KEGG   REACTION: R02736
Entry
R02736                      Reaction                               
Name
beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
Definition
beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
Equation
C01172 + C00006 <=> C01236 + C00005 + C00080
Comment
irreversible
Reaction class
RC00001  C00005_C00006
RC00066  C01172_C01236
Enzyme
1.1.1.49        1.1.1.363
Pathway
rn00030  Pentose phosphate pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00004  Pentose phosphate pathway (Pentose phosphate cycle)
M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.49
     R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
    1.1.1.363
     R02736  beta-D-Glucose 6-phosphate + NADP+ <=> D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.49
   R00835  D-Glucose 6-phosphate
    R02736  beta-D-Glucose 6-phosphate
  1.1.1.363
   R00835  D-Glucose 6-phosphate
    R02736  beta-D-Glucose 6-phosphate
Orthology
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
Reference
1  [PMID:14275652]
  Authors
SALAS M, VINUELA E, SOLS A.
  Title
SPONTANEOUS AND ENZYMATICALLY CATALYZED ANOMERIZATION OF GLUCOSE 6-PHOSPHATE AND  ANOMERIC SPECIFICITY OF RELATED ENZYMES.
  Journal
J Biol Chem 240:561-8 (1965)
Reference
2  [PMID:11457850]
  Authors
Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F.
  Title
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.
  Journal
J Biol Chem 276:34840-6 (2001)
DOI:10.1074/jbc.M105174200
Reference
3  [PMID:9485426]
  Authors
Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR
  Title
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
  Journal
Biochemistry 37:2759-67 (1998)
DOI:10.1021/bi972069y
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