KEGG   REACTION: R02497
Entry
R02497                      Reaction                               
Name
dihydrotestosterone:NADP+ delta4-oxidoreductase
Definition
Dihydrotestosterone + NADP+ <=> Testosterone + NADPH + H+
Equation
C03917 + C00006 <=> C00535 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00145  C00535_C03917
Enzyme
1.3.1.22
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.22
     R02497  Dihydrotestosterone + NADP+ <=> Testosterone + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.1.22
   R13214  3-Oxo-5alpha-steroid <=> 3-Oxo-Delta4-steroid
    R02497  Dihydrotestosterone <=> Testosterone
Orthology
K12343  3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]
K12344  3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22]
K12345  3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]
Other DBs
RHEA: 50823
LinkDB

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