KEGG   ORTHOLOGY: K12560
Entry
K12560                      KO                                     
Symbol
FCGR2B, CD32
Name
low affinity immunoglobulin gamma Fc receptor II-b
Pathway
map04145  Phagosome
map04380  Osteoclast differentiation
map04662  B cell receptor signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05162  Measles
Disease
H00080  Systemic lupus erythematosus
H00361  Malaria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
   04666 Fc gamma R-mediated phagocytosis
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
   05152 Tuberculosis
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K12560  FCGR2B, CD32; low affinity immunoglobulin gamma Fc receptor II-b
CD molecules [BR:ko04090]
 Proteins
  K12560  CD32b, FCGR2B; Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Other DBs
GO: 0019770
Genes
HSA: 2213(FCGR2B)
PTR: 748765
PPS: 100984838(FCGR2B)
GGO: 101128757(FCGR2B) 115932911
PON: 100453137(FCGR2B)
NLE: 101176250(FCGR2B)
MCC: 720009(FCGR2B)
MCF: 102139530(FCGR2B)
CSAB: 103223672(FCGR2B)
CATY: 105589236(FCGR2B)
PANU: 101011136(FCGR2B)
TGE: 112609495(FCGR2B)
RRO: 104670387(FCGR2B)
RBB: 108542588(FCGR2B)
TFN: 117074577(FCGR2B)
PTEH: 111533804(FCGR2B)
CJC: 100412558(FCGR2B)
SBQ: 101039367(FCGR2B)
CSYR: 103277310(FCGR2B)
MMUR: 105873560(FCGR2B)
LCAT: 123635230
OGA: 100958885(FCGR2B)
MMU: 14130(Fcgr2b)
MCAL: 110299221
MPAH: 110321728
RNO: 289211(Fcgr2b)
MCOC: 116103280
MUN: 110554428
CGE: 103161893
MAUA: 101844813(Fcgr2b)
PLEU: 114689890(Fcgr2b)
AAMP: 119827205(Fcgr2b)
NGI: 103746773(Fcgr2b)
HGL: 101704179(Fcgr2b)
CPOC: 100192391(Fcgr2b)
CCAN: 109693504(Fcgr2b)
DORD: 105996454
DSP: 122109326
OCU: 100359306
OPI: 101523293(FCGR2B)
TUP: 102500089(FCGR2B)
CFA: 100856270(FCGR2B)
CLUD: 112643042(FCGR2B)
VVP: 112914296(FCGR2B)
VLG: 121472254(FCGR2B)
AML: 100479420
UMR: 103658249(FCGR2B)
UAH: 113268760(FCGR2B)
UAR: 123783523(FCGR2B)
ORO: 101363428(FCGR2B)
EJU: 114210517(FCGR2B)
ZCA: 113933575
MLX: 118014025(FCGR2B)
FCA: 101087550(FCGR2B)
PYU: 121020941(FCGR2B)
PBG: 122475591
PTG: 102959619(FCGR2B)
PPAD: 109276672(FCGR2B)
AJU: 106986772(FCGR2B)
HHV: 120241067(FCGR2B)
BTA: 282229(FCGR2B)
BOM: 102273069
BIU: 109578097(FCGR2B)
BBUB: 102394636
CHX: 102186356
OAS: 100192432(FCGR2B)
ODA: 120855416
CCAD: 122430161(FCGR2B)
SSC: 613131(FCGR2B)
CFR: 102516047
CBAI: 105068021(FCGR2B)
VPC: 102534080
BACU: 103008029
LVE: 103088736
PCAD: 102983864
PSIU: 116758779(FCGR2B)
ECB: 102150150
EPZ: 103555970(FCGR2B)
EAI: 106831114
MYB: 102248290
MYD: 102754992
MMYO: 118673458
MNA: 107535132
HAI: 109392296(FCGR2B)
DRO: 112297192(FCGR2B)
SHON: 118979067(FCGR2B)
AJM: 119052404(FCGR2B)
PDIC: 114489494
PHAS: 123818559(FCGR2B)
MMF: 118637095(FCGR2B)
RFQ: 117014583(FCGR2B)
PALE: 102893641
PGIG: 120584192
PVP: 105303406
RAY: 107502477
MJV: 108388266(FCGR2B)
TOD: 119241334(FCGR2B)
SARA: 101553708
LAV: 104846347
TMU: 101360526
DNM: 101417741(FCGR2B)
MDO: 100015202 100619042(FCGR2B)
SHR: 100924400(FCGR2B)
PCW: 110209906
SCAN: 108964832
BBUF: 120982450
 » show all
Reference
PMID:9232445
  Authors
Sarmay G, Koncz G, Pecht I, Gergely J
  Title
Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell.
  Journal
Immunol Lett 57:159-64 (1997)
DOI:10.1016/S0165-2478(97)00055-2
  Sequence
[hsa:2213]
Reference
  Authors
Willcocks LC, Carr EJ, Niederer HA, Rayner TF, Williams TN, Yang W, Scott JA, Urban BC, Peshu N, Vyse TJ, Lau YL, Lyons PA, Smith KG
  Title
A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.
  Journal
Proc Natl Acad Sci U S A 107:7881-5 (2010)
DOI:10.1073/pnas.0915133107
  Sequence
[hsa:2213]
Reference
PMID:2531080
  Authors
Stuart SG, Simister NE, Clarkson SB, Kacinski BM, Shapiro M, Mellman I
  Title
Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.
  Journal
EMBO J 8:3657-66 (1989)
DOI:10.1002/j.1460-2075.1989.tb08540.x
  Sequence
[hsa:2213]
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