KEGG ORTHOLOGY: K11222

ORTHOLOGY: K11222

Entry

K11222                      KO

Symbol

STAT4

Name

signal transducer and activator of transcription 4

Pathway

map04217

Necroptosis

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map05161

Hepatitis B

map05200

Pathways in cancer

map05321

Inflammatory bowel disease

Disease

H00080

Systemic lupus erythematosus

H01493

Localized Scleroderma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K11222  STAT4; signal transducer and activator of transcription 4
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11222  STAT4; signal transducer and activator of transcription 4
09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K11222  STAT4; signal transducer and activator of transcription 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11222  STAT4; signal transducer and activator of transcription 4
  09172 Infectious disease: viral
   05161 Hepatitis B
    K11222  STAT4; signal transducer and activator of transcription 4
  09163 Immune disease
   05321 Inflammatory bowel disease
    K11222  STAT4; signal transducer and activator of transcription 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K11222  STAT4; signal transducer and activator of transcription 4
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    K11222  STAT4; signal transducer and activator of transcription 4

Genes

HSA:	6775(STAT4)

PTR:	100610925(STAT4)

PPS:	100972895(STAT4)

GGO:	101137064(STAT4)

PON:	129054459(STAT4)

PPYG:

129031866(STAT4)

NLE:	100596678(STAT4)

HMH:	116810527(STAT4)

SSYN:

129488194(STAT4)

MCC:	693854(STAT4)

MCF:	101925110(STAT4)

MTHB:

126932635

MNI:	105468202(STAT4)

CSAB:

103217530(STAT4)

CATY:

105580191(STAT4)

PANU:

101007479(STAT4)

TGE:	112635949(STAT4)

MLEU:

105535215(STAT4)

RRO:	104675283(STAT4)

RBB:	108527864(STAT4)

TFN:	117094711(STAT4)

PTEH:

111546394(STAT4)

CANG:

105507775(STAT4)

CJC:	100402355(STAT4)

SBQ:	101030273(STAT4)

CIMI:

108284047(STAT4)

ANAN:

105710136(STAT4)

CSYR:

103255989

MMUR:

105877908(STAT4)

LCAT:

123643618(STAT4)

ERUF:

138383983(STAT4)

PCOQ:

105813277(STAT4)

OGA:	100957076(STAT4)

MMU:	20849(Stat4)

MCAL:

110293862(Stat4)

MPAH:

110321473(Stat4)

RNO:	367264(Stat4)

MCOC:

116088411(Stat4)

ANU:	117705420(Stat4)

ASYL:

127692200(Stat4)

MUN:	110552026(Stat4)

CGE:

100769249

MAUA:

101828236(Stat4)

PROB:

127226209(Stat4)

PLEU:

114705439(Stat4)

PMAV:

102914811(Stat4)

MORG:

121442187 121458897

MFOT:

126511871

AAMP:

119803873(Stat4)

CNL:	130866813(Stat4)

NGI:	103736155(Stat4)

HGL:	101718558(Stat4)

CPOC:

100726892(Stat4)

CCAN:

109682739(Stat4)

DORD:

105996111(Stat4)

DSP:	122115048(Stat4)

DMER:

138809216(Stat4)

PLOP:

125350457(Stat4)

NCAR:

124980984

SVUL:

306658415(STAT4)

MMMA:

107138552(Stat4)

ITI:	101977093(Stat4)

SCIL:

308631111(STAT4)

MAVE:

308279746(STAT4)

OCU:	100344146 127488925

OPI:	101529407(STAT4)

OCZ:	121150738(STAT4)

TUP:	102475477(STAT4)

GVR:	103588073(STAT4)

CFA:	478845(STAT4)

CLUD:

112656334(STAT4)

VVP:	112922921(STAT4)

VLG:	121480498(STAT4)

NPO:	129523046(STAT4)

AML:	100471596(STAT4)

UMR:	103659686(STAT4)

UAH:	113250651(STAT4)

UAR:	123798149(STAT4)

ELK:

111141082

LLV:

125095870

MPUF:

101687459(STAT4)

MNP:	132013400(STAT4)

MLK:	131827655(STAT4)

NVS:	122902130(STAT4)

MMAQ:

308340010(STAT4)

ORO:	101379077(STAT4)

EJU:	114223552(STAT4)

ZCA:	113920911(STAT4)

MLX:	118012203(STAT4)

MANO:

123839003(STAT4)

NSU:	110592072(STAT4)

LWW:	102739329(STAT4)

FCA:	101080650(STAT4)

PYU:	121030839(STAT4)

PCOO:

112868399(STAT4)

PBG:	122481580(STAT4)

PVIV:

125173413(STAT4)

LRUF:

124515342

LGF:	123599237(STAT4)

AJU:

106979739

PTG:	102953648(STAT4)

PPAD:

109274706(STAT4)

PUC:

125911432

PLEZ:

122226404(STAT4)

HHV:	120233461(STAT4)

CCRU:

144244865(STAT4)

BTA:	515988(STAT4)

BOM:	102283979(STAT4)

BIU:	109575487(STAT4)

BJV:	133261785(STAT4)

BBUB:

102414384(STAT4)

BKE:	129646570(STAT4)

BBIS:

105003594(STAT4)

CHX:	102189443(STAT4)

OAS:	101117562(STAT4)

OCAN:

138434052(STAT4)

BTAX:

128066701(STAT4)

CSUM:

138075344(STAT4)

ODA:	120854683(STAT4)

CCAD:

122426650(STAT4)

MREE:

136163272(STAT4)

OVR:	110142375(STAT4)

MBEZ:

129538285(STAT4)

SSC:	397261(STAT4)

CFR:	102509760(STAT4)

CBAI:

105063980(STAT4)

CDK:	105088786(STAT4)

VPC:	102544953(STAT4)

BACU:

103013312(STAT4)

BMUS:

118898551(STAT4)

LVE:	103068832(STAT4)

OOR:	101272876(STAT4)

LALB:

132522210(STAT4)

GMF:	115847669(STAT4)

DDP:	132428482(STAT4)

SCOO:

307187995(STAT4)

PCRS:

137226398(STAT4)

DLE:	111171668(STAT4)

PCAD:

102977366(STAT4)

PSIU:

116757074(STAT4)

PPHC:

136125600(STAT4)

NASI:

112392136(STAT4)

HAMP:

307056991(STAT4)

ECB:	100054693(STAT4)

EPZ:	103548657(STAT4)

EAI:	106828795(STAT4)

MYB:	102244347(STAT4)

MYD:	102757535(STAT4)

MMYO:

118661772(STAT4)

MLF:	102424971(STAT4)

MDT:	132238059(STAT4)

MYUM:

139014872(STAT4)

PKL:	118709760(STAT4)

EFUS:

103290571(STAT4)

POTS:

308248184(STAT4)

MNA:	107540906(STAT4)

DRO:	112307984(STAT4)

SHON:

118985298(STAT4)

AJM:	119062106(STAT4)

PDIC:

114494417(STAT4)

PHAS:

123831244(STAT4)

MMF:	118625631(STAT4)

PPAM:

129065442(STAT4)

RFQ:	117025897(STAT4)

RHII:

308499119(STAT4)

PALE:

102886854(STAT4)

PGIG:

120587476(STAT4)

PVP:	105289302(STAT4)

RAY:	107519219(STAT4)

MJV:	108400081(STAT4)

TOD:	119256042(STAT4)

SARA:

101554621(STAT4)

SFUM:

130021045(STAT4)

SETR:

126008918(STAT4)

LAV:	100668145(STAT4)

TMU:

101351364

ETF:	101651148(STAT4)

DNM:	101435559(STAT4)

MDO:	100617910(STAT4)

GAS:	123239192(STAT4)

SHR:	100933645(STAT4)

AFZ:

127554458

PCW:	110213328(STAT4)

TVP:	118837836(STAT4)

PBRV:

138147612(STAT4)

MLAO:

141507625(STAT4)

OAA:	100680834(STAT4)

TACU:

119930568(STAT4)

GGA:	768406(STAT4)

PCOC:

116235962(STAT4)

MGP:	100544968(STAT4)

CJO:	107316323(STAT4)

TPAI:

128077103(STAT4)

LMUT:

125696993(STAT4)

NMEL:

110399458(STAT4)

APLA:

101794819(STAT4)

AACU:

137858576(STAT4)

OJA:	118169538(STAT4)

BCLA:

308445798(STAT4)

ACYG:

106039968(STAT4)

ABRC:

308197780(STAT4)

CATA:

118261542(STAT4)

AFUL:

116490742(STAT4)

TGU:	100224258(STAT4)

LSR:	110471108(STAT4)

VMC:	128809825(STAT4)

VCHA:

128790937(STAT4)

AIB:	137477380(STAT4)

SCAN:

103814538(STAT4)

PMOA:

120511478(STAT4)

OTC:	121335323(STAT4)

PRUF:

121364369(STAT4)

ATRC:

139593532(STAT4)

MATE:

118689077(STAT4)

MAEN:

136558577(STAT4)

GFR:	102035832(STAT4)

FAB:	101811067(STAT4)

OMA:	130255733(STAT4)

PHI:	102100630(STAT4)

PMAJ:

107207703(STAT4)

CCAE:

111931931(STAT4)

CCW:	104693739(STAT4)

CBRC:

103612432(STAT4)

ACOE:

138113556(STAT4)

ETL:	114057452(STAT4)

ZAB:	102075479(STAT4)

ZLE:	135450154(STAT4)

ACHL:

103801734(STAT4)

SVG:	106855937(STAT4)

MMEA:

130578197(STAT4)

HRT:	120755499(STAT4)

SATI:

136363362(STAT4)

CFAI:

136293165(STAT4)

CCIC:

134052361(STAT4)

NNT:	104399491(STAT4)

SHAB:

115608874(STAT4)

POCC:

134159264(STAT4)

FPG:	101922376(STAT4)

FCH:	102054863(STAT4)

FRS:	119152655(STAT4)

CCRI:

104168560(STAT4)

ACUN:

113482457(STAT4)

ANOC:

141962468(STAT4)

SURA:

141945130(STAT4)

TALA:

104359993(STAT4)

ACHC:

115342510(STAT4)

HALD:

104321135(STAT4)

HLE:	104829610(STAT4)

AGEN:

126042753

HHAR:

128143801(STAT4)

BBUT:

142031115(STAT4)

GCL:

127018116

CSTI:

104553565(STAT4)

LDI:	104340450(STAT4)

MNB:	103782407(STAT4)

DPUB:

104309848(STAT4)

PPUS:

135187771

IIN:	128967311(STAT4)

AVIT:

104279797(STAT4)

BRHI:

104500824(STAT4)

EGZ:	104130543(STAT4)

NNI:	104014266(STAT4)

PCRI:

104023784(STAT4)

PCAO:

104039651(STAT4)

PARX:

142057600(STAT4)

PADL:

103925471(STAT4)

AFOR:

103897148(STAT4)

FGA:	104075350(STAT4)

CBOR:

142083742(STAT4)

GSTE:

104250746(STAT4)

CBOY:

140657211(STAT4)

MAME:

142414296(STAT4)

CLV:	102097927(STAT4)

CNIC:

135990086(STAT4)

NMAY:

308041803(STAT4)

MUI:	104545319(STAT4)

PGUU:

104465139(STAT4)

PLET:

104614061(STAT4)

EHS:	104503240(STAT4)

CMAC:

104478179(STAT4)

CUCA:

104058326(STAT4)

PCUR:

138722493(STAT4)

TEO:	104381472(STAT4)

BREG:

104642563(STAT4)

GAME:

129208109(STAT4)

OHA:	104328393(STAT4)

ACAR:

104518025(STAT4)

CEUR:

306722814(STAT4)

CPEA:

104386614(STAT4)

CVF:	104290960(STAT4)

RTD:	128912908(STAT4)

CRID:

134518118(STAT4)

LMIC:

141746894(STAT4)

NARQ:

141463289(STAT4)

AAM:	106492457(STAT4)

AROW:

112978337(STAT4)

NPD:	112955364(STAT4)

TGT:	104565535(STAT4)

DNE:	112982903(STAT4)

SCAM:

104143405(STAT4)

ASN:	102377767(STAT4) 102380863

AMJ:	102571515(STAT4)

CPOO:

109323158(STAT4)

GGN:	109301853(STAT4)

PSS:	102463308(STAT4)

CIZ:	142016612(STAT4)

CMY:	102934439(STAT4)

CCAY:

125645003(STAT4)

LKP:	140895752(STAT4)

NDS:	141996076(STAT4)

DCC:	119863417(STAT4)

CPIC:

101932470(STAT4)

TST:	117885060(STAT4)

EOB:	135885922(STAT4)

CABI:

116815205(STAT4)

MRV:	120374670(STAT4)

EMQ:	137153540(STAT4)

ACS:	100556501(stat4)

ASAO:

132778057(STAT4)

PVT:	110083962(STAT4)

SUND:

121919723(STAT4)

PBI:	103060923(STAT4)

PMUR:

107289221(STAT4)

CTIG:

120298335(STAT4)

TSR:	106537874(STAT4) 106554672

PGUT:

117672718(STAT4)

PCAE:

139327134(STAT4)

APRI:

131201008(STAT4)

PTEX:

113433883(STAT4)

NSS:	113412337(STAT4)

VKO:	123021845(STAT4)

PMUA:

114607458(STAT4)

PRAF:

128399329(STAT4)

ZVI:	118095210(STAT4)

HCG:	128335399(STAT4)

EMC:	129324128(STAT4)

XLA:	108701493(stat4.L)

XTR:	100496013(stat4)

PWL:	138285648(STAT4)

MUO:	115474668(STAT4)

GSH:	117361026(STAT4)

DRE:	368519(stat4)

DAES:

130235257(stat4)

SRX:	107714380 107728930

SANH:

107657497 107660593

SGH:	107565030(stat4) 107602137

CCAR:

109081475 109096055(stat4)

CAUA:

113053016 113108357

CGIB:

127965266 128020162

PTET:

122351952(stat4)

LROH:

127171022(stat4)

PPRM:

120477614(stat4)

RKG:	130072555(stat4)

SCEP:

307164300(stat4)

MAMB:

125270610(stat4)

CIDE:

127519047

MASI:

127447312 127447993

TROS:

130555683(stat4)

TDW:	130427369(stat4)

IPU:

108266777

IFU:	128608463(stat4)

PHYP:

113525972(stat4)

SMEO:

124382671

TFD:	113657016(stat4)

TVC:	132850465(stat4)

CGAR:

128523818(stat4)

NGRA:

132891463(stat4)

TRN:	134324529(stat4)

AMEX:

103031322(stat4)

CMAO:

118818707(stat4)

EEE:	113581351(stat4)

CHAR:

105913249

SPIL:

134078540(stat4)

ASAD:

121700810(stat4)

TRU:

101068057

TFS:	130523099(stat4)

TNG:	GSTEN00033157G001

NCC:

104961600

TBEN:

117485647(stat4)

CGOB:

115026731(stat4)

PGEO:

117466514(stat4)

GACU:

117536944(stat4)

EMAC:

134867185(stat4)

ELY:	117251530(stat4)

EFO:

125899276

PLEP:

121948956(stat4)

SLUC:

116043143(stat4)

SVIT:

144525999(stat4)

ECRA:

117952365(stat4)

ESP:	116698332(stat4)

PFLV:

114564065(stat4)

PFLT:

120569562(stat4)

GAT:	120834091(stat4)

PPUG:

119228640(stat4)

AFB:	129105076(stat4)

CLUM:

117750170(stat4)

PSWI:

130200879(stat4)

CANA:

137783312

TBU:	306747418(stat4)

CVE:	137868347(stat4)

AMIR:

142965108(stat4)

MSAM:

119903419(stat4)

SCHU:

122885809(stat4)

EARM:

139292079

CUD:

121522543

SPUL:

138592098(stat4)

ALAT:

119025601

LCO:	104920796(stat4)

AMMM:

307258895(stat4)

MZE:

101482935

ONL:	100711701(stat4)

OAU:	116309449(stat4)

OLA:

101161521

OML:	112155517(stat4)

XMA:	102223424(stat4)

XCO:	114148404(stat4)

XHE:	116723259(stat4)

PRET:

103460697

PFOR:

103130255(stat4)

PLAI:

106951656(stat4)

PMEI:

GAF:

PPRL:

CVG:

CTUL:

119792759(stat4)

GMU:

124871847

NFU:	107397170(stat4)

KMR:	108250769(stat4)

ALIM:

106530557(stat4)

NWH:	119418980(stat4)

LTU:	140319033(stat4)

MCEP:

125017357(stat4)

AOCE:

111563280

EJA:

138201419

BFRE:

138621040(stat4)

LCF:

108897211

CSEM:

103392405(stat4)

POV:	109637377(stat4)

SSEN:

122758582(stat4)

SSOE:

131477138

HHIP:

117755127(stat4)

HSP:	118120298(stat4)

PPLT:

128455913

SMAU:

118282786(stat4)

SDU:	111218102(stat4)

SLAL:

111667431(stat4)

XGL:	120801383(stat4)

HCQ:	109517577(stat4)

SSCV:

125973514(stat4)

BPEC:

110156165(stat4)

ENY:

140359950

MALB:

109971734

BSPL:

114847246(stat4)

SJO:	128367600(stat4)

SSCO:

133992718(stat4)

TTY:	137192363(stat4)

GMH:	115533224(stat4)

SASA:

100380385(stat4) 106586145

STRU:

115156112(stat4) 115160669

OTW:	112225151(stat4) 112235400

OMY:	110501546(stat4) 110520023

OGO:	124041987 124043796

ONE:	115108086 115138591

OKI:	109865765 109870786

OKE:	118367153 118385955(stat4)

OMM:	135547139(stat4)

OCLA:

139380382

SALP:

111973981 111974244(stat4)

SNH:	120058215 120064424(stat4)

SFON:

129816363(stat4) 129821357

CCLU:

121536667 121551556(stat4)

ELS:	105022416(stat4)

OEP:	134017591(stat4)

SFM:	108924290 108929374

PKI:	111842925(stat4) 111845442

AANG:

118214570 118223247(stat4)

AROT:

135250385(stat4)

CCOG:

133123804

LOC:	102684153(stat4)

PSPA:

121322144 121323308

ARUT:

117409430 117426897

PSEX:

120522444(stat4)

LCM:	102353506(STAT4)

CMK:

103176542

RTP:	109920378 109926024

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

GAE:

TAD:	TRIADDRAFT_53947

» show all

Reference

PMID:7545930

Authors

Zhong Z, Wen Z, Darnell JE Jr

Title

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

Journal

Proc Natl Acad Sci U S A 91:4806-10 (1994)
DOI:10.1073/pnas.91.11.4806

Sequence

[mmu:20849]

Reference

PMID:17216035

Authors

Lim CP, Cao X

Title

Structure, function, and regulation of STAT proteins.

Journal

Mol Biosyst 2:536-50 (2006)
DOI:10.1039/b606246f

LinkDB

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