KEGG ORTHOLOGY: K12470

ORTHOLOGY: K12470

Entry

K12470                      KO

Symbol

SH3KBP1, CIN85

Name

SH3 domain-containing kinase-binding protein 1

Pathway

map04144

Endocytosis

Disease

H00085

Agammaglobulinemias

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K12470  SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12470  SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Other core components
    K12470  SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1
Others
  Actin-binding proteins
   Nucleation-promoting factors (NPFs)
    K12470  SH3KBP1, CIN85; SH3 domain-containing kinase-binding protein 1

Genes

HSA:	30011(SH3KBP1)

PTR:	465527(SH3KBP1)

PPS:	100985113(SH3KBP1)

GGO:	101130648(SH3KBP1)

PON:	100450340(SH3KBP1)

PPYG:

129024271(SH3KBP1)

NLE:	100591281(SH3KBP1)

HMH:	116812283(SH3KBP1)

SSYN:

129476366(SH3KBP1)

MCC:	694764(SH3KBP1)

MCF:	102127625(SH3KBP1)

MTHB:

126946401

MNI:	105478200(SH3KBP1)

CSAB:

103231684(SH3KBP1)

CATY:

105574643(SH3KBP1)

PANU:

101022676(SH3KBP1)

TGE:	112615501(SH3KBP1)

MLEU:

105550778(SH3KBP1)

RRO:	104682409(SH3KBP1)

RBB:

108538908

TFN:	117077359(SH3KBP1)

PTEH:

111531657

CANG:

105510425(SH3KBP1)

CJC:	100409963(SH3KBP1) 100894858

SBQ:	101049648(SH3KBP1)

CIMI:

108312646(SH3KBP1)

ANAN:

105704657(SH3KBP1)

CSYR:

103258039(SH3KBP1)

MMUR:

105882372(SH3KBP1)

LCAT:

123645732

PCOQ:

105816317(SH3KBP1)

OGA:	100960167(SH3KBP1)

MMU:	58194(Sh3kbp1)

MCAL:

110286205(Sh3kbp1)

MPAH:

110314275(Sh3kbp1)

RNO:	84357(Sh3kbp1)

MCOC:

116090164(Sh3kbp1)

ANU:	117694380(Sh3kbp1)

ASYL:

127674407(Sh3kbp1)

MUN:	110565477(Sh3kbp1)

CGE:	100750373(Sh3kbp1)

MAUA:

101830870(Sh3kbp1)

PROB:

127217904(Sh3kbp1)

PLEU:

114695792(Sh3kbp1)

MORG:

121441178(Sh3kbp1) 121441312

MFOT:

126515027

AAMP:

119804732(Sh3kbp1)

NGI:	103736227(Sh3kbp1)

HGL:	101717745(Sh3kbp1)

CPOC:

100720414(Sh3kbp1)

DORD:

105993305(Sh3kbp1)

DSP:	122100104(Sh3kbp1)

PLOP:

125343537(Sh3kbp1)

NCAR:

124971975

MMMA:

107144261(Sh3kbp1)

ITI:	101954941(Sh3kbp1)

OCU:

100357864

OPI:	101523325(SH3KBP1)

TUP:	102467955(SH3KBP1)

GVR:	103592898(SH3KBP1)

CLUD:

112653812(SH3KBP1)

VVP:	112919125(SH3KBP1)

VLG:	121482233(SH3KBP1)

NPO:	129517651(SH3KBP1)

AML:	100471577(SH3KBP1)

UMR:	103668167(SH3KBP1)

UAH:	113242243(SH3KBP1)

UAR:	123794855(SH3KBP1)

ELK:

111150333

LLV:

125091617

MPUF:

101687817(SH3KBP1)

MNP:	132006743(SH3KBP1)

MLK:	131822150(SH3KBP1)

NVS:	122896331(SH3KBP1)

ORO:	101385688(SH3KBP1)

EJU:	114223630(SH3KBP1)

ZCA:	113931079(SH3KBP1)

MLX:	118007461(SH3KBP1)

NSU:	110575039(SH3KBP1)

LWW:

102745893

FCA:	101081024(SH3KBP1)

PYU:	121025627(SH3KBP1)

PCOO:

112871695(SH3KBP1)

PBG:	122477521(SH3KBP1)

PVIV:

125157220(SH3KBP1)

LRUF:

124509401

LGF:	123595060(SH3KBP1)

AJU:

106981923

PTG:	102963969(SH3KBP1)

PPAD:

109256385(SH3KBP1)

PUC:

125931531

HHV:	120241965(SH3KBP1)

BTA:	510489(SH3KBP1)

BOM:	102276186(SH3KBP1)

BIU:	109555281(SH3KBP1)

BBUB:

102413085(SH3KBP1)

CHX:	102186673(SH3KBP1)

OAS:	101110388(SH3KBP1)

BTAX:

128069789(SH3KBP1)

CSUM:

138070778(SH3KBP1)

ODA:	120882522(SH3KBP1)

CCAD:

122435334(SH3KBP1)

MREE:

136153679(SH3KBP1)

OVR:	110151128(SH3KBP1)

MBEZ:

129564323(SH3KBP1)

SSC:	100522530(SH3KBP1)

CFR:	102523996(SH3KBP1)

CBAI:

105068632(SH3KBP1)

CDK:	105095312(SH3KBP1)

VPC:	102533368(SH3KBP1)

BACU:

103016032(SH3KBP1)

BMUS:

118888929(SH3KBP1)

LVE:	103089062(SH3KBP1)

OOR:	101269186(SH3KBP1)

LALB:

132512886(SH3KBP1)

DLE:	111170377(SH3KBP1)

PCAD:

102977116(SH3KBP1)

PSIU:

116746949(SH3KBP1)

NASI:

112394992(SH3KBP1)

ECB:	100058644(SH3KBP1)

EPZ:	103565537(SH3KBP1)

EAI:	106835502(SH3KBP1)

MYB:	102245537(SH3KBP1)

MYD:	102765399(SH3KBP1)

MMYO:

118653831(SH3KBP1)

MLF:	102435213(SH3KBP1)

MDT:	132225251(SH3KBP1)

PKL:	118719847(SH3KBP1)

EFUS:

103297813(SH3KBP1)

MNA:	107526788(SH3KBP1)

DRO:	112313329(SH3KBP1)

SHON:

118987202(SH3KBP1)

AJM:	119058360(SH3KBP1)

PDIC:

114504690(SH3KBP1)

PHAS:

123830054(SH3KBP1)

MMF:	118635958(SH3KBP1)

PPAM:

129076932(SH3KBP1)

HAI:	109395884(SH3KBP1)

RFQ:	117026143(SH3KBP1)

PALE:

102882213(SH3KBP1)

PGIG:

120594295(SH3KBP1)

PVP:	105294028(SH3KBP1)

RAY:	107500167(SH3KBP1)

MJV:	108400932(SH3KBP1)

TOD:	119246291(SH3KBP1)

SARA:

101542853(SH3KBP1)

SFUM:

130039227(SH3KBP1)

SETR:

125998722(SH3KBP1)

LAV:	100657462(SH3KBP1)

TMU:

101361453

ETF:	101649843(SH3KBP1)

DNM:	101435239(SH3KBP1)

MDO:	100013895(SH3KBP1)

GAS:	123242406(SH3KBP1)

SHR:	100932601(SH3KBP1)

AFZ:

127553983

PCW:	110210840(SH3KBP1)

TVP:	118838344(SH3KBP1)

PBRV:

138142389(SH3KBP1)

OAA:	100083478(SH3KBP1)

TACU:

119937487(SH3KBP1)

GGA:	418608(SH3KBP1)

PCOC:

116232758(SH3KBP1)

MGP:	100551401(SH3KBP1)

CJO:	107325446(SH3KBP1)

TPAI:

128076304(SH3KBP1)

LMUT:

125687240(SH3KBP1)

NMEL:

110404639(SH3KBP1)

APLA:

101791340(SH3KBP1)

ACYG:

106037808(SH3KBP1)

CATA:

118245659(SH3KBP1)

AFUL:

116486119(SH3KBP1)

TGU:	100225064(SH3KBP1)

LSR:	110483220(SH3KBP1)

SCAN:

103815842(SH3KBP1)

PMOA:

120504523(SH3KBP1)

OTC:	121333482(SH3KBP1)

PRUF:

121356158(SH3KBP1)

ATRC:

139591630(SH3KBP1)

GFR:	102034855(SH3KBP1)

FAB:	101810014(SH3KBP1)

OMA:	130258404(SH3KBP1)

PHI:	102112220(SH3KBP1)

PMAJ:

107207656(SH3KBP1)

CCAE:

111922873(SH3KBP1)

CCW:	104686184(SH3KBP1)

CBRC:

103611696(SH3KBP1)

ACOE:

138103355(SH3KBP1)

ETL:	114058908(SH3KBP1)

ZAB:	102069330(SH3KBP1)

ZLE:	135445308(SH3KBP1)

ACHL:

103811061(SH3KBP1)

SVG:	106852875(SH3KBP1)

MMEA:

130586061

HRT:	120748553(SH3KBP1)

SATI:

136358094(SH3KBP1)

CCIC:

134058068(SH3KBP1)

FPG:	101924149(SH3KBP1)

FCH:	102048159(SH3KBP1)

NNT:	104406229(SH3KBP1)

SHAB:

115603800(SH3KBP1)

ACUN:

113480332(SH3KBP1)

TALA:

104367093(SH3KBP1)

ACHC:

115343764(SH3KBP1)

HALD:

104315875(SH3KBP1)

HLE:	104834143(SH3KBP1)

AGEN:

126053129

HHAR:

128144879(SH3KBP1)

GCL:

127029547

LDI:	104351174(SH3KBP1)

DPUB:

104300479(SH3KBP1)

PPUS:

135179918(SH3KBP1)

BRHI:

104489277(SH3KBP1)

EGZ:	104135180(SH3KBP1)

NNI:	104022516(SH3KBP1)

PCRI:

104024812(SH3KBP1)

PADL:

103918222(SH3KBP1)

AFOR:

103896958(SH3KBP1)

FGA:	104079818(SH3KBP1)

GSTE:

104258326(SH3KBP1)

CLV:	102088281(SH3KBP1)

PGUU:

104469304(SH3KBP1)

PLET:

104625012(SH3KBP1)

EHS:	104507215(SH3KBP1)

CMAC:

104486307(SH3KBP1)

CUCA:

104063385(SH3KBP1)

TEO:	104375488(SH3KBP1)

OHA:	104334980(SH3KBP1)

CPEA:

104388289(SH3KBP1)

CVF:

104294849

RTD:	128904521(SH3KBP1)

CRID:

134519129(SH3KBP1)

AAM:	106492038(SH3KBP1)

AROW:

112960531

NPD:	112958333(SH3KBP1)

TGT:

104568877

DNE:	112995642(SH3KBP1)

SCAM:

104140461(SH3KBP1)

ASN:	102368193(SH3KBP1)

AMJ:	102573255(SH3KBP1)

CPOO:

109305993(SH3KBP1)

GGN:	109302880(SH3KBP1)

PSS:	102451260(SH3KBP1)

CMY:	102935495(SH3KBP1)

CCAY:

125641966(SH3KBP1)

DCC:	119849647(SH3KBP1)

CPIC:

101941882(SH3KBP1)

TST:	117869158(SH3KBP1)

CABI:

116823447(SH3KBP1)

MRV:	120394495 120400488(SH3KBP1)

ACS:	100551600(sh3kbp1)

ASAO:

132771716(SH3KBP1)

PVT:	110076718(SH3KBP1)

SUND:

121926098(SH3KBP1)

PBI:	103060890(SH3KBP1)

PMUR:

107295918(SH3KBP1)

CTIG:

120314288(SH3KBP1)

TSR:	106539793(SH3KBP1)

PGUT:

117675453(SH3KBP1)

APRI:

131199743(SH3KBP1)

PTEX:

113445172(SH3KBP1)

NSS:	113416837(SH3KBP1)

VKO:	123029091(SH3KBP1)

PMUA:

114596238(SH3KBP1)

PRAF:

128413166(SH3KBP1)

ZVI:	118085794(SH3KBP1)

HCG:	128350178(SH3KBP1)

GJA:	107115850(SH3KBP1)

STOW:

125430946(SH3KBP1)

EMC:	129325748(SH3KBP1)

XLA:	108705547 108708009 108709328(sh3kbp1.S)

XTR:	100151706(sh3kbp1)

NPR:	108785715(SH3KBP1)

RTEM:

120927509(SH3KBP1)

BBUF:

120994843(SH3KBP1)

BGAR:

122930519(SH3KBP1)

PWL:	138250161(SH3KBP1)

MUO:	115469528(SH3KBP1)

GSH:	117362531(SH3KBP1)

DRE:	793623(sh3kbp1)

SRX:	107721874 107725869

SANH:

107663662(sh3kbp1)

SGH:	107586741(sh3kbp1) 107590295

CCAR:

109062124 109069747(sh3kbp1)

CAUA:

113042396 113066177 113080051

CGIB:

127946165 128012897

PTET:

122329870(sh3kbp1)

LROH:

127155659(sh3kbp1)

OMC:	131533740(sh3kbp1)

PPRM:

120488312(sh3kbp1)

RKG:	130083981(sh3kbp1)

MAMB:

125258015(sh3kbp1)

CIDE:

127505943

CERY:

137013786(sh3kbp1)

MASI:

127431616 127434149

TROS:

130547226(sh3kbp1)

TDW:	130413474(sh3kbp1)

MANU:

129425554(sh3kbp1)

PDAB:

135740222(sh3kbp1)

IPU:

108256316

IFU:	128600039(sh3kbp1)

PHYP:

113541186(sh3kbp1)

SMEO:

124403683(sh3kbp1)

TFD:	113660345(sh3kbp1)

TVC:	132840018(sh3kbp1)

CGAR:

128513958(sh3kbp1)

NGRA:

132867015(sh3kbp1)

TRN:	134301065(sh3kbp1)

AMEX:

103025305(sh3kbp1)

CMAO:

118798651(sh3kbp1)

EEE:	113576138(sh3kbp1)

TRU:	101076581(sh3kbp1)

TFS:	130514136(sh3kbp1)

TNG:	GSTEN00025479G001

LCO:	104940023(sh3kbp1)

NCC:

104949750

TBEN:

117495658(sh3kbp1)

CGOB:

115025542(sh3kbp1)

PGEO:

117465576(sh3kbp1)

GACU:

117544745(sh3kbp1)

EMAC:

134884101(sh3kbp1)

ELY:	117264811(sh3kbp1)

EFO:	125881608(sh3kbp1)

PLEP:

121960486(sh3kbp1)

SLUC:

116048548(sh3kbp1)

ECRA:

117937773(sh3kbp1)

ESP:	116671957(sh3kbp1)

PFLV:

114549643(sh3kbp1)

GAT:	120811531(sh3kbp1)

PPUG:

119198986(sh3kbp1)

AFB:	129110771(sh3kbp1)

CLUM:

117749338(sh3kbp1)

PSWI:

130206000(sh3kbp1)

CANA:

137788873(sh3kbp1)

CVE:	137872046(sh3kbp1)

MSAM:

119912491(sh3kbp1)

SCHU:

122866624(sh3kbp1)

CUD:	121527552(sh3kbp1)

SPUL:

138595844(sh3kbp1)

LMIX:

132994578(sh3kbp1)

ALAT:

119008707(sh3kbp1)

ASTR:

137614158(sh3kbp1)

MZE:	101486118(sh3kbp1)

ONL:	100692237(sh3kbp1)

OAU:	116324431(sh3kbp1)

OLA:	101157013(sh3kbp1)

OML:	112151195(sh3kbp1)

CSAI:

133423026(sh3kbp1)

XMA:	102222214(sh3kbp1)

XCO:	114136721(sh3kbp1)

XHE:	116711820(sh3kbp1)

PRET:

103456752(sh3kbp1)

PFOR:

103140537(sh3kbp1)

PLAI:

106935767

PMEI:

106914951(sh3kbp1)

GAF:	122823951(sh3kbp1)

PPRL:

129378900(sh3kbp1)

CVG:	107094812(sh3kbp1)

CTUL:

119771467(sh3kbp1)

GMU:	124858089(sh3kbp1)

NFU:	107383063(sh3kbp1)

KMR:	108234731(sh3kbp1)

ALIM:

106515508(sh3kbp1)

NWH:	119426854(sh3kbp1)

AOCE:

111570229(sh3kbp1)

EJA:	138204474(sh3kbp1)

BFRE:

138619761(sh3kbp1)

MCEP:

124995524(sh3kbp1)

CSEM:

103377322(sh3kbp1)

POV:

109644971

SSEN:

122780371(sh3kbp1)

SSOE:

131461015(sh3kbp1)

HHIP:

117754191(sh3kbp1)

HSP:	118098413(sh3kbp1)

PPLT:

128425511(sh3kbp1)

SMAU:

118291051(sh3kbp1)

LCF:

108885108

SDU:	111224324(sh3kbp1)

SLAL:

111645765(sh3kbp1)

XGL:	120789579(sh3kbp1)

HCQ:	109524704(sh3kbp1)

SSCV:

125986166(sh3kbp1)

SBIA:

133492831(sh3kbp1)

PEE:	133396574(sh3kbp1)

PTAO:

133470063(sh3kbp1)

BPEC:

110161275(sh3kbp1)

ENY:	140364400(sh3kbp1)

MALB:

109961080(sh3kbp1)

BSPL:

114853817(sh3kbp1)

SJO:	128382567(sh3kbp1)

SSCO:

134002348(sh3kbp1)

GMH:	115537482(sh3kbp1)

SASA:

100195508(sh3k1) 106579452

STRU:

115195469(sh3kbp1)

OTW:	112215421(sh3kbp1) 112247514

OMY:	110489648 110535365(sh3kbp1)

OGO:	123991296(sh3kbp1) 124039537

ONE:	115122943(sh3kbp1) 115130113

OKI:	109899241 109909887(sh3kbp1)

OKE:	118369943 118373643(sh3kbp1)

OMM:	135517216 135522806(sh3kbp1)

OCLA:

139366957 139420270

SNH:	120027966(sh3kbp1) 120050962

CCLU:

121549822(sh3kbp1) 121569274

ELS:	105021977(sh3kbp1)

OEP:	134034892(sh3kbp1)

SFM:	108927718(sh3kbp1)

PKI:	111836770(sh3kbp1)

AANG:

118224988(sh3kbp1)

AROT:

135253410(sh3kbp1)

CCOG:

133126254(sh3kbp1)

LOC:

102697728

PSPA:

121302900(sh3kbp1)

ARUT:

117406360 117406442

PSEX:

120523869(sh3kbp1)

LCM:	102358503(SH3KBP1)

CMK:	103177511(sh3kbp1)

RTP:

109930959

CPLA:

122554979(sh3kbp1)

HOC:	132820990(sh3kbp1)

LERI:

129702862(sh3kbp1)

PMRN:

116953392(SH3KBP1)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

AJJ:

ARUN:

AAMU:

AFIL:

PFLL:

AGB:

LDC:

AFRA:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

DSV:

RSAN:

RMP:

VDE:

VJA:

CVS:

ABRU:

SDM:

LPOL:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CVN:

OED:

AIRR:

MAEA:

OSN:	115218265 115221994

LLON:

NVE:

XEN:

HMG:

HSY:

Reference

PMID:15090612

Authors

Kowanetz K, Husnjak K, Holler D, Kowanetz M, Soubeyran P, Hirsch D, Schmidt MH, Pavelic K, De Camilli P, Randazzo PA, Dikic I

Title

CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.

Journal

Mol Biol Cell 15:3155-66 (2004)
DOI:10.1091/mbc.E03-09-0683

Sequence

[hsa:30011]

Reference

PMID:16256071

Authors

Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P

Title

CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.

Journal

Biochem Biophys Res Commun 338:808-14 (2005)
DOI:10.1016/j.bbrc.2005.10.032

Sequence

[hsa:30011]

LinkDB

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