| Entry |
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| Symbol |
oxyT, ctcO, cts6
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| Name |
4-amino-anhydrotetracycline N4-methyltransferase [EC: 2.1.1.335]
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| Pathway |
| map01057 | Biosynthesis of type II polyketide products |
| map01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00780 | Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline |
| M00823 | Chlortetracycline biosynthesis, pretetramide => chlortetracycline |
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| Reaction |
| R09191 | S-adenosyl-L-methionine:4-amino-anhydrotetracycline N-methyltransferase |
| R11520 | S-adenosyl-L-methionine:4-amino-anhydrotetracycline N-methyltransferase |
| R11521 | S-adenosyl-L-methionine:4-methylamino-4-de(dimethylamino)anhydrotetracycline N-methyltransferase |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01057 Biosynthesis of type II polyketide products
K14255 oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
00253 Tetracycline biosynthesis
K14255 oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K14255 oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.335 4-amino-anhydrotetracycline N4-methyltransferase
K14255 oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
Methylase
K14255 oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
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| Genes |
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| Reference |
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| Authors |
Zhang W, Ames BD, Tsai SC, Tang Y |
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| Title |
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J |
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| Title |
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. |
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| Journal |
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| LinkDB |
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