcaos1)

MBE:

MBM_02371

PSCO:

LY89DRAFT_687844

GLZ:	GLAREA_11158

ANI:

AN2298.2

AFM:	AFUA_5G06100

ACT:	ACLA_009420

NFI:	NFIA_037000

AOR:	AO090009000648

ANG:	ANI_1_482154(An17g01740)

AFV:	AFLA_010722

ALUC:

AKAW2_70819A

ACHE:

ACHE_20479A

APUU:

APUU_20634S

PCS:	Pc20g01250

PDP:	PDIP_22820

TMF:	PMAA_084980

TRG:	TRUGW13939_08003

CIM:	CIMG_05976

CPW:	CPC735_025620

URE:	UREG_04385

PBL:	PAAG_00488

PBN:	PADG_02197

ABE:

ARB_07104

TVE:

TRV_04914

AJE:	HCAG_08393

BGH:	BDBG_03731

PNO:	SNOG_09302

PTE:

PTT_19025

BZE:	COCCADRAFT_84056

BSC:	COCSADRAFT_291919

BOR:	COCMIDRAFT_90773

AALT:

CC77DRAFT_137648

ZTR:	MYCGRDRAFT_74650

PFJ:	MYCFIDRAFT_188653

FFU:	CLAFUR5_06708

BCOM:

BAUCODRAFT_54821

NPA:	UCRNP2_1459

TML:	GSTUM_00005268001

SPO:	SPAC4C5.04(rad31)

CNE:

CNN00720

CNB:

CNBN0700

CNG:	CNAG_06342

CGI:	CGB_N1110W

TMS:	TREMEDRAFT_45154

TASA:

A1Q1_00291

TVS:	TRAVEDRAFT_157308

DSQ:	DICSQDRAFT_140680

PCO:	PHACADRAFT_150830

SHS:	STEHIDRAFT_147609

HIR:	HETIRDRAFT_475279

PSQ:	PUNSTDRAFT_97317

ADL:	AURDEDRAFT_182534

FME:	FOMMEDRAFT_143448

GTR:	GLOTRDRAFT_81695

LBC:	LACBIDRAFT_309256

MPR:	MPER_10762

MRR:	Moror_12410

E1B28_012252

CCI:	CC1G_02933

SCM:	SCHCODRAFT_14921

ABP:	AGABI1DRAFT113952(AGABI1DRAFT_113952)

ABV:	AGABI2DRAFT193789(AGABI2DRAFT_193789)

CPUT:

CONPUDRAFT_103924

SLA:	SERLADRAFT_470642

WSE:	WALSEDRAFT_58393

WIC:	J056_003031

UMA:	UMAG_01081

PFP:	PFL1_02398

MGL:

MGL_0434

MRT:

MRET_2296

MSYM:

MSY001_1434

PGR:	PGTG_15286

MLR:	MELLADRAFT_88698

MBR:	MONBRDRAFT_29549

SRE:	PTSG_01692

DDI:	DDB_G0279641(sae1)

DPP:	DICPUDRAFT_158804

DFA:	DFA_02637(sae1)

EIV:	EIN_409860

ACAN:

ACA1_296360

PFA:	PF3D7_1144500

PFH:	PFHG_05258

PREI:

PRSY57_1142900

PGAB:

PGSY75_1144500

PYO:	PY17X_0905900

PCB:	PCHAS_070570(PC000199.02.0)

PBE:	PBANKA_0904500

PVV:	PVVCY_0904280

PKN:	PKNH_0942400

PVX:	PVX_092830

PCY:	PCYB_095010

TPV:

TP03_0841

TOT:	TOT_030000045

BEQ:	BEWA_044850

BBO:	BBOV_I000150(16.m00769)

BMIC:

BmR1_04g07980

BBIG:

BBBOND_0301260

TGO:	TGME49_211390

TET:	TTHERM_00519760

PTM:	GSPATT00017092001

PTI:	PHATRDRAFT_40111

FCY:	FRACYDRAFT_180734

TPS:	THAPSDRAFT_1215

PIF:	PITG_17312

PSOJ:

PHYSODRAFT_471007

SPAR:

SPRG_20000

EHX:	EMIHUDRAFT_439421 EMIHUDRAFT_468225

GTT:	GUITHDRAFT_137429

TBR:	Tb11.02.5410

TBG:	TbgDal_XI8600

TCR:	508177.100

LMA:	LMJF_28_0360

LIF:	LINJ_28_0500

LDO:	LDBPK_280500

LMI:	LMXM_28_0360

LBZ:	LBRM_28_0370 LBRM_32_2470

LPAN:

LPMP_280360

NGR:	NAEGRDRAFT_33321

» show all

Reference

PMID:15660128

Authors

Lois LM, Lima CD

Title

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.

Journal

EMBO J 24:439-51 (2005)
DOI:10.1038/sj.emboj.7600552

Sequence

[hsa:10055]

LinkDB

DBGET integrated database retrieval system