KEGG ORTHOLOGY: K12642

ORTHOLOGY: K12642

Entry

K12642                      KO

Symbol

PKP2

Name

plakophilin 2

Pathway

map04820

Cytoskeleton in muscle cells

map05412

Arrhythmogenic right ventricular cardiomyopathy

Disease

H00293

Arrhythmogenic right ventricular cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K12642  PKP2; plakophilin 2
09160 Human Diseases
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K12642  PKP2; plakophilin 2

Genes

HSA:	5318(PKP2)

PTR:	465265(PKP2)

PPS:	100980070 100980846(PKP2)

GGO:	101150898(PKP2)

PON:	100458828(PKP2)

NLE:	100584224(PKP2)

HMH:	116472821(PKP2)

MCC:	100429378(PKP2)

MCF:	102126874(PKP2)

MTHB:

126931790

MNI:	105484283(PKP2)

CSAB:

103218840(PKP2)

CATY:

105591357(PKP2)

PANU:

101019446(PKP2)

TGE:	112635367(PKP2)

MLEU:

105530190(PKP2)

RRO:	104668326(PKP2)

RBB:	108538140(PKP2)

TFN:	117090306(PKP2)

PTEH:

111540580(PKP2)

CANG:

105521117(PKP2)

CJC:	100389815(PKP2)

SBQ:	101041717(PKP2)

CIMI:

108288826(PKP2)

CSYR:

103276331(PKP2)

MMUR:

105884877(PKP2)

LCAT:

123639866(PKP2)

PCOQ:

105807615(PKP2)

OGA:	100963425(PKP2)

MMU:	67451(Pkp2)

MCAL:

110311414(Pkp2)

MPAH:

110329672(Pkp2)

RNO:	287925(Pkp2)

MCOC:

116085628(Pkp2)

ANU:	117718048(Pkp2)

MUN:	110562071(Pkp2)

CGE:	100751405(Pkp2)

MAUA:

101830795(Pkp2)

PROB:

127226879(Pkp2)

PLEU:

114710536(Pkp2)

MORG:

121464943(Pkp2)

MFOT:

126490288

AAMP:

119824863(Pkp2)

NGI:	103731289(Pkp2)

HGL:	101710970(Pkp2)

CPOC:

100728409(Pkp2)

CCAN:

109699966(Pkp2)

DORD:

105998623(Pkp2)

DSP:	122106353(Pkp2)

PLOP:

125366440(Pkp2)

NCAR:

124983014

MMMA:

107148544(Pkp2)

OCU:

100347738

OPI:	101536372(PKP2)

TUP:	102475525(PKP2)

GVR:	103593632(PKP2)

CFA:	486613(PKP2)

CLUD:

112665600(PKP2)

VVP:	112921047(PKP2)

VLG:	121480132(PKP2)

NPO:	129505705(PKP2)

AML:	100473614(PKP2)

UMR:	103656158(PKP2)

UAH:	113257739(PKP2)

UAR:	123801678(PKP2)

ELK:

111161331

LLV:

125106687

MPUF:

101679436(PKP2)

MNP:	132019584(PKP2)

MLK:	131838888(PKP2)

NVS:	122891154(PKP2)

ORO:	101378952(PKP2)

EJU:	114216615(PKP2)

ZCA:	113922466(PKP2)

MLX:	118025516(PKP2)

NSU:	110580823(PKP2)

LWW:	102734119(PKP2)

FCA:	101091710(PKP2)

PYU:	121038737(PKP2)

PCOO:

112867523(PKP2)

PBG:	122473016(PKP2)

PVIV:

125171207(PKP2)

LRUF:

124501737

PTG:	102959417(PKP2)

PPAD:

109268816(PKP2)

PUC:

125918945

AJU:

106977407

HHV:	120242157(PKP2)

BTA:	537784(PKP2)

BOM:	102268065(PKP2)

BIU:	109559541(PKP2)

BBUB:

102391192(PKP2)

BBIS:

105003421(PKP2)

CHX:	102180831(PKP2)

OAS:	101104733(PKP2)

BTAX:

128047981(PKP2)

ODA:	120858547 120861168

CCAD:

122423765(PKP2)

MBEZ:

129536698(PKP2)

SSC:	100526169(PKP2)

CFR:	102519320(PKP2)

CBAI:

105068270(PKP2)

CDK:	105090582(PKP2)

VPC:	102531506(PKP2)

BACU:

103015188(PKP2)

BMUS:

118901780(PKP2)

LVE:	103084859(PKP2)

OOR:	101270039(PKP2)

DLE:	111176537(PKP2)

PCAD:

102974722(PKP2)

PSIU:

116761256(PKP2)

NASI:

112401040(PKP2)

ECB:	100070065(PKP2)

EPZ:	103552056(PKP2)

EAI:	106846941(PKP2)

MYB:	102241130(PKP2)

MYD:	102772596(PKP2)

MMYO:

118650923(PKP2)

MLF:	102435203(PKP2)

PKL:	118729109(PKP2)

EFUS:

103285193(PKP2)

MNA:	107528355(PKP2)

DRO:	112318308(PKP2)

AJM:	119045099(PKP2)

PDIC:

114513661(PKP2)

PHAS:

123812811(PKP2)

MMF:	118623998(PKP2)

PPAM:

129084937(PKP2)

HAI:	109372447(PKP2)

RFQ:	117029307(PKP2)

PALE:

102883913(PKP2)

PGIG:

120618287(PKP2)

PVP:	105294097(PKP2)

RAY:	107498425(PKP2)

MJV:	108398062(PKP2)

TOD:	119247547(PKP2)

SARA:

101549992(PKP2)

SETR:

126022852(PKP2)

LAV:	100666897(PKP2)

TMU:

101353217

ETF:	101647391(PKP2)

DNM:

101440750

MDO:	100012832(PKP2)

GAS:	123250304(PKP2)

SHR:	100914490(PKP2)

AFZ:

127538397

PCW:	110200462(PKP2)

OAA:	100089626(PKP2)

GGA:	418130(PKP2)

PCOC:

116226832(PKP2)

MGP:	100541032(PKP2)

CJO:	107315736(PKP2)

TPAI:

128073978(PKP2)

LMUT:

125697972(PKP2)

NMEL:

110398241(PKP2)

APLA:

101795655(PKP2)

ACYG:

106030976(PKP2)

CATA:

118250180(PKP2)

AFUL:

116489813(PKP2)

TGU:	100220559(PKP2)

LSR:	110480423(PKP2)

SCAN:

103819629(PKP2)

PMOA:

120501701(PKP2)

OTC:	121332879(PKP2)

PRUF:

121364334(PKP2)

GFR:	102034840(PKP2)

FAB:	101818495(PKP2)

OMA:	130248677(PKP2)

PHI:	102102575(PKP2)

PMAJ:

107205123(PKP2)

CCAE:

111936604(PKP2)

CCW:	104696204(PKP2)

CBRC:

103619562(PKP2)

ETL:	114062602(PKP2)

ZAB:	102069750(PKP2)

ACHL:

103808469(PKP2)

SVG:	106856332(PKP2)

MMEA:

130582835(PKP2)

HRT:	120752098(PKP2)

FPG:	101918476(PKP2)

FCH:	102051823(PKP2)

CLV:	102091612(PKP2)

EGZ:	104126130(PKP2)

NNI:	104020258(PKP2)

PCRI:

104038536(PKP2)

PLET:

104623677(PKP2)

EHS:	104507833(PKP2)

PCAO:

104042983(PKP2)

ACUN:

113491455(PKP2)

TALA:

104360685(PKP2)

PADL:

103924392(PKP2)

AFOR:

103906430(PKP2)

ACHC:

115352712(PKP2)

HALD:

104310407(PKP2)

HLE:	104830959(PKP2)

AGEN:

126047895

GCL:

127022734

CCRI:

104168681(PKP2)

CSTI:

104559387(PKP2)

CMAC:

104473302(PKP2)

MUI:	104540293(PKP2)

BREG:

104632196

FGA:	104076472(PKP2)

GSTE:

104262526(PKP2)

MNB:	103768584(PKP2)

OHA:	104336043(PKP2)

NNT:	104399196(PKP2)

SHAB:

115605424(PKP2)

DPUB:

104299480(PKP2)

PGUU:

104468688(PKP2)

ACAR:

104523102(PKP2)

CPEA:

104398147(PKP2)

AVIT:

104275862(PKP2)

CVF:	104288289(PKP2)

RTD:	128904077(PKP2)

CUCA:

104056345(PKP2)

TEO:	104374417(PKP2)

AAM:	106488825(PKP2)

AROW:

112974967(PKP2)

NPD:	112948145(PKP2)

TGT:	104570904(PKP2)

DNE:	112995051(PKP2)

SCAM:

104147305(PKP2)

ASN:	102380892(PKP2)

AMJ:	102570415(PKP2)

CPOO:

109316505(PKP2)

GGN:	109296186(PKP2)

PSS:	102453372(PKP2)

CMY:	102938054(PKP2)

CCAY:

125626706(PKP2)

DCC:	119860055(PKP2)

CPIC:

101947263(PKP2)

TST:	117881995(PKP2)

CABI:

116825690(PKP2)

MRV:	120388962(PKP2)

ACS:	100565701(pkp2)

ASAO:

132775678(PKP2)

PVT:	110078267(PKP2)

SUND:

121931763(PKP2)

PBI:	103058934(PKP2)

PMUR:

107287197(PKP2)

CTIG:

120307496(PKP2)

TSR:	106542819(PKP2)

PGUT:

117655320(PKP2)

APRI:

131202252(PKP2)

PTEX:

113450931(PKP2)

NSS:	113432853(PKP2)

VKO:	123025374(PKP2)

PMUA:

114605400(PKP2)

PRAF:

128422067(PKP2)

ZVI:	118091483(PKP2)

HCG:	128327974(PKP2)

GJA:	107111846(PKP2)

STOW:

125435824(PKP2)

EMC:	129335986(PKP2)

XLA:	108712244(pkp2.S) 443776(pkp2.L)

XTR:	100124891(pkp2)

NPR:	108786736(PKP2)

RTEM:

120932825(PKP2)

BBUF:

121003827(PKP2)

BGAR:

122928520(PKP2)

MUO:	115477407(PKP2)

GSH:	117364002(PKP2)

DRE:	568060(pkp2)

SRX:

107725677

SANH:

107659846 107694692

SGH:	107586091 107589947

CAUA:

113048023 113063455 113065354

CGIB:

127956523 127975079

PTET:

122343460(pkp2)

LROH:

127164478(pkp2)

OMC:	131539586(pkp2)

PPRM:

120477052(pkp2)

RKG:	130071134(pkp2)

MAMB:

125244535(pkp2)

CIDE:

127510808

MASI:

127436939

TROS:

130548235(pkp2)

TDW:	130421006(pkp2)

MANU:

129432180(pkp2) 129432569

IPU:

108274996

IFU:	128617804(pkp2)

PHYP:

113530092

SMEO:

124392516(pkp2)

TFD:	113653878(pkp2)

TVC:	132857076(pkp2)

AMEX:

103028799(pkp2)

CMAO:

118812010(pkp2)

EEE:	113577997(pkp2)

CHAR:

105897492(pkp2)

TRU:	101067050(pkp2)

TFS:	130519046(pkp2)

TNG:	GSTEN00034209G001

LCO:	104933917(pkp2)

TBEN:

117483308(pkp2)

CGOB:

115028463(pkp2)

PGEO:

117442731(pkp2)

GACU:

117535962(pkp2)

EMAC:

134879411(pkp2)

ELY:	117249013(pkp2)

EFO:	125883152(pkp2)

PLEP:

121961384(pkp2)

SLUC:

116060169(pkp2)

ECRA:

117938603(pkp2)

ESP:	116673468(pkp2)

PFLV:

114550140(pkp2)

GAT:	120817783(pkp2)

PPUG:

119211623(pkp2)

AFB:	129112527(pkp2)

CLUM:

117725907(pkp2)

PSWI:

130200548(pkp2)

MSAM:

119918357(pkp2)

SCHU:

122870986(pkp2)

CUD:	121505276(pkp2)

ALAT:

119032156(pkp2)

MZE:	101479702(pkp2)

ONL:	100692162(pkp2)

OAU:	116309819(pkp2)

OLA:

101170562

OML:

112157121

CSAI:

133424370(pkp2)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

CVG:

CTUL:

119783958(pkp2)

GMU:	124882665(pkp2)

NFU:	107384871(pkp2)

KMR:	108235040(pkp2)

ALIM:

106521778(pkp2)

NWH:	119428066(pkp2)

AOCE:

111565845(pkp2)

MCEP:

124999898(pkp2)

CSEM:

103382817

POV:	109632652(pkp2)

SSEN:

122766095(pkp2)

HHIP:

117757562(pkp2)

HSP:	118101269(pkp2)

SMAU:

118317468(pkp2)

LCF:

108890166

SDU:	111224830(pkp2)

SLAL:

111663638(pkp2)

XGL:	120797260(pkp2)

HCQ:	109520103(pkp2)

SSCV:

125992323

SBIA:

133493533(pkp2)

PEE:	133397045(pkp2)

PTAO:

133472248(pkp2)

BPEC:

110161804(pkp2)

MALB:

109959779(pkp2)

SJO:	128353092(pkp2)

SASA:

106576400 106609524(pkp2)

STRU:

115180223 115199044

OTW:	112264544(pkp2)

OMY:	110490526 110499941

OGO:	124014067(pkp2)

ONE:

115132952

OKI:	109878975 109896569(pkp2)

OKE:	118392519(pkp2)

SALP:

111981758 112079311

SNH:	120031862 120049991

CCLU:

121543476 121543617 123489415

ELS:	105005927(pkp2)

SFM:

108933875

PKI:

111842412

AANG:

118230987(pkp2)

LOC:

102693356

PSPA:

121318411 121319686

ARUT:

117414882 117419948

PSEX:

120534238(pkp2)

LCM:	102361364(PKP2)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

Reference

PMID:8922383

Authors

Mertens C, Kuhn C, Franke WW

Title

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque.

Journal

J Cell Biol 135:1009-25 (1996)
DOI:10.1083/jcb.135.4.1009

Sequence

[hsa:5318]

Reference

PMID:22781308

Authors

Kirchner F, Schuetz A, Boldt LH, Martens K, Dittmar G, Haverkamp W, Thierfelder L, Heinemann U, Gerull B

Title

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.

Journal

Circ Cardiovasc Genet 5:400-11 (2012)
DOI:10.1161/CIRCGENETICS.111.961854

Sequence

[hsa:5318]

LinkDB

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