KEGG   ORTHOLOGY: K15849
Entry
K15849                      KO                                     
Symbol
PAT, AAT
Name
bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
Pathway
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00950  Isoquinoline alkaloid biosynthesis
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Reaction
R00694  L-phenylalanine:2-oxoglutarate aminotransferase
R00734  L-tyrosine:2-oxoglutarate aminotransferase
R01731  L-arogenate:2-oxoglutarate aminotransferase
R07276  L-arogenate:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00360 Phenylalanine metabolism
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.1  aspartate transaminase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
    2.6.1.78  aspartate---prephenate aminotransferase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
    2.6.1.79  glutamate---prephenate aminotransferase
     K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Other DBs
GO: 0004069 0033853 0033854
Genes
BCOO: 119079593
ATH: AT2G22250(AAT)
ALY: 9316505
CRB: 17887943
CSAT: 104713666 104751865 109124540
EUS: EUTSA_v10000093mg
BRP: 103837904 103864337
BNA: 106368705 106375928 106411660 106446400
BOE: 106311364 106337354
RSZ: 108811314 108848628
THJ: 104824869
CPAP: 110819109
CIT: 102629885
CIC: CICLE_v10025279mg
PVY: 116122609
MINC: 123199312 123229657
TCC: 18611614
GRA: 105783269 105804256
GHI: 107913684 107920431 107954697
GAB: 108464392 108467508
HSYR: 120123584 120169913 120196201
DZI: 111291853 111316949
EGR: 104418243 104418244 104418246 104420254 120286347
RARG: 115744092
GMX: 100776446 100780254 100801361
GSJ: 114381509 114381810 114413137 114421887
PVU: 137812385 137815147 137815148
VRA: 106755649 106755872 106775438
VAR: 108323878 108326905 108326906
VUN: 114179800 114194136 114194144
VUM: 124846732 124847293
CCAJ: 109800268 109816378
APRC: 113851376 113872548
MTR: 11440930 25499524
TPRA: 123915658
CAM: 101498423
PSAT: 127101572
VVO: 131607796 131641736
LJA: 130713316 130726534
ADU: 107469242 107480382
AIP: 107623376 107631110
AHF: 112715229 112733285 112771274 112783620 112791255
LANG: 109361317 109362679
PCIN: 129320331
QSA: O6P43_023239 O6P43_030440
FVE: 101298618
AANS: 126795834
RCN: 112186138
PPER: 18772763
PMUM: 103332445
PAVI: 110745611
PDUL: 117631225
MDM: 103409994 103422257
MSYL: 126602376 126623350
PXB: 103959277 103959279 103967024
PCOX: 137720171 137734297 137739645
ZJU: 107425444
MNT: 21399659
CSAV: 115712503 115712504
CSV: 101212914
CMO: 103494808
BHJ: 120070262
MCHA: 111008458
CMAX: 111480013
CMOS: 111447760
CPEP: 111809015
RCU: 8265602
MEAN: 126656522
JCU: 105650883
HBR: 110648820 110649712
MESC: 110628459
POP: 7471529 7490231
PEU: 105113924 105136058
PALZ: 118031765 118043552
PNZ: 133672487 133695174
JRE: 108987596 109013250 109018267
CILL: 122303583 122307721
CAVE: 132165269
AGLU: 133857426 133873233
QSU: 111986756 112024944
QLO: 115973736 115975363 115993922
TWL: 119998211 120012002
VVI: 100245826 104882479
VRI: 117905333 117918672
SLY: 100736464(PAT)
SPEN: 107018133
SOT: 102601259
SSTN: 125855225
SDUL: 129902433
CANN: 107851006
LBB: 132614443
NTA: 107800597 107801356
NSY: 104225971
NTO: 104111606
NAU: 109237300
INI: 109177882 109178510
ITR: 115999250 116012860
SIND: 105171137
OEU: 111390067 111408519
EGT: 105965191 105973105
SSPL: 121769029 121771598 121772660
SMIL: 131001395 131003542
SHIS: 125213417
APAN: 127258587
HPUM: 140886976
PHUA: 140964742
PEBU: 140836991
HAN: 110878774 110911986
ECAD: 122588969 122589495 122589687
LSV: 111876622 111876627
CCAV: 112515145
DCR: 108204769
CSIN: 114279547 114301446 114314303 114322129 114322130
RVL: 131298190 131298191 131324330
AEW: 130784834 130785629 130785639
DLT: 127800707 127803831 127803832
BVG: 104890616 104908254
SOE: 110797171
CQI: 110694240 110701458 110702963 110736023
ATRI: 130818043
SLAF: 141595852 141595853
MOF: 131159196
NNU: 104600083 104605921
MING: 122071457 122072807
TSS: 122666669
PSOM: 113331727 113347486
OSA: 4324941
DOSA: Os01g0871300
OBR: 102703547
OGL: 127760981
BDI: 100830498 100840215
ATS: 109754578
TDC: 119280710 119345275
TAES: 123045393 123057120 123134544 123182128
TUA: 125519452
LPER: 127323909
LRD: 124707469
SBI: 8062394 8077154
ZMA: 100274472 100276531
MFLO: 136450814 136512366
SITA: 101768098
SVS: 117851002
PVIR: 120665372 120698586
PHAI: 112884505
PAUA: 133885701 133928939
TANG: 140773404
PDA: 103702661 103721058 120112852
EGU: 105033000 105037948
MUS: 103986371
ZOF: 121971164 121976504 121980881 121984758
DCT: 110116229
PEQ: 110020052
AOF: 109838859 109839520
MSIN: 131232763
ACAK: 137936519
NCOL: 116262782
ATR: 18422116
CJF: 131071892
SMO: SELMODRAFT_143343 SELMODRAFT_234146
PPP: 112280653
CRE: CHLRE_02g147302v5
VCN: VOLCADRAFT_103084
CSL: COCSUDRAFT_66020
CVR: CHLNCDRAFT_48481
APRO: F751_2191
OLU: OSTLU_89248
OTA: OT_ostta16g00710
BPG: Bathy07g04340
MIS: MICPUN_59090(ASP2)
MPP: MICPUCDRAFT_71025(ASP2)
TATV: 25784928(TrAtP1_010648)
TASP: 36617376(TrAFT101_009415)
PCHM: VFPPC_10485
APUU: APUU_20113A
PTI: PHATRDRAFT_bd870
FCY: FRACYDRAFT_238714(PAT)
TPS: THAPSDRAFT_12030
AAF: AURANDRAFT_21970
PIF: PITG_01188 PITG_01195
PSOJ: PHYSODRAFT_331275 PHYSODRAFT_346122 PHYSODRAFT_500717 PHYSODRAFT_559953
SPAR: SPRG_20135
 » show all
Reference
PMID:20883697
  Authors
Graindorge M, Giustini C, Jacomin AC, Kraut A, Curien G, Matringe M
  Title
Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: the last homeless enzyme of aromatic amino acids biosynthesis.
  Journal
FEBS Lett 584:4357-60 (2010)
DOI:10.1016/j.febslet.2010.09.037
  Sequence
[ath:AT2G22250]
LinkDB

KEGG   ENZYME: 2.6.1.79
Entry
EC 2.6.1.79                 Enzyme                                 
Name
glutamate---prephenate aminotransferase;
prephenate transaminase (ambiguous);
PAT (ambiguous);
L-glutamate:prephenate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-arogenate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-arogenate + 2-oxoglutarate = prephenate + L-glutamate [RN:R07276]
Reaction(KEGG)
R07276
Substrate
L-arogenate [CPD:C00826];
2-oxoglutarate [CPD:C00026]
Product
prephenate [CPD:C00254];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate---prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1].
History
EC 2.6.1.79 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
Orthology
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase
Genes
BCOO: 119079593
ATH: AT2G22250(AAT)
ALY: 9316505
CRB: 17887943
CSAT: 104713666 104751865 109124540
EUS: EUTSA_v10000093mg
BRP: 103837904 103864337
BNA: 106368705 106375928 106411660 106446400
BOE: 106311364 106337354
RSZ: 108811314 108848628
THJ: 104824869
CPAP: 110819109
CIT: 102629885
CIC: CICLE_v10025279mg
PVY: 116122609
MINC: 123199312 123229657
TCC: 18611614
GRA: 105783269 105804256
GHI: 107913684 107920431 107954697
GAB: 108464392 108467508
HSYR: 120123584 120169913 120196201
DZI: 111291853 111316949
EGR: 104418243 104418244 104418246 104420254 120286347
RARG: 115744092
GMX: 100776446 100780254 100801361
GSJ: 114381509 114381810 114413137 114421887
PVU: 137812385 137815147 137815148
VRA: 106755649 106755872 106775438
VAR: 108323878 108326905 108326906
VUN: 114179800 114194136 114194144
VUM: 124846732 124847293
CCAJ: 109800268 109816378
APRC: 113851376 113872548
MTR: 11440930 25499524
TPRA: 123915658
CAM: 101498423
PSAT: 127101572
VVO: 131607796 131641736
LJA: 130713316 130726534
ADU: 107469242 107480382
AIP: 107623376 107631110
AHF: 112715229 112733285 112771274 112783620 112791255
LANG: 109361317 109362679
PCIN: 129320331
QSA: O6P43_023239 O6P43_030440
FVE: 101298618
AANS: 126795834
RCN: 112186138
PPER: 18772763
PMUM: 103332445
PAVI: 110745611
PDUL: 117631225
MDM: 103409994 103422257
MSYL: 126602376 126623350
PXB: 103959277 103959279 103967024
PCOX: 137720171 137734297 137739645
ZJU: 107425444
MNT: 21399659
CSAV: 115712503 115712504
CSV: 101212914
CMO: 103494808
BHJ: 120070262
MCHA: 111008458
CMAX: 111480013
CMOS: 111447760
CPEP: 111809015
RCU: 8265602
MEAN: 126656522
JCU: 105650883
HBR: 110648820 110649712
MESC: 110628459
POP: 7471529 7490231
PEU: 105113924 105136058
PALZ: 118031765 118043552
PNZ: 133672487 133695174
JRE: 108987596 109013250 109018267
CILL: 122303583 122307721
CAVE: 132165269
AGLU: 133857426 133873233
QSU: 111986756 112024944
QLO: 115973736 115975363 115993922
TWL: 119998211 120012002
VVI: 100245826 104882479
VRI: 117905333 117918672
SLY: 100736464(PAT)
SPEN: 107018133
SOT: 102601259
SSTN: 125855225
SDUL: 129902433
CANN: 107851006
LBB: 132614443
NTA: 107800597 107801356
NSY: 104225971
NTO: 104111606
NAU: 109237300
INI: 109177882 109178510
ITR: 115999250 116012860
SIND: 105171137
OEU: 111390067 111408519
EGT: 105965191 105973105
SSPL: 121769029 121771598 121772660
SMIL: 131001395 131003542
SHIS: 125213417
APAN: 127258587
HPUM: 140886976
PHUA: 140964742
PEBU: 140836991
HAN: 110878774 110911986
ECAD: 122588969 122589495 122589687
LSV: 111876622 111876627
CCAV: 112515145
DCR: 108204769
CSIN: 114279547 114301446 114314303 114322129 114322130
RVL: 131298190 131298191 131324330
AEW: 130784834 130785629 130785639
DLT: 127800707 127803831 127803832
BVG: 104890616 104908254
SOE: 110797171
CQI: 110694240 110701458 110702963 110736023
ATRI: 130818043
SLAF: 141595852 141595853
MOF: 131159196
NNU: 104600083 104605921
MING: 122071457 122072807
TSS: 122666669
PSOM: 113331727 113347486
OSA: 4324941
DOSA: Os01g0871300
OBR: 102703547
OGL: 127760981
BDI: 100830498 100840215
ATS: 109754578
TDC: 119280710 119345275
TAES: 123045393 123057120 123134544 123182128
TUA: 125519452
LPER: 127323909
LRD: 124707469
SBI: 8062394 8077154
ZMA: 100274472 100276531
MFLO: 136450814 136512366
SITA: 101768098
SVS: 117851002
PVIR: 120665372 120698586
PHAI: 112884505
PAUA: 133885701 133928939
TANG: 140773404
PDA: 103702661 103721058 120112852
EGU: 105033000 105037948
MUS: 103986371
ZOF: 121971164 121976504 121980881 121984758
DCT: 110116229
PEQ: 110020052
AOF: 109838859 109839520
MSIN: 131232763
ACAK: 137936519
NCOL: 116262782
ATR: 18422116
CJF: 131071892
SMO: SELMODRAFT_143343 SELMODRAFT_234146
PPP: 112280653
CRE: CHLRE_02g147302v5
VCN: VOLCADRAFT_103084
CSL: COCSUDRAFT_66020
CVR: CHLNCDRAFT_48481
APRO: F751_2191
OLU: OSTLU_89248
OTA: OT_ostta16g00710
BPG: Bathy07g04340
MIS: MICPUN_59090(ASP2)
MPP: MICPUCDRAFT_71025(ASP2)
TATV: 25784928(TrAtP1_010648)
TASP: 36617376(TrAFT101_009415)
PCHM: VFPPC_10485
APUU: APUU_20113A
PTI: PHATRDRAFT_bd870
FCY: FRACYDRAFT_238714(PAT)
TPS: THAPSDRAFT_12030
AAF: AURANDRAFT_21970
PIF: PITG_01188 PITG_01195
PSOJ: PHYSODRAFT_331275 PHYSODRAFT_346122 PHYSODRAFT_500717 PHYSODRAFT_559953
SPAR: SPRG_20135
 » show all
Reference
1  [PMID:3985619]
  Authors
Bonner CA, Jensen RA.
  Title
Novel features of prephenate aminotransferase from cell cultures of Nicotiana silvestris.
  Journal
Arch Biochem Biophys 238:237-46 (1985)
DOI:10.1016/0003-9861(85)90161-4
Reference
2  [PMID:2939644]
  Authors
Siehl DL, Connelly JA, Conn EE.
  Title
Tyrosine biosynthesis in Sorghum bicolor: characteristics of prephenate aminotransferase.
  Journal
Z Naturforsch [C] 41:79-86 (1986)
DOI:10.1515/znc-1986-1-213
Reference
3  [PMID:3298985]
  Authors
Bonner C, Jensen R.
  Title
Prephenate aminotransferase.
  Journal
Methods Enzymol 142:479-87 (1987)
DOI:10.1016/s0076-6879(87)42059-4
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.79
IUBMB Enzyme Nomenclature: 2.6.1.79
ExPASy - ENZYME nomenclature database: 2.6.1.79
BRENDA, the Enzyme Database: 2.6.1.79
LinkDB

KEGG   REACTION: R07276
Entry
R07276                      Reaction                               
Name
L-arogenate:2-oxoglutarate aminotransferase
Definition
L-Arogenate + 2-Oxoglutarate <=> Prephenate + L-Glutamate
Equation
C00826 + C00026 <=> C00254 + C00025
Reaction class
RC00006  C00025_C00026  C00254_C00826
Enzyme
2.6.1.79
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01230  Biosynthesis of amino acids
Module
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.79
     R07276  L-Arogenate + 2-Oxoglutarate <=> Prephenate + L-Glutamate
Orthology
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
Other DBs
RHEA: 22883
LinkDB

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