KEGG ORTHOLOGY: K13937

ORTHOLOGY: K13937

Entry

K13937                      KO

Symbol

H6PD

Name

hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]

Pathway

map00030

Pentose phosphate pathway

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01200

Carbon metabolism

Module

M00004

Pentose phosphate pathway (Pentose phosphate cycle)

M00006

Pentose phosphate pathway, oxidative phase, glucose-6P => ribulose-5P

Reaction

R02035

6-phospho-D-glucono-1,5-lactone lactonohydrolase

R02736

beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase

Disease

H01111

Cortisone reductase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13937  H6PD; hexose-6-phosphate dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.47  glucose 1-dehydrogenase [NAD(P)+]
     K13937  H6PD; hexose-6-phosphate dehydrogenase
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.31  6-phosphogluconolactonase
     K13937  H6PD; hexose-6-phosphate dehydrogenase

Other DBs

GO:	0047936 0017057

Genes

HSA:	9563(H6PD)

PTR:	100610187(H6PD)

PPS:	100993268(H6PD)

GGO:	101142424(H6PD)

PON:	100439160(H6PD)

PPYG:

129008374(H6PD)

NLE:	100588208(H6PD)

HMH:	116812882(H6PD)

SSYN:

129472624(H6PD)

MCC:	710107(H6PD)

MCF:	102115057(H6PD)

MTHB:

126952981

MNI:	105479099(H6PD)

CSAB:

103225643(H6PD)

CATY:

105580901(H6PD)

PANU:

100998776(H6PD)

TGE:	112636643(H6PD)

MLEU:

105549593(H6PD)

RRO:	104663055(H6PD)

RBB:	108517948(H6PD)

TFN:	117093357(H6PD)

PTEH:

111544637(H6PD)

CANG:

105507327(H6PD)

CJC:	100386191(H6PD)

SBQ:	101028058(H6PD)

CIMI:

108285950(H6PD)

ANAN:

105731794(H6PD)

CSYR:

103274437(H6PD)

MMUR:

105886073(H6PD)

LCAT:

123634513(H6PD)

ERUF:

138390431(H6PD)

PCOQ:

105824894(H6PD)

OGA:	100952840(H6PD)

MMU:	100198(H6pd)

MCAL:

110292201(H6pd)

MPAH:

110323039(H6pd)

RNO:	298655(H6pd)

MCOC:

116097046(H6pd)

ANU:	117708942(H6pd)

ASYL:

127681693(H6pd)

MUN:	110565586(H6pd)

CGE:	100770090(H6pd)

MAUA:

101827522(H6pd)

PROB:

127213403(H6pd)

PLEU:

114684027(H6pd)

PMAV:

102927194(H6pd)

MORG:

121441804 121448395

MFOT:

126508138

AAMP:

119817546(H6pd)

CNL:	130883584(H6pd)

NGI:	103733152(H6pd)

HGL:	101715539(H6pd)

CPOC:

100729270(H6pd)

CCAN:

109682341(H6pd)

DORD:

106000645(H6pd)

DSP:	122121493(H6pd)

DMER:

138838144(H6pd)

PLOP:

125354545(H6pd)

NCAR:

124985143

MMMA:

107155527(H6pd)

ITI:	101977122(H6pd)

OCU:

100357500

OPI:	101534992(H6PD)

OCZ:	121161469(H6PD)

TUP:	102502621(H6PD)

GVR:	103586578(H6PD)

CFA:	489642(H6PD)

CLUD:

112646880(H6PD)

VVP:	112924670(H6PD)

VLG:	121499630(H6PD)

NPO:	129497075(H6PD)

AML:	100476557(H6PD)

UMR:	103666677(H6PD)

UAH:	113270543(H6PD)

UAR:	123796185(H6PD)

ELK:

111154817

LLV:

125097582

MPUF:

101678627(H6PD)

MNP:	132000941(H6PD)

MLK:	131808943(H6PD)

NVS:	122899420(H6PD)

ORO:	101384136(H6PD)

EJU:

114213401

ZCA:	113928523(H6PD)

MLX:	118020035(H6PD)

MANO:

123860103(H6PD)

NSU:	110575118(H6PD)

LWW:	102743913(H6PD)

FCA:	101098066(H6PD)

PYU:	121020455(H6PD)

PCOO:

112848620(H6PD)

PBG:	122479905(H6PD)

PVIV:

125172593(H6PD)

LRUF:

124514849

LGF:	123597155(H6PD)

AJU:

106984893

PTG:	102961280(H6PD)

PPAD:

109274062(H6PD)

PUC:

125913608

PLEZ:

122226347(H6PD)

HHV:	120233658(H6PD)

CCRU:

144231402(H6PD)

BOM:

102267212

BIU:	109570359(SPSB1)

BJV:

133227823

BBUB:

102403227(H6PD)

BKE:	129653084(H6PD)

BBIS:

104996060(H6PD)

CHX:	102174863(H6PD)

OAS:	101114124(H6PD)

OCAN:

138416508(H6PD)

BTAX:

128061459(H6PD)

CSUM:

138090748(H6PD)

ODA:	120880179(H6PD)

CCAD:

122452568(H6PD)

MREE:

136168402(H6PD)

OVR:	110129676(H6PD)

MBEZ:

129551501(H6PD)

SSC:	110261091(H6PD)

CFR:	102515995(H6PD)

CBAI:

105070998(H6PD)

CDK:	105106995(H6PD)

VPC:	102545334(H6PD)

BACU:

103015524(H6PD)

BMUS:

118894723(H6PD)

LVE:	103083939(H6PD)

OOR:	101277991(H6PD)

LALB:

132515259(H6PD)

GMF:	115865060(H6PD)

DDP:	132426863(H6PD)

DLE:	111187044(H6PD)

PCAD:

102979692(H6PD)

PSIU:

116753126(H6PD)

PPHC:

136136236(H6PD)

NASI:

112402666(H6PD)

ECB:	100057646(H6PD)

EPZ:	103549083(H6PD)

EAI:	106826224(H6PD)

MYB:	102257733(H6PD)

MYD:	102767216(H6PD)

MMYO:

118676175(H6PD)

MLF:	106695221(H6PD)

MDT:	132231717(H6PD)

MYUM:

139002842(H6PD)

PKL:	118731964(H6PD)

EFUS:

103295302(H6PD)

MNA:	107538438(H6PD)

DRO:	112299077(H6PD)

SHON:

118986382(H6PD)

AJM:	119064079(H6PD)

PDIC:

114497935(H6PD)

PHAS:

123831789(H6PD)

MMF:	118626855(H6PD)

PPAM:

129075681(H6PD)

HAI:	109381286(H6PD)

RFQ:	117026789(H6PD)

PALE:

102883153(H6PD)

PGIG:

120583122 120585684(H6PD)

PVP:	105307224(H6PD)

RAY:	107520164(H6PD)

MJV:	108398242(H6PD)

TOD:	119235632(H6PD)

SARA:

101549889(H6PD)

SFUM:

130020362(H6PD)

SETR:

126011512(H6PD)

LAV:	100663707(H6PD)

TMU:

101347869

ETF:	101644358(H6PD)

DNM:	101437516(H6PD)

MDO:	100009940(H6PD)

GAS:	123240955(H6PD) 123253917

SHR:	100924302(H6PD)

AFZ:

127555905

PCW:	110199547(H6PD)

TVP:	118836066(H6PD)

PBRV:

138154422(H6PD)

MLAO:

141509186(H6PD)

OAA:	100082409(H6PD)

TACU:

119928944(H6PD)

GGA:	428188(H6PD)

PCOC:

116242547(H6PD)

MGP:	100545189(H6PD)

CJO:	107323555(H6PD)

TPAI:

128085136(H6PD)

LMUT:

125703255(H6PD)

NMEL:

110408549(H6PD)

APLA:

101804195(H6PD)

AACU:

137843581(H6PD)

OJA:	118177031(H6PD)

ACYG:

106044323(H6PD)

CATA:

118253413(H6PD)

AFUL:

116497492(H6PD)

TGU:	100228049(H6PD)

LSR:	110474401(H6PD)

VMC:	128818398(H6PD)

VCHA:

128798992(H6PD)

AIB:	137461967(H6PD)

SCAN:

103820784(H6PD)

PMOA:

120511102(H6PD)

OTC:	121344088(H6PD)

PRUF:

121349649(H6PD)

ATRC:

139600630(H6PD)

MATE:

118695039(H6PD)

MAEN:

136565347(H6PD)

GFR:	102045426(H6PD)

FAB:	101813192(H6PD)

OMA:	130261713(H6PD)

PHI:	102103089(H6PD)

PMAJ:

107213774(H6PD)

CCAE:

111938679(H6PD)

CCW:	104693331(H6PD)

CBRC:

103622285(H6PD)

ACOE:

138121404(H6PD)

ETL:	114056872(H6PD)

ZAB:	102064031(H6PD)

ZLE:	135456678(H6PD)

ACHL:

103808221

SVG:	106858871(H6PD)

MMEA:

130579302(H6PD)

HRT:	120762391(H6PD)

SATI:

136370870(H6PD)

CFAI:

136300498(H6PD)

CCIC:

134052903(H6PD)

FPG:	101919545(H6PD)

FCH:	102049461(H6PD)

FRS:	119144445(H6PD)

CCRI:

104167209

NNT:

104403605

SHAB:

115617342(H6PD)

ACUN:

113487806(H6PD)

ANOC:

141969326(H6PD)

SURA:

141953877(H6PD)

TALA:

104364568(H6PD)

ACHC:

115343018(H6PD)

HALD:

104324653

HLE:	104837919(H6PD)

AGEN:

126042575

HHAR:

128144107(H6PD)

BBUT:

142030874(H6PD)

GCL:

CSTI:

LDI:

MNB:

DPUB:

104305863(H6PD)

PPUS:

135190511(H6PD)

IIN:	128977476(H6PD)

AVIT:

104273490

BRHI:

104496113(H6PD)

EGZ:	104133127(H6PD)

NNI:	104008976(H6PD)

PCRI:

104024374(H6PD)

PCAO:

104048139

PARX:

142066639(H6PD)

PADL:

103917966(H6PD)

AFOR:

103907471(H6PD)

FGA:

104074404

CBOR:

142092414(H6PD)

GSTE:

104254407

CBOY:

140661587(H6PD)

MAME:

142418426(H6PD)

CLV:	102095298(H6PD)

CNIC:

135997553(H6PD)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104055577(H6PD)

PCUR:

138729998(H6PD)

TEO:	104374960(H6PD)

BREG:

104641001

GAME:

129215751(H6PD)

OHA:	104329319(H6PD)

ACAR:

104527207(H6PD)

CPEA:

104395459(H6PD)

CVF:	104290473(H6PD)

RTD:	128918261(H6PD)

CRID:

134524090(H6PD)

LMIC:

141732105(H6PD)

NARQ:

141474046(H6PD)

AAM:	106499029(H6PD)

AROW:

112970092(H6PD)

NPD:	112957379(H6PD)

TGT:	104565768(H6PD)

DNE:	112980546(H6PD)

SCAM:

104141890(H6PD)

ASN:	102369764(H6PD)

AMJ:	102562599(H6PD)

CPOO:

109314451(H6PD)

GGN:	109293705(H6PD)

PSS:	102461733(H6PD)

CIZ:	142000969(H6PD)

CMY:	102932628(H6PD)

CCAY:

125624206(H6PD)

LKP:	140900109(H6PD)

NDS:	142000828(H6PD)

DCC:	119845136(H6PD)

CPIC:

101951423(H6PD)

TST:	117867793(H6PD)

CABI:

116821947(H6PD)

MRV:	120387906(H6PD)

ACS:	100551772(h6pd)

ASAO:

132764821(H6PD)

PVT:	110073255(H6PD)

SUND:

121936550(H6PD)

PBI:	103060486(H6PD)

PMUR:

107292353(H6PD)

CTIG:

120319024(H6PD)

TSR:	106547251(H6PD)

PGUT:

117678129(H6PD)

PCAE:

139326071(H6PD)

APRI:

131187041(H6PD)

PTEX:

113446262(H6PD)

NSS:	113424636(H6PD)

VKO:	123031051(H6PD)

PMUA:

114602477(H6PD)

PRAF:

128419759(H6PD)

ZVI:	118087086(H6PD)

HCG:	128338514(H6PD)

GJA:	107110280(H6PD)

STOW:

125446066(H6PD)

EMC:	129344813(H6PD)

XLA:	108696534(h6pd.L) 108697628(h6pd.S)

XTR:	100127695(h6pd)

NPR:	108787846(H6PD)

RTEM:

120915432(H6PD)

ACAT:

141111058(H6PD)

PADS:

140340403(H6PD)

BBUF:

120997302(H6PD)

BGAR:

122928701(H6PD)

DTC:	141097875(H6PD)

PWL:	138301079(H6PD)

MUO:	115482475(H6PD)

GSH:	117349114(H6PD)

DRE:	569348(h6pd)

SRX:	107708743 107713525

SANH:

107666990 107680711

SGH:	107555977(h6pd)

CCAR:

109058644 109090282

CAUA:

113050323 113096461

CGIB:

127959241 128015869

PTET:

122347317(h6pd)

LROH:

127166861(h6pd)

GRF:	141346458(h6pd)

OMC:	131542979(h6pd)

PPRM:

120459825(h6pd)

RKG:	130089098(h6pd)

MAMB:

125273480(h6pd)

CIDE:

127514064

CERY:

137011198(h6pd)

MASI:

127445665

TROS:

130556666(h6pd)

TDW:	130424300(h6pd)

MANU:

129449933(h6pd)

PDAB:

135770097(h6pd)

IPU:

108271794

IFU:	128614666(h6pd)

PHYP:

113534509(h6pd)

SMEO:

124384136(h6pd)

TFD:	113643016(h6pd)

TVC:	132844575(h6pd)

CGAR:

128527160(h6pd)

NGRA:

132885095(h6pd)

TRN:	134316906(h6pd)

AMEX:

103045767(h6pd)

CMAO:

118808467(h6pd)

EEE:	113577968(h6pd)

CHAR:

105901908(h6pd)

SPIL:

134091892(h6pd)

ASAD:

121707400(h6pd)

TRU:	101073312(h6pd)

TFS:	130524222(h6pd)

TNG:	GSTEN00027502G001

LCO:	104920493(h6pd)

NCC:	104956358(h6pd)

TBEN:

117489519(h6pd)

CGOB:

115008689(h6pd)

PGEO:

117446277(h6pd)

GACU:

117548085(h6pd)

EMAC:

134883282(h6pd)

ELY:	117257356(h6pd)

EFO:	125898173(h6pd)

PLEP:

121949736(h6pd)

SLUC:

116051263(h6pd)

ECRA:

117942968(h6pd)

ESP:	116688466(h6pd)

PFLV:

114554348(h6pd)

GAT:	120834651(h6pd)

PPUG:

119230052(h6pd)

AFB:	129106463(h6pd)

CLUM:

117731298(h6pd)

PSWI:

130207861(h6pd)

CANA:

137796477(h6pd)

CVE:	137873797(h6pd)

MSAM:

119886350(h6pd)

SCHU:

122885297(h6pd)

EARM:

139282756(h6pd)

CUD:	121506743(h6pd)

SPUL:

138606260(h6pd)

LMIX:

132978033(h6pd)

HTC:	141807772(h6pd)

ALAT:

119020448(h6pd)

ASTR:

137595175(h6pd)

PKLU:

139211501(h6pd)

MZE:	101464302(h6pd)

ONL:	100705236(h6pd)

OAU:	116334205(h6pd)

OLA:	101167199(h6pd)

OML:	112145329(h6pd)

CSAI:

133448622(h6pd)

XMA:	102223104(h6pd)

XCO:	114136110(h6pd)

XHE:	116711040(h6pd)

PRET:

103464522(h6pd)

PFOR:

103137123(h6pd)

PLAI:

106936584(h6pd)

PMEI:

106916317(h6pd)

GAF:	122833590(h6pd)

PPRL:

129353285(h6pd)

CVG:	107089356(h6pd)

CTUL:

119775095(h6pd)

GMU:	124857025(h6pd)

NFU:	107385214(h6pd)

KMR:	108231149(h6pd)

ALIM:

106516050(h6pd)

NWH:	119412372(h6pd)

AOCE:

111584759(h6pd)

EJA:	138195548(h6pd)

BFRE:

138616458(h6pd)

MCEP:

125006267(h6pd)

CSEM:

103385698(h6pd)

POV:	109638583(h6pd)

SSEN:

122768732(h6pd)

SSOE:

131461117(h6pd)

HHIP:

117761613(h6pd)

HSP:	118104725(h6pd)

PPLT:

128461668(h6pd)

SMAU:

118309983(h6pd)

LCF:

108889991

SDU:	111222868(h6pd)

SLAL:

111648426 111651100(h6pd)

XGL:	120807414(h6pd)

HCQ:	109510667(h6pd)

SSCV:

125977164(h6pd)

SBIA:

133507270(h6pd)

PEE:	133409274(h6pd)

PTAO:

133483001(h6pd)

BPEC:

110168637(h6pd)

ENY:	140365899(h6pd)

MALB:

109959016(h6pd)

BSPL:

114855024(h6pd)

SJO:	128354960(h6pd)

SSCO:

133977621(h6pd)

TTY:	137181385(h6pd)

GMH:	115557601(h6pd)

SASA:

106565995 106582765

STRU:

115150953 115207473

OTW:	112247063 112254242

OMY:	110494665(h6pd) 110527799

OGO:	124004235 124031560

ONE:	115136313 115143453

OKI:	109890875 109898702

OKE:	118388282 118400000

OMM:	135540286 135542231

OCLA:

139369912 139413290

SALP:

111969778 111970174

SNH:	120058917(h6pd) 120065049

SFON:

129814947 129851195(h6pd)

CCLU:

121574866(h6pd) 121578400

ELS:	105025428(h6pd)

OEP:	134018575(h6pd)

SFM:	108933884(h6pd)

PKI:	111852979(h6pd)

AANG:

118211715(h6pd)

AROT:

135237448(h6pd)

CCOG:

133109979(h6pd)

LOC:	102696021(h6pd)

PSPA:

121328817(h6pd) 121328964

ARUT:

117425883 117432038

PSEX:

120530846(h6pd)

LCM:	102349672(H6PD)

CMK:

103184186

RTP:	109918006(h6pd)

CPLA:

122540427(h6pd)

CPUN:

140486935(h6pd)

HOC:	132833593(h6pd)

SCAU:

119950787(h6pd)

LERI:

129711728(h6pd)

HAKA:

140718460(h6pd)

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

CLEP:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	100372939(H6PD)

PFLL:

139139940

HRO:	HELRODRAFT_111140

LGI:	LOTGIDRAFT_135691

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:	124268791 124269089

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

RES:

TAD:	TRIADDRAFT_20384

AQU:

105314200

CCLM:

134180947

SRE:	PTSG_02535

» show all

Reference

PMID:12831846

Authors

Clarke JL, Mason PJ

Title

Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity.

Journal

Arch Biochem Biophys 415:229-34 (2003)
DOI:10.1016/S0003-9861(03)00229-7

Sequence

[mmu:100198]

Reference

PMID:10349511

Authors

Mason PJ, Stevens D, Diez A, Knight SW, Scopes DA, Vulliamy TJ

Title

Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression.

Journal

Blood Cells Mol Dis 25:30-7 (1999)
DOI:10.1006/bcmd.1999.0224

Sequence

[hsa:9563]

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