KEGG   ORTHOLOGY: K15849
Entry
K15849                      KO                                     
Symbol
PAT, AAT
Name
bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
Pathway
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00950  Isoquinoline alkaloid biosynthesis
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00360 Phenylalanine metabolism
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.1  aspartate transaminase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
    2.6.1.78  aspartate---prephenate aminotransferase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
    2.6.1.79  glutamate---prephenate aminotransferase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Other DBs
RN: R00694 R00734 R01731 R07276
GO: 0004069 0033853 0033854
Genes
ONE: 115119215
SDM: 118196575
ATH: AT2G22250(AAT)
ALY: 9316505
CRB: 17887943
CSAT: 104713666 104751865 109124540
EUS: EUTSA_v10000093mg
BRP: 103837904 103864337
BNA: 106368705 106375928 106411660 106446400
BOE: 106311364 106337354
THJ: 104824869
CPAP: 110819109
CIT: 102629885
PVY: 116122609
TCC: 18611614
CAM: 101498423
LJA: Lj4g3v2819890.1(Lj4g3v2819890.1) Lj6g3v0527170.1(Lj6g3v0527170.1)
FVE: 101298618
RCN: 112186138
PPER: 18772763
PMUM: 103332445
PAVI: 110745611
PDUL: 117631225
ZJU: 107425444
MNT: 21399659
CSV: 101212914
CMO: 103494808
BHJ: 120070262
MCHA: 111008458
CMAX: 111480013
CMOS: 111447760
CPEP: 111809015
RCU: 8265602
JCU: 105650883
MESC: 110628459
SLY: 100736464(PAT)
SPEN: 107018133
SOT: 102601259
CANN: 107851006
NSY: 104225971
NTO: 104111606
NAU: 109237300
SIND: 105171137
CCAV: 112515145
DCR: 108204769
TSS: 122666669
NCOL: 116262782
OSA: 4324941
DOSA: Os01t0871300-01(Os01g0871300)
OBR: 102703547
ATS: 109754578
SITA: 101768098
SVS: 117851002
PHAI: 112884505
MUS: 103986371
DCT: 110116229
PEQ: 110020052
ATR: 18422116
PPP: 112280653
APRO: F751_2191
MIS: MICPUN_59090(ASP2)
MPP: MICPUCDRAFT_71025(ASP2)
SPAR: SPRG_20135
 » show all
Reference
  Authors
Graindorge M, Giustini C, Jacomin AC, Kraut A, Curien G, Matringe M
  Title
Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: the last homeless enzyme of aromatic amino acids biosynthesis.
  Journal
FEBS Lett 584:4357-60 (2010)
DOI:10.1016/j.febslet.2010.09.037
  Sequence
[ath:AT2G22250]
LinkDB

KEGG   ENZYME: 2.6.1.79
Entry
EC 2.6.1.79                 Enzyme                                 
Name
glutamate---prephenate aminotransferase;
prephenate transaminase (ambiguous);
PAT (ambiguous);
L-glutamate:prephenate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-arogenate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate [RN:R07276]
Reaction(KEGG)
R07276
Substrate
L-arogenate [CPD:C00826];
2-oxoglutarate [CPD:C00026]
Product
prephenate [CPD:C00254];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate---prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1].
History
EC 2.6.1.79 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
Orthology
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Genes
ONE115119215
SDM118196575
ATHAT2G22250(AAT)
ALY9316505
CRB17887943
CSAT104713666 104751865 109124540
EUSEUTSA_v10000093mg
BRP103837904 103864337
BNA106368705 106375928 106411660 106446400
BOE106311364 106337354
RSZ108808584 108811314 108848628
THJ104824869
CPAP110819109
CIT102629885
CICCICLE_v10025279mg
PVY116122609
MINC123199312 123229657
TCC18611614
GRA105783269 105804256
GHI107913684 107920431 107954697
GAB108464392 108467508
DZI111291853 111316949
EGR104418243 104418244 104418246 104420254
GMX100776446 100780254 100801361
GSJ114381509 114381810 114413137 114421887
PVUPHAVU_001G250500g PHAVU_001G250600g PHAVU_002G262100g
VRA106755649 106755872 106775438
VAR108323878 108326905 108326906
VUN114179800 114194136 114194144
CCAJ109800268 109816378
APRC113851376 113872548
MTRMTR_7g106830 MTR_8g091280
CAM101498423
LJALj4g3v2819890.1(Lj4g3v2819890.1) Lj6g3v0527170.1(Lj6g3v0527170.1)
ADU107469242 107480382
AIP107623376 107631110
AHF112715229 112733285 112771274 112783620 112791255
LANG109361317 109362679
FVE101298618
RCN112186138
PPER18772763
PMUM103332445
PAVI110745611
PDUL117631225
MDM103409994 103422257
PXB103959277 103959279 103967024
ZJU107425444
MNT21399659
CSV101212914
CMO103494808
BHJ120070262
MCHA111008458
CMAX111480013
CMOS111447760
CPEP111809015
RCU8265602
JCU105650883
HBR110648820 110649712
MESC110628459
POP112328244 7471529 7490231
PEU105113924 105136058
PALZ118031765 118043552
JRE108987596 109013250 109018267
QSU111986756 112024944
QLO115973736 115975363 115993922
TWL119998211 120012002
VVI100245826 104882479
VRI117905333 117918672
SLY100736464(PAT)
SPEN107018133
SOT102601259
CANN107851006
NTA107800597 107801356
NSY104225971
NTO104111606
NAU109237300
INI109177882 109178510
ITR115999250 116012860
SIND105171137
OEU111390067 111408519
EGT105965191 105973105
SSPL121769029 121771598 121772660 121791701
HAN110878774 110911986
ECAD122588969 122589495 122589687
LSV111876622 111876627
CCAV112515145
DCR108204769
CSIN114279547 114301446 114314303 114322129 114322130
BVG104890616 104908254
SOE110787117 110797171
CQI110694240 110701458 110702963 110736023
NNU104600083 104605921
MING122071457 122072807
TSS122666669
PSOM113331727 113347486
NCOL116262782
OSA4324941
DOSAOs01t0871300-01(Os01g0871300)
OBR102703547
BDI100830498 100840215
ATS109754578
TDC119280710 119345275
TAES123045393 123057120 123134544 123182128
SBI8062394 8077154
ZMA100274472 100276531
SITA101768098
SVS117851002
PVIR120665372 120698586
PHAI112884505
PDA103702661 103721058 120112852
EGU105033000 105037948
MUS103986371
DCT110116229
PEQ110020052
AOF109838859 109839520
ATR18422116
SMOSELMODRAFT_143343 SELMODRAFT_234146
PPP112280653
CRECHLRE_02g147302v5
VCNVOLCADRAFT_103084
CSLCOCSUDRAFT_66020
CVRCHLNCDRAFT_48481
APROF751_2191
OLUOSTLU_89248
OTAOT_ostta16g00710
BPGBathy07g04340
MISMICPUN_59090(ASP2)
MPPMICPUCDRAFT_71025(ASP2)
APUUAPUU_20113A
PTIPHATRDRAFT_bd870
FCYFRACYDRAFT_238714(PAT)
TPSTHAPSDRAFT_12030
AAFAURANDRAFT_21970
PIFPITG_01188 PITG_01195
PSOJPHYSODRAFT_331275 PHYSODRAFT_346122 PHYSODRAFT_500717 PHYSODRAFT_559953
SPARSPRG_20135
 » show all
Reference
1  [PMID:3985619]
  Authors
Bonner CA, Jensen RA.
  Title
Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris.
  Journal
Arch Biochem Biophys 238:237-46 (1985)
DOI:10.1016/0003-9861(85)90161-4
Reference
2  [PMID:2939644]
  Authors
Siehl DL, Connelly JA, Conn EE.
  Title
Tyrosine biosynthesis in Sorghum bicolor: characteristics of prephenate aminotransferase.
  Journal
Z Naturforsch [C] 41:79-86 (1986)
DOI:10.1515/znc-1986-1-213
Reference
3  [PMID:3298985]
  Authors
Bonner C, Jensen R.
  Title
Prephenate aminotransferase.
  Journal
Methods Enzymol 142:479-87 (1987)
DOI:10.1016/s0076-6879(87)42059-4
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.79
IUBMB Enzyme Nomenclature: 2.6.1.79
ExPASy - ENZYME nomenclature database: 2.6.1.79
BRENDA, the Enzyme Database: 2.6.1.79
LinkDB

KEGG   REACTION: R07276
Entry
R07276                      Reaction                               
Name
L-arogenate:2-oxoglutarate aminotransferase
Definition
L-Arogenate + 2-Oxoglutarate <=> Prephenate + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026  C00254_C00826
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01230  Biosynthesis of amino acids
Module
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Orthology
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
Other DBs
RHEA: 22883
LinkDB

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