KEGG   ORTHOLOGY: K13318
Entry
K13318                      KO                                     
Symbol
eryBIV, tylCIV, tylC2
Name
dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00798  dTDP-L-mycarose biosynthesis
Reaction
R06436  dTDP-L-mycarose:NADP+ 4-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13318  eryBIV, tylCIV, tylC2; dTDP-4-keto-6-deoxy-L-hexose 4-reductase
Genes
SCYE: R2B67_24705
SAMB: SAM23877_5606(srm31)
SNR: SNOUR_10150(eryBIV)
SALJ: SMD11_1676(eryBIV)
SBRO: GQF42_07455
SMOB: J7W19_00840
SMAO: CAG99_12100
SAOV: G3H79_01865
SCAE: IHE65_08950
SPRF: K4G22_02645
STRJ: H7827_10080
KNB: ACF9IK_31685
SAIU: J4H86_24135
SEN: SACE_0720(eryBIV)
AROO: NQK81_15395
ACOR: LCL61_00275
AMYS: CVV72_21500
KUT: JJ691_70320
AAUR: V5P93_001201(knm29)
AG: AAD41822(tylCIV) AAG13916(megBIV)
 » show all
Reference
PMID:9353926
  Authors
Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.
  Title
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.
  Journal
Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251
  Sequence
[sen:SACE_0720]
Reference
PMID:10658660
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence
[ag:AAD41822]
Reference
PMID:15984840
  Authors
Takahashi H, Liu YN, Chen H, Liu HW
  Title
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
  Journal
J Am Chem Soc 127:9340-1 (2005)
DOI:10.1021/ja051409x
LinkDB

KEGG   REACTION: R06436
Entry
R06436                      Reaction                               
Name
dTDP-L-mycarose:NADP+ 4-oxidoreductase
Definition
dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose + NADPH + H+ <=> dTDP-L-mycarose + NADP+
Equation
C11915 + C00005 + C00080 <=> C11916 + C00006
Comment
4-oxoreductase,EryB4 TylC4
Reaction class
RC00001  C00005_C00006
RC00261  C11915_C11916
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00798  dTDP-L-mycarose biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R06436  dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose + NADPH + H+ <=> dTDP-L-mycarose + NADP+
Orthology
K13318  dTDP-4-keto-6-deoxy-L-hexose 4-reductase [EC:1.1.1.-]
LinkDB

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