KEGG   ORTHOLOGY: K13394
Entry
K13394                      KO                                     
Symbol
COR1
Name
codeinone reductase [EC:1.1.1.247]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00944  Morphine biosynthesis, (S)-reticuline => morphine
Reaction
R03592  morphine:NAD(P)+ 6-oxidoreductase
R05124  codeine:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13394  COR1; codeinone reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.247  codeinone reductase (NADPH)
     K13394  COR1; codeinone reductase
Other DBs
GO: 0047036
Genes
MING: 122080318
PSOM: 113293958 113294469 113328200 113328201
AG: AAF13736(COR1)
Reference
PMID:10417697
  Authors
Unterlinner B, Lenz R, Kutchan TM
  Title
Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum.
  Journal
Plant J 18:465-75 (1999)
DOI:10.1046/j.1365-313X.1999.00470.x
  Sequence
[ag:AAF13736]
LinkDB

KEGG   ENZYME: 1.1.1.247
Entry
EC 1.1.1.247                Enzyme                                 
Name
codeinone reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
codeine:NADP+ oxidoreductase
Reaction(IUBMB)
codeine + NADP+ = codeinone + NADPH + H+ [RN:R05124]
Reaction(KEGG)
R05124;
(other) R03592
Substrate
codeine [CPD:C06174];
NADP+ [CPD:C00006]
Product
codeinone [CPD:C06171];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.
History
EC 1.1.1.247 created 1999, modified 2001
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13394  codeinone reductase
Genes
MING: 122080318
PSOM: 113293958 113294469 113328200 113328201
Reference
1
  Authors
Lenz R, Zenk MH.
  Title
Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum.
  Journal
Tetrahedron Lett 36:2449-2452 (1995)
Reference
2  [PMID:7588736]
  Authors
Lenz R, Zenk MH.
  Title
Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants.
  Journal
Eur J Biochem 233:132-9 (1995)
DOI:10.1111/j.1432-1033.1995.132_1.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.247
IUBMB Enzyme Nomenclature: 1.1.1.247
ExPASy - ENZYME nomenclature database: 1.1.1.247
BRENDA, the Enzyme Database: 1.1.1.247
CAS: 153302-41-1
LinkDB

KEGG   REACTION: R05124
Entry
R05124                      Reaction                               
Name
codeine:NADP+ oxidoreductase
Definition
Codeine + NADP+ <=> Codeinone + NADPH + H+
Equation
C06174 + C00006 <=> C06171 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00206  C06171_C06174
Enzyme
1.1.1.247
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.247
     R05124  Codeine + NADP+ <=> Codeinone + NADPH + H+
Orthology
K13394  codeinone reductase [EC:1.1.1.247]
Other DBs
RHEA: 19212
LinkDB

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